Cited by 164Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchPain Management and Treatment

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Pain and post traumatic stress disorder - review of clinical and experimental evidence

Moeller-Bertram, Tobias, Keltner, John, Strigo, Irina A.·2012·Neuropharmacology

DOI 10.1016/j.neuropharm.2011.04.028

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Abstract

Pain and Post Traumatic Stress Disorder (PTSD) are highly comorbid conditions. Patients with chronic pain have higher rates of PTSD. Likewise, patients with PTSD are often diagnosed with numerous chronic pain conditions. Despite the high pain-PTSD comorbidity, the neurobehavioral mechanisms underlying this phenomenon are incompletely understood and only recently researchers have started investigating it using experimental models. In this article, we systematically review the substantial clinical evidence on the co-occurrence of pain and PTSD, and the limited experimental evidence of pain processing in this disorder. We provide a detailed overview of the psychophysical and brain imaging experiments that compared somatosensory and pain processing in PTSD and non-PTSD populations. Based on the presented evidence, an extensive body of literature substantiates the clinical coexistence of pain and PTSD in patients but the limited experimental data show inconsistent results highlighting the need for well-controlled future studies. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.

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Authors: Moeller-Bertram, T., Keltner, J., & Strigo, I. A.
Affiliations: University of California San Diego (US)
ORCID: Keltner, John
Strigo, Irina A.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2012-02
Volume: 62
Issue: 2
Pages: 586-597
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2011.04.028
OpenAlex: W2021224881
Cited by: 163
References: 191
Citations by year: 2026: 2 · 2025: 10 · 2024: 7 · 2023: 10 · 2022: 16 · 2021: 6 · 2020: 12 · 2019: 10 · 2018: 9 · 2017: 13 · 2016: 22 · 2015: 13 · 2014: 18 · 2013: 10 · 2012: 5
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: post-traumatic stress disorder, chronic pain, pain processing, somatosensory processing, neuroimaging, psychophysical experiments, neurobehavioral mechanisms
MeSH terms: Brain, Humans, Pain, Stress Disorders, Post-Traumatic, Pain Threshold, Neuroimaging

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Pain and post traumatic stress disorder - review of clinical and experimental evidence

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