Visuomotor behaviors in larval zebrafish after GFP-guided laser ablation of the optic tectum
Open accessAbstract
The optic tectum is the largest visual center in most vertebrates and the main target for retinal ganglion cells (RGCs) conveying visual information from the eye to the brain. The retinotectal projection has served as an important model in many areas of developmental neuroscience. However, knowledge of the function of the tectum is limited. We began to address this issue using laser ablations and subsequent behavioral testing in zebrafish. We used a transgenic zebrafish line that expresses green-fluorescent protein in RGCs projecting to the tectum. By aiming a laser beam at the labeled retinal fibers demarcating the tectal neuropil, the larval tectum could be selectively destroyed. We tested whether tectum-ablated zebrafish larvae, when presented with large-field movements in their surroundings, displayed optokinetic responses (OKR) or optomotor responses (OMR), two distinct visuomotor behaviors that compensate for self-motion. Neither OKR nor OMR were found to be dependent on intact retinotectal connections. Also, visual acuity remained unaffected. Tectum ablation, however, slowed down the OKR by reducing the frequency of saccades but left tracking velocity, gain, and saccade amplitude unaffected. Removal of the tectum had no effect on the processing of second-order motion, to which zebrafish show both OKR and OMR, suggesting that the tectum is not an integral part of the circuit that extracts higher-order cues in the motion pathway.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The OMR continues even without the optic tectum.
“The OMR is known to persist in the absence of the optic tectum, the largest of these processing areas (Roeser and Baier, 2003)”
From Neural control and modulation of swimming speed in the larval zebrafish (2014) · cites this paper as Roeser and Baier, 2003
The OMR results report that most larval zebrafish retained a vigorous response after bilateral tectum ablation. But the “OMR without a tectum” section specifies that the ablation left deeper parts of the tectum intact, so the paper does not establish persistence in the complete absence of the optic tectum. Page numbers were not provided in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Spatiotemporal energy models for the perception of motion
Adelson, E. H., & Bergen, J. R. (1985) · Journal of the Optical Society of America A · doi:10.1364/josaa.2.000284 · Cited by 3,442 · see citing works
A critical window for cooperation and competition among developing retinotectal synapses
Zhang, L. I., Tao, H. W., Holt, C. E., Harris, W. A., & Poo, M. (1998) · Nature · doi:10.1038/25665 · Cited by 895 · see citing works
Drift-balanced random stimuli: a general basis for studying non-Fourier motion perception
Chubb, C. F., & Sperling, G. (1988) · Journal of the Optical Society of America A · doi:10.1364/josaa.5.001986 · Cited by 657 · see citing works
Motion: The long and short of it
Mather, G., & Cavanagh, P. (1989) · Spatial Vision · doi:10.1163/156856889x00077 · Cited by 627 · see citing works
Hogben, L. T., & Slome, D. (1931) · Proceedings of the Royal Society of London Series B Containing Papers of a Biological Character · doi:10.1098/rspb.1931.0020 · Cited by 608 · see citing works
The Development of Vision in the Zebrafish (Danio rerio)
Easter, S. S., & Nicola, G. N. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0335 · Cited by 536 · see citing works
A psychophysically motivated model for two-dimensional motion perception
Wilson, H. R., Ferrera, V. P., & Yo, C. (1992) · Visual Neuroscience · doi:10.1017/s0952523800006386 · Cited by 524 · see citing works
The brainstem burst generator for saccadic eye movements
Scudder, C. A., Kaneko, C. R. S., & Fuchs, A. F. (2002) · Experimental Brain Research · doi:10.1007/s00221-001-0912-9 · Cited by 487 · see citing works
A behavioral screen for isolating zebrafish mutants with visual system defects.
Brockerhoff, S. E., Hurley, J. B., Janssen‐Bienhold, U., Neuhauss, S. C. F., Driever, W., & Dowling, J. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10545 · Cited by 485 · see citing works
The functional architecture of human visual motion perception
Lu, Z., & Sperling, G. (1995) · Vision Research · doi:10.1016/0042-6989(95)00025-u · Cited by 458 · see citing works
Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases
Sin, W. C., Haas, K. Z., Ruthazer, E. S., & Cline, H. T. (2002) · Nature · doi:10.1038/nature00987 · Cited by 433 · see citing works
Laser ablations reveal functional relationships of segmental hindbrain neurons in zebrafish.
Liu, K. S., & Fetcho, J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80783-7 · Cited by 424 · see citing works
Retinal Ganglion Cell Genesis Requires lakritz, a Zebrafish atonal Homolog
Kay, J. N., Finger‐Baier, K., Roeser, T., Staub, W., & Baier, H. (2001) · Neuron · doi:10.1016/s0896-6273(01)00312-9 · Cited by 417 · see citing works
Self-citationGenetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish
Neuhauss, S. C. F., Biehlmaier, O., Seeliger, M. W., Das, T., Kohler, K., Harris, W. A., & Baier, H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08603.1999 · Cited by 414 · see citing works
Self-citationPatterning of the Zebrafish Retina by a Wave of Sonic Hedgehog Activity
Neumann, C. J., & Nuesslein-Volhard, C. (2000) · Science · doi:10.1126/science.289.5487.2137 · Cited by 385 · see citing works
Beiträge zur Physiologie der Pigmentzellen in der Fischhaut
von Frisch, K. (1911) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01680752 · Cited by 338 · see citing works
Chapter 10 Laser Killing of Cells in Caenorhabditis elegans
Bargmann, C. I., & Avery, L. (1995) · Methods in cell biology · doi:10.1016/s0091-679x(08)61390-4 · Cited by 306 · see citing works
Retinotopic organization of the developing retinotectal projection in the zebrafish embryo
Stuermer, C. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-12-04513.1988 · Cited by 280 · see citing works
Two Visual Systems in the Frog
Ingle, D. (1973) · Science · doi:10.1126/science.181.4104.1053 · Cited by 275 · see citing works
The Superior Colliculi and Eye Movements
Pasik, T. (1966) · Archives of Neurology · doi:10.1001/archneur.1966.00470160086012 · Cited by 252 · see citing works
Burrill, J. D., & Easter, S. S. (1994) · Journal of Comparative Neurology · doi:10.1002/cne.903460410 · Cited by 248 · see citing works
Activity of superior colliculus in behaving monkey. IV. Effects of lesions on eye movements.
Wurtz, R. H., & Goldberg, M. E. (1972) · Journal of Neurophysiology · doi:10.1152/jn.1972.35.4.587 · Cited by 238 · see citing works
Perception of Fourier and non-Fourier motion by larval zebrafish
Orger, M. B., Smear, M. C., Anstis, S., & Baier, H. (2000) · Nature Neuroscience · doi:10.1038/80649 · Cited by 211 · see citing works
Self-citationDirection specific neurons in the pretectum of the frog (Rana esculenta)
Katte, O., & Hoffmann, K. P. (1980) · Journal of Comparative Physiology A · doi:10.1007/bf00613747 · Cited by 198 · see citing works
Oculomotor areas in the rabbit's midbrain and pretectum
Collewijn, H. (1975) · Journal of Neurobiology · doi:10.1002/neu.480060106 · Cited by 197 · see citing works
Montgomery, N., Fite, K. V., Taylor, M., & Bengston, L. (2008) · Brain Behavior and Evolution · doi:10.1159/000121622 · Cited by 181 · see citing works
Tectal Mechanisms That Underlie Prey-Catching and Avoidance Behaviors in Toads
Ewert, J.-P. (1984) · Springer eBooks · doi:10.1007/978-1-4899-5376-6_11 · Cited by 166 · see citing works
Central neural mechanisms for detecting second-order motion
Baker, C. L. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80069-5 · Cited by 150 · see citing works
Moving visual stimuli rapidly induce direction sensitivity of developing tectal neurons
Engert, F., Tao, H. W., Zhang, L. I., & Poo, M. (2002) · Nature · doi:10.1038/nature00988 · Cited by 144 · see citing works
The pigmentary effector system.—II
Hogben, L. T., Winton, F. R., & MacBride, E. W. (1922) · Proceedings of the Royal Society of London Series B Containing Papers of a Biological Character · doi:10.1098/rspb.1922.0052 · Cited by 129 · see citing works
Pathways mediating optokinetic responses of vestibular nucleus neurons in the rat
Cazin, L., Precht, W., & Lannou, J. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00589510 · Cited by 121 · see citing works
The role of the optic tectum in various visually mediated behaviors of goldfish
Springer, A. D., Easter, S. S., & Agranoff, B. W. (1977) · Brain Research · doi:10.1016/0006-8993(77)90166-4 · Cited by 120 · see citing works
Activity-dependent mapping in the retinotectal projection
Debski, E. A., & Cline, H. T. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00295-7 · Cited by 119 · see citing works
Effects on eye movements of a GABA agonist and antagonist injected into monkey superior colliculus
Hikosaka, O., & Wurtz, R. H. (1983) · Brain Research · doi:10.1016/0006-8993(83)90586-3 · Cited by 118 · see citing works
Role of the Accessory Optic System in the Optokinetic Nystagmus of the Frog
Lázár, G. (2008) · Brain Behavior and Evolution · doi:10.1159/000123761 · Cited by 118 · see citing works
Vaina, L. M., & Cowey, A. (1996) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1996.0180 · Cited by 113 · see citing works
Gioanni, H., Rey, J., Villalobos, J., Richard, D., & Dalbera, A. (1983) · Experimental Brain Research · doi:10.1007/bf00239188 · Cited by 84 · see citing works
Gnügge, L., Schmid, S., & Neuhauss, S. C. F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03542.2001 · Cited by 82 · see citing works
Brockerhoff, S. E., Dowling, J. E., & Hurley, J. B. (1998) · Vision Research · doi:10.1016/s0042-6989(97)00227-7 · Cited by 81 · see citing works
Zebrafish on the move: towards a behavior–genetic analysis of vertebrate vision
Baier, H. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00116-1 · Cited by 79 · see citing works
Self-citationCellular Basis for the Response to Second-Order Motion Cues in Y Retinal Ganglion Cells
Demb, J. B., Zaghloul, K. A., & Sterling, P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00484-6 · Cited by 78 · see citing works
Pursuit eye movements in goldfish (Carassius auratus)
Easter, S. S. (1972) · Vision Research · doi:10.1016/0042-6989(72)90161-7 · Cited by 71 · see citing works
Visual Discrimination in Sharks without Optic Tectum
Graeber, R. C., Ebbesson, S. O. E., & Jane, J. A. (1973) · Science · doi:10.1126/science.180.4084.413 · Cited by 69 · see citing works
Optokinetic nystagmus in the pigeon (Columba livia)
Gioanni, H., Rey, J., Villalobos, J., Bouyer, J. J., & Gioanni, Y. (1981) · Experimental Brain Research · doi:10.1007/bf00238829 · Cited by 64 · see citing works
Motion defined exclusively by second-order characteristics does not evoke optokinetic nystagmus
Harri, L. R., & Smith, A. T. (1992) · Visual Neuroscience · doi:10.1017/s0952523800001802 · Cited by 60 · see citing works
Tectal codification of eye movements in goldfish studied by electrical microstimulation
Salas, C., Herrero, L., Rodrı́guez, F., & Torres, B. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)83048-5 · Cited by 59 · see citing works
Visual Pathways for Postural Control and Negative Phototaxis in Lamprey
Ullén, F., Deliagina, T. G., Orlovsky, G. N., & Grillner, S. E. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.2.960 · Cited by 59 · see citing works
Comparative study on the teleostean optic tectum. Lamination and cytoarchitecture.
Kishida, R. (1979) · PubMed · Cited by 50 · see citing works
Flux, Wavelength and Movement Discrimination in Frogs: Forebrain and Midbrain Contributions
Kicliter, E. (2008) · Brain Behavior and Evolution · doi:10.1159/000124363 · Cited by 49 · see citing works
Target selection: invasion, mapping and cell choice
Holt, C. E., & Harris, W. A. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80013-5 · Cited by 46 · see citing works
Wullimann, M. F. (1994) · PubMed · Cited by 39 · see citing works
Rapid lesioning of large numbers of identified vertebrate neurons: applications in zebrafish
Gahtan, E., & O’Malley, D. M. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00382-x · Cited by 38 · see citing works
Visual function in goldfish with unilateral and bilateral tectal ablation
Yager, D., Sharma, S. C., & Grover, B. G. (1977) · Brain Research · doi:10.1016/0006-8993(77)90338-9 · Cited by 36 · see citing works
Meyer, D. L., Schott, D., & Schaefer, K. P. (1970) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00592249 · Cited by 35 · see citing works
The paths and destinations of the induced ipsilateral retinal projection in goldfish
Easter, S. S., Schmidt, J. T., & Leber, S. M. (1978) · Development · doi:10.1242/dev.45.1.145 · Cited by 34 · see citing works
Flandrin, J. M., & Jeannerod, M. (1981) · Experimental Brain Research · doi:10.1007/bf00235731 · Cited by 32 · see citing works
The Duration of the Motion Aftereffect following Adaptation to First-Order and Second-Order Motion
Ledgeway, T., & Smith, A. T. (1994) · Perception · doi:10.1068/p231211 · Cited by 29 · see citing works
The Role of Torus longitudinalis in Equilibrium Orientation Measured with the Dorsal Light Reflex
Gibbs, M., & NORTHMORE, D. P. M. (2008) · Brain Behavior and Evolution · doi:10.1159/000113190 · Cited by 29 · see citing works
Lázár, G., Alkonyi, B., & Tóth, P. P. (1983) · PubMed · Cited by 28 · see citing works
Visual direction-selective neurons in the pretectum of the rainbow trout
Klar, M., & Hoffmann, K. ‐. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00706-7 · Cited by 26 · see citing works
Akert, K. (1949) · PubMed · Cited by 26 · see citing works
Lokalisationsversuche am Fischgehirn
Dijkgraaf, S. (1949) · Cellular and Molecular Life Sciences · doi:10.1007/bf02164653 · Cited by 24 · see citing works
Effects of Lesions of the Optic Tectum on the Ability of Turtles to Locate Food Stimuli
Bass, A. H. (2008) · Brain Behavior and Evolution · doi:10.1159/000125665 · Cited by 16 · see citing works
Stehouwer, D. J. (1987) · Behavioral Neuroscience · doi:10.1037//0735-7044.101.3.378 · Cited by 11 · see citing works
Stehouwer, D. J. (1987) · Behavioral Neuroscience · doi:10.1037/0735-7044.101.3.378 · Cited by 11 · see citing works
Mori, S. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90149-k · Cited by 10 · see citing works
Spatial discrimination in goldfish following bilateral tectal ablation
DAVIS, R., & Klinger, P. D. (1987) · Behavioural Brain Research · doi:10.1016/0166-4328(87)90073-8 · Cited by 9 · see citing works
The Central Nervous Control of Colour Change in the Minnow (Phoxinus Phoxinus L.)
Gentle, M. J. (1971) · Journal of Experimental Biology · doi:10.1242/jeb.54.1.83 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zebrafish Larvae as a Behavioral Model in Neuropharmacology
Basnet, R., Zizioli, D., Taweedet, S., Finazzi, D., & Memo, M. (2019) · Biomedicines · doi:10.3390/biomedicines7010023 · Cited by 328 · see citing works
Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior
Portugues, R., Feierstein, C. E., Engert, F., & Orger, M. B. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.019 · Cited by 305 · see citing works
Gahtan, E., Tanger, P., & Baier, H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2678-05.2005 · Cited by 350 · see citing works
Self-citationForward genetic analysis of visual behavior in zebrafish
Muto, A., Orger, M. B., Wehman, A. M., Smear, M. C., Kay, J. N., Page-McCaw, P. S., Gahtan, E., Xiao, T., Nevin, L. M., Gosse, N. J., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010066 · Cited by 321 · see citing works
Self-citationFrom Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response
Naumann, E. A., Fitzgerald, J. E., Dunn, T. W., Rihel, J., Sompolinsky, H., & Engert, F. (2016) · Cell · doi:10.1016/j.cell.2016.10.019 · Cited by 315 · see citing works
Xiao, T., Roeser, T., Staub, W., & Baier, H. (2005) · Development · doi:10.1242/dev.01861 · Cited by 308 · see citing works
Self-citationPanula, P., Sallinen, V. J., Sundvik, M., Kolehmainen, J., Torkko, V., Tiittula, A., Moshnyakov, M., & Podlasz, P. (2006) · Zebrafish · doi:10.1089/zeb.2006.3.235 · Cited by 296 · see citing works
A visual pathway for looming-evoked escape in larval zebrafish
Temizer, I., Donovan, J. C., Baier, H., & Semmelhack, J. L. (2015) · Current Biology · doi:10.1016/j.cub.2015.06.002 · Cited by 292 · see citing works
Self-citationNeural control and modulation of swimming speed in the larval zebrafish
Severi, K. E., Portugues, R., Marques, J. C., O’Malley, D. M., Orger, M. B., & Engert, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.032 · Cited by 239 · see citing works
“The OMR is known to persist in the absence of the optic tectum, the largest of these processing areas (Roeser and Baier, 2003), and when we imaged larvae expressing the fluorescent protein dendra under the control of a promoter that drives expression in RGCs (atoh7/ath5) (Kay et al.”
A Cellular-Resolution Atlas of the Larval Zebrafish Brain
Kunst, M., Laurell, E., Mokayes, N., Kramer, A., Kubo, F., Fernandes, A. M., Förster, D., Maschio, M. D., & Baier, H. (2018) · Neuron · doi:10.1016/j.neuron.2019.04.034 · Cited by 272 · see citing works
Self-citationFiltering of Visual Information in the Tectum by an Identified Neural Circuit
Bene, F. D., Wyart, C., Robles, E., Tran, A. P., Looger, L. L., Scott, E. K., Isacoff, E. Y., & Baier, H. (2010) · Science · doi:10.1126/science.1192949 · Cited by 249 · see citing works
Self-citationZebrafish: A model system for the study of eye genetics
Fadool, J. M., & DOWLING, J. A. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.08.002 · Cited by 217 · see citing works
Circuit Neuroscience in Zebrafish
Friedrich, R. W., Jacobson, G. A., & Zhu, P. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.039 · Cited by 207 · see citing works
A dedicated visual pathway for prey detection in larval zebrafish
Semmelhack, J. L., Donovan, J. C., Thiele, T. R., Kuehn, E., Laurell, E., & Baier, H. (2014) · eLife · doi:10.7554/elife.04878 · Cited by 204 · see citing works
Self-citationBerghmans, S., Butler, P., Goldsmith, P., Waldron, G. J., Gardner, I. B., Golder, Z. J., Richards, F. M., Kimber, G. M., Roach, A. G., ALDERTON, W. K., et al. (2008) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2008.05.130 · Cited by 187 · see citing works
Kubo, F., Hablitzel, B., Dal Maschio, M., Driever, W., Baier, H., & Arrenberg, A. B. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.043 · Cited by 182 · see citing works
Self-citationThe neural basis of visual behaviors in the larval zebrafish
Portugues, R., & Engert, F. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.10.007 · Cited by 171 · see citing works
Beck, J. C., Gilland, E., Tank, D. W., & Baker, R. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00311.2004 · Cited by 167 · see citing works
The cellular architecture of the larval zebrafish tectum, as revealed by Gal4 enhancer trap lines
Scott, E. K. (2009) · Frontiers in Neural Circuits · doi:10.3389/neuro.04.013.2009 · Cited by 161 · see citing works
Parametric Functional Maps of Visual Inputs to the Tectum
Nikolaou, N., Lowe, A., Walker, A., Abbas, F. H., Hunter, P. R., Thompson, I. D., & Meyer, M. P. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.040 · Cited by 162 · see citing works
Liao, J. C. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02487 · Cited by 161 · see citing works
Prey Tracking by Larval Zebrafish: Axial Kinematics and Visual Control
McElligott, M. B., & O’Malley, D. M. (2005) · Brain Behavior and Evolution · doi:10.1159/000087158 · Cited by 160 · see citing works
Contrast Sensitivity, Spatial and Temporal Tuning of the Larval Zebrafish Optokinetic Response
Rinner, O., Rick, J. M., & Neuhauss, S. C. F. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0682 · Cited by 158 · see citing works
The Dorsal Raphe Modulates Sensory Responsiveness during Arousal in Zebrafish
Yokogawa, T., Hannan, M. C., & Burgess, H. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1019-12.2012 · Cited by 153 · see citing works
The optokinetic response in zebrafish and its applications
Huang, Y. (2007) · Frontiers in bioscience · doi:10.2741/2810 · Cited by 142 · see citing works
Whole-brain functional imaging with two-photon light-sheet microscopy
Wolf, S., Supatto, W., Debrégeas, G., Mahou, P., Kruglik, S. G., Sintès, J.-M., Beaurepaire, E., & Candelier, R. (2015) · Nature Methods · doi:10.1038/nmeth.3371 · Cited by 147 · see citing works
OFF ganglion cells cannot drive the optokinetic reflex in zebrafish
Emran, F., Rihel, J., Adolph, A. R., Wong, K. Y., Kraves, S., & Dowling, J. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709337104 · Cited by 141 · see citing works
Zebrafish embryos and larvae in behavioural assays
Tegelenbosch, R. A. J., Noldus, L. P. J. J., Richardson, M. K., & Ahmad, F. (2012) · Behaviour · doi:10.1163/1568539x-00003020 · Cited by 140 · see citing works
Focusing on optic tectum circuitry through the lens of genetics
Nevin, L. M., Robles, E., Baier, H., & Scott, E. K. (2010) · BMC Biology · doi:10.1186/1741-7007-8-126 · Cited by 135 · see citing works
Self-citationSensorimotor Decision Making in the Zebrafish Tectum
Barker, A. J., & Baier, H. (2015) · Current Biology · doi:10.1016/j.cub.2015.09.055 · Cited by 138 · see citing works
Self-citationSelective attention without a neocortex
Krauzlis, R. J., Bogadhi, A. R., Herman, J. P., & Bollimunta, A. (2017) · Cortex · doi:10.1016/j.cortex.2017.08.026 · Cited by 123 · see citing works
Zebrafish as a neurotoxicological model
Linney, E. A., Upchurch, L. M., & Donerly, S. (2004) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2004.06.015 · Cited by 122 · see citing works
Learning and memory in zebrafish larvae
Roberts, A. C., Bill, B., & Glanzman, D. L. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00126 · Cited by 121 · see citing works
Fish do not feel pain and its implications for understanding phenomenal consciousness
Key, B. (2014) · Biology & Philosophy · doi:10.1007/s10539-014-9469-4 · Cited by 118 · see citing works
Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway
Zhang, B.-B., Yao, Y.-Y., Zhang, H.-F., Kawakami, K., & Du, J.-L. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.011 · Cited by 115 · see citing works
Kay, J. N., Link, B. A., & Baier, H. (2005) · Development · doi:10.1242/dev.01831 · Cited by 115 · see citing works
Self-citationDistinct Retinal Pathways Drive Spatial Orientation Behaviors in Zebrafish Navigation
Burgess, H. A., Schoch, H., & Granato, M. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.022 · Cited by 110 · see citing works
Topography of a Visuomotor Transformation
Helmbrecht, T. O., dal Maschio, M., Donovan, J. C., Koutsouli, S., & Baier, H. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.021 · Cited by 113 · see citing works
Self-citationTectal Control of Locomotion, Steering, and Eye Movements in Lamprey
Saitoh, K., Ménard, A., & Grillner, S. E. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00639.2006 · Cited by 112 · see citing works
Dong, W., Lee, R., Xu, H., Yang, S., Pratt, K. G., Cao, V. Y., Song, Y., Nurmikko, A. V., & Aizenman, C. D. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90848.2008 · Cited by 109 · see citing works
The Behavioral Repertoire of Larval Zebrafish
Fero, K. C., Yokogawa, T., & Burgess, H. A. (2010) · Neuromethods · doi:10.1007/978-1-60761-922-2_12 · Cited by 109 · see citing works
Abraham, E., Palevitch, O., Gothilf, Y., & Zohar, Y. (2009) · Endocrinology · doi:10.1210/en.2009-0548 · Cited by 108 · see citing works
Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
Xiao, Y. C., Petrucco, L., Hoodless, L. J., Portugues, R., & Czopka, T. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01023-7 · Cited by 99 · see citing works
Smear, M. C., Tao, H. W., Staub, W., Orger, M. B., Gosse, N. J., Liu, Y., Takahashi, K., Poo, M., & Baier, H. (2007) · Neuron · doi:10.1016/j.neuron.2006.12.013 · Cited by 101 · see citing works
Self-citationRay, K., Chaki, M., & Sengupta, M. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2007.01.001 · Cited by 95 · see citing works
Fleisch, V. C., Fraser, B., & Allison, W. T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.10.012 · Cited by 92 · see citing works
Shams, S., Rihel, J., Ortíz, J. G., & Gerlai, R. T. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.002 · Cited by 94 · see citing works
Behavioral Screening Assays in Zebrafish
Orger, M. B., Gahtan, E., Muto, A., Page-McCaw, P., Smear, M. C., & Baier, H. (2004) · Methods in cell biology · doi:10.1016/s0091-679x(04)77003-x · Cited by 91 · see citing works
Self-citationRetinal network adaptation to bright light requires tyrosinase
Page-McCaw, P., Chung, S. C., Muto, A., Roeser, T., Staub, W., Finger‐Baier, K., Korenbrot, J. I., & Baier, H. (2004) · Nature Neuroscience · doi:10.1038/nn1344 · Cited by 91 · see citing works
Self-citationRheotaxis revisited: a multi-behavioral and multisensory perspective on how fish orient to flow
Coombs, S., Bak-Coleman, J., & Montgomery, J. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.223008 · Cited by 88 · see citing works
Predation pressure shapes brain anatomy in the wild
Kotrschal, A., Deacon, A. E., Magurran, A. E., & Kolm, N. (2017) · Evolutionary Ecology · doi:10.1007/s10682-017-9901-8 · Cited by 87 · see citing works
Visual recognition of social signals by a tectothalamic neural circuit
Kappel, J. M., Förster, D., Slangewal, K., Shainer, I., Svara, F., Donovan, J. C., Sherman, S., Januszewski, M., Baier, H., & Larsch, J. (2022) · Nature · doi:10.1038/s41586-022-04925-5 · Cited by 83 · see citing works
Self-citationHardwiring of fine synaptic layers in the zebrafish visual pathway
Nevin, L. M., Taylor, M. R., & Baier, H. (2008) · Neural Development · doi:10.1186/1749-8104-3-36 · Cited by 83 · see citing works
Self-citationAudira, G., Siregar, P., Strungaru, Ș.-A., Huang, J., & Hsiao, C. (2020) · Biology · doi:10.3390/biology9080200 · Cited by 80 · see citing works
Using imaging and genetics in zebrafish to study developing spinal circuits in vivo
McLean, D. L., & Fetcho, J. R. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20617 · Cited by 80 · see citing works
Burgess, H. A., Johnson, S. L., & Granato, M. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00499.x · Cited by 76 · see citing works
White, D. T., & Mumm, J. S. (2013) · Methods · doi:10.1016/j.ymeth.2013.03.017 · Cited by 77 · see citing works
Vladimirov, N., Wang, C., Höckendorf, B., Pujala, A., Tanimoto, M., Mu, Y., Yang, C.-T., Wittenbach, J. D., Freeman, J., Preibisch, S., et al. (2018) · Nature Methods · doi:10.1038/s41592-018-0221-x · Cited by 76 · see citing works
Analysis of the Retina in the Zebrafish Model
Avanesov, A. S., & Malicki, J. J. (2010) · Methods in cell biology · doi:10.1016/b978-0-12-384892-5.00006-2 · Cited by 68 · see citing works
The Behavioral Space of Zebrafish Locomotion and Its Neural Network Analog
Girdhar, K., Gruebele, M., & Chemla, Y. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128668 · Cited by 60 · see citing works
“I chose zebrafish larvae 6-10 days post-fertilization (dpf) as a behavioral model organism because of the following reasons: It is complex enough as a vertebrate and yet has small number of (200-220) locomotor neurons projecting from brainstem [17] to exhibit interesting behaviors like prey tracking, escape response t…”
MethodOf lasers, mutants, and see‐through brains: Functional neuroanatomy in zebrafish
Gahtan, E., & Baier, H. (2004) · Journal of Neurobiology · doi:10.1002/neu.20000 · Cited by 68 · see citing works
Self-citationLee, R., Mills, E. A., Schwartz, N., Bell, M. R., Deeg, K. E., Ruthazer, E. S., Marsh‐Armstrong, N., & Aizenman, C. D. (2010) · Neural Development · doi:10.1186/1749-8104-5-2 · Cited by 66 · see citing works
Technologies for micromanipulating, imaging, and phenotyping small invertebrates and vertebrates.
Yanik, M., Rohde, C., & Pardo-Martín, C. (2011) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124703 · Cited by 74 · see citing works
An interhemispheric neural circuit allowing binocular integration in the optic tectum
Gebhardt, C., Auer, T. O., Henriques, P. M., Rajan, G., Duroure, K., Bianco, I. H., & Bene, F. D. (2019) · Nature Communications · doi:10.1038/s41467-019-13484-9 · Cited by 65 · see citing works
Acute exposure to DE-71 causes alterations in visual behavior in zebrafish larvae
Chen, L., Huang, Y., Huang, C., Hu, B., Hu, C., & Zhou, B. (2013) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2168 · Cited by 62 · see citing works
Westphal, R. E., & O'Malley, D. M. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00108 · Cited by 58 · see citing works
Wang, K., Hinz, J., Haikala, V., Reiff, D. F., & Arrenberg, A. B. (2019) · BMC Biology · doi:10.1186/s12915-019-0648-2 · Cited by 60 · see citing works
The Gal4/UAS toolbox in zebrafish: new approaches for defining behavioral circuits
Scott, E. K. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06161.x · Cited by 60 · see citing works
Emergence of binocular functional properties in a monocular neural circuit
Ramdya, P. P., & Engert, F. (2008) · Nature Neuroscience · doi:10.1038/nn.2166 · Cited by 58 · see citing works
Kretschmer, F., Kretschmer, V., Kunze, V. P., & Kretzberg, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078058 · Cited by 56 · see citing works
Kist, A. M., & Portugues, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.024 · Cited by 55 · see citing works
Kohli, V., & Elezzabi, A. Y. (2008) · BMC Biotechnology · doi:10.1186/1472-6750-8-7 · Cited by 55 · see citing works
Feierstein, C. E., Portugues, R., & Orger, M. B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.046 · Cited by 52 · see citing works
Laminar circuit formation in the vertebrate retina
Mumm, J. S., Godinho, L., Morgan, J., Oakley, D. M., Schroeter, E. H., & Wong, R. (2004) · Progress in brain research · doi:10.1016/s0079-6123(04)47012-5 · Cited by 53 · see citing works
Anatomy and function of retinorecipient arborization fields in zebrafish
Baier, H., & Wullimann, M. F. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25204 · Cited by 51 · see citing works
Self-citationA profile of auditory‐responsive neurons in the larval zebrafish brain
Vanwalleghem, G. C., Heap, L. A., & Scott, E. K. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24258 · Cited by 45 · see citing works
Engineering a light-activated caspase-3 for precise ablation of neurons in vivo
Smart, A. D., Pache, R. A., Thomsen, N. D., Kortemme, T., Davis, G. W., & Wells, J. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705064114 · Cited by 51 · see citing works
Cardiac response to startle stimuli in larval zebrafish: sympathetic and parasympathetic components
Mann, K., Hoyt, C., Feldman, S., Blunt, L. A., Raymond, A., & Page-McCaw, P. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00302.2009 · Cited by 48 · see citing works
An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System
Donato, V. D., Santis, F. D., Albadri, S., Auer, T. O., Duroure, K., Charpentier, M., Concordet, J., Gebhardt, C., & Bene, F. D. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.030 · Cited by 46 · see citing works
The utility of zebrafish for studies of the comparative biology of motor systems
Fetcho, J. R. (2006) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21127 · Cited by 48 · see citing works
Control of a specific motor program by a small brain area in zebrafish
Fajardo, O., Zhu, P., & Friedrich, R. W. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00067 · Cited by 47 · see citing works
Wagle, M. D., Mathur, P., & Guo, S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3339-10.2011 · Cited by 47 · see citing works
Zebrafish – The Neurobehavioural Model in Trend
Mrinalini, R., Tamilanban, T., Kumar, V., & Manasa, K. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.12.016 · Cited by 46 · see citing works
Early retinoic acid deprivation in developing zebrafish results in microphthalmia
LE, H.-G. T., DOWLING, J. E., & CAMERON, D. J. (2012) · Visual Neuroscience · doi:10.1017/s0952523812000296 · Cited by 46 · see citing works
Continued growth and circuit building in the anamniote visual system
Cerveny, K. L., Varga, M., & Wilson, S. W. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20917 · Cited by 45 · see citing works
Synaptic dynamics mediate sensitivity to motion independent of stimulus details
Luksch, H., Khanbabaie, R., & Weßel, R. (2004) · Nature Neuroscience · doi:10.1038/nn1204 · Cited by 44 · see citing works
Effects of lorazepam and WAY-200070 in larval zebrafish light/dark choice test
Chen, F., Chen, S., Liu, S., Zhang, C., & Peng, G. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.022 · Cited by 43 · see citing works
Zhang, J., Jeradi, S., Strähle, U., & Akimenko, M. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.03.008 · Cited by 41 · see citing works
Fish Swimming in a Kármán Vortex Street: Kinematics, Sensory Biology and Energetics
Liao, J. C., & Akanyeti, O. (2017) · Marine Technology Society Journal · doi:10.4031/mtsj.51.5.8 · Cited by 39 · see citing works
Conserved subcortical processing in visuo-vestibular gaze control
Wibble, T., Pansell, T., Grillner, S. E., & Pérez‐Fernández, J. (2022) · Nature Communications · doi:10.1038/s41467-022-32379-w · Cited by 39 · see citing works
Application of zebrafish oculomotor behavior to model human disorders
Berg, C. V., Huang, Y., & Neuhauss, S. C. F. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.003 · Cited by 39 · see citing works
Approaches to Study Neurogenesis in the Zebrafish Retina
Avanesov, A. S., & Malicki, J. J. (2004) · Methods in cell biology · doi:10.1016/s0091-679x(04)76016-1 · Cited by 39 · see citing works
An open-source method to analyze optokinetic reflex responses in larval zebrafish
Scheetz, S. D., Shao, E., Zhou, Y., Cario, C. L., Bai, Q., & Burton, E. A. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.10.012 · Cited by 37 · see citing works
An Optical Illusion Pinpoints an Essential Circuit Node for Global Motion Processing
Wu, Y., Maschio, M. D., Kubo, F., & Baier, H. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.027 · Cited by 37 · see citing works
Self-citationTopographic wiring of the retinotectal connection in zebrafish
Kita, E. M., Scott, E. K., & Goodhill, G. J. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22256 · Cited by 37 · see citing works
Sampaio, E., Maulvault, A. L., Lopes, V. M., Paula, J. R., Barbosa, V., Alves, R., Pousão‐Ferreira, P., Repolho, T., Marques, A., & Rosa, R. (2016) · Marine Biology · doi:10.1007/s00227-016-2994-8 · Cited by 35 · see citing works
Using the optokinetic response to study visual function of zebrafish
Zou, S., Wu, Y., Zhang, M., Hu, C., Huang, Y., & Hu, B. (2010) · Journal of Visualized Experiments · doi:10.3791/1742 · Cited by 36 · see citing works
A Neural Representation of Naturalistic Motion-Guided Behavior in the Zebrafish Brain
Yildizoglu, T., Riegler, C., Fitzgerald, J. E., & Portugues, R. (2020) · Current Biology · doi:10.1016/j.cub.2020.04.043 · Cited by 34 · see citing works
Functional neuronal circuits emerge in the absence of developmental activity
Barabási, D. L., Schuhknecht, G. F. P., & Engert, F. (2024) · Nature Communications · doi:10.1038/s41467-023-44681-2 · Cited by 31 · see citing works
Using a variant of the optomotor response as a visual defect detection assay in zebrafish
LeFauve, M. K., Rowe, C. J., Crowley-Perry, M., Wiegand, J. L., & Shapiro, A. (2021) · Journal of Biological Methods · doi:10.14440/jbm.2021.341 · Cited by 34 · see citing works
- Authors
- Roeser, T., & Baier, H.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Baier, Herwig
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-05-01
- Volume
- 23
- Issue
- 9
- Pages
- 3726-3734
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6742205
- OpenAlex
- W2150958067
- Semantic Scholar
- fe7a175f2bfdb09b95fe04e44714ab7c8b7a31ac
- Cited by
- 222
- References
- 67
- Citations by year
- 2026: 12 · 2025: 10 · 2024: 8 · 2023: 3 · 2022: 14 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 12 · 2016: 7 · 2015: 11 · 2014: 10 · 2013: 17 · 2012: 11
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Journal of Neuroscience (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Boehringer Ingelheim Fonds
- National Institutes of Health
- National Eye Institute (R01EY012406)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- optic tectum, retinotectal projection, zebrafish larvae, optokinetic response, optomotor response, visuomotor behavior, laser ablation, retinal ganglion cells, saccades, visual acuity, second-order motion
- MeSH terms
- Animals, Behavior, Animal, Cues, Eye Movements, Larva, Luminescent Proteins, Motion Perception, Retinal Ganglion Cells, Saccades, Superior Colliculi, Visual Acuity, Visual Pathways, Zebrafish, Animals, Genetically Modified, Green Fluorescent Proteins, Laser Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
