Cited by 40Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

The rostromedial tegmental (RMTg) “brake” on dopamine and behavior: A decade of progress but also much unfinished work

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Jhou, Thomas C.·2021·Neuropharmacology

Abstract

Between 2005 and 2009, several research groups identified a strikingly dense inhibitory input to midbrain dopamine neurons arising from a previously uncharted region posterior to the ventral tegmental area (VTA). This region is now denoted as either the rostromedial tegmental nucleus (RMTg) or the "tail of the VTA" (tVTA), and is recognized to express distinct genetic markers, encode negative "prediction errors" (inverse to dopamine neurons), and play critical roles in behavioral inhibition and punishment learning. RMTg neurons are also influenced by many categories of abused drugs, and may drive some aversive responses to such drugs, particularly cocaine and alcohol. However, despite much progress, many important questions remain about RMTg molecular/genetic properties, diversity of projection targets, and applications to addiction, depression, and other neuropsychiatric disorders. This article is part of the special Issue on 'Neurocircuitry Modulating Drug and Alcohol Abuse'.

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Authors
Jhou, T. C.
Affiliations
Medical University of South Carolina (US)
Corresponding author
Jhou, Thomas C.
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2021-10
Volume
198
Pages
108763
ISSN
0028-3908 (ISSN-L)
OpenAlex
W3196076979
Cited by
40
References
110
Citations by year
2026: 6 · 2025: 6 · 2024: 9 · 2023: 3 · 2022: 15 · 2021: 1
FWCI
1.06
Type
journal article
Language
en
Open access
Locations
  • Neuropharmacology (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Drug Abuse (R01DA037327, R03DA034431, R21DA032898)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
rostromedial tegmental nucleus, midbrain dopaminergic neurons, behavioral inhibition, punishment learning, drug abuse, cocaine, alcohol, depression, neuropsychiatric disorders
MeSH terms
Animals, Behavior, Behavior, Animal, Dopamine, Humans, Tegmentum Mesencephali, Ventral Tegmental Area, Substance-Related Disorders, Dopaminergic Neurons

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