Motion perception in schizophrenia

Chen, Yue; Palafox, Germán P.; Nakayama, Ken; Levy, Deborah L.; Matthysse, Steven; Holzman, Philip S.

doi:10.1001/archpsyc.56.2.149

Cited by 225Schizophrenia research and treatmentVisual perception and processing mechanismsHallucinations in medical conditions

Motion perception in schizophrenia

Chen, Yue, Palafox, Germán P., Nakayama, Ken, Levy, Deborah L., Matthysse, Steven, Holzman, Philip S.·1999·Archives of General Psychiatry

DOI 10.1001/archpsyc.56.2.149

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Abstract

BACKGROUND: Eye-tracking dysfunction has been found in many patients with schizophrenia and in about 40% of their first-degree biological relatives. We hypothesized that a deficit in motion processing is associated with eye-tracking dysfunction because both motion signals and the brain regions responsible for processing motion signals are implicated in the generation of smooth pursuit. We examined several aspects of visual perception, including motion perception, in patients with schizophrenia. METHODS: To evaluate motion perception, contrast sensitivity for velocity discrimination was measured in patients with schizophrenia (n=15) and normal control subjects (n=18). Contrast sensitivities for orientation discrimination and contrast detection were measured as control tasks. RESULTS: Patients with schizophrenia showed significantly lower contrast sensitivity (ie, higher thresholds) than normal controls for the discrimination of small velocity differences (eg, 11 vs 9 degrees/s). This reduction in contrast sensitivity was severe (up to 10-fold) in about 40% of the patients. No group differences were found on the other tasks. CONCLUSION: The discrimination of small velocity differences is impaired in a subgroup of patients with schizophrenia.

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A large number of studies have reported motion processing deficits in schizophrenia.
“A large number of studies have reported motion processing deficits in schizophrenia (28–32).”
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Authors: Chen, Y., Palafox, G. P., Nakayama, K., Levy, D. L., Matthysse, S., & Holzman, P. S.
Affiliations: Harvard University (US)
ORCID: Chen, Yue
Palafox, Germán P.
Levy, Deborah L.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1999-02-01
Volume: 56
Issue: 2
Pages: 149
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.56.2.149
OpenAlex: W1982163126
Cited by: 225
References: 25
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 9
FWCI: 8.55
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01MH049487, MH 31340, P01MH031154, MH-31154, MH 49487, R01MH031340)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords: schizophrenia, motion perception, velocity discrimination, contrast sensitivity, smooth pursuit eye movements, visual perception deficits
MeSH terms: Brain, Eye Movements, Female, Form Perception, Humans, Male, Motion Perception, Psychiatric Status Rating Scales, Pursuit, Smooth, Random Allocation, Sampling Studies, Schizophrenia, Space Perception, Contrast Sensitivity

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Motion perception in schizophrenia

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