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The human amygdala is necessary for developing and expressing normal interpersonal trust
Open accessAbstract
The human amygdala is known to be involved in processing social, emotional, and reward-related information. Previous reports have indicated that the amygdala is involved in extracting trustworthiness information from faces. Interestingly, functional neuroimaging research using economic tasks that presumably require developing and/or expressing interpersonal trust, such as the Trust Game (TG), have not routinely identified involvement of the amygdala. The present study sought to explore the role of the amygdala in developing and expressing interpersonal trust, via a multi-round, multiplayer economic exchange, a version of the TG, in a large sample of participants with focal brain damage. Participants with unilateral damage to the amygdala displayed increased benevolent behavior in the TG, and specifically, they tended to increase trust in response to betrayals. On the other hand, neurologically normal adults tended to repay trust in kind, i.e., they decreased interpersonal trust in response to betrayals or increased trust in response to increases from others. Comparison participants, with brain damage that does not include the amygdala, ventromedial prefrontal or insular cortices, tended to behave ambivalently to the expressed trust or betrayal of others. Our data suggest that the amygdala is necessary for developing and expressing normal interpersonal trust. This increased tendency to behave benevolently in response to defections from others may be related to the abnormal social behavior observed in this group. Moreover, increased benevolence may increase the likelihood or opportunity to be taken advantage of by others.
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“The amygdala is crucially involved in the processing of social information, such as the trustworthiness or ambiguity of social stimuli, and previous lesion studies provide strong evidence that an intact amygdala is necessary for developing appropriate interpersonal trust.[ 30 , 43 ]”
From Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions (2021) · cites this paper as [43]
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“previous lesion studies provide strong evidence that an intact amygdala is necessary for developing appropriate interpersonal trust.[ 30 , 43 ]”
From Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions (2021) · cites this paper as [43]
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The amygdala as a hub in brain networks that support social life
Bickart, K. C., Dickerson, B. C., & Feldman Barrett, L. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2014.08.013 · Cited by 344
The Neural Basis of Following Advice
Biele, G., Rieskamp, J., Krugel, L. K., & Heekeren, H. R. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001089 · Cited by 157
Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions
Lieberz, J., Shamay‐Tsoory, S. G., Saporta, N., Esser, T., Kuskova, E., Stoffel‐Wagner, B., Hurlemann, R., & Scheele, D. (2021) · Advanced Science · doi:10.1002/advs.202102076 · Cited by 116
Bickart, K. C., Brickhouse, M., Negreira, A., Sapolsky, D., Barrett, L. F., & Dickerson, B. C. (2014) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304656 · Cited by 75
Damage to the insula is associated with abnormal interpersonal trust
Belfi, A. M., Koscik, T. R., & Tranel, D. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.04.003 · Cited by 35
Self-citation
Metadata
- Authors
- Koscik, T. R., & Tranel, D.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Koscik, Timothy R.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 49
- Issue
- 4
- Pages
- 602-611
- ISSN
- 0028-3932 (ISSN-L)
- PMC
- PMC3056169
- OpenAlex
- W2026386101
- Cited by
- 105
- References
- 14
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 16 · 2020: 3 · 2019: 8 · 2018: 11 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 13 · 2013: 7 · 2012: 5
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p50ns019632-28)
- National Institute on Drug Abuse (R01DA022549)
- National Institute of Neurological Disorders and Stroke (P01NS019632, P50-NS019632, P50NS19632)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- amygdala, interpersonal trust, trust game, betrayal, trustworthiness, social behavior, focal brain injury, ventromedial prefrontal cortex, insula, economic exchange, benevolence, social cognition
- MeSH terms
- Adult, Amygdala, Brain Damage, Chronic, Female, Games, Experimental, Humans, Imitative Behavior, Interpersonal Relations, Functional Laterality, Male, Reference Values, Social Perception, Case-Control Studies, Beneficence, Trust
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