The vasopressin 1b receptor and the neural regulation of social behavior
Open accessAbstract
To date, much of the work in rodents implicating vasopressin (Avp) in the regulation of social behavior has focused on its action via the Avp 1a receptor (Avpr1a). However, there is mounting evidence that the Avp 1b receptor (Avpr1b) also plays a significant role in Avp's modulation of social behavior. The Avpr1b is heavily expressed on the anterior pituitary cortiocotrophs where it acts as an important modulator of the endocrine stress response. In the brain, the Avpr1b is prominent in the CA2 region of the hippocampus, but can also be found in areas such as the paraventricular nucleus of the hypothalamus and the olfactory bulb. Studies that have employed genetic knockouts or pharmacological manipulation of the Avpr1b point to the importance of central Avpr1b in the modulation of social behavior. However, there continues to be a knowledge gap in our understanding of where in the brain this is occurring, as well as how and if the central actions of Avp acting via the Avpr1b interact with the stress axis. In this review we focus on the genetic and pharmacological studies that have implicated the Avpr1b in the neural regulation of social behaviors, including social forms of aggressive behavior, social memory, and social motivation. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.
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V1bRs appear to have a much more restricted distribution, although they are expressed prominently in the hippocampus and at lower levels in the hypothalamus and amygdala.
“V1bRs appear to have a much more restricted distribution, although they are expressed prominently in the hippocampus and at lower levels in the hypothalamus and amygdala [23; 24].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [24]
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Cites
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059 · see citing works
An Exteroceptive Block to Pregnancy in the Mouse
Bruce, H. M. (1959) · Nature · doi:10.1038/184105a0 · Cited by 746 · see citing works
PSYCHONEUROENDOCRINOLOGY OF DEPRESSION
Plotsky, P. M., Owens, M. J., & Nemeroff, C. B. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70006-x · Cited by 672 · see citing works
Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636 · see citing works
Intraadrenal interactions in the regulation of adrenocortical steroidogenesis.
Ehrhart-Bornstein, M., Hinson, J. P., Bornstein, S. R., Scherbaum, W. A., & Vinson, G. P. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.2.0326 · Cited by 600 · see citing works
Herkenham, M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90268-5 · Cited by 520 · see citing works
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504 · see citing works
Self-citationGriebel, G., Simiand, J., Serradeil-Le Gal, C., Wagnon, J., Pascal, M., Scatton, B., Maffrand, J.-P., & Soubrié, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092012099 · Cited by 471 · see citing works
Vasopressin and oxytocin receptors in the central nervous system
Tribollet, E., & Barberis, C. (1996) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v10.i1.60 · Cited by 399 · see citing works
Vasopressin V1b receptor knockout reduces aggressive behavior in male mice
Wersinger, S. R., Ginns, E. I., O'Carroll, A.-M., Lolait, S. J., & Young III, W. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001195 · Cited by 397 · see citing works
A BLOCK TO PREGNANCY IN THE MOUSE CAUSED BY PROXIMITY OF STRANGE MALES
Bruce, H. M. (1960) · Reproduction · doi:10.1530/jrf.0.0010096 · Cited by 373 · see citing works
Dissociation of ACTH and glucocorticoids
Bornstein, S. R., Engeland, W. C., Ehrhart-Bornstein, M., & Herman, J. P. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.01.009 · Cited by 345 · see citing works
Extrapituitary expression of the rat V1b vasopressin receptor gene.
Lolait, S. J., O’Carroll, A., Mahan, L. C., Felder, C. C., Button, D. C., Young, W. S., Mezey, É., & Brownstein, M. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6783 · Cited by 337 · see citing works
Vaccari, C., Lolait, S. J., & Ostrowski, N. L. (1998) · Endocrinology · doi:10.1210/endo.139.12.6382 · Cited by 308 · see citing works
Knepper, M. A. (1997) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1997.272.1.f3 · Cited by 283 · see citing works
Jard, S., Gaillard, R. C., Guillon, G., Marie, J., Schoenenberg, P., Muller, A. F., Manning, M., & Sawyer, W. H. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10336-2 · Cited by 276 · see citing works
Hernando, F., Schoots, O., Lolait, S. J., & Burbach, J. P. H. (2001) · Endocrinology · doi:10.1210/endo.142.4.8067 · Cited by 275 · see citing works
Tanoue, A., Ito, S., Honda, K., Oshikawa, S., Kitagawa, Y., Koshimizu, T., Mori, T., & Tsujimoto, G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19656 · Cited by 258 · see citing works
Young, W. S., Li, J., Wersinger, S. R., & Palkovits, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.040 · Cited by 222 · see citing works
Koshimizu, T., Nasa, Y., Tanoue, A., Oikawa, R., Kawahara, Y., Kiyono, Y., Adachi, T., Tanaka, T., Kuwaki, T., Mori, T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600875103 · Cited by 179 · see citing works
Update on stress and depression: the role of the hypothalamic-pituitary-adrenal (HPA) axis
Mello, A. F., Mello, M. F., Carpenter, L. L., & Price, L. H. (2003) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462003000400010 · Cited by 169 · see citing works
Role of Olfactory Sense in Pregnancy Block by Strange Males
Bruce, H. M., & PARROTT, D. M. V. (1960) · Science · doi:10.1126/science.131.3412.1526 · Cited by 166 · see citing works
Bellringer, J. F., Pratt, H. P. M., & Keverne, E. B. (1980) · Reproduction · doi:10.1530/jrf.0.0590223 · Cited by 166 · see citing works
Chapter 16 Neurohypophyseal hormone receptor systems in brain and periphery
Jard, S., Barberis, C., Audigier, S., & Tribollet, E. (1987) · Progress in brain research · doi:10.1016/s0079-6123(08)60206-x · Cited by 164 · see citing works
Intraadrenal Interactions in the Regulation of Adrenocortical Steroidogenesis
Ehrhart‐Bornstein, M. (1998) · Endocrine Reviews · doi:10.1210/er.19.2.101 · Cited by 162 · see citing works
Novel Ligand Specificity of Pituitary Vasopressin Receptors in the Rat
Antoni, F. A. (2008) · Neuroendocrinology · doi:10.1159/000123976 · Cited by 159 · see citing works
Lein, E. S., Callaway, E. M., Albright, T. D., & Gage, F. H. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20426 · Cited by 158 · see citing works
Vasopressin 1b Receptor Knock-Out Impairs Memory for Temporal Order
DeVito, L. M., Konigsberg, R., Lykken, C., Sauvage, M., Young, W. S., & Eichenbaum, H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5488-08.2009 · Cited by 147 · see citing works
Lolait, S. J., Stewart, L. Q., Jessop, D. S., Young, W. S., & O’Carroll, A. (2006) · Endocrinology · doi:10.1210/en.2006-1309 · Cited by 146 · see citing works
Landgraf, R., Neumann, I. D., & Pittman, Q. J. (2008) · Neuroendocrinology · doi:10.1159/000125917 · Cited by 137 · see citing works
Wersinger, S. R., Kelliher, K. R., Zufall, F., Lolait, S. J., O’Carroll, A., & Young, W. S. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.07.004 · Cited by 132 · see citing works
Wersinger, S. R., Caldwell, H. K., Christiansen, M., & Young, W. S. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00294.x · Cited by 130 · see citing works
Self-citationSaito, M., Sugimoto, T., Tahara, A., & Kawashima, H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2033 · Cited by 124 · see citing works
Yang, M. (2007) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.001.2007 · Cited by 124 · see citing works
Stemmelin, J., Lukovic, L., Salome, N., & Griebel, G. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300562 · Cited by 112 · see citing works
Gal, C. S., Wagnon, J., Tonnerre, B., Roux, R., Garcia, G., Griebel, G., & Aulombard, A. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00035.x · Cited by 110 · see citing works
Roles of the basolateral amygdala and hippocampus in social recognition in rats
Maaswinkel, H., Baars, A. M., Gispen, W. H., & Spruijt, B. M. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02233-3 · Cited by 97 · see citing works
Chapter 14 Molecular pharmacology and modeling of vasopressin receptors
Thibonnier, M., Coles, P., Thibonnier, A., & Shoham, M. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39016-2 · Cited by 96 · see citing works
AVP V selective antagonist SSR149415 blocks aggressive behaviors in hamsters
Blanchard, R. J., Griebel, G., Farrokhi, C. B., Markham, C. M., YANG, M., & Blanchard, D. C. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.10.024 · Cited by 94 · see citing works
Litvin, Y., Murakami, G., & Pfaff, D. W. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.007 · Cited by 90 · see citing works
Salomé, N., Stemmelin, J., Cohen, C., & Griebel, G. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0424-1 · Cited by 89 · see citing works
Wommack, J. C., Taravosh-Lahn, K., David, J. T., & Delville, Y. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00029-6 · Cited by 86 · see citing works
Wersinger, S. R., Temple, J. L., Caldwell, H. K., & Young, W. S. (2008) · Endocrinology · doi:10.1210/en.2007-1056 · Cited by 83 · see citing works
Self-citationHodgson, R. A., Higgins, G. A., Guthrie, D. H., Lu, S. X., Pond, A. J., Mullins, D. E., Guzzi, M. F., Parker, E. M., & Varty, G. B. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.021 · Cited by 82 · see citing works
Shimazaki, T., Iijima, M., & Chaki, S. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.06.032 · Cited by 78 · see citing works
The role of the vasopressin 1b receptor in aggression and other social behaviours
CALDWELL, H., WERSINGER, S., & YOUNGIII, W. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00406-8 · Cited by 64 · see citing works
Self-citationGriffante, C., Green, A., Curcuruto, O., Haslam, C. P., Dickinson, B. A., & Arban, R. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706383 · Cited by 60 · see citing works
Borhegyi, Z., & Léránth, C. (1997) · Experimental Brain Research · doi:10.1007/pl00005706 · Cited by 59 · see citing works
Parallel activation of field CA2 and dentate gyrus by synaptically elicited perforant path volleys
Bartesaghi, R., & GESSI, T. (2004) · Hippocampus · doi:10.1002/hipo.20011 · Cited by 59 · see citing works
Overstreet, D. H., & Griebel, G. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.07.021 · Cited by 58 · see citing works
Hippocampus lesions induced deficits in social and spatial recognition in Octodon degus
Uekita, T., & Okanoya, K. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.042 · Cited by 57 · see citing works
Bartesaghi, R., Migliore, M., & Gessi, T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.001 · Cited by 54 · see citing works
OXYTOCIN RECEPTORS IN RAT ADENOHYPOPHYSIS: EVIDENCE FROM RADIOLIGAND BINDING STUDIES.
Antoni, F. A. (1986) · Endocrinology · doi:10.1210/endo-119-5-2393 · Cited by 50 · see citing works
Stewart, L. Q., Roper, J. A., Young, W. S., O'Carroll, A.-M., & Lolait, S. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01704.x · Cited by 48 · see citing works
Oost, T. K., Backfisch, G., Bhowmik, S., van Gaalen, M. M., Geneste, H., Hornberger, W., Lubisch, W., Netz, A., Unger, L., & Wernet, W. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.03.012 · Cited by 47 · see citing works
Foletta, V. C., Brown, F. D., & Young, W. S. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00448-5 · Cited by 46 · see citing works
Lolait, S. J., Stewart, L. Q., Roper, J. A., Harrison, G., Jessop, D., Young, W. S., & O’Carroll, A. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01560.x · Cited by 43 · see citing works
Stewart, L. Q., Roper, J. A., Young, W. S., O’Carroll, A., & Lolait, S. J. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.12.009 · Cited by 42 · see citing works
Oxytocin and the anterior pituitary gland.
Samson, W. K., & Schell, D. A. (1995) · PubMed · Cited by 40 · see citing works
The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors
Caldwell, H. K., Stewart, J., Wiedholz, L. M., Millstein, R. A., Iacangelo, A. L., Holmes, A., Young, W. S., & Wersinger, S. R. (2006) · Neuropeptides · doi:10.1016/j.npep.2006.08.001 · Cited by 39 · see citing works
Self-citationEly, D., Greene, E. G., & Henry, J. P. (1977) · Physiology & Behavior · doi:10.1016/0031-9384(77)90014-2 · Cited by 34 · see citing works
Social dominance in male vasopressin 1b receptor knockout mice
Caldwell, H. K., Dike, O. E., Stevenson, E. L., Storck, K. E., & Young, W. S. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.008 · Cited by 34 · see citing works
Self-citationRegulation of Vasopressin V1b Receptors and Stress Adaptation
Volpi, S., Rabadan‐Diehl, C., & Aguilera, G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.035 · Cited by 33 · see citing works
Iijima, M., & Chaki, S. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.008 · Cited by 33 · see citing works
Roper, J. A., Craighead, M. W., O'Carroll, A.-M., & Lolait, S. J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02070.x · Cited by 28 · see citing works
Delville, Y., Newman, M. L., Wommack, J. C., Taravosh‐Lahn, K., & Cervantes, M. (2005) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195168761.003.0014 · Cited by 28 · see citing works
Caldwell, H. K., & Young, W. S. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.006 · Cited by 27 · see citing works
Self-citationArsenijévic, Y., Dubois‐Dauphin, M., Tribollet, E., Manning, M., Sawyer, W. H., & Dreifuss, J. J. (1994) · Journal of Endocrinology · doi:10.1677/joe.0.1410383 · Cited by 24 · see citing works
Chadio, S. E., & Antoni, F. A. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1220465 · Cited by 22 · see citing works
Flagged first, then by citations
1 of the 72 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The hippocampal CA2 region is essential for social memory
Hitti, F. L., & Siegelbaum, S. A. (2014) · Nature · doi:10.1038/nature13028 · Cited by 976 · see citing works
Oxytocin pathways and the evolution of human behavior
Carter, C. S. (2014) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115110 · Cited by 714 · see citing works
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“The V1bR has been more recently getting recognized as a modulator of various social behaviors, such as social recognition, aggression, and maternal care (Stevenson & Caldwell, 2012).”
BackgroundIs oxytocin “nature’s medicine”
Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394 · see citing works
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244 · see citing works
Lesions to the <scp>CA</scp>2 region of the hippocampus impair social memory in mice
Stevenson, E. L., & Caldwell, H. K. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12689 · Cited by 222 · see citing works
Self-citationBaribeau, D. A., & Anagnostou, E. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00335 · Cited by 229 · see citing works
Oxytocin and vasopressin: powerful regulators of social behavior
Caldwell, H. K. (2017) · The Neuroscientist · doi:10.1177/1073858417708284 · Cited by 216 · see citing works
Self-citationKo, J. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00041 · Cited by 212 · see citing works
Albers, H. E. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.07.001 · Cited by 200 · see citing works
Social and novel contexts modify hippocampal CA2 representations of space
Alexander, G. M., Farris, S., Pirone, J. R., Zheng, C., Colgin, L. L., & Dudek, S. M. (2016) · Nature Communications · doi:10.1038/ncomms10300 · Cited by 191 · see citing works
Developmental Perspectives on Oxytocin and Vasopressin
Hammock, E. A. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.120 · Cited by 177 · see citing works
Piskorowski, R. A., Nasrallah, K., Diamantopoulou, A., Mukai, J., Hassan, S. I., Siegelbaum, S. A., Gogos, J. A., & Chevaleyre, V. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.036 · Cited by 180 · see citing works
The Oxytocin–Vasopressin Pathway in the Context of Love and Fear
Carter, C. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00356 · Cited by 162 · see citing works
Lukas, M., & Neumann, I. D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.08.011 · Cited by 136 · see citing works
The neuroscience of social feelings: mechanisms of adaptive social functioning
Eslinger, P. J., Anders, S., Ballarini, T., Boutros, S., Krach, S., Mayer, A. V., Moll, J., Newton, T. L., Schroeter, M. L., de Oliveira-Souza, R., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.028 · Cited by 130 · see citing works
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129 · see citing works
Self-citationDiagnosis and management of diabetes insipidus for the internist: an update
Christ‐Crain, M., Winzeler, B. F., & Refardt, J. C. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13261 · Cited by 118 · see citing works
Sala, M., Braida, D., Donzelli, A., Martucci, R., Busnelli, M., Bulgheroni, E., Rubino, T., Parolaro, D., Nishimori, K., & Chini, B. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02385.x · Cited by 99 · see citing works
Sano, K., Isobe, T., Yang, J., Win‐Shwe, T., Yoshikane, M., Nakayama, S. F., Kawashima, T., Suzuki, G., Hashimoto, S., Nohara, K., et al. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00228 · Cited by 88 · see citing works
Sex differences in the regulation of offensive aggression and dominance by arginine-vasopressin
Terranova, J. I., Ferris, C. F., & Albers, H. E. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00308 · Cited by 85 · see citing works
Doom, J. R., Doyle, C., & Gunnar, M. R. (2016) · Social Neuroscience · doi:10.1080/17470919.2016.1149095 · Cited by 82 · see citing works
Editorial comment: Oxytocin, vasopressin and social behavior
Young, L. J., & Flanagan-Cato, L. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.019 · Cited by 81 · see citing works
Oxytocin and vasopressin: signalling, behavioural modulation and potential therapeutic effects
Rae, M., Lemos Duarte, M., Gomes, I., Camarini, R., & Devi, L. A. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15481 · Cited by 72 · see citing works
Neuropeptide diversity and the regulation of social behavior in New World primates
French, J. A., Taylor, J. H., Mustoe, A. C., & Cavanaugh, J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.004 · Cited by 66 · see citing works
Monogenic mouse models of social dysfunction: Implications for autism
Oddi, D., Crusio, W. E., D'Amato, F. R., & Pietropaolo, S. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.002 · Cited by 62 · see citing works
Sparapani, S., Millet-Boureima, C., Oliver, J., Mu, K., Hadavi, P., Kalostian, T., Ali, N., Avelar, C. M., Bardies, M., Barrow, B., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9010089 · Cited by 63 · see citing works
Diabetes Insipidus: Celebrating a Century of Vasopressin Therapy
Qureshi, S., Galiveeti, S., Bichet, D. G., & Roth, J. (2014) · Endocrinology · doi:10.1210/en.2014-1385 · Cited by 62 · see citing works
Ophir, A. G. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00397 · Cited by 62 · see citing works
New opportunities in vasopressin and oxytocin research: a perspective from the amygdala.
Stoop, R., Hegoburu, C., & van den Burg, E. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033904 · Cited by 56 · see citing works
Dhakar, M. B., Rich, M. E., Reno, E. L., Lee, H.-J., & Caldwell, H. K. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.05.007 · Cited by 54 · see citing works
Self-citationAMIGO2 mRNA expression in hippocampal CA2 and CA3a
Laeremans, A., Nys, J., Luyten, W. H. M. L., D’Hooge, R., Paulussen, M., & Arckens, L. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0387-4 · Cited by 53 · see citing works
Zheng, D., Larsson, B., Phelps, S. M., & Ophir, A. G. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.024 · Cited by 48 · see citing works
D’Souza, M. S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00509 · Cited by 46 · see citing works
Neuroendocrine underpinning of social recognition in males and females
Aspesi, D., & Choleris, E. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13070 · Cited by 41 · see citing works
Social Context, Stress, Neuropsychiatric Disorders, and the Vasopressin 1b Receptor
Caldwell, H. K., Aulino, E. A., Rodriguez, K. M., Witchey, S. K., & Yaw, A. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00567 · Cited by 39 · see citing works
Self-citationBader, A., Klein, B., Breer, H., & Strotmann, J. M. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00084 · Cited by 39 · see citing works
Vasopressin and alcohol: a multifaceted relationship
Harper, K. M., Knapp, D. J., Criswell, H. E., & Breese, G. R. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5099-x · Cited by 34 · see citing works
Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice
Zhang, J., Chen, L., Lv, Z.-M., Niu, X.-Y., Shao, C.-C., Zhang, C., Pruski, M., Huang, Y., Qi, C., Song, N., et al. (2016) · Molecular Brain · doi:10.1186/s13041-016-0278-3 · Cited by 33 · see citing works
Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study
Hou, D., & Jin, F. (2016) · Biochemistry & Pharmacology Open Access · doi:10.4172/2167-0501.1000211 · Cited by 32 · see citing works
Bayerl, D. S., Kaczmarek, V., Jurek, B., van den Burg, E. H., Neumann, I. D., Gaßner, B. M., Klampfl, S. M., & Bosch, O. J. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.12.003 · Cited by 28 · see citing works
Stoesz, B. M., Hare, J. F., & Snow, W. M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.007 · Cited by 28 · see citing works
The effects of vasopressin deficiency on aggression and impulsiveness in male and female rats
Fodor, A., Barsvári, B., Aliczki, M., Balogh, Z., Zelena, D., Goldberg, S. R., & Haller, J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.010 · Cited by 28 · see citing works
Kayyal, M., Javkar, T., Mian, M. F., Binyamin, D., Koren, O., Neufeld, K. M., & Forsythe, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-67271-4 · Cited by 26 · see citing works
Barsegyan, A., Atsak, P., Hornberger, W., Jacobson, P. B., van Gaalen, M. M., & Roozendaal, B. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.48 · Cited by 25 · see citing works
Carter, C. S. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_18 · Cited by 25 · see citing works
Brown, L. Y., Alexander, G. M., Cushman, J. D., & Dudek, S. M. (2020) · eNeuro · doi:10.1523/eneuro.0084-20.2020 · Cited by 25 · see citing works
Bayerl, D. S., Klampfl, S. M., & Bosch, O. J. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12226 · Cited by 23 · see citing works
Examining the Role of Vasopressin in the Modulation of Parental and Sexual Behaviors
Zimmermann-Peruzatto, J. M., Lazzari, V. M., de Moura, A. C., Almeida, S., & Giovenardi, M. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00130 · Cited by 23 · see citing works
Williams Avram, S. K., Lee, H.-J., Fastman, J., Cymerblit-Sabba, A., Smith, A., Vincent, M., Song, J., Granovetter, M. C., Lee, S.-H., Cilz, N. I., et al. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00218 · Cited by 22 · see citing works
Pirrone, F., Pierantoni, L., Bossetti, A., Uccheddu, S., & Albertini, M. (2019) · Animals · doi:10.3390/ani9121033 · Cited by 22 · see citing works
Vasopressin Proves Essential: Vasopressin and the Modulation of Sensory Processing in Mammals
Bester‐Meredith, J. K., Fancher, A. P., & Mammarella, G. E. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00005 · Cited by 23 · see citing works
Borie, A. M., Theofanopoulou, C., & Andari, E. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819973-2.00009-5 · Cited by 18 · see citing works
Pitcher, M. H., González‐Cano, R., Vincent, K. F., Lehmann, M. L., Cobos, E. J., Coderre, T. J., Baeyens, J. M., & Cerveró, F. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.02.422 · Cited by 16 · see citing works
Clarke, L., Zyga, O., Pineo-Cavanaugh, P. L., Jeng, M., Fischbein, N. J., Partap, S., Katznelson, L. J., & Parker, K. J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104770 · Cited by 13 · see citing works
Vasopressin as Possible Treatment Option in Autism Spectrum Disorder
László, K., Vörös, D., Correia, P., Fazekas, C. L., Török, B., Plangár, I., & Zelena, D. (2023) · Biomedicines · doi:10.3390/biomedicines11102603 · Cited by 13 · see citing works
Control of the brain microcirculation following traumatic brain injury and stroke
Rafols, J. A. (2015) · Brain Circulation · doi:10.4103/2394-8108.172892 · Cited by 13 · see citing works
Cudnoch‐Jędrzejewska, A., Puchalska, L., Szczepanska‐Sadowska, E. K., Wsół, A., Kowalewski, S., & Czarzasta, K. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.06.011 · Cited by 12 · see citing works
Mouse Behavior and Models for Autism Spectrum Disorders
Ricceri, L., Michetti, C., & Scattoni, M. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00017-0 · Cited by 11 · see citing works
Copeptin: A Neuroendocrine Biomarker in Acute Myocardial Infarction
Elshafei, A., Abd‐Alla, G. M., El-motaal, O. A., & Salman, T. M. (2013) · Annual Research & Review in Biology · doi:10.13140/2.1.3444.3045 · Cited by 11 · see citing works
Conformational selection of vasopressin upon V 1a receptor binding
Che, K., Muttenthaler, M., & Kurzbach, D. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.10.024 · Cited by 11 · see citing works
Expression of vasopressin mRNA in the hypothalamus of individuals with a diagnosis of schizophrenia
Busch, J. R., Jacobsen, C., Lynnerup, N., Banner, J., & Møller, M. (2019) · Brain and Behavior · doi:10.1002/brb3.1355 · Cited by 11 · see citing works
Vasopressin as a Stress Hormone
Antoni, F. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00009-7 · Cited by 10 · see citing works
Genetic signatures of socio-communicative abilities in primates
Staes, N., Bradley, B. J., Hopkins, W. D., & Sherwood, C. C. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.11.013 · Cited by 11 · see citing works
Freeman, A. R., Hare, J. F., & Caldwell, H. K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24400 · Cited by 10 · see citing works
Self-citationMiklos, Z., Flynn, F. W., & Lessard, A. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.043 · Cited by 10 · see citing works
Modulation of male mouse sociosexual and anxiety-like behaviors by vasopressin receptors
Shimizu, K., Nakamura, K., Yokosuka, M., & Kondo, Y. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.09.016 · Cited by 10 · see citing works
The Role of Vasopressin in Anxiety and Depression
Morales‐Medina, J. C., Witchey, S. K., & Caldwell, H. K. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_40 · Cited by 9 · see citing works
Self-citationWitchey, S. K., Stevenson, E. L., & Caldwell, H. K. (2016) · BMC Neuroscience · doi:10.1186/s12868-016-0310-7 · Cited by 9 · see citing works
Self-citationLazzari, V. M., Zimmermann-Peruzatto, J. M., Agnes, G., Becker, R. O., de Moura, A. C., Almeida, S., Guedes, R. P., & Giovenardi, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.10.034 · Cited by 8 · see citing works
Die Rolle des Genotyps bei der generationsübergreifenden Übertragung belastender Kindheitserlebnisse
Reichl, C., Kaess, M., Resch, F., & Brunner, R. M. (2014) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000310 · Cited by 8 · see citing works
Wang, J., & Zou, Z. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1072896 · Cited by 6 · see citing works
Borrow, A. P., Stover, S. A., Bales, N. J., & Handa, R. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00010-9 · Cited by 5 · see citing works
Nicotine and Neurokinin Signaling
Biasi, M. D., McLaughlin, I., & Klima, M. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00018-3 · Cited by 5 · see citing works
AVPR1b variation and the emergence of adaptive phenotypes in Platyrrhini primates
Fam, B. S. D. O., Reales, G., Vargas‐Pinilla, P., Paré, P., Viscardi, L. H., Sortica, V. A., Felkl, A. B., Franco, Á. D. O., Lucion, A. B., Costa-Neto, C. M., et al. (2019) · American Journal of Primatology · doi:10.1002/ajp.23028 · Cited by 4 · see citing works
Situating Cerebral Blood Flow in the Pathotrajectory of Head Trauma
Graves, J., Betrus, C., & Rafols, J. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4148-9_2 · Cited by 4 · see citing works
Adult Neurogenesis and the Initiation of Social Aggression in Male Mice
Tsuda, M. C., Akoh-Arrey, T., Mercurio, J. C., Rucker, A., Airey, M. L., Jacobs, H., Lukasz, D., Wang, L., & Cameron, H. A. (2024) · Hippocampus · doi:10.1002/hipo.23643 · Cited by 3 · see citing works
CHARACTERISTICS OF PEDESTRIAN ACCIDENTS IN MONTREAL CENTRAL BUSINESS DISTRICT
Seneviratne, P. N., Shuster, E. M., & Seneviratne, P. N. (1989) · Transportation Research Record Journal of the Transportation Research Board · Cited by 3 · see citing works
Body weight modulates the impact of oxytocin on chronic cold-immobilization stress response
Önal, D., Korkmaz, H., Önal, G., & Pehli̇vanoğlu, B. (2024) · Peptides · doi:10.1016/j.peptides.2024.171202 · Cited by 2 · see citing works
Yamasaki, F., Nakata, Y., Kanahara, N., Miyazawa, A., Mashimo, Y., Hirose, Y., Oda, Y., Niitsu, T., Onouchi, Y., & Iyo, M. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03149-5 · Cited by 1 · see citing works
Liebl, A. L., Anderson, S., Russell, A. F., Wesner, J. S., & Petersen, J. L. (2026) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2025.0014 · Cited by 1 · see citing works
Bolivar, V. J. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.012 · Cited by 1 · see citing works
Profile of maternal serum oxytocin in postpartum and non-pregnant rats
Tjokroprawiro, B. A., Akbar, M. I. A., Luqman, E. M., & Widijati, W. (2023) · Veterinarska stanica · doi:10.46419/vs.54.6.8 · Cited by 1 · see citing works
Taniguchi, M., Murata, Y., Yamaguchi, M., & Kaba, H. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1466817 · Cited by 1 · see citing works
Genomic analysis of stress, aggression and boldness in rainbow trout
Sims, A. M. (2013) · University of Liverpool · doi:10.17638/00009535 · Cited by 1 · see citing works
Silkis, I. G. (2021) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-021-01169-0 · Cited by 1 · see citing works
Social dysfunction and mental retardation
Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.010
Behavioral Phenotyping in Genetic Mouse Models of Autism Spectrum Disorders: A Translational Outlook
Scattoni, M. L., Michetti, C., Caruso, A., & Ricceri, L. (2017) · Wiley eBooks · doi:10.1002/9781118540770.ch11
Hodges, T. E. (2018) · Brock University Digital Repository (Brock University)
The Effect of Birth on Neural Activation in the Rodent Brain
Hoffiz, Y. C. (2022) · Digital Archive @ GSU · doi:10.57709/17328404
(2015) · Elsevier eBooks · doi:10.1016/b978-0-12-416040-8.16001-8
Anti-stress Effect of Octopus Cephalotocin in Rats
Kim, Y., Jo, S., Jung, S.-H., & Woo, D. H. (2022) · Experimental Neurobiology · doi:10.5607/en22010
New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
Martucci, L. L. (2021) · theses.fr (ABES) · doi:10.70675/027d1ae2zd2ebz4677za019ze6ccd94cafe9
Inada, K. (2026) · Neuroscience Research · doi:10.1016/j.neures.2026.105109
- Authors
- Stevenson, E. L., & Caldwell, H. K.
- Affiliations
- Kent State University (US)
- Corresponding author
- Caldwell, Heather K.
- ORCID
- Caldwell, Heather K.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 61
- Issue
- 3
- Pages
- 277-282
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC3310934
- OpenAlex
- W2073524837
- Cited by
- 100
- References
- 72
- Citations by year
- 2026: 3 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 10 · 2020: 3 · 2019: 8 · 2018: 3 · 2017: 13 · 2016: 11 · 2015: 11 · 2014: 13 · 2013: 6 · 2012: 8
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R21MH083963, MH083963)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, AVPR1B, social behavior, social aggression, social memory, social motivation, corticotrophs, stress response, hippocampal CA2, paraventricular nucleus, olfactory bulb, oxytocin, pharmacological manipulation
- MeSH terms
- Affect, Aggression, Animals, Brain Chemistry, Humans, Memory, Motivation, Social Behavior, Stress, Psychological, Receptors, Vasopressin, Mice, Knockout, Recognition, Psychology, Mice
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