Cited by 20Neural and Behavioral Psychology StudiesFace Recognition and PerceptionSocial and Intergroup Psychology

Causal role of a neural system for separating and selecting multidimensional social cognitive information

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Mahmoodi, Ali, Nili, Hamed, Harbison, Caroline, Hamilton, Sorcha, Trudel, Nadescha, Bang, Dan, Rushworth, Matthew F.S.·2023·Neuron

Abstract

People are multi-faceted, typically good at some things but bad at others, and a critical aspect of social judgement is the ability to focus on those traits relevant for the task at hand. However, it remains unknown how the brain supports such context-dependent social judgement. Here, we examine how people represent multidimensional individuals, and how the brain extracts relevant information and filters out irrelevant information when comparing individuals within a specific dimension. Using human fMRI, we identify distinct neural representations in dorsomedial prefrontal cortex (dmPFC) and anterior insula (AI) supporting separation and selection of information for context-dependent social judgement. Causal evaluation using non-invasive brain stimulation shows that AI disruption alters the impact of relevant information on social comparison, whereas dmPFC disruption only affects the impact of irrelevant information. This neural circuit is distinct from the one supporting integration across, as opposed to separation of, different features of a multidimensional cognitive space.

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    From Two prefrontal-subcortical circuits estimate controllability and reflect its impact on learning (2026) · cites this paper as [77]

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Authors
Mahmoodi, A., Nili, H., Harbison, C., Hamilton, S., Trudel, N., Bang, D., & Rushworth, M. F. S.
Affiliations
  • University of Oxford (GB)
  • Wellcome Centre for Human Neuroimaging (GB)
Corresponding author
Mahmoodi, Ali
Venue
Neuron
Publisher
Elsevier BV
Published
2023-04
Volume
111
Issue
7
Pages
1152-1164.e6
ISSN
0896-6273 (ISSN-L)
OpenAlex
W4317708748
Cited by
20
References
43
Citations by year
2026: 9 · 2025: 4 · 2024: 3 · 2023: 4
FWCI
2.99
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion, cc-by)
Funders
Wellcome Trust (221794/Z/20/Z, 203139/Z/16/Z, WT100973AIA, 213630/Z/18/Z, 203147/Z/16/Z)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
  • Social Sciences › Sociology and Political Science › Social and Intergroup Psychology
Keywords
social judgment, dorsomedial prefrontal cortex, anterior insula, non-invasive brain stimulation, causal manipulation
MeSH terms
Brain, Brain Mapping, Cognition, Humans, Judgment, Magnetic Resonance Imaging, Prefrontal Cortex

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