Schizophrenia patients show augmented spatial frame illusion for visual and visuomotor tasks
Open accessAbstract
Previous research has identified several key processes of visual perception and visually guided action that are implicated in schizophrenia. Yet, it is not well understood whether similar or different brain mechanisms mediate the abnormalities in these two processes. To explore this issue, we examined visual and visuomotor processing in schizophrenia, utilizing an illusion known as the Roelofs effect. This illusion refers to the spatial mislocalization of an object within an off-centered frame, with the object appearing to be shifted towards the opposite direction of the frame offset. In this study, localization of the object was measured either by a direct visual response or by an immediate or delayed visuomotor (reaching-to-touch) response. Patients demonstrated significantly greater magnitudes of the Roelofs effect in all response modes, indicating the existence of excessive spatial contextual effects of the frame during the processing of visual and visuomotor information, and when the two types of information are integrated over a delayed visuomotor response condition. These results provide evidence for a hypothesis of improper inhibitory control as a common mechanism underpinning abnormal visual and visuomotor processes in this mental disorder.
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Paradigms that test an illusory effect via visuomotor performances are thought to engage complex cross-modal coordination and are of particular interest in schizophrenia.
“In this regard, paradigms that test an illusory effect via visuomotor performances are thought to engage a complex cross-modal coordination and, thus, are of particular interest in schizophrenia (Pessoa et al., 2008; Chen et al., 2011).”
From What visual illusions teach us about schizophrenia (2014) · cites this paper as Chen et al., 2011
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Cites
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378 · see citing works
Separate visual pathways for perception and action
Goodale, M. A., & Milner, A. D. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90344-8 · Cited by 6,519 · see citing works
Dementia Praecox or the Group of Schizophrenias
(1951) · Journal of the American Medical Association · doi:10.1001/jama.1951.02920270079043 · Cited by 4,407 · see citing works
Ungerleider, L. G. (1982) · Medical Entomology and Zoology · Cited by 4,139 · see citing works
Segregation of Form, Color, Movement, and Depth: Anatomy, Physiology, and Perception
Livingstone, M. S., & Hubel, D. H. (1988) · Science · doi:10.1126/science.3283936 · Cited by 3,358 · see citing works
Dopamine in schizophrenia: a review and reconceptualization
Davis, K. L., Kahn, R. S., Ko, G., & Davidson, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.11.1474 · Cited by 2,021 · see citing works
How parallel are the primate visual pathways?
Merigan, W. H., & Maunsell, J. H. R. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.002101 · Cited by 1,597 · see citing works
Friston, K. J. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00140-0 · Cited by 882 · see citing works
Synaptic plasticity and dysconnection in schizophrenia
Stephan, K. E., Baldeweg, T., & Friston, K. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.005 · Cited by 841 · see citing works
A review of diffusion tensor imaging studies in schizophrenia
Kubicki, M., McCarley, R., Westin, C.-F., Park, H.-J., Maier, S., Kikinis, R., Jolesz, F. A., & Shenton, M. E. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.05.005 · Cited by 769 · see citing works
Visual space perception and visually directed action.
Loomis, J. M., Silva, J. A. D., Fujita, N., & Fukusima, S. S. (1992) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037//0096-1523.18.4.906 · Cited by 698 · see citing works
Accurate control of contrast on microcomputer displays
Pelli, D. G., & Zhang, L. (1991) · Vision Research · doi:10.1016/0042-6989(91)90055-a · Cited by 479 · see citing works
Visual space perception and visually directed action.
Loomis, J. M., Silva, J. A. D., Fujita, N., et al. (1992) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037/0096-1523.18.4.906 · Cited by 473 · see citing works
Visual perception and its impairment in schizophrenia
Butler, P. D., Silverstein, S. M., & Dakin, S. C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.023 · Cited by 472 · see citing works
Interaction of cognitive and sensorimotor maps of visual space
Bridgeman, B., Peery, S., & Anand, S. (1997) · Perception & Psychophysics · doi:10.3758/bf03211912 · Cited by 395 · see citing works
Diffusion Tensor Imaging in Schizophrenia
Kanaan, R., Kim, J.-S., Kaufmann, W. E., Pearlson, G. D., Barker, G. J., & McGuire, P. K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.015 · Cited by 332 · see citing works
Early-stage visual processing deficits in schizophrenia
Butler, P. D., & Javitt, D. C. (2005) · Current Opinion in Psychiatry · doi:10.1097/00001504-200503000-00008 · Cited by 282 · see citing works
Milner, A. D., Paulignan, Y., Dijkerman, H. C., Michel, F., & Jeannerod, M. (1999) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1999.0912 · Cited by 240 · see citing works
Silverstein, S. M., Kovács, I., Corry, R., & Valone, C. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00180-2 · Cited by 240 · see citing works
Weak suppression of visual context in chronic schizophrenia
Dakin, S., Carlin, P., & Hemsley, D. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.015 · Cited by 227 · see citing works
Motion perception in schizophrenia
Chen, Y., Palafox, G. P., Nakayama, K., Levy, D. L., Matthysse, S., & Holzman, P. S. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.2.149 · Cited by 225 · see citing works
Saccadic programming and perceived location
Wong, E., & Mack, A. (1981) · Acta Psychologica · doi:10.1016/0001-6918(81)90054-8 · Cited by 195 · see citing works
Selective deficits in visual perception and recognition in schizophrenia
O’Donnell, B. F., Swearer, J. M., Smith, L. T., Nestor, P. G., Shenton, M. E., & McCarley, R. W. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.5.687 · Cited by 154 · see citing works
Perceptual grouping in disorganized schizophrenia
Uhlhaas, P. J., Phillips, W. A., Mitchell, G., & Silverstein, S. M. (2006) · Psychiatry Research · doi:10.1016/j.psychres.2005.10.016 · Cited by 149 · see citing works
Dorsal and Ventral Stream Interaction: Contributions from Optic Ataxia
Himmelbach, M., & Karnath, H. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929053467514 · Cited by 140 · see citing works
Semantics affect the planning but not control of grasping
Glover, S., & Dixon, P. (2002) · Experimental Brain Research · doi:10.1007/s00221-002-1222-6 · Cited by 130 · see citing works
Differential use of distance and location information for spatial localization
Abrams, R. A., & Landgraf, J. Z. (1990) · Perception & Psychophysics · doi:10.3758/bf03210875 · Cited by 122 · see citing works
Chen, Y., Levy, D. L., Sheremata, S., Nakayama, K., Matthysse, S., & Holzman, P. S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.10.1795 · Cited by 115 · see citing works
Diminished Orientation-Specific Surround Suppression of Visual Processing in Schizophrenia
Yoon, J. H., Rokem, A., Silver, M. A., Minzenberg, M., Ursu, S., Ragland, J. D., & Carter, C. S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp064 · Cited by 114 · see citing works
Corticocortical and thalamocortical information flow in the primate visual system
Essen, D. C. V. (2005) · Progress in brain research · doi:10.1016/s0079-6123(05)49013-5 · Cited by 105 · see citing works
Processing spatial information in the sensorimotor branch of the visual system
Bridgeman, B., Gemmer, A., Forsman, T., & Huemer, V. (2000) · Vision Research · doi:10.1016/s0042-6989(00)00193-0 · Cited by 102 · see citing works
Seeing the World Dimly: The Impact of Early Visual Deficits on Visual Experience in Schizophrenia
Kantrowitz, J. T., Butler, P. D., Schecter, I., Silipo, G. S., & Javitt, D. C. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp100 · Cited by 97 · see citing works
Renshaw, P. F., Yurgelun-Todd, D. A., & Cohen, B. M. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.10.1493 · Cited by 76 · see citing works
Comparing measures of monocular distance perception: Verbal and reaching errors are not correlated.
Pagano, C. C., & Bingham, G. P. (1998) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037//0096-1523.24.4.1037 · Cited by 71 · see citing works
The induced Roelofs effect: two visual systems or the shift of a single reference frame?
Dassonville, P., Bridgeman, B., Bala, J. K., Thiem, P. D., & Sampanes, A. C. (2003) · Vision Research · doi:10.1016/j.visres.2003.10.017 · Cited by 71 · see citing works
Compromised late-stage motion processing in schizophrenia
Chen, Y., Levy, D. L., Sheremata, S., & Holzman, P. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.12.024 · Cited by 70 · see citing works
Must, A., Janka, Z., Benedek, G., & Kéri, S. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.046 · Cited by 68 · see citing works
Comparing measures of monocular distance perception: Verbal and reaching errors are not correlated.
Pagano, C. C., & Bingham, G. P. (1998) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037/0096-1523.24.4.1037 · Cited by 59 · see citing works
CHEN, Y., Grossman, E. D., Bidwell, L. C., Yurgelun-Todd, D. A., Gruber, S. A., Levy, D. L., NAKAYAMA, K., & Holzman, P. S. (2008) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.8.3.293 · Cited by 54 · see citing works
Very Short-Term Memory Dysfunction in Schizophrenia
BRAFF, D. L. (1977) · Archives of General Psychiatry · doi:10.1001/archpsyc.1977.01770130027002 · Cited by 53 · see citing works
Altered center-surround motion inhibition in schizophrenia
Chen, Y., Norton, D., & Ongur, D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.017 · Cited by 51 · see citing works
Walter, E., & Dassonville, P. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.016 · Cited by 42 · see citing works
Do visual illusions probe the visual brain?
Coello, Y., Danckert, J. A., Blangero, A., & Rossetti, Y. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.12.010 · Cited by 26 · see citing works
An investigation into movement planning and execution deficits in individuals with schizophrenia
Carnahan, H., Aguilar, O., MALLA, A. K., & Norman, R. M. G. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(96)00106-5 · Cited by 24 · see citing works
Immediate and delayed reaching in hemispatial neglect
Rossit, S., Muir, K. W., Reeves, I., Duncan, G., Birschel, P., & Harvey, M. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.08.008 · Cited by 23 · see citing works
Grasping behavior in schizophrenia suggests selective impairment in the dorsal visual pathway.
King, J. P., Christensen, B. K., & Westwood, D. A. (2008) · Journal of Abnormal Psychology · doi:10.1037/a0013500 · Cited by 20 · see citing works
Temporal-Contrast Discrimination and its Neural Correlates
Chen, Y., Bedell, H. E., & Frishman, L. J. (1996) · Perception · doi:10.1068/p250505 · Cited by 10 · see citing works
Deficits in Auditory and Visual Context-Dependent Processing in Schizophrenia
Javitt, D. C., Shelley, A.-M., Silipo, G., & Lieberman, J. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1131 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- First MB Spitzer RL Gibbon M William JB Structure Clinical Interview for DSM -IV-TR Axis I Disorders - Non-patient Edition (SCID-I/NP, 11/2002 revision) 2002 New York, NY Biometric Research Department, New York State Psychiatric Institute
- First MB Spitzer RL Gibbon M Williams JB Structured Clinical Interview for DSM-IV Disorders (SCID) 1994 Washington, DC American Psychiatric Press
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Silverstein, S. M. (2016) · Nebraska Symposium on Motivation/The Nebraska symposium on motivation · doi:10.1007/978-3-319-30596-7_4 · Cited by 144 · see citing works
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Griffiths-King, D. J., Hodgekins, J., Chouinard, P. A., Chouinard, V., & Sperandio, I. (2016) · Psychonomic Bulletin & Review · doi:10.3758/s13423-016-1168-5 · Cited by 112 · see citing works
Phillips, W. A., & Silverstein, S. M. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00307 · Cited by 75 · see citing works
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Kim, J., Norton, D. J., McBain, R. K., Öngür, D., & Chen, Y. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00391 · Cited by 63 · see citing works
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Grzeczkowski, L., Roinishvili, M., Chkonia, E. D., Brand, A., Mast, F. W., Herzog, M. H., & Shaqiri, A. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.10.063 · Cited by 51 · see citing works
Developmental heterochrony and the evolution of autistic perception, cognition and behavior
Crespi, B. J. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-119 · Cited by 44 · see citing works
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Boettger, M. K., Grossmann, D., & Bär, K. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00188.x · Cited by 38 · see citing works
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- Authors
- Chen, Y., McBain, R., Norton, D., & Ongur, D.
- Affiliations
- Harvard University (US)
- Corresponding author
- Chen, Y.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 172
- Pages
- 419-426
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3010461
- OpenAlex
- W1976971145
- Cited by
- 16
- References
- 47
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH R01 61824, R01MH061824)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- schizophrenia, visuomotor processing, visual perception, inhibitory control
- MeSH terms
- Adolescent, Adult, Aged, Female, Humans, Illusions, Male, Middle Aged, Neural Inhibition, Neuropsychological Tests, Perceptual Disorders, Photic Stimulation, Psychomotor Performance, Reaction Time, Schizophrenia, Schizophrenic Psychology, Task Performance and Analysis, Time Factors, Young Adult
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