Molecular Mechanisms of Presynaptic Membrane Retrieval and Synaptic Vesicle Reformation
Open accessAbstract
The function of the nervous system depends on the exocytotic release of neurotransmitter from synaptic vesicles (SVs). To sustain neurotransmission, SV membranes need to be retrieved, and SVs have to be reformed locally within presynaptic nerve terminals. In spite of more than 40 years of research, the mechanisms underlying presynaptic membrane retrieval and SV recycling remain controversial. Here, we review the current state of knowledge in the field, focusing on the molecular mechanism involved in presynaptic membrane retrieval and SV reformation. We discuss the challenges associated with studying these pathways and present perspectives for future research.
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After exocytosis, vesicle membrane must be retrieved from the plasma membrane through endocytosis to keep the area of the plasma membrane constant.
“After exocytosis, vesicle membrane must be retrieved from the plasma membrane through endocytosis to keep the area of the plasma membrane constant and maintain a sufficient number of synaptic vesicles at presynapses1–4.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [4]
Endocytosis after exocytosis maintains a sufficient number of synaptic vesicles at presynapses.
“After exocytosis, vesicle membrane must be retrieved from the plasma membrane through endocytosis to keep the area of the plasma membrane constant and maintain a sufficient number of synaptic vesicles at presynapses1–4.”
From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [4]
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The road to restoring neural circuits for the treatment of Alzheimer's disease
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Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis
Ogunmowo, T. H., Jing, H., Raychaudhuri, S., Kusick, G. F., Imoto, Y., Li, S., Itoh, K., Ma, Y., Jafri, H., Dalva, M. B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38595-2 · Cited by 51 · see citing works
SynapsEM: Computer-Assisted Synapse Morphometry
Watanabe, S., Davis, M. W., Kusick, G. F., Iwasa, J., & Jorgensen, E. M. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.584549 · Cited by 34 · see citing works
- Authors
- Kononenko, N. L., & Haucke, V.
- Affiliations
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (DE)
- Corresponding author
- Haucke, Volker
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 85
- Issue
- 3
- Pages
- 484-496
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2063376214
- Cited by
- 220
- References
- 13
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 25 · 2023: 16 · 2022: 19 · 2021: 22 · 2020: 21 · 2019: 15 · 2018: 17 · 2017: 27 · 2016: 19 · 2015: 11
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- synaptic vesicle recycling, neurotransmitter release, exocytosis, presynaptic terminals, synaptic vesicle membrane
- MeSH terms
- Animals, Endocytosis, Exocytosis, Humans, Synaptic Membranes, Synaptic Vesicles, Presynaptic Terminals
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