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Flow of Cortical Activity Underlying a Tactile Decision in Mice
Open accessAbstract
Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of interconnected areas contribute at the same time? Here we delineate when and how activity in specific areas drives a whisker-based decision in mice. A short-term memory component temporally separated tactile "sensation" and "action" (licking). Using optogenetic inhibition (spatial resolution, 2 mm; temporal resolution, 100 ms), we surveyed the neocortex for regions driving behavior during specific behavioral epochs. Barrel cortex was critical for sensation. During the short-term memory, unilateral inhibition of anterior lateral motor cortex biased responses to the ipsilateral side. Consistently, barrel cortex showed stimulus-specific activity during sensation, whereas motor cortex showed choice-specific preparatory activity and movement-related activity, consistent with roles in motor planning and movement. These results suggest serial information flow from sensory to motor areas during perceptual decision making.
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“Hence, peak 4 is likely to reflect participation of the primary somatosensory cortex in motor preparatory activity, often observed in higher motor cortices (12–14).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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“Serial transformation of sensory inputs along bottom–up hierarchical pathways has been observed in rodents engaged in whisker-discrimination tasks (8, 9) with an increasingly stronger association with perceptual choice in S2 (10, 11) and premotor areas (12–14) rather than whisker-related wS1 (9).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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“Therefore, this global regulation is unlikely to originate directly from frontal cortical premotor areas (12–14) since frontal cortices have a high degree of symmetry for both ipsilateral and contralateral projections (59).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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Gated feedforward inhibition in the frontal cortex releases goal-directed action
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Top-Down-Mediated Facilitation in the Visual Cortex Is Gated by Subcortical Neuromodulation
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“Optogenetic silencing of cortex by activating ChR expressed specifically in locally projecting inhibitory neurons (Kuhlman and Huang, 2008) has proven to be a reliable and repeatable method (Li et al., 2013; Lien and Scanziani, 2013; Guo et al., 2014).”
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BackgroundThe Posterior Parietal Cortex as Integrative Hub for Whisker Sensorimotor Information
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InfluentialThalamic afferents to prefrontal cortices from ventral motor nuclei in decision‐making
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Barrel Cortex: What is it Good for?
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BackgroundABLE: An Activity-Based Level Set Segmentation Algorithm for Two-Photon Calcium Imaging Data
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MethodAccurate Localization of Linear Probe Electrode Arrays across Multiple Brains
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MethodInfluentialSelf-citationEnhanced population coding for rewarded choices in the medial frontal cortex of the mouse
Siniscalchi, M., Wang, H., & Kwan, A. (2018) · bioRxiv · doi:10.1101/429852 · Cited by 42
“This basic two-choice setup was modeled after an earlier study (Guo et al. 2014).”
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Sources of widefield fluorescence from the brain
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BackgroundA neural substrate of sex-dependent modulation of motivation
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Neocortical dynamics during whisker-based sensory discrimination in head-restrained mice
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“1A), first in a go/no-go paradigm (Chen et al., 2013a; Guo et al., 2014b; Huber et al.; O'Connor et al., 2010a), later as a 2AFC task (Guo et al., 2014a; Li et al., 2015).”
InfluentialCortico-cerebellar interactions during goal-directed behavior
Li, N., & Mrsic‐Flogel, T. D. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.08.010 · Cited by 39
“The anterior lateral motor cortex (ALM) in the mouse is critical for motor planning and movement initiation [46-48].”
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Self-citationA stable, distributed code for cue value in mouse cortex during reward learningPreprint
Ottenheimer, D. J., Hjort, M. M., Bowen, A. J., Steinmetz, N. A., & Stuber, G. D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.13.499930 · Cited by 7
The role of motor cortex in motor sequence execution depends on demands for flexibility
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“Extracting behaviorally relevant environmental state information (and keeping it in WM) likely involves cortical processing 54,55,65 , and our results suggest that MC is an essential conduit for conveying this information to subcortical motor circuits.”
Forgetting Leads to Chaos in Attractor Networks
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Dynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning
Chéreau, R., Bawa, T., Fodoulian, L., Carleton, A., Pagès, S., & Holtmaat, A. J. D. G. (2020) · Nature Communications · doi:10.1038/s41467-020-17005-x · Cited by 52
“To control for general responses that are associated with the choice to lick (Guo et al., 2014; Li et al., 2016), we monitored task-related calcium transients, as well as whisking and licking activity, prior to the training at which the sound cue, texture presentation, and spout opening were…”
MethodPerceptual Decision-Making: A Field in the Midst of a Transformation
Najafi, F., & Churchland, A. K. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.017 · Cited by 41
Selective Suppression of Local Circuits during Movement Preparation in the Mouse Motor Cortex
Hasegawa, M., Majima, K., Itokazu, T., Maki, T., Albrecht, U.-R., Castner, N., Izumo, M., Sohya, K., Sato, T. K., Kamitani, Y., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.043 · Cited by 36
“A previous study showed robust preparatory activity of neurons just before mice initiated a licking behavior (Guo et al., 2014; rs. creativecommons.org/licenses/by-nc-nd/4.0/).”
InfluentialCortical sensory processing across motivational states during goal-directed behavior
Matteucci, G., Guyoton, M., Mayrhofer, J. M., Auffret, M., Foustoukos, G., Petersen, C. C. H., & El‐Boustani, S. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.032 · Cited by 43
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“(6)) computed the information at a single time bin that covers the whole stimulus period,”
BackgroundMethodMapping Functional Connectivity from the Dorsal Cortex to the Thalamus.
Huo, Y., Chen, H., & Guo, Z. V. (2020) · Neuron · doi:10.2139/ssrn.3427282 · Cited by 34
Self-citationAutomated home cage training of mice in a hold-still center-out reach task.
Bollu, T., Whitehead, S. C., Prasad, N., Walker, J., Shyamkumar, N., Subramaniam, R., Kardon, B., Cohen, I., & Goldberg, J. H. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00667.2018 · Cited by 34
Inactivation of medial frontal cortex changes risk preference
Chen, X.-M., & Stuphorn, V. (2018) · bioRxiv · doi:10.1101/390021 · Cited by 34
Algorithms of whisker-mediated touch perception
Maravall, M., & Diamond, M. E. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.01.014 · Cited by 34
The diversity and specificity of functional connectivity across spatial and temporal scales
Engel, T. A., Schölvinck, M. L., & Lewis, C. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118692 · Cited by 42
“The activation of local inhibitory interneurons can be used to identify key nodes in distributed networks by producing temporary lesions [106, 107, 108].”
Gilis, J., Vitting‐Seerup, K., den Berge, K. V., & Clement, L. (2021) · F1000Research · doi:10.12688/f1000research.51749.1 · Cited by 34
“49,50 Based on marker genes, Tasic et al .”
Catanese, J., & Jaeger, D. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1204-20.2020 · Cited by 33
Single-Cell Stimulation in Barrel Cortex Influences Psychophysical Detection Performance
Tanke, N., Borst, J. G. G., & Houweling, A. R. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2155-17.2018 · Cited by 38
“Whisker motion detection improves when multiple PV neurons in barrel cortex are optogenetically inhibited (Sachidhanandam et al., 2016) and gets worse when multiple PV or somatostatin interneurons are optogenetically stimulated (Guo et al., 2014; Takahashi et al., 2016; Yang et al., 2016).”
BackgroundInfluentialOptogenetic Stimulation of Cortex to Map Evoked Whisker Movements in Awake Head-Restrained Mice
Auffret, M., Ravano, V., Rossi, G. M. C., Hankov, N., Petersen, M. F. A., & Petersen, C. C. H. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.004 · Cited by 38
“The blue light was generated by a 473 nm fiber-coupled laser (Thorlabs), focused onto the mouse cortex through a 50 mm focal length camera lens (Nikon), and directed to specific locations on the mouse cortex using 2D scanning galvanometer mirrors (Thorlabs) controlled by a computer via a digital-to-analog converter (N…”
Piet, A. T., Erlich, J. C., Kopec, C. D., & Brody, C. D. (2017) · Neural Computation · doi:10.1162/neco_a_01005 · Cited by 35
“A recent study in mouse premotor cortex (ALM) found that cells are not lateralized by firing preference, but the cells that project subcortically are lateralized (Li, Chen, Guo, Gerfen, & Svoboda, 2015).”
BackgroundInfluentialHwang, E. J., Dahlen, J. E., Mukundan, M., & Komiyama, T. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3049-20.2021 · Cited by 66
“A number of studies have used this indirect photoinhibition to successfully inactivate local cortical regions (Olsen et al., 2012; Z. V. Guo et al., 2014; Peters et al., 2014; J. Z. Guo et al., 2015; Hwang et al., 2019a).”
BackgroundEmerging experience-dependent dynamics in primary somatosensory cortex reflect behavioral adaptation
Waiblinger, C., McDonnell, M., Reedy, A. R., Borden, P. Y., & Stanley, G. B. (2022) · Nature Communications · doi:10.1038/s41467-022-28193-z · Cited by 35
Murphy, T. H., Michelson, N. J., Boyd, J. D., Fong, T. L., Bolaños, L. A., Bierbrauer, D., Siu, T., Balbi, M., Bolaños, F., Vanni, M. P., et al. (2020) · eLife · doi:10.7554/elife.55964 · Cited by 42
Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task
Kyriakatos, A., Sadashivaiah, V., Zhang, Y., Motta, A., Auffret, M., & Petersen, C. C. H. (2016) · Neurophotonics · doi:10.1117/1.nph.4.3.031204 · Cited by 33
“A key future experiment will therefore be to inactivate many different cortical regions and examine the impact upon task performance, as recently carried out in a whisker object localization task.(41,43) It will be equally important to investigate where in the cortex one can stimulate to substitute for whisker stimula…”
BackgroundWhen and why does motor preparation arise in recurrent neural network models of motor control?Preprint
Schimel, M., Kao, T.-C., & Hennequin, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.03.535429 · Cited by 7
“Details of animal care, surgery, electrophysiological recordings, and behavioral task for those data can be found in the Methods section of the respective papers.”
BackgroundPeripersonal encoding of forelimb proprioception in the mouse somatosensory cortex
Alonso, I., Scheer, I., Palacio-Manzano, M., Frezel, N., Philippides, A., & Prsa, M. (2023) · Nature Communications · doi:10.1038/s41467-023-37575-w · Cited by 39
Cognitive experience alters cortical involvement in goal-directed navigation
Arlt, C., Barroso-Luque, R., Kira, S., Bruno, C. A., Xia, N., Chettih, S. N., Soares, S., Pettit, N. L., & Harvey, C. D. (2022) · eLife · doi:10.7554/elife.76051 · Cited by 34
“Photoinhibition experiments Clear skull cap surgery We followed procedures described previously (Guo et al., 2014; Minderer et al., 2019).”
BackgroundMethodInfluentialPhasic Off responses of auditory cortex underlie perception of sound duration
Li, H., Wang, J., Liu, G., Xu, J., Huang, W., Song, C., Wang, D., Tao, H. W., Zhang, L. I., & Liang, F. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109003 · Cited by 32
“These so-called "anticipatory" licks (Guo et al., 2014) gradually reduced in number with the progression of training.”
BackgroundBae, J. W., Jeong, H., Yoon, Y. J., Bae, C., Lee, H., Paik, S., & Jung, M. W. (2021) · Nature Communications · doi:10.1038/s41467-021-24565-z · Cited by 34
Shimuta, M., Sugihara, I., & Ishikawa, T. (2020) · Communications Biology · doi:10.1038/s42003-020-1110-2 · Cited by 32
Integrating multimodal data to understand cortical circuit architecture and function
Arkhipov, A. S., da Costa, N. M., de Vries, S. E. J., Bakken, T. E., Bennett, C., Bernard, A., Berg, J., Buice, M. A., Collman, F., Daigle, T. L., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01904-7 · Cited by 27
“Chen and colleagues 131 carried out Neuropixels recordings with a focus on areas that receive projections from anterolateral motor cortex (ALM), a region selective for upcoming choice in memory-guided decision-making tasks 132–134 .”
Self-citationInstant, multiscale dry transfer printing by atomic diffusion control at heterogeneous interfaces
Heo, S., Ha, J., Son, S. J., Choi, I. S., Lee, H., Oh, S., Jekal, J., Kang, M. H., Lee, G. J., Jung, H. H., et al. (2021) · Science Advances · doi:10.1126/sciadv.abh0040 · Cited by 42
“The optogenetic scalp patch, designed to locate the -LEDs on the intact or cleared skull (42) of the corresponding stimulation sites (fig.”
BackgroundSeparating cognitive and motor processes in the behaving mouse
Hasnain, M. A., Birnbaum, J. E., Nunez, J. L. U., Hartman, E. K., Chandrasekaran, C., & Economo, M. N. (2025) · Nature Neuroscience · doi:10.1038/s41593-024-01859-1 · Cited by 35
“Previous work established the necessity of the anterior lateral motor cortex (ALM) and tongue–jaw motor cortex (tjM1) for the planning and execution of tongue movements 9,31–33 .”
InfluentialSun, W., Tang, P., Liang, Y., Li, J., Feng, J., Zhang, N., Lu, D., He, J., & Chen, X. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110506 · Cited by 37
Multi-Scale Light-Sheet Fluorescence Microscopy for Fast Whole Brain Imaging
Zhang, Z., Yao, X., Yin, X., Ding, Z., Huang, T., Huo, Y., Ji, R., Peng, H., & Guo, Z. V. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.732464 · Cited by 36
“Reconstruction of Recording Locations The procedure of extracellular recording is the same as before (Guo et al., 2014; Huo et al., 2020).”
MethodSelf-citationKondo, M., & Matsuzaki, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108704 · Cited by 32
Ruediger, S., & Scanziani, M. (2020) · eLife · doi:10.7554/elife.59247 · Cited by 30
State-dependent regulation of cortical processing speed via gain modulationPreprint
Wyrick, D. G., & Mazzucato, L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.07.030700 · Cited by 3
“, 2016), or more precise corticocortical projections from prefrontal areas toward primary sensory areas (Nelson et al., 2013; Guo et al., 2014; Zhang et al., 2014; Chen et al., 2017; Leinweber et al., 2017).”
BackgroundControl of adaptive action selection by secondary motor cortex during flexible visual categorization
Wang, T.-Y., Liu, J., & Yao, H. (2020) · eLife · doi:10.7554/elife.54474 · Cited by 34
Mouse parabrachial neurons signal a relationship between bitter taste and nociceptive stimuli
Li, J., & Lemon, C. H. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2000-18.2018 · Cited by 30
“VGAT-ChR2-EYFP mice afford reversible photoinhibition of small volumes of neural tissue through selective activation of local inhibitory interneurons with blue light (Guo et al., 2014; Sofroniew et al., 2015; Wiegert et al., 2017).”
BackgroundFully autonomous mouse behavioral and optogenetic experiments in home-cage
Hao, Y., Thomas, A. M., & Li, N. (2021) · eLife · doi:10.7554/elife.66112 · Cited by 36
Self-citationNeuroSeg: automated cell detection and segmentation for in vivo two-photon Ca2+ imaging data
Guan, J., Li, J., Liang, S., Li, R., Li, X., Shi, X., Huang, C., Zhang, J., Pan, J., Jia, H., et al. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1545-5 · Cited by 29
“Information processing and computation in the brain are implemented by activity involving large numbers of neurons (Romo and de Lafuente 2013; Guo et al. 2014).”
BackgroundA combinatorial neural code for long-term motor memory
Kim, J., Daie, K., & Li, N. (2024) · Nature · doi:10.1038/s41586-024-08193-3 · Cited by 38
Self-citationNeuropixels Opto: Combining high-resolution electrophysiology and optogenetics
Lakunina, A. A., Socha, K. Z., Ladd, A., Bowen, A. J., Chen, S.-S., Colonell, J., Doshi, A., Karsh, B., Krumin, M., Kulik, P., et al. (2025) · bioRxiv · doi:10.1101/2025.02.04.636286 · Cited by 26
Self-citationUnraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model
van den Boom, B. J. G., Fernandez, A. E., Rasmussen, P. A., van Beest, E. H., Parthasarathy, A., Denys, D. A. J. P., & Willuhn, I. (2023) · Nature Communications · doi:10.1038/s41467-023-41026-x · Cited by 25
Park, J. M., Hong, Y. K., Rodgers, C. C., Dahan, J. B., Harano, N., Schmidt, E. R. E., & Bruno, R. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.12.245381 · Cited by 30
“Neurons in S1 have activity that correlates with touch, and manipulating their activity can alter detection behavior (Guo et al 2014b, Miyashita & Feldman 2013, O’Connor et al 2010, Sachidhanandam et al 2013, Yu et al 2016).”
BackgroundInfluentialInyushin, M. Y., Мешалкина, Д. А., Zueva, L. V., & Zayas‐Santiago, A. (2019) · Molecules · doi:10.3390/molecules24132388 · Cited by 33
“…made significantly thinner by mechanical removal of the external bone surface, which was replaced with an artificial transparent material (e.g., glass, silicone, acrylic, or cyanoacrylate,) to form a window into the brain (Guo et al., 2014; Kalchenko et al., 2014; Steinzeig et al., 2017) [99–101].”
BackgroundPresynaptic supervision of cortical spine dynamics in motor learning
Sohn, J., Mototaka Suzuki, A., Youssef, M., Hatada, S., Larkum, M. E., Kawaguchi, Y., & Kubota, Y. (2022) · Science Advances · doi:10.1126/sciadv.abm0531 · Cited by 29
“Given that higher-order motor areas are associated with context-dependent motor commands, goal-directed behaviors, and motor planning (12, 19, 20, 74), cognitively demanding processes during the early phase of learning involve top-down CC inputs to cortical layer 1 (75).”
BackgroundOpposing Influence of Sensory and Motor Cortical Input on Striatal Circuitry and Choice BehaviorPreprint
Lee, C. R., Yonk, A. J., Wiskerke, J., Paradiso, K. G., Tepper, J. M., & Margolis, D. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/446708 · Cited by 1
“…to secondary somatosensory cortex (S2) and primary motor cortex (M1) have been well studied (Chen et al., 2013a, 2015; Ferezou et al., 2007; Guo et al., 2014a; Helmchen et al., 2018; Kwon et al., 2016; Yamashita et al., 2013), but there is still little known about the circuitry or…”
Neural mechanisms of sensorimotor transformation and action selection
Huda, R., Goard, M. J., Pho, G. N., & Sur, M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14069 · Cited by 34
“Enabled by temporally-specific causal manipulations made possible by optogenetics, recent studies have highlighted how information flow across brain areas contributes to perceptual behaviors driven by somatosensory, auditory, and visual stimuli in mice (Chen et al., 2013; Znamenskiy & Zador, 2013; Guo et al., 2014; Li…”
Sreenivasan, V., Kyriakatos, A., Matéo, C., Jaeger, D., & Petersen, C. C. H. (2016) · Neurophotonics · doi:10.1117/1.nph.4.3.031203 · Cited by 27
Overwriting an instinct: visual cortex instructs learning to suppress fear responsesPreprint
Mederos, S., Blakely, P. R., Vissers, N., Clopath, C., & Hofer, S. B. (2024) · bioRxiv · doi:10.1101/2024.07.31.605567 · Cited by 24
“To test if neural activity in plHVAs is important for this learned suppression of escape responses, we used transgenic mice expressing channelrhodopsin-2 (ChR2) in GABAergic neurons and implanted optical fibers to silence neural activity bilaterally in plHVAs with blue light ( 36 ) .”
MethodBoucher, P. O., Wang, T., Carceroni, L., Kane, G. A., Shenoy, K. V., & Chandrasekaran, C. (2023) · Nature Communications · doi:10.1038/s41467-023-41752-2 · Cited by 30
Working memory gates visual input to primate prefrontal neurons
Noudoost, B., Clark, K., & Moore, T. (2021) · eLife · doi:10.7554/elife.64814 · Cited by 24
Single-cell molecular connectomics of intracortically-projecting neuronsPreprint
Klingler, E., Prados, J., Kebschull, J. M., Dayer, A. G., Zador, A. M., & Jabaudon, D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/378760 · Cited by 18
Variable Temporal Integration of Stimulus Patterns in the Mouse Barrel Cortex
Pitas, A., Albarracín, A. L., Molano‐Mazón, M., & Maravall, M. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw006 · Cited by 21
“Rodents are capable of integrating whisker stimulus parameters and storing them over time to arrive at a sensory discrimination choice (Fassihi et al. 2014, 2015; Guo et al. 2014).”
BackgroundHow distributed is the brain-wide network that is recruited for cognition?
Rosen, M. C., & Freedman, D. J. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00992-5 · Cited by 22
“One study applied photoinhibition across an array of 55 cortical volumes, spaced by 1 mm, as mice performed a memory-guided tactile discrimination task 125 .”
Oryshchuk, A., Sourmpis, C., Weverbergh, J., Asri, R., Esmaeili, V., Modirshanechi, A., Wulfram Gerstner, B., Petersen, C. C. H., & Crochet, S. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113618 · Cited by 44
Wang, J., Niu, J., Sha, W., Dai, X., Huang, T., Hua, Q., Long, Y., Xiao, J., & Hu, W. (2023) · Nano Research · doi:10.1007/s12274-023-5731-x · Cited by 28
Presynaptic GABAA Receptors Modulate Thalamocortical Inputs in Layer 4 of Rat V1
Wang, L., Kloc, M. L., Maher, E. E., Erişir, A., & Maffei, A. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhx364 · Cited by 31
“1998; Fagiolini and Hensch 2000), activity of inhibitory neurons (Guo et al. 2014), or activity of GABAA receptors (Burchfiel and Duffy 1981; Mower et al.”
BackgroundMethodSavage, M. A., McQuade, R., & Thiele, A. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24186 · Cited by 24
“Behaviorally, M2 has been implicated in top–down modulation of somatosensory based orienting and appetitive approach behaviors (Erlich et al., 2011; Guo et al., 2014).”
BackgroundA neural coding scheme reproducing foraging trajectories
Gutiérrez, E. D., & Cabrera, J. L. (2015) · Scientific Reports · doi:10.1038/srep18009 · Cited by 18
Xie, H., Han, X., Xiao, G., Xu, H., Zhang, Y., Zhang, G., Li, Q., He, J., Zhu, D. Y., Yu, X., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01155-6 · Cited by 26
“Recent progress in skull window techniques has facilitated direct optical access to extensive regions of the mouse cortex, achieved by employing curved glass 1 or polymer optical windows 2 or through the use of biocompatible reagents for cranium clearance 3–6 .”
Ferguson, B. R., Glick, C., & Huguenard, J. R. (2023) · eLife · doi:10.7554/elife.78349 · Cited by 33
“As optogenetic activation of interneurons has been shown to inactivate cortical network activity (Guo et al. 2014), this would allow for inhibition of mPFC during distinct task epochs (Fig.”
BackgroundAruljothi, K., Marrero, K., Zhang, Z.-R., Zareian, B., & Zagha, E. (2020) · Journal of Neuroscience · doi:10.1101/2020.03.23.004028 · Cited by 22
Kimura, R., Saiki, A., Fujiwara‐Tsukamoto, Y., Sakai, Y., & Isomura, Y. (2016) · The Journal of Physiology · doi:10.1113/jp272794 · Cited by 32
“The group with longer durations was considered to represent regular-spiking (RS) pyramidal neurons, whereas the group with shorter durations was considered to represent fast-spiking (FS) interneurons (spike duration threshold: 0.5 ms for multiple single-unit recording, 0.45 ms for juxtacellular recording; Barthó et al…”
BackgroundInfluentialDistinct contributions of mouse cortical areas to visual discriminationPreprint
Zatka-Haas, P., Steinmetz, N. A., Carandini, M., & Harris, K. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/501627 · Cited by 21
Dopamine encodes deep network teaching signals for individual learning trajectories
Garcia, S. L., Laffere, A., Toschi, C., Schilling, L., Moretti, J., Podlaski, J., Fritsche, M., Zatka-Haas, P., Li, Y., Bogacz, R., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.025 · Cited by 26
Superior colliculus bidirectionally modulates choice activity in frontal cortex
Thomas, A. M., Yang, W., Wang, C., Tipparaju, S. L., Chen, G., Sullivan, B. J., Swiekatowski, K. R., Tatam, M., Gerfen, C. R., & Li, N. (2023) · Nature Communications · doi:10.1038/s41467-023-43252-9 · Cited by 24
“Micewerepreparedforphotostimulationandelectrophysiologywitha clear-skull cap and a headpost 43,80 .”
BackgroundMethodSelf-citationSong, X., Guo, Y., Li, H., Chen, C., Lee, J. H., Zhang, Y., Schmidt, Z., & Wang, X. (2022) · Nature Communications · doi:10.1038/s41467-022-29864-7 · Cited by 26
Cortical circuits for transforming whisker sensation into goal-directed licking
Esmaeili, V., Tamura, K., Foustoukos, G., Oryshchuk, A., Crochet, S., & Petersen, C. C. H. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.08.003 · Cited by 28
Reconsidering the border between the visual and posterior parietal cortex of mice
Gilissen, S. R. J., Farrow, K., Bonin, V., & Arckens, L. (2020) · bioRxiv · doi:10.1101/2020.03.24.005462 · Cited by 21
“Besides the privileged anatomical location, also functional evidence accumulates and confirms the multisensory nature of the mouse PPC, yet few studies looked at the specific functions of the proposed sub-regions (Guo et al., 2014; Lyamzin and Benucci, 2019; Mohan et al., 2018; Pho et al., 2018).”
Background
Metadata
- Authors
- Guo, Z. V., Li, N., Huber, D., Ophir, E., Gutnisky, D., Ting, J. T., Feng, G., & Svoboda, K.
- Affiliations
- Howard Hughes Medical Institute (US)
- McGovern Institute for Brain Research (US)
- Corresponding author
- Svoboda, Karel
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 81
- Issue
- 1
- Pages
- 179-194
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3984938
- OpenAlex
- W2040707073
- Cited by
- 715
- References
- 0
- Citations by year
- 2026: 65 · 2025: 56 · 2024: 74 · 2023: 84 · 2022: 60 · 2021: 64 · 2020: 69 · 2019: 62 · 2018: 57 · 2017: 47 · 2016: 32 · 2015: 27 · 2014: 18
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- perceptual decision making, barrel cortex, anterior lateral motor cortex, short-term memory, optogenetic inhibition, sensorimotor integration, mice
- MeSH terms
- Channelrhodopsins, Action Potentials, Afferent Pathways, Animals, Cerebral Cortex, Conditioning, Operant, Decision Making, Discrimination, Psychological, Female, Male, Mice, Transgenic, Motion Perception, Nerve Net, Neurons, Photic Stimulation, Touch, Vibrissae, Green Fluorescent Proteins, Vesicular Inhibitory Amino Acid Transport Proteins, Mice
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