Cited by 435Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases

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Bacioglu, Mehtap, Maia, Luis F., Preische, Oliver, Schelle, Juliane, Apel, Anja, Kaeser, Stephan A., Schweighauser, Manuel, Eninger, Timo +10 more·2016·Neuron

Abstract

A majority of current disease-modifying therapeutic approaches for age-related neurodegenerative diseases target their characteristic proteopathic lesions (α-synuclein, Tau, Aβ). To monitor such treatments, fluid biomarkers reflecting the underlying disease process are crucial. We found robust increases of neurofilament light chain (NfL) in CSF and blood in murine models of α-synucleinopathies, tauopathy, and β-amyloidosis. Blood and CSF NfL levels were strongly correlated, and NfL increases coincided with the onset and progression of the corresponding proteopathic lesions in brain. Experimental induction of α-synuclein lesions increased CSF and blood NfL levels, while blocking Aβ lesions attenuated the NfL increase. Consistently, we also found NfL increases in CSF and blood of human α-synucleinopathies, tauopathies, and Alzheimer's disease. Our results suggest that CSF and particularly blood NfL can serve as a reliable and easily accessible biomarker to monitor disease progression and treatment response in mouse models and potentially in human proteopathic neurodegenerative diseases.

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Crossref · 10.1016/j.neuron.2016.05.018

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Authors
Bacioglu, M., Maia, L. F., Preische, O., Schelle, J., Apel, A., Kaeser, S. A., Schweighauser, M., Eninger, T., Lambert, M., Pilotto, A., Shimshek, D. R., Neumann, U., Kahle, P. J., Staufenbiel, M., Neumann, M., Maetzler, W., Kuhle, J., & Jucker, M.
Affiliations
  • German Center for Neurodegenerative Diseases (DE)
  • Novartis (Switzerland) (CH)
Corresponding author
Jucker, Mathias
Venue
Neuron
Publisher
Elsevier BV
Published
2016-07
Volume
91
Issue
1
Pages
56-66
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2418840920
Cited by
435
References
54
Citations by year
2026: 21 · 2025: 33 · 2024: 47 · 2023: 64 · 2022: 45 · 2021: 50 · 2020: 63 · 2019: 41 · 2018: 32 · 2017: 29 · 2016: 10
FWCI
30.02
Type
journal article
Language
en
Update notices
erratum (2016-07-20)
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion, public-domain)
  • Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel) (submittedVersion, cc-by)
  • DZNE Pub (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
neurofilament light chain, cerebrospinal fluid biomarkers, blood biomarkers, disease progression monitoring, synucleinopathies, tauopathy, beta-amyloidosis, Alzheimer's disease, mouse model, treatment response monitoring
MeSH terms
Animals, Axons, Brain, Intermediate Filaments, Mice, Inbred C57BL, Mice, Transgenic, Biomarkers, Neurofilament Proteins, Disease Progression, Neurodegenerative Diseases, alpha-Synuclein

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