Altered center-surround motion inhibition in schizophrenia
Open accessAbstract
Background Schizophrenia is a brain disorder that spans across biological and behavioral levels. The links between altered neural circuitry and abnormal behaviors are yet to be understood. Visual motion perception has been established in basic neuroscience and may provide an opportunity to link different levels of brain functions in schizophrenia. Center-surround interaction is a ubiquitous neural mechanism underlying the organization of visual information over different spatial locations.Methods We applied a psychophysical paradigm to examine center-surround interaction in schizophrenia. Patients (n = 24) and control subjects (n = 33) judged the direction of a moving random dot pattern (RDP, center) with and without the presence of another concentric surrounding RDP (surround).Results The presence of a moving surround shifted the perceptual judgments of center motion in the opposite direction from the surround in both subject groups but the magnitude of the perceptual shift was significantly larger in patients. The increased perceptual shift was not correlated with psychotic symptoms, which were mild in this patient sample, or antipsychotic medication.Conclusions The increased perceptual shift suggests that the putative surround suppression on visual motion perception is abnormally increased in schizophrenia. This result provides perceptual evidence for altered basic inhibitory control of visual motion context in schizophrenia.
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Dakin's findings of decreased susceptibility to context-based illusions in schizophrenia were replicated using the same type of context-based illusion paradigms.
“Dakin's findings were notably replicated using the same type of context-based illusion paradigms (Uhlhaas et al., 2004; Tadin et al., 2006; Chen et al., 2008)”
From What visual illusions teach us about schizophrenia (2014) · cites this paper as Chen et al., 2008
Chen et al. (2008) proposed that context interaction impairment in schizophrenia may be better accounted for by alterations of surround inhibition rather than surround facilitation.
“The authors proposed that context interaction impairment in schizophrenia may be better accounted for by alterations of surround inhibition rather than surround facilitation.”
From What visual illusions teach us about schizophrenia (2014) · cites this paper as Chen et al., 2008
The single phenomenon of contextual effect is not uniform and may be variously affected in its subcomponents.
“The single phenomenon of contextual effect is not uniform and may be variously affected in its subcomponents as suggested by Chen et al. (2008).”
From What visual illusions teach us about schizophrenia (2014) · cites this paper as Chen et al., 2008
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- Authors
- Chen, Y., Norton, D., & Ongur, D.
- Affiliations
- Harvard University (US)
- Corresponding author
- Chen, Yue
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 64
- Issue
- 1
- Pages
- 74-77
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2483430
- OpenAlex
- W1967104529
- Cited by
- 51
- References
- 20
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2020: 1 · 2018: 2 · 2016: 2 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 3
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH061824)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- schizophrenia, center-surround interactions, visual motion perception, random dot motion, surround suppression, perceptual shift, inhibitory control, visual cortex
- MeSH terms
- Adult, Attention, Discrimination Learning, Female, Field Dependence-Independence, Humans, Inhibition, Psychological, Male, Middle Aged, Motion Perception, Orientation, Pattern Recognition, Visual, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology
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