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Cited by 54Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Input-output relations in the entorhinal cortex-dentate-hippocampal system: evidence for a non-linear transfer of signals

Bartesaghi, R., Migliore, M., Gessi, T.·2006·Neuroscience
DOI 10.1016/j.neuroscience.2006.06.001
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Abstract

In the current study we analyzed the input-output relations in the entorhinal-dentate-hippocampal system, a major network involved in long-term memory. In anesthetized guinea pigs, the system was driven by activation of perforant path neurons in the entorhinal cortex (ENT), via presubicular fibers directly stimulated in the dorsal psalterium. Perforant path neuron discharge activated in parallel the dentate gyrus (DG) and hippocampal field CA2. Whereas the output from the DG activated hippocampal field CA3, the output from the sole field CA2 was sufficient for activation of field CA1. Signals from field CA3 operated in concert with CA2, likely contributing to discharge field CA1. These findings indicate the existence of two in parallel disynaptic systems: an ENT-CA2-CA1 and an ENT-DG-CA3 system. The convergence of the latter with the former gives origin the classical trisynaptic circuit, the ENT-DG-CA3-CA1 system. The input-output relations between the population excitatory postsynaptic potentials (pEPSP) evoked in the DG, CA3, CA2 and CA1 and the population spike (PS) evoked in the structure upstream (the input) were described by smooth sigmoid curves. In contrast, the input-output relations of the PS versus the pEPSP within each structure were described by steep sigmoid curves. The net input-output functions of the DG (ENT-DG system), field CA2 (ENT-CA2 system), field CA3 (ENT-DG-CA3 system) and field CA1 (ENT-CA2-CA1&ENT-DG-CA3-CA1 system) were described by sigmoid curves. While the DG and field CA2 exhibited steep sigmoids, fields CA3 and CA1 had less steep sigmoid functions. The present study demonstrates that all structures downstream to the ENT operate according to sigmoid input-output functions, characterized by specific parameters. These different behaviors may contribute to different memory processes. We additionally demonstrate that field CA1 can be activated by field CA2, independently from field CA3. This functional dissociation between CA3 and CA1 may subserve specific roles of each field in memory encoding/retrieval.

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Crossref · 10.1016/j.neuroscience.2006.06.001

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  • The differential synaptic responses observed among CA1, CA2 and CA3 neurons are genuine and not an artifact of the hippocampal slice preparation.

    “The good agreement between these in vivo recordings and our findings indicates that the differential synaptic responses we observe among CA1, CA2 and CA3 neurons are genuine and not an artifact of the hippocampal slice preparation.”

    From Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop (2010) · cites this paper as Bartesaghi et al., 2006

  • The powerful excitatory disynaptic circuit linking EC to CA2 to CA1, combined with marked feed-forward inhibition from CA3 to CA2, can explain how in vivo electrical stimulation of entorhinal cortex inputs leads to initial firing of CA2 neurons, followed by firing of CA1 and then CA3 neurons.

    “Thus the powerful excitatory disynaptic circuit linking EC to CA2 to CA1, combined with the marked feed-forward inhibition from CA3 to CA2, can explain how in vivo electrical stimulation of entorhinal cortex inputs leads to the initial firing of CA2 neurons, followed by firing of CA1 and then CA3 neurons (Bartesaghi and Gessi, 2004; Bartesaghi et al., 2006).”

    From Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop (2010) · cites this paper as Bartesaghi et al., 2006

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Authors
Bartesaghi, R., Migliore, M., & Gessi, T.
Affiliations
  • University of Bologna (IT)
  • Yale University (US)
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2006-09
Volume
142
Issue
1
Pages
247-265
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2006.06.001
OpenAlex
W1972720886
Cited by
54
References
52
Citations by year
2026: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 5
FWCI
0.97
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
entorhinal cortex, dentate gyrus, hippocampus, perforant path, input-output relationship, sigmoid transfer function, trisynaptic circuit, CA2, CA3, CA1, long-term memory, excitatory postsynaptic potentials, population spike, guinea pig
MeSH terms
Action Potentials, Animals, Electric Stimulation, Female, Guinea Pigs, Hippocampus, Models, Neurological, Neural Pathways, Neurons, Entorhinal Cortex, Excitatory Postsynaptic Potentials

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