Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to social impairments measured using the social impairment rating scale
Open accessAbstract
Patients with frontotemporal dementia (FTD) often exhibit prominent, early and progressive impairments in social behaviour. We developed the Social Impairment Rating Scale (SIRS), rated by a clinician after a structured interview, which grades the types and severity of social behavioural symptoms in seven domains. In 20 FTD patients, we used the SIRS to study the anatomic basis of social impairments. In support of hypotheses generated from a prior study of healthy adults, we found that the relative magnitude of brain atrophy in three partially dissociable corticolimbic networks anchored in the amygdala predicted the severity of distinct social impairments measured using the SIRS. Patients with the greatest atrophy in a mesolimbic, reward-related (affiliation) network exhibited the most severe socioemotional detachment, whereas patients with the greatest atrophy in an interoceptive, pain-related (aversion) network exhibited the most severe lack of social apprehension. Patients with the greatest atrophy in a perceptual network exhibited the most severe lack of awareness or understanding of others' social and emotional behaviour. Our findings underscore observations that FTD is associated with heterogeneous social symptoms that can be understood in a refined manner by measuring impairments in component processes subserved by dissociable neural networks. Furthermore, these findings support the validity of the SIRS as an instrument to measure the social symptoms of patients with FTD. Ultimately, we hope it will be useful as a longitudinal outcome measure in natural history studies and in clinical trials of putative interventions to improve social functioning.
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A cross-sectional study associated distinct social symptoms, as measured by the Social Impairment Rating Scale, with three socially relevant corticolimbic networks.
“Lastly, a cross-sectional study associated distinct social symptoms, as measured by the Social Impairment Rating Scale (SIRS), with three socially relevant (corticolimbic) networks to (Bickart et al., 2014).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Bickart et al., 2014
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- Authors
- Bickart, K. C., Brickhouse, M., Negreira, A., Sapolsky, D., Barrett, L. F., & Dickerson, B. C.
- Affiliations
- Boston University (US)
- Harvard University (US)
- Northeastern University (US)
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2013-10-16
- Volume
- 85
- Issue
- 4
- Pages
- 438-448
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC4315506
- OpenAlex
- W2044766870
- Cited by
- 75
- References
- 52
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 4 · 2021: 6 · 2020: 10 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 1
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Pfizer
- Massachusetts General Hospital
- National Institutes of Health (DP1OD003312)
- National Institute on Aging (R01AG030311, P50AG005134, R01AG029411, P30AG062421)
- National Institute of Mental Health (R21MH097094)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, social dysfunction, brain atrophy, cortico-limbic network, amygdala, theory of mind, social behavior, outcome measures
- MeSH terms
- Aged, Atrophy, Brain Mapping, Cerebral Cortex, Female, Humans, Limbic System, Male, Middle Aged, Neural Pathways, Psychiatric Status Rating Scales, Social Behavior Disorders, Reproducibility of Results, Case-Control Studies, Frontotemporal Dementia
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