Cited by 258Substance Abuse Treatment and OutcomesStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.

Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders

Open access

Blaine, Sara K., Sinha, Rajita·2017·Neuropharmacology

DOI 10.1016/j.neuropharm.2017.01.037PMC PMC5479733

Open this paper in CoChat — free account

Abstract

In this review, we detail the clinical evidence supporting the role of psychological and physiological stress in instrumental motivation for alcohol consumption during the development of mild to moderate alcohol use disorders (AUDs) and in the compulsive, habitual alcohol consumption seen in severe, chronic, relapsing AUDs. Traditionally, the study of AUDs has focused on the direct and indirect effects of alcohol on striatal dopaminergic pathways and their role in the reinforcing effects of alcohol. However, growing evidence also suggests that alcohol directly stimulates the hypothalamic pituitary adrenal (HPA) axis and has effects on glucocorticoid receptors in extrahypothalamic, limbic forebrain, and medial Prefrontal Cortex (PFC) circuits, which contribute to the development of AUDs and their progression in severity, chronicity, and relapse risk. Evidence indicates HPA axis, glucocorticoid, and PFC dysfunction during protracted withdrawal and under high arousal conditions in those with severe AUDs, and novel evidence is also emerging to suggest HPA axis dysfunction with binge/heavy drinking, which is associated with motivation for alcohol in non-dependent individuals. Specifically, alcohol-associated alterations in HPA axis responses to stress and alcohol cues may serve as interoceptive physiological signals and facilitate conditioning mechanisms to influence alcohol motivation. Thus, this dysfunction may serve as a potential biomarker of both risk and of relapse. Based on this emerging data, we conceptualize and present early evidence for treatment targets that may improve PFC function and/or normalize HPA axis functioning and may be beneficial in the treatment and relapse prevention of AUDs. Finally, we suggest that individual differences in alcohol-related pathophysiology in these circuits may modulate treatment and recovery response, thereby supporting the need for building personalized medicine algorithms to understand and treat AUDs. This article is part of the Special Issue entitled "Alcoholism".

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2017.01.037

Cites

134 of 134 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010
Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., Charlson, F. J., Norman, R. E., Flaxman, A. D., Johns, N., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61611-6 · Cited by 6,006
Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092 · cited 1×
“This return to a healthy normal set-point occurs via allostatic processes, which allow the brain and body to achieve physiological stability through challenges to homeostasis by altering cellular structure and function (McEwen, 1998).”
The cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495 · cited 2×
“…relays leads to damage via glucocorticoid -induced excitotoxicity, then self-directed behavior may be even more likely to be replaced by habit and sensory-driven automatic responding (Bechara, 2005; Ochsner and Gross, 2005; Ochsner et al., 2004; Rosenkranz and Grace, 2002; Thayer et al., 2009).”
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318 · cited 1×
“Under normal conditions, the PFC can inhibit the physiological response to stress that is related to activation of the HPA axis and the autonomic nervous system (Spencer et al., 2005; Ulrich-Lai and Herman, 2009).”
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · cited 2×
“…AUDs, i.e., decreases in working memory function, poor attention and flexibility, lower behavioral control, and increases in impulsive responding (Arnsten, 2009a; Bechara, 2005; Koob and Le Moal, 2005; Matikainen et al., 1986; Piazza and Le Moal, 1997; Rosenkranz and Grace, 2002; Volkow et al.,…”
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059
Prevalence, Correlates, Disability, and Comorbidity of DSM-IV Alcohol Abuse and Dependence in the United States: Results From the National Epidemiologic Survey on Alcohol and Related Conditions
Hasin, D. S., Stinson, F. S., Ogburn, E., & Grant, B. F. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.7.830 · Cited by 2,908 · cited 1×
“…. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145 Eighteen percent of Americans suffer from an alcohol use disorder (AUD) at some point during their lifetime and up to 8% of Americans go on to develop severe AUDs (Hasin et al., 2007).”
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535 · cited 2×
“…consumption results in larger-scale adaptations and wear and tear (allostatic overload) to the reward and neuroendocrine regulation circuits (Koob and Le Moal, 2005; Sinha, 2001); these adaptations may represent the pathophysiology underlying the transition from controlled to compulsive…”
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396 · cited 1×
“A wealth of preclinical and clinical data indicates that acute stressors may play a role in the motivation for alcohol consumption in those with and without AUDs (Chaplin et al., 2008; Goeders, 2004; Sinha, 2001; Uhart and Wand, 2009).”
Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective
Bechara, A. (2005) · Nature Neuroscience · doi:10.1038/nn1584 · Cited by 2,149 · cited 3×
“…relays leads to damage via glucocorticoid -induced excitotoxicity, then self-directed behavior may be even more likely to be replaced by habit and sensory-driven automatic responding (Bechara, 2005; Ochsner and Gross, 2005; Ochsner et al., 2004; Rosenkranz and Grace, 2002; Thayer et al., 2009).”

Show all 133 references

Research works printed but not linked: 8

Arnsten, 2009, Stress signalling pathways that impair prefrontal cortex structure and function, Nat. Rev. Neurosci., 10, 410, 10.1038/nrn2648 · DOI · Paper page
D’Sa, 2012, Alterations in serum cytokines, chemokines, interferons, growth factors and C-Reactive protein in alcohol-dependent individuals compared with social drinkers, Alcohol. Clin. Exp. Res., 36
Glassman, 1993, Clinical trials and therapeutics smokng vulnerabi lity to, Clini. Pharmaco. Ther., 54
Seo, 2014, Neurobiol. alcohol craving relapse Handb. Clin. Neurosci., 125, 355
Sinha, 2012, Pharmacotherapy development to target dysfunction of stress and craving regulation in alcohol dependence, Alcohol. Clin. Exp. Res., S234, 36
Sinha R, Fox H, Tuit K, Morgan P (2011a) Chronic alcohol related adaptations in stress arousal: Effects on Relapse Susceptibility and Treatment Outcome. Presented at the Stress and Alcoholism: New Approaches to Treatment Conference, Volterra, Italy, May 3–6. Alcohol Supplement S57.
Sinha, 2009, Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology, Official Publ. Am. Coll. Neuropsychopharmacol., 34, 1198, 10.1038/npp.2008.78 · DOI · Paper page
Sinha, 2013, Alcohol effects on neuroendocrine and metabolic responses to stress and motivation for alcohol intake, Alcohol. Clin. Exp. Res., 254A

Sorted by citations

Stress and Obesity: Are There More Susceptible Individuals?
van der Valk, E. S., Savas, M., & van Rossum, E. F. C. (2018) · Current Obesity Reports · doi:10.1007/s13679-018-0306-y · Cited by 402
Alcohol use disorder relapse factors: A systematic review.
Sliedrecht, W., de Waart, R., Witkiewitz, K., & Roozen, H. G. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.05.038 · Cited by 358
Diseases, Disorders, and Comorbidities of Interoception
Bonaz, B., Lane, R. D., Oshinsky, M. L., Kenny, P. J., Sinha, R., Mayer, E. A., & Critchley, H. D. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.09.009 · Cited by 260
Sex Differences in the Neurobiology of Alcohol Use Disorder
Flores‐Bonilla, A. (2020) · Alcohol research · doi:10.35946/arcr.v40.2.04 · Cited by 218
The Role of Stress, Trauma, and Negative Affect in the Development of Alcohol Misuse and Alcohol Use Disorders in Women
Guinle, M. I. B. (2020) · Alcohol research · doi:10.35946/arcr.v40.2.05 · Cited by 211
Addiction as a coping response: hyperkatifeia, deaths of despair, and COVID-19
Koob, G. F., Powell, P., & White, A. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20091375 · Cited by 166
Psychological, addictive, and health behavior implications of the COVID-19 pandemic
Zvolensky, M. J., Garey, L., Rogers, A. H., Schmidt, N. B., Vujanovic, A. A., Storch, E. A., Buckner, J. D., Paulus, D. J., Alfano, C. A., Smits, J. A. J., et al. (2020) · Behaviour Research and Therapy · doi:10.1016/j.brat.2020.103715 · Cited by 175
“It is well-documented that stress, both acute and chronic, is a trigger for alcohol (mis) use (Becker, Lopez, & Doremus-Fitzwater, 2011; Blaine & Sinha, 2017).”
Suicide Risk and Addiction: The Impact of Alcohol and Opioid Use Disorders
Rizk, M., Herzog, S., Dugad, S., & Stanley, B. (2021) · Current Addiction Reports · doi:10.1007/s40429-021-00361-z · Cited by 195
Drug-induced stress responses and addiction risk and relapse
Wemm, S. E., & Sinha, R. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100148 · Cited by 144
Stress and substance use disorders: risk, relapse, and treatment outcomes
Sinha, R. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172883 · Cited by 145
“…disruption can change the basal subjective state and physiologic tone, the phasic stress response, as well as the stress recovery phase without a return to homeostasis, as discussed in previous psychosocial and psychobiological stress adaptation models (43, 44) and illustrated in Figure 1, C and D.”
Craving, cortisol and behavioral alcohol motivation responses to stress and alcohol cue contexts and discrete cues in binge and non‐binge drinkers
Blaine, S. K., Nautiyal, N., Hart, R. L. D., Guarnaccia, J. B., & Sinha, R. (2018) · Addiction Biology · doi:10.1111/adb.12665 · Cited by 128
Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability
Milivojevic, V., & Sinha, R. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.12.010 · Cited by 126
“In humans, enhanced stress-system activity has been associated with chronic smoking as well as with cocaine and alcohol consumption [38, 39].”
Background
Covid-19 and Persons with Substance Use Disorders: Inequities and Mitigation Strategies
Melamed, O. C., Hauck, T. S., Buckley, L., Selby, P. L., & Mulsant, B. H. (2020) · Substance Abuse · doi:10.1080/08897077.2020.1784363 · Cited by 116
The role of the orbitofrontal cortex in alcohol use, abuse, and dependence
Moorman, D. E. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.010 · Cited by 114
“Furthermore, these results indicate that the ventromedial PFC, including OFC, may be a key component of the influence of stress on problematic alcohol use (Blaine and Sinha, 2017).”
Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder
Farokhnia, M., Faulkner, M. L., Piacentino, D., Lee, M. R., & Leggio, L. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.02.008 · Cited by 107
Mechanisms of Behavior Change in Substance Use Disorder With and Without Formal Treatment
Witkiewitz, K. A., Pfund, R. A., & Tucker, J. A. (2022) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-072720-014802 · Cited by 107
Alcohol Consumption during a Pandemic Lockdown Period and Change in Alcohol Consumption Related to Worries and Pandemic Measures
Alpers, S. E., Skogen, J. C., Mæland, S., Pallesen, S., Rabben, Å. K., Lunde, L.-H., & Fadnes, L. T. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031220 · Cited by 93
“Both acute and chronic stress are documented risk factors of increased alcohol use [8,9].”
BackgroundResult
Sex Differences in Risk and Resilience: Stress Effects on the Neural Substrates of Emotion and Motivation
Wellman, C. L., Bangasser, D. A., Bollinger, J. L., Coutellier, L., Logrip, M. L., Moench, K. M., & Urban, K. R. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1673-18.2018 · Cited by 88
“Importantly, women with AUD experience greater craving to drink following exposure to stressful images (Hartwell and Ray, 2013) and stronger relationships between past trauma severity and craving (Heffner et al., 2011), relative to men.”
BackgroundInfluential
Early life stress and substance use disorders: The critical role of adolescent substance use
Kirsch, D. E., & Lippard, E. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173360 · Cited by 86
Alcohol and Stress Activation of Microglia and Neurons: Brain Regional Effects
Walter, T. J., Vetreno, R. P., & Crews, F. T. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13511 · Cited by 71
“Stress and the release of stress hormones by the hypothalamic–pituitary–adrenal (HPA) axis have been implicated in binge/heavy drinking, motivation to drink, and the chronic relapsing nature of AUD (Blaine and Sinha, 2017; Stephens and Wand, 2012).”
Background
Genome-wide methylation in alcohol use disorder subjects: implications for an epigenetic regulation of the cortico-limbic glucocorticoid receptors (NR3C1)
Gatta, E., Grayson, D. R., Auta, J., Saudagar, V., Dong, E., Chen, Y., Krishnan, H. R., Drnevich, J. M., Pandey, S. C., & Guidotti, A. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0449-6 · Cited by 81
Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications
Wiss, D. A., Avena, N., & Gold, M. (2020) · Nutrients · doi:10.3390/nu12113521 · Cited by 66
Association of Prefrontal-Striatal Functional Pathology With Alcohol Abstinence Days at Treatment Initiation and Heavy Drinking After Treatment Initiation
Blaine, S. K., Wemm, S., Fogelman, N., Lacadie, C., Seo, D., Scheinost, D., & Sinha, R. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19070703 · Cited by 60
“These results are consistent with current understanding of the underlying neurobiology of AUD, that chronic alcohol-related neuroadaptations in prefrontal-ventral striatal circuits may hamper a person’s ability to recruit prefrontal executive control functions in response to stress cues, while also showing hypoactivat…”
Neurodevelopmental origins of substance use disorders: Evidence from animal models of early‐life adversity and addiction
Levis, S. C., Baram, T. Z., & Mahler, S. V. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15223 · Cited by 63
“For example, relative to controls, MS increases dopamine, endogenous opioid, and CRH expression simultaneously in NAc in male mice that also show increased ethanol consumption relative to controls (García- Gutiérrez et al., 2016).”
BackgroundInfluential
Early Life Stress and Substance Use Disorders: Underlying Neurobiology and Pathways to Adverse Outcomes
Kirsch, D. E., Nemeroff, C. B., & Lippard, E. (2020) · Adversity and Resilience Science · doi:10.1007/s42844-020-00005-7 · Cited by 61
The Endocrine System and Alcohol Drinking in Females
Finn, D. A. (2020) · Alcohol research · doi:10.35946/arcr.v40.2.02 · Cited by 52
Neurobiology of alcohol seeking behavior
Domi, E., Domi, A., Adermark, L., Heilig, M. A., & Augier, E. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15343 · Cited by 53
“The latter effect is in line with a well-documented clinical relationship between HPA axis activity, craving, and relapse to alcohol use (Blaine & Sinha, 2017; Sinha et al., 2011; Stephens & Wand, 2012).”
Alcohol Consumption and Smoking During Covid-19 Pandemic: Association with Sociodemographic, Behavioral, and Mental Health Characteristics
Schäfer, A. A., Santos, L. P., Quadra, M. R., Dumith, S. C., & Meller, F. D. O. (2022) · Journal of Community Health · doi:10.1007/s10900-022-01085-5 · Cited by 51
“Stress, depression and anxiety are conditions associated with alcohol consumption and smoking during the SARSCoV-2 outbreak [7, 13, 15, 16], as they act as triggers for consumption as a way of coping [7, 17, 18].”
Background
Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes
Ramchandani, V. A., Stangl, B. L., Blaine, S. K., Plawecki, M. H., Schwandt, M. L., Kwako, L. E., Sinha, R., Cyders, M. A., O’Connor, S., & Zakhari, S. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.06.001 · Cited by 49
“King and colleagues (King et al, 2006; King et al, 2014) demonstrated in a series of longitudinal studies that problem drinkers who experience high stimulation in response to alcohol consumption go on to develop AUDs, whereas those drinkers who experienced sedative effects of alcohol Alcohol.”
BackgroundInfluential
Alcohol craving and withdrawal at treatment entry prospectively predict alcohol use outcomes during outpatient treatment
Martins, J. S., Fogelman, N., Wemm, S., Hwang, S., & Sinha, R. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.109253 · Cited by 51
New steps for treating alcohol use disorder
Campbell, E. J., Lawrence, A. J., & Perry, C. J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4887-7 · Cited by 49
Closing the brain–heart loop: Towards more holistic models of addiction and addiction recovery
Eddie, D., Bates, M. E., & Buckman, J. F. (2020) · Addiction Biology · doi:10.1111/adb.12958 · Cited by 48
“diovascular system in the same way flexibility is thought to be lost in other body systems such as the hypothalamic–pituitary adrenal axis under repeated intoxication–withdrawal.(31) Thus, less accurate infor-”
Background
A coordinate-based meta-analysis of white matter alterations in patients with alcohol use disorder
Spindler, C., Mallien, L., Trautmann, S., Alexander, N., & Muehlhan, M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01809-0 · Cited by 36
The Impact of Social Media & Technology on Child and Adolescent Mental Health
Masri-zada, T., Martirosyan, S., Abdou, A., Barbar, R., Kades, S., Makki, H., Haley, G., & K Agrawal, D. (2025) · Journal of Psychiatry and Psychiatric Disorders · doi:10.26502/jppd.2572-519x0242 · Cited by 45
“Chronic activation of the HPA axis causes sustained cortisol to increase and altered stress responses, which is a common occurrence in substance addiction [35].”
Sex- and hormone-dependent alterations in alcohol withdrawal-induced anxiety and corticolimbic endocannabinoid signaling
Henricks, A. M., Berger, A. L., Lugo, J. M., Baxter-Potter, L. N., Bieniasz, K. V., Petrie, G. N., Sticht, M. A., Hill, M. N., & McLaughlin, R. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.05.023 · Cited by 42
“Alternatively, deficits in 2-AG could be altering the ability of the vmPFC to exert efficient glucocorticoid-mediated negative feedback inhibition over the HPA axis, which has recently been suggested as a potential biomarker of alcohol dependence risk and relapse (Blaine and Sinha, 2017).”
cAMP/PKA/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11β-HSD2 expression
Yu, L., Zhou, J., Zhang, G., Huang, W. M., Pei, L., Lv, F., Zhang, Y., Zhang, W., & Wang, H. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.05.029 · Cited by 41
Alcohol�s Negative Emotional Side: The Role of Stress Neurobiology in Alcohol Use Disorder
Sinha, R. (2022) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v42.1.12 · Cited by 39
“Binge and hazardous alcohol drinking patterns are associated with well-documented changes both in the brain stress and emotion regions, such as the amygdala,(8,12) and in associated brain networks, including the ventral and dorsal striatum as well as the OFC, VmPFC, and dorsolateral prefrontal cortex.(9,12,14,15)”
BackgroundInfluential
Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review
Kuhns, L., Kroon, E., Lesscher, H. M. B., Mies, G. W., & Cousijn, J. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02100-y · Cited by 44
“, reinstatement drug seeking, withdrawal) [149].”
Targeting the Glucocorticoid Receptor Reduces Binge‐Like Drinking in High Drinking in the Dark (HDID‐1) Mice
Savarese, A. M., Ozburn, A. R., Metten, P., Schlumbohm, J. P., Hack, W. R., LeMoine, K., Hunt, H., Hausch, F., Bauder, M., & Crabbe, J. C. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14318 · Cited by 36
“There is a rich literature documenting alterations in HPA reactivity after alcohol exposure and dependence (Stephens and Wand, 2012, Blaine and Sinha, 2017), but dysregulated HPA responses may also precede and be predictive of high alcohol intake.”
Background
Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation
Pinheiro, J. D. A., Freitas, F. V., Borçoi, A. R., Mendes, S. O., Conti, C. L., Arpini, J. K., Vieira, T. D. S., de Souza, R. A., dos Santos, D. P., Barbosa, W. M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-86189-z · Cited by 39
Neural correlates of alcohol use disorder severity among nontreatment‐seeking heavy drinkers: An examination of the incentive salience and negative emotionality domains of the alcohol and addiction research domain criteria
Al‐Khalil, K., Vakamudi, K., Witkiewitz, K. A., & Claus, E. D. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14614 · Cited by 41
Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways
Mineur, Y. S., Garcia‐Rivas, V., Thomas, M. A., Soares, A. R., McKee, S. A., & Picciotto, M. R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06120-w · Cited by 34
“Withdrawal is thought to promote negative reinforcement drinking via alterations of the HPA axis (Blaine and Sinha 2017; Koob 2003; Rasmussen et al.”
Background
Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol
Patel, R. R., Wolfe, S. A., Borgonetti, V., Gandhi, P. J., Rodriguez, L., Snyder, A. E., D’Ambrosio, S., Bajo, M., Domissy, A., Head, S., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01642-3 · Cited by 33
“Ethanol activates neuroendocrine stress systems, which become dysregulated following chronic exposure contributing to AUD [9, 10].”
BackgroundInfluential
On the interaction between BDNF and serotonin systems: The effects of long-term ethanol consumption in mice
Popova, N. K., Ilchibaeva, T. V., Antonov, E. V., Pershina, A., Базовкина, Д. В., & Naumenko, V. S. (2020) · Alcohol · doi:10.1016/j.alcohol.2020.04.002 · Cited by 36
Effects of Prazosin on Provoked Alcohol Craving and Autonomic and Neuroendocrine Response to Stress in Alcohol Use Disorder
Milivojevic, V., Angarita, G. A., Hermes, G., Sinha, R., & Fox, H. C. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14378 · Cited by 36
“…treatment of alcoholism (Davies et al., 2012), particularly to specifically target stress-system psychopathology during early and protracted abstinence, known to underlie high craving, anxiety and excessive drinking and relapse risk (Blaine and Sinha, 2017, Milivojevic and Sinha, 2018, Koob, 2008).”
Background
Dynorphin/Kappa Opioid Receptor Activity Within the Extended Amygdala Contributes to Stress-Enhanced Alcohol Drinking in Mice
Haun, H. L., Lebonville, C. L., Solomon, M. G., Griffin, W. C., Lopez, M. F., & Becker, H. C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.01.002 · Cited by 34
Cross-Species Alterations in Synaptic Dopamine Regulation After Chronic Alcohol Exposure
Siciliano, C. A., Karkhanis, A. N., Holleran, K. M., Melchior, J. R., & Jones, S. R. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_106 · Cited by 32
“2007), which may contribute to the maintenance of alcohol use as an anxiolytic (Blaine and Sinha 2017).”
Background
Synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys
Jimenez, V. A., Herman, M. A., Cuzon Carlson, V. C., Walter, N. A., Grant, K. A., & Roberto, M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0290-7 · Cited by 29
Unhealthy lifestyle impacts on biological systems involved in stress response: hypothalamic–pituitary–adrenal axis, inflammation and autonomous nervous system
Mandelli, L., Milaneschi, Y., Hiles, S. A., Serretti, A., & Penninx, B. W. J. H. (2022) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000437 · Cited by 33
“Alcohol also has activating effects and interacts with glucocorticoid receptors (Blaine and Sinha, 2017).”
Background
Alcohol withdrawal symptoms predict corticostriatal dysfunction that is reversed by prazosin treatment in alcohol use disorder
Sinha, R., Fogelman, N., Wemm, S., Angarita, G. A., Seo, D., & Hermes, G. (2021) · Addiction Biology · doi:10.1111/adb.13116 · Cited by 31
“Repeated exposure to alcohol withdrawal and concomitant AW results in disruption of the PFC-striatal pathway that in turn facilitates stress-related and alcohol cue-related excessive drinking to influence AUD course and risk of treatment failure.(12,40) Significant heterogeneity in AUD clinical features has resulted i…”
Background
Abnormal stress responsiveness and suicidal behavior: a risk phenotype
Steinberg, L. J., & Mann, J. J. (2020) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2020.100011 · Cited by 29
Drug-Induced Glucocorticoids and Memory for Substance Use
Goldfarb, E. V., & Sinha, R. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.08.005 · Cited by 30
Microbiota and Alcohol Use Disorder: Are Psychobiotics a Novel Therapeutic Strategy?
Rodríguez‐González, A., & Orío, L. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200122153541 · Cited by 29
Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy
Gatta, E., Camussi, D., Auta, J., Guidotti, A., & Pandey, S. C. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108299 · Cited by 28
Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
Milivojevic, V., Sullivan, L., Tiber, J., Fogelman, N., Simpson, C. A., Hermes, G., & Sinha, R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06278-3 · Cited by 30
“While acute low to moderate alcohol in social drinkers stimulates autonomic and neuroendocrine arousal (see (Blaine and Sinha 2017) for review), chronic alcohol use results in significant adaptations in stress arousal with increased basal autonomic tone and blunted autonomic and HPA axis responsivity (Adinoff et al.”
Background
Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis
Campbell, R. R., Domingo, R. D., Williams, A. R., Wroten, M. G., McGregor, H. A., Waltermire, R. S., Greentree, D. I., Goulding, S. P., Thompson, A. B., Lee, K. M., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1909-18.2018 · Cited by 27
“Interrupting mGlu5 phosphorylation reduces anxiety and increases novelty-seeking Alcohol is an anxiolytic and this property can contribute to its abuse liability, particularly in hyper-anxious individuals (Becker, 2017; Blaine and Sinha, 2017).”
Background
COVID-19 related employment change is associated with increased alcohol consumption during the pandemic
Weerakoon, S. M., Jetelina, K. K., Knell, G., & Messiah, S. E. (2021) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2021.1912063 · Cited by 27
Underlying mechanisms in the relationship between stress and alcohol consumption in regular and risky drinkers (MESA): methods and design of a randomized laboratory study
Wittgens, C., Muehlhan, M., Kräplin, A., Wolff, M., & Trautmann, S. (2022) · BMC Psychology · doi:10.1186/s40359-022-00942-1 · Cited by 34
“These effects potentiate both stress and alcohol-related effects on motivation and reinforcement learning [40] which can further facilitate alcohol use as a stress-related coping mechanism [38].”
Background
Novel approaches to alcohol rehabilitation: Modification of stress-responsive brain regions through environmental enrichment
Pang, T. Y., Hannan, A. J., & Lawrence, A. J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.021 · Cited by 27
Predisposing factors for increased cortisol levels in oral cancer patients
Figueira, J. A., Sarafim-Silva, B. A. M., Gonçalves, G. M., Aranha, L. N., Lopes, F. L., Corrente, J. E., Biasoli, É. R., Miyahara, G. I., & Bernabé, D. G. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2022.100110 · Cited by 27
Subjective stress and alcohol use among young adult and adult drinkers: Systematic review of studies using Intensive Longitudinal Designs
Wolkowicz, N. R., Peltier, M. R., Wemm, S., & MacLean, R. R. (2022) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2022.100039 · Cited by 25
HPA axis stress reactivity and hair cortisol concentrations in recently detoxified alcoholics and healthy controls with and without childhood maltreatment
Muehlhan, M., Höcker, A., Miller, R. E., Trautmann, S., Wiedemann, K., Lotzin, A., Barnow, S., & Schäfer, I. (2018) · Addiction Biology · doi:10.1111/adb.12681 · Cited by 25
“Chronic heavy alcohol use and alcohol withdrawal can also alter the regulation of the HPA axis.(16,17) Alcohol directly stimulates the secretion of CRH within the paraventricular nuclei of the hypothalami with high doses of alcohol leading to elevated circulating adrenocorticotropic hormone (ACTH) and cortisol levels.”
BackgroundInfluential
Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress
Varodayan, F. P., Khom, S., Patel, R. R., Steinman, M. Q., Hedges, D. M., Oleata, C. S., Homanics, G. E., Roberto, M., & Bajo, M. (2017) · Alcohol and Alcoholism · doi:10.1093/alcalc/agx114 · Cited by 24
“, 2010), while stress is a primary trigger for alcohol craving and relapse in alcoholic patients (Blaine and Sinha, 2017).”
Background
Daily stress predicts later drinking initiation via craving in heavier social drinkers: A prospective in-field daily diary study.
Wemm, S., Tennen, H. A., Sinha, R., & Seo, D. (2022) · Journal of Psychopathology and Clinical Science · doi:10.1037/abn0000771 · Cited by 24
Brain Regional and Temporal Changes in BDNF mRNA and microRNA-206 Expression in Mice Exposed to Repeated Cycles of Chronic Intermittent Ethanol and Forced Swim Stress
Solomon, M. G., Griffin, W. C., Lopez, M. F., & Becker, H. C. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.02.012 · Cited by 23
“Given that stress is known to significantly influence ethanol consumption (Becker, 2017; Becker et al., 2011; Blaine and Sinha, 2017; Sinha, 2012; Spanagel et al., 2014) and that both stress and ethanol exposure alter BDNF activity in brain, it is surprising that very little is known about their combined effects on BD…”
Background
Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats
Khom, S., Rodriguez, L., Gandhi, P., Kirson, D., Bajo, M., Oleata, C. S., Vendruscolo, L. F., Mason, B. J., & Roberto, M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105610 · Cited by 23
“…cortisol levels in both dependent animals and humans and alcohol withdrawal is associated with increased cortisol levels, which remain elevated even during sustained abstinence compared to healthy subjects, suggesting persistent HPA neuroadaptations (Blaine and Sinha, 2017; Wemm and Sinha, 2019).”
Background
Sex Differences in Alcohol Use: Is It All About Hormones?
Maddern, X. J., Ursich, L. T., Bailey, G., Pearl, A. J., Anversa, R. G., Lawrence, A. J., & Walker, L. C. (2024) · Endocrinology · doi:10.1210/endocr/bqae088 · Cited by 23
Differential effects of acute versus chronic stress on ethanol sensitivity: Evidence for interactions on both behavioral and neuroimmune outcomes
Doremus‐Fitzwater, T. L., Paniccia, J. E., Gano, A., Vore, A. S., & Deak, T. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.02.009 · Cited by 23
“…arthritis; Affleck et al., 1997; Verhoeven et al., 2009), visceral pain disorders (Moloney et al., 2016), anxiety (Faravelli et al., 2012), depression (Hammen, 2005; Mazure et al., 2000), and drug and alcohol dependence (Blaine and Sinha, 2017; Lemieux and al’Absi, 2016; Piazza and Le Moal, 1996).”
Background
The synthetically produced predator odor 2,5-dihydro-2,4,5-trimethylthiazoline increases alcohol self-administration and alters basolateral amygdala response to alcohol in rats
Makhijani, V. H., Franklin, J. P., Voorhies, K. J. V., Fortino, B., & Besheer, J. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05659-w · Cited by 22
“We examined subregions of the mPFC and amygdala, which are implicated in both PTSD, AUD, and activated by predator odor (Asok et al., 2013, Edwards et al., 2013, Hwa et al., 2019).”
BackgroundInfluential
Memory biases in alcohol use disorder: enhanced memory for contexts associated with alcohol prospectively predicts alcohol use outcomes
Goldfarb, E. V., Fogelman, N., & Sinha, R. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0650-y · Cited by 21
“As AUD is associated with elevated basal stress hormones [36] and hippocampal volume changes [37], we hypothesized that chronic alcohol intake in AUD could result in an unusual memory bias: enhanced memory for alcohol-related associations, but not items [12].”
Background
The physiological responses to acute stress in alcohol-dependent patients: A systematic review
Chen, K., Hollunder, B., Garbusow, M., Sebold, M., & Heinz, A. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.09.003 · Cited by 21
Mifepristone decreases chronic voluntary ethanol consumption in Rhesus macaques
Jimenez, V. A., Walter, N. A. R., Shnitko, T. A., Newman, N., Diem, K., Vanderhooft, L., Hunt, H., & Grant, K. A. (2020) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000169 · Cited by 20
“Furthermore, stress is a salient risk factor for relapse (Blaine and Sinha, 2017), suggesting treatments that target the HPA response may be efficacious in treating AUD.”
Background
Adolescent social stress and social context influence the intake of ethanol and sucrose in male rats soon and long after the stress exposures
Marcolin, M. L., Hodges, T. E., Baumbach, J. L., & McCormick, C. M. (2018) · Developmental Psychobiology · doi:10.1002/dev.21800 · Cited by 20
Acupuncture Alleviates Anxiety and 22-kHz Ultrasonic Vocalizations in Rats Subjected to Repeated Alcohol Administration by Modulating the Brain-Derived Neurotrophic Factor/Corticotropin-Releasing Hormone Signaling Pathway
Seo, S. Y., Bang, S. K., Kang, S.-Y., Cho, S. J., Choi, K. H., & Ryu, Y. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084037 · Cited by 20
“As described in studies of various types of alcoholism, including chronic alcohol administration, withdrawal and binge models, HT7 stimulation alleviates depression and anxiety behaviors and alters the plasma CORT levels [16,34].”
Background
Alcohol binge drinking in adolescence and psychological profile: Can the preclinical model crack the chicken-or-egg question?
Castelli, V., Plescia, F., Maniaci, G., Lavanco, G., Pizzolanti, G., Brancato, A., & Cannizzaro, C. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.996965 · Cited by 20
“Growing evidence suggests that ABD in adolescence correlates with higher tonic levels of heart rate and cortisol, which indicate a hypersensitivity of the brain stress system (68).”
Background
Cross-talk between the HPA axis and addiction-related regions in stressful situations
Nikbakhtzadeh, M., Ranjbar, H., Moradbeygi, K., Zahedi, E., Bayat, M., Soti, M., & Shabani, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15525 · Cited by 24
Mifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study
Haass‐Koffler, C. L., Magill, M., Cannella, N., Brown, J. C., Aoun, E. G., Cioe, P. A., Sinha, R., Swift, R. M., Ciccocioppo, R., & Leggio, L. (2023) · Addiction Biology · doi:10.1111/adb.13288 · Cited by 20
“The mechanisms underlying these relationships are complex and include noradrenergic,(9) corticotropin releasing factor (CRF)(10) and glucocorticoid receptor (GR) pathways.(11,12)”
Background
The association between psychological distress and alcohol consumption and physical activity: a population-based cohort study
Alpers, S. E., Pallesen, S., Vold, J. H., Haug, E., Lunde, L.-H., Skogen, J. C., Mamen, A., Mæland, S., & Fadnes, L. T. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1181046 · Cited by 21
Effects of stress, alcohol prime dose, and sex on ad libitum drinking.
Patock‐Peckham, J. A., Corbin, W. R., Smyth, H. L., Canning, J. R., Ruof, A. K., & Williams, J. G. (2021) · Psychology of Addictive Behaviors · doi:10.1037/adb0000801 · Cited by 19
Social stress under binge-like alcohol withdrawal in adolescence: evidence of cannabidiol effect on maladaptive plasticity in rats
Brancato, A., Castelli, V., Lavanco, G., D’Amico, C., Feo, S., Pizzolanti, G., Kuchař, M., & Cannizzaro, C. (2022) · Psychological Medicine · doi:10.1017/s0033291722002744 · Cited by 19
Involvement of Activated Brain Stress Responsive Systems in Excessive and “Relapse” Alcohol Drinking in Rodent Models: Implications for Therapeutics
Zhou, Y., & Kreek, M. J. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.245621 · Cited by 19
“…stress-responsive systems such as corticotrophin-releasing factor, neuropeptide Y, and glucocorticoid receptor (Koob and Mason, 2016; Mantsch et al., 2016; Blaine and Sinha, 2017; Mason, 2017; Pomrenze et al., 2017; Robinson and Thiele, 2017; Spierling and Zorrilla, 2017; Tunstall et al., 2017).”
Background
Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations
Johnson, K. A., & Lovinger, D. M. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.02.002 · Cited by 18
Neuroendocrine Response to Exogenous Ghrelin Administration, Combined With Alcohol, in Heavy-Drinking Individuals: Findings From a Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study
Farokhnia, M., Abshire, K. M., Hammer, A., Deschaine, S. L., Saravanakumar, A., Cobbina, E., You, Z., Haass‐Koffler, C. L., Lee, M. R., Akhlaghi, F., et al. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab004 · Cited by 19
“Moreover, previous studies indicate that alterations in the HPA axis may facilitate the transition from mild-to-moderate alcohol drinking to AUD and may contribute to the risk of relapse (Koob, 2010; Blaine and Sinha, 2017).”
Background
High-Risk Drinkers Engage Distinct Stress-Predictive Brain Networks
Goldfarb, E. V., Scheinost, D., Fogelman, N., Seo, D., & Sinha, R. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.02.010 · Cited by 19
Chronic alcohol consumption alters home‐cage behaviors and responses to ethologically relevant predator tasks in mice
Neira, S., Hassanein, L. A., Stanhope, C. M., Buccini, M. C., D’Ambrosio, S., Flanigan, M. E., Haun, H. L., Boyt, K. M., Bains, J. S., & Kash, T. L. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14901 · Cited by 21
Advancing Pharmacotherapy Development from Preclinical Animal Studies
Egli, M. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2017_85 · Cited by 19
Long‐term consequences of alcohol use in early adolescent mice: Focus on neuroadaptations in GR, CRF and BDNF
Sampedro‐Piquero, P., Moreno‐Fernández, R. D., Begega, A., López, M., & Santín, L. J. (2022) · Addiction Biology · doi:10.1111/adb.13158 · Cited by 19
“Besides this, these brain regions regulate the hypothalamic-pituitary-adrenal (HPA) axis activity, which is also a critical mechanism contributing to protracted alcoholism.(15,16) Clinical and experimental studies in both humans and rodents have shown that”
Background
HPA axis function in alcohol use disorder: A systematic review and meta-analysis
Dunne, N., & Ivers, J. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100114 · Cited by 22
The role of resilience in the relationship between stress and alcohol
Schwandt, M. L., Cullins, E., & Ramchandani, V. A. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100644 · Cited by 20
Hormonal responses in gambling versus alcohol abuse: A review of human studies
Li, Y., Ramoz, N., Derrington, E. A., & Dreher, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109880 · Cited by 18
Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics
Gatta, E., Saudagar, V., Auta, J., Grayson, D. R., & Guidotti, A. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.08.002 · Cited by 19
Citrate Synthase and OGDH as Potential Biomarkers of Atherosclerosis under Chronic Stress
Meng, L., Hu, G.-F., Shan, M., Zhang, Y.-M., Yu, Z.-M., Liu, Y.-Q., Xu, H., Wang, L., Gong, T., & Liu, D. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9957908 · Cited by 16
Stress and gonadal steroid influences on alcohol drinking and withdrawal, with focus on animal models in females
Finn, D. A. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101094 · Cited by 15
The neural, behavioral, and epidemiological underpinnings of comorbid alcohol use disorder and post-traumatic stress disorder
Carlson, H. N., & Weiner, J. L. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.006 · Cited by 16
Voluntary binge‐patterned alcohol drinking and sex‐specific influences on monoamine‐related neurochemical signatures in the mouse gut and brain
Bauer, E. E., Shoeman, A., Buhr, T. J., Daniels, K. M., Lyte, M., & Clark, P. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14592 · Cited by 15
“Monoamine activity in other brain regions that comprise parts of the limbic, motor, reward, and stress circuits remains less characterized, despite probable contributions to the motivation to consume alcohol or cognitive dysfunction related to alcohol ingestion (Blaine & Sinha, 2017).”
Background
Mechanisms of quality-of-life improvement in treatment for alcohol use disorder.
Carlon, H. A., Hurlocker, M. C., & Witkiewitz, K. A. (2022) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000750 · Cited by 15
Cortisol as a Biomarker of Alcohol Use in Combat Veterans: A Literature Review and Framework for Future Research
Szabo, Y. Z., Breeding, T., Hejl, C., Guleria, R. S., Nelson, S. M., & Zambrano‐Vazquez, L. (2020) · Journal of Dual Diagnosis · doi:10.1080/15504263.2020.1771504 · Cited by 15
“Indeed, previous studies have posited that glucocorticoids and the HPA axis may have an important role for the development and chronicity for AUDs due to their connection with limbic and prefrontal cortex circuits (Blaine & Sinha, 2017).”
Background
Interaction of chronic intermittent ethanol and repeated stress on structural and functional plasticity in the mouse medial prefrontal cortex
Cannady, R., Nguyen, T., Padula, A. E., Rinker, J. A., Lopez, M. F., Becker, H. C., Woodward, J. J., & Mulholland, P. J. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108396 · Cited by 16
“, 2012; Becker, 2017), and heavy alcohol drinking causes adaptations in HPA axis function and stress-related brain systems and neurocircuitry (Stephens and Wand, 2012; Lu and Richardson, 2014; Blaine and Sinha, 2017; Weera and Gilpin, 2019).”
Background
The future is now: A 2020 view of alcoholism research
Harris, R. A., & Koob, G. F. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.001 · Cited by 16
“At the clinical level, Blaine and Sinha (2017) review the role of *Corresponding author. harris@austin.utexas.edu (R.A. Harris).”
Background
Systematic Review
Sarkar, S., Tom, A., Das, S., Bharadwaj, B., & Ghosh, A. (2022) · Journal of Mental Health and Human Behaviour · doi:10.4103/jmhhb.jmhhb_191_20 · Cited by 14

Authors: Blaine, S. K., & Sinha, R.
Affiliations: Yale University (US)
Corresponding author: Sinha, Rajita
ORCID: Blaine, Sara K.
Sinha, Rajita
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2017-08
Volume: 122
Pages: 136-147
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2017.01.037
PMC: PMC5479733
OpenAlex: W2583762848
Cited by: 257
References: 133
Citations by year: 2026: 21 · 2025: 20 · 2024: 25 · 2023: 35 · 2022: 38 · 2021: 30 · 2020: 39 · 2019: 13 · 2018: 29 · 2017: 7
FWCI: 3.19
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Alcoholism (R01-AA13892, R01-AA020504)
Alcohol Abuse at the National Institutes of Health (R21-AA025277)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: alcoholism, stress, glucocorticoids, hypothalamic-pituitary-adrenal axis, relapse, drinking motives, binge drinking, prefrontal cortex, alcohol withdrawal, alcohol cue reactivity, interoception, conditioning, biomarkers, personalized medicine, treatment goals
MeSH terms: Alcohol Drinking, Alcoholism, Animals, Brain, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Recurrence, Stress, Physiological, Stress, Psychological, Prefrontal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks