Ensemble Dynamics of Hippocampal Regions CA3 and CA1
Open accessAbstract
Computational models based on hippocampal connectivity have proposed that CA3 is uniquely positioned as an autoassociative memory network, capable of performing the competing functions of pattern completion and pattern separation. Recently, three independent studies, two using parallel neurophysiological recording methods and one using immediate-early gene imaging, have examined the responses of CA3 and CA1 ensembles to alterations of environmental context in rats. The results provide converging evidence that CA3 is capable of performing nonlinear transformations of sensory input patterns, whereas CA1 may represent changes in input in a more linear fashion.
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This feature seems to depend on a pattern completion mechanism that is able to reinstate complete memories after partial cueing, based on the operation of hippocampal autoassociative neural networks.
“This feature seems to depend on a pattern completion mechanism that is able to reinstate complete memories after partial cueing, based on the operation of hippocampal autoassociative neural networks”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [77]
According to mechanistic models of hippocampal memory function, the hippocampal neural network can shift between encoding and retrieval modes depending on the novelty degree of incoming spatial information.
“Thus, according to the mechanistic models of hippocampal memory function, the hippocampal neural network can shift between two functional modes, encoding and retrieval, depending on the novelty degree of the incoming spatial information [77,78,79].”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [77]
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Contributions of human hippocampal subfields to spatial and temporal pattern separation
Azab, M., Stark, S. M., & Stark, C. E. L. (2013) · Hippocampus · doi:10.1002/hipo.22223 · Cited by 72 · see citing works
Tests of pattern separation and pattern completion in humans—A systematic review
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Theta Coordinated Error-Driven Learning in the Hippocampus
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- Authors
- Guzowski, J. F., Knierim, J. J., & Moser, E. I.
- Affiliations
- University of New Mexico (US)
- The University of Texas Health Science Center at Houston (US)
- Norwegian University of Science and Technology (NO)
- Corresponding author
- Guzowski, John F.
- Knierim, James J.
- Moser, Edvard I.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 44
- Issue
- 4
- Pages
- 581-584
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1983540839
- Cited by
- 354
- References
- 21
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 17 · 2023: 17 · 2022: 12 · 2021: 21 · 2020: 14 · 2019: 15 · 2018: 23 · 2017: 19 · 2016: 16 · 2015: 15 · 2014: 22 · 2013: 19 · 2012: 15
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3180 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, CA3, CA1, ensemble coding, pattern completion, pattern separation, autoassociative memory, environmental context, nonlinear transformation, sensory input, immediate early genes, hippocampal connectivity
- MeSH terms
- Animals, Hippocampus, Humans, Memory, Models, Neurological, Neural Pathways, Pattern Recognition, Physiological
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