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Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs)
Open accessAbstract
The serotonin transporter gene (SLC6A4; synonyms, SERT, 5-HTT) is expressed much more broadly during development than in adulthood. To obtain a full picture of all sites of SERT expression during development we used a new mouse model where Cre recombinase was inserted into the gene encoding the serotonin transporter. Two reporter mouse lines, ROSA26R and the Tau(mGFP), allowed to map all the cells that express SERT at any point during development. Combined LacZ histochemistry and GFP immunolabelling showed neuronal cell bodies and axon fiber tracts. Earliest recombination in embryos was visible in the periphery in the heart and liver by E10.5 followed by recombination in the brain in raphe serotonergic neurons by E12.5. Further, recombination in non-serotonin neurons was visible in the choroid plexus, roof plate, and neural crest derivatives; by E15.5, recombination was found in the dorsal thalamus, cingulate cortex, CA3 field of the hippocampus, retinal ganglion cells, superior olivary nucleus and cochlear nucleus. Postnatally, SERT mediated recombination was visible in the medial prefrontal cortex and layer VI neurons in the isocortex. Recombined cells were co-labelled with Neu-N, but not with GAD67, and were characterized by long range projections (corpus callosum, fornix, thalamocortical). This fate map of serotonin transporter expressing cells emphasizes the broad expression of SERT in non-serotonin neurons during development and clarifies the localization of SERT expression in the hippocampus and limbic cortex. The identification of targets of SSRIs and serotonin releasers during embryonic and early postnatal life helps understanding the very diverse physiological consequences of administration of these drugs during development.
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“Receptors, transporters as well as synthesizing enzymes are already expressed (~E10 rodent and week 4–5 human) even when the actual axonal projections have not yet arrived in the PFC [236–240].”
From Development of prefrontal cortex (2022) · cites this paper as [237]
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BackgroundModality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons
Pouchelon, G., Gambino, F., Bellone, C., Telley, L., Vitali, I., Lüscher, C., Holtmaat, A. J. D. G., & Jabaudon, D. (2014) · Nature · doi:10.1038/nature13390 · Cited by 143
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“…(embryonic day 11 in mice) expression of the 5-HTT gene begins in the 5-HT neurons of the raphe nuclei, and subsequently 5-HTT expression is found in other brain areas (sensory systems, corticolimbic pathways, and prefrontal/cingulated cortex) (Narboux-Nême et al., 2008; Homberg et al., 2010).”
BackgroundLugo-Candelas, C. I., Cha, J., Hong, S. N., Bastidas, V., Weissman, M. M., Fifer, W. P., Myers, M. D., Talati, A., Bansal, R., Peterson, B. S., et al. (2018) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2017.5227 · Cited by 128
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“For example, in BALB/c and C57BL/6 mice, adult hippocampal neurogenesis only occurred when treatment commenced in adolescence (PD35), and this effect was abolished by stress (Navailles et al., 2008).”
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Myllynen, P. K., Immonen, E., Kummu, M., & Vähäkangas, K. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903304049 · Cited by 107
Narboux‐Nême, N., Evrard, A., Férézou, I., Erzurumlu, R. S., Kaeser, P. S., Lainé, J., Rossier, J., Ropert, N., Südhof, T. C., & Gaspar, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0343-12.2012 · Cited by 92
“Sert is strongly expressed in the major thalamic sensory relay nuclei during development (Lebrand et al., 1998), and Cre expression driven by the Sert promoter is efficient in the thalamus, occurring by embryonic day 15 (E15) (Narboux-Nême et al., 2008).”
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“SERT is a major regulator of this essential 5HT signaling during neurodevelopment [41], and is transiently expressed on non-serotonergic neurons in early life, facilitating organization of neuronal projections by regulating the duration of 5-HT signaling [28].”
Vitalis, T., Ansorge, M. S., & Dayer, A. G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00093 · Cited by 90
“Fate mapping of SERT-expressing cells in mice revealed that in addition to the thalamus, also the cortex, hippocampus, hypothalamus, and brainstem harbor neurons that transiently adopt a serotonergic phenotype (Narboux-Nême et al., 2008).”
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Self-citationPostnatal Growth Defects in Mice with Constitutive Depletion of Central Serotonin
Narboux‐Nême, N., Angenard, G., Mosienko, V., Klempin, F., Pitychoutis, P. M., Deneris, E. S., Bäder, M., Giros, B., Alenina, N. V., & Gaspar, P. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn300165x · Cited by 82
Self-citationMillard, S. J., Weston–Green, K., & Newell, K. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.008 · Cited by 83
“Developmental SERT expression on non- serotonergic neurons in the rodent brain ceases in the first two weeks of postnatal life (equivalent to birth in humans (Semple et al., 2013), and is localised to serotonergic neurons in the mature brain (Narboux-Nême et al., 2008).”
BackgroundHippocampal HDAC4 Contributes to Postnatal Fluoxetine-Evoked Depression-Like Behavior
Sarkar, A., Chachra, P., Kennedy, P., Pena, C. J., Desouza, L. A., Nestler, E. J., & Vaidya, V. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.73 · Cited by 79
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“Using 5-HTT-cre mice to drive reporter gene expression, labeling was seen in dorsal thalamus, cingulate cortex, hippocampal CA3 neurons, retinal ganglion cells, superior olivary and cochlear nuclei during embryonic development and postnatally in medial prefrontal cortex (97).”
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Maddaloni, G., Bertero, A., Pratelli, M., Barsotti, N., Boonstra, A., Giorgi, A. U. D., Migliarini, S., & Pasqualetti, M. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00202 · Cited by 71
“Furthermore, SERT is transiently expressed in non-serotonergic neurons in the developing brain (Lebrand et al., 1998; Narboux-Nême et al., 2008).”
BackgroundLeptin Does Not Directly Affect CNS Serotonin Neurons to Influence Appetite
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“onto the conditional Leprfl background and the ROSA26-reporter alleles that express EGFP/EYFP following cre-dependent excision (Mao et al., 1999; McMinn et al., 2005; Narboux-Neme et al., 2008).”
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Excess of serotonin affects neocortical pyramidal neuron migration
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“cortical anlage receives the innervation of thalamo-cortical axons that express high levels of SERT allowing them to actively reuptake serotonin from the extracellular space.(31,32)”
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“…htr2a gene rescue experiment for the thalamus appears to have been compromised by the use of a promoter that is weakly expressed in the midline and intralaminar thalamic nuclei compared to a robust expression in the primary sensory thalamic nuclei (Lebrand et al. 1996; Narboux-Neme et al. 2008).”
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“…other systems as well, because the transient ectopic expression of 5-HT transporter during development is also observed in other sensory, thalamic, hippocampal, hypothalamic, and prefrontal cortical neurons throughout development in rodents (Lebrand et al., 1996, 1998; Narboux-Neme et al., 2008).”
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“The direct contributions of synaptic transmission to this process, however, remain unclear.”
Sprowles, J. L. N., Wendel, J. R. H., Gutierrez, A., Bailey, R. A., Jablonski, S. A., Williams, M. T., & Vorhees, C. V. (2016) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2016.08.007 · Cited by 62
“This spanned virtually all stages of brain 5-HT development (Hansson et al., 1998; Homberg et al., 2010; Johnston and Coyle 1980; Lauder and Bloom 1975; Narboux-Neme et al., 2008; Olivier et al., 2011; Zhou et al., 2000).”
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“Apart from being expressed in 5-HT neurons, the 5-HTT is also transiently expressed in non-aminergic neurons, belonging to many topographically distinct brain areas (Lebrand et al., 1998; Zhou et al., 2000; Narboux-Neme et al., 2008; Kalueff et al., 2010).”
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“However, SERT has been shown to be expressed in nonserotonergic cells in other parts of the developing PNS and in the CNS (Narboux-Nême et al., 2008; Chen et al., 2015).”
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“most part similar between Tg208 and Tg810 (n 90 in total) and similar to those previously reported for 5-HTTCre knock-in mice, in which an allele of endogenous 5-HTT gene is inserted and disrupted by the Cre recombinase gene (Zhuang et al., 2005; Narboux-Nême et al., 2008).”
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“A specific population of neuroepithelial cells in Xenopus gills has also been shown to contain 5-HT (Saltys et al., 2006) and 5-HT uptake sites have been described in mammalian branchial arches and cranial NCCs (Shuey et al., 1993; Hansson et al., 1999; Narboux-Neme et al., 2008).”
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Diaz, S. L., Narboux‐Nême, N., Trowbridge, S., Scotto‐Lomassese, S., Kleine Borgmann, F. B., Jessberger, S., Giros, B., Maroteaux, L., Deneris, E., & Gaspar, P. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12297 · Cited by 41
Self-citationThalamic neuronal specification and early circuit formation
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“The Sert gene has been used as a driver to generate various mouse lines with selective activity in principal neurons of the thalamus (Narboux-Nême et al., 2008; Arakawa et al., 2014; Mizuno et al., 2014).”
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“It was shown that SERT is transiently expressed during early postnatal days in the cortical layer VI, layer II of retrosplenial cortex, and CA3 of HPC [30,31].”
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Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats
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Thalamus mediates neocortical Down state transition via GABAB-receptor-targeting interneurons
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Divergent Roles of Central Serotonin in Adult Hippocampal Neurogenesis
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“In Sert-Cre mice, however, Cre recombinase expression is not limited in 5-HTergic neurons (Narboux-Neme et al., 2008), and this may lead to Vmat2 deletion in other neurons.”
BackgroundSprowles, J. L. N., Wendel, J. R. H., Gutierrez, A., Bailey, R. A., Jablonski, S. A., Williams, M. T., & Vorhees, C. V. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.06.004 · Cited by 33
“SERT is transiently expressed in some regions as early as embryonic day (E) 11 and aids organization of neuronal connectivity by maintaining 5-HT near target receptors (Gaspar et al., 2003; Homberg et al., 2010; Narboux-Neme et al., 2008; Olivier et al., 2011a).”
BackgroundRORα Coordinates Thalamic and Cortical Maturation to Instruct Barrel Cortex Development
Vitalis, T., Dauphinot, L., Gressèns, P., Potier, M., Mariani, J., & Gaspar, P. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx262 · Cited by 28
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“Narboux-Nème and colleagues [60] elegantly showed a transient 5-HTTexpression within layers II, V, and VI of the mPFC at E15.”
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Ranzil, S., Walker, D. W., Borg, A. J., Wallace, E. M., Ebeling, P. R., & Murthi, P. (2018) · Biochimie · doi:10.1016/j.biochi.2018.12.016 · Cited by 28
The deletion of the microtubule‐associated STOP protein affects the serotonergic mouse brain network
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Zhou, X., Lu, J. Y.-F., Darling, R. D., Simpson, K. L., Zhu, X., Wang, F., Yu, L., Sun, X., Merzenich, M. M., & Lin, R. C. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416582111 · Cited by 26
“Serotonin is also known to take up (via norepinephrine transporter) 5-HT transiently in the noradrenergic locus coeruleus (LC) system during early development (31, 33), and it is again likely that noradrenergic circuitry may be affected by CTM exposure.”
BackgroundUnraveling new roles for serotonin receptor 2B in development: key findings from Xenopus
Ori, M., Lucchini, S. D., Marras, G., & Nardi, I. (2013) · The International Journal of Developmental Biology · doi:10.1387/ijdb.130204mo · Cited by 25
“In mice uptake of 5-HT during early development is first observed in non-neural tissues such as the heart, the liver, the cranial mesenchyme, the migrating cranial neural crest cells (NCCs), dorsal ganglia and retinal ganglion cells (Lauder and Zimmerman, 1988; Narboux-Nème et al., 2008).”
BackgroundOlusakin, J., Moutkine, I., Dumas, S., Ponimaskin, E. G., Païzanis, E., Soiza‐Reilly, M., & Gaspar, P. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0775-z · Cited by 27
“While SERT is expressed exclusively in the 5-HT-producing neurons of the raphe nuclei in adult brain, it has a broader expression during fetal and early postnatal life in rodents [12, 13] and primates including humans [[14, 15]; http://www.”
BackgroundSelf-citationHeart valve cardiomyocytes of mouse embryos express the serotonin transporter SERT
Pavone, L. M., Spina, A., Muto, R. L., Santoro, D., Mastellone, V., & Avallone, L. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.152 · Cited by 23
Self-citationThalamic adenylyl cyclase 1 is required for barrel formation in the somatosensory cortex
Suzuki, A., Lee, L., Hayashi, Y., Muglia, L. M., Itohara, S., Erzurumlu, R. S., & Iwasato, T. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.043 · Cited by 23
“043 thalamus and raphe during early postnatal development (Allen-Developing-Mouse-Brain-Atlas; Lebrand et al., 1998; Narboux-Neme et al., 2008).”
BackgroundInfluentialWhitaker‐Azmitia, P. M. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70086-2 · Cited by 23
Molecular biology of serotonergic systems in avian brains
Fujita, T., Aoki, N., Mori, C., Homma, K. J., & Yamaguchi, S. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1226645 · Cited by 22
“It should be noted that Sert is transiently expressed in non-serotonergic neurons in several brain regions during development (Lebrand et al., 1996; Narboux-Nême et al., 2008).”
BackgroundDopamine–mediated immunomodulation affects choroid plexus function
Castellani, G., Contarini, G., Mereu, M., Albanesi, E., Devroye, C., D’Amore, C., Ferretti, V., Martin, S. D., & Papaleo, F. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.006 · Cited by 22
Serotonin activates cell survival and apoptotic death responses in cultured epithelial thyroid cells
Cerulo, G., Tafuri, S., Pasquale, V. D., Rea, S., Romano, S., Costagliola, A., Morte, R. D., Avallone, L., & Pavone, L. M. (2014) · Biochimie · doi:10.1016/j.biochi.2014.06.020 · Cited by 21
“The transporter SERT is targeted by many antidepressant drugs, including the selective serotonin reuptake inhibitors (SSRI), and psycho-stimulants such as cocaine, amphetamine and related drugs [14].”
BackgroundSelf-citationPinheiro, I. L., da Silva, A. I., Reginato, A., Silva‐Filho, R., Galindo, L. C. M., de Matos, R. J. B., Ferraz, J. C., Toscano, A. E., Milanski, M., Manhães‐de‐Castro, R., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.038 · Cited by 22
“The use of SSRIs during gestation or childhood can modify properties of neurons expressing SERT through changes in their specific transcription or changes in their gene expression [37].”
Grieb, Z. A., & Ragan, C. M. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.07.239 · Cited by 21
Kast, R. J., Wu, H.-H., Williams, P., Gaspar, P., & Levitt, P. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00020 · Cited by 20
Self-citationSerotonergic regulation of bipolar cell survival in the developing cerebral cortex
Wong, F. K., Selten, M. M., Rosés-Novella, C., Sreenivasan, V., Pallas‐Bazarra, N., Serafeimidou‐Pouliou, E., Hanusz-Godoy, A., Oozeer, F., Edwards, R. H., & Marín, Ó. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111037 · Cited by 20
Hou, G., & Zhang, Z. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00353 · Cited by 20
“The hyperpolarization-activated current (Ih) plays important roles in the regulation of neuronal intrinsic excitability during development and in adult (Robinson and Siegelbaum, 2003; Bender and Baram, 2008; Biel et al., 2009; Noam et al., 2011).”
BackgroundPrenatal antidepressant exposure and sex differences in neonatal corpus callosum microstructure
Campbell, K. S. J., Williams, L. J., Björnson, B., Weik, E., Brain, U. M., GRUNAU, R. E., Miller, S. P., & Oberlander, T. F. (2021) · Developmental Psychobiology · doi:10.1002/dev.22125 · Cited by 19
Beyond Gene Inactivation: Evolution of Tools for Analysis of Serotonergic Circuitry
Hainer, C., Mosienko, V., Koutsikou, S., Crook, J. J., Gloss, B. R., Kasparov, S., Lumb, B. M., & Alenina, N. V. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00045 · Cited by 20
Murray, K., Liu, X.-B., King, A. N., Luu, J., & Cheng, H.-J. (2020) · eNeuro · doi:10.1523/eneuro.0030-20.2020 · Cited by 18
“CreERT2 recombinase activity in Gli1-CreERT2;TaumGFP mice leads to expression of membrane localized EGFP (Narboux-Nême et al., 2008; Dondzillo et al., 2010; Gangarossa et al., 2012).”
Assali, A., Magueresse, C. L., Bennis, M., Nicol, X., Gaspar, P., & Rebsam, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-03361-0 · Cited by 18
Self-citationIn Utero Exposure to Citalopram Mitigates Maternal Stress Effects on Fetal Brain Development
Velasquez, J. C., Zhao, Q., Chan, Y., Galindo, L. C. M., Simasotchi, C., Wu, D., Hou, Z., Herod, S. M., Oberlander, T. F., Gil, S., et al. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00180 · Cited by 19
ErbB4 knockdown in serotonergic neurons in the dorsal raphe induces anxiety-like behaviors
Zhang, S.-R., Wu, J., Chen, H. H., Luo, R., Chen, W., Tang, L., Li, X., Yang, J., & Gao, T. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0601-7 · Cited by 18
Maternal Pharmacokinetics and Fetal Disposition of (±)-Citalopram during Mouse Pregnancy
Velasquez, J. C., Goeden, N., Herod, S. M., & Bonnin, A. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00287 · Cited by 17
Dudok, J. J., Groffen, A. J. A., Toonen, R. F. G., & Verhage, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028137 · Cited by 16
“However, SERT is also transiently expressed in some other brain regions during development, such as the thalamocortical neurons [16,17].”
Backgroundde Leeuw, V. C., Hessel, E. V. S., Pennings, J. L. A., Hodemaekers, H. M., Wackers, P. F. K., van Oostrom, C. T. M., & Piersma, A. H. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.09.014 · Cited by 18
Kurahashi, H., Kunisawa, K., Tanaka, K. F., Kubota, H., Hasegawa, M., Miyachi, M., Moriya, Y., Hasegawa, Y., Nagai, T., Saito, K., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02004-z · Cited by 21
Cortical influences of serotonin and glutamate on layer V pyramidal neurons
Marek, G. J., & Schoepp, D. D. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2020.11.002 · Cited by 18
Fate Map of Serotonin Transporter‐Expressing Cells in Developing Mouse Thyroid
Spina, A., Rea, S., Pasquale, V. D., Mastellone, V., Avallone, L., & Pavone, L. M. (2011) · The Anatomical Record · doi:10.1002/ar.21353 · Cited by 15
“During development, SERT is expressed much more broadly than in adults in several non-serotonin neurons of the brain and in neural crest derivatives (Hansson et al., 1999; Narboux-Nême et al., 2008).”
BackgroundSelf-citationPavone, L. M., & Norris, R. A. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9606-8 · Cited by 15
“[6] suggest that blocking 5-HT uptake during pregnancy could affect fetal valve development and may provide an explanation for why selective serotonin reuptake inhibitors (SSRIs) have been associated with increased risk of cardiac malformations [26].”
Self-citationThe teratogenic effects of sertraline in mice
Cabrera, R. M., Lin, Y. L., Law, E., Kim, J., & Wlodarczyk, B. J. (2020) · Birth Defects Research · doi:10.1002/bdr2.1660 · Cited by 14
Perinatal SSRI exposure impacts innate fear circuit activation and behavior in mice and humans
Zanni, G., van Dijk, M. T., Cagliostro, M. K. C., Sepúlveda, P., Pini, N., Rose, A. L., Kesin, A. L., Lugo-Candelas, C. I., Gonçalves, P. D., MacKay, A. S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58785-4 · Cited by 12
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Serotonin regulates contractile activity of the uterus in non-pregnant rabbits
Lychkova, A. E., Pasquale, V. D., Avallone, L., Puzikov, A. M., & Pavone, L. M. (2014) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2014.05.006 · Cited by 13
Self-citationImpact of selective serotonin reuptake inhibitors on neural crest stem cell formation
Vichier-Guerre, C., Parker, M. M., Pomerantz, Y., Finnell, R. H., & Cabrera, R. M. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.08.012 · Cited by 12
Baudat, M., de Kort, A. R., van den Hove, D., & Joosten, E. A. J. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15544 · Cited by 12
“In the PFC, SERT is expressed in glutamatergic pyramidal neurons between P 0 and P 10 (Narboux-Nême et al., 2008; Soiza-Reilly et al., 2019).”
BackgroundSex differences in serotonergic control of rat social behaviour
Poceviciute, I., Kasperaviciute, K., Buišas, R., Rukšėnas, O., & Vengeliene, V. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173533 · Cited by 11
Metadata
- Authors
- Narboux-Nême, N., Pavone, L. M., Avallone, L., Zhuang, X., & Gaspar, P.
- Affiliations
- University of Naples Federico II (IT)
- University of Chicago (US)
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 55
- Issue
- 6
- Pages
- 994-1005
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2013740680
- Cited by
- 148
- References
- 72
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 13 · 2020: 16 · 2019: 11 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 6 · 2014: 11 · 2013: 6 · 2012: 6
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- European Commission (201714)
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- serotonin transporter, selective serotonin reuptake inhibitors, developmental gene expression, Cre recombinase, fate mapping, embryonic development, choroid plexus, neural crest derivatives, hippocampus, limbic cortex, medial prefrontal cortex, axonal projections
- MeSH terms
- Animals, Embryo, Mammalian, Mice, Transgenic, Neurons, Raphe Nuclei, Serotonin, tau Proteins, Selective Serotonin Reuptake Inhibitors, Gene Expression Regulation, Developmental, Integrases, Green Fluorescent Proteins, Serotonin Plasma Membrane Transport Proteins, Mice
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