A tale of two species: Neural integration in zebrafish and monkeys
Open accessAbstract
Selection of a model organism creates tension between competing constraints. The recent explosion of modern molecular techniques has revolutionized the analysis of neural systems in organisms that are amenable to genetic techniques. Yet, the non-human primate remains the gold-standard for the analysis of the neural basis of behavior, and as a bridge to the operation of the human brain. The challenge is to generalize across species in a way that exposes the operation of circuits as well as the relationship of circuits to behavior. Eye movements provide an opportunity to cross the bridge from mechanism to behavior through research on diverse species. Here, we review experiments and computational studies on a circuit function called "neural integration" that occurs in the brainstems of larval zebrafish, primates, and species "in between". We show that analysis of circuit structure using modern molecular and imaging approaches in zebrafish has remarkable explanatory power for details of the responses of integrator neurons in the monkey. The combination of research from the two species has led to a much stronger hypothesis for the implementation of the neural integrator than could have been achieved using either species alone.
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Our work informs line attractor network models, for which the VPNI has served as a model system.
“Our work similarly informs line attractor network models, for which the VPNI has served as a model system53,54.”
From Predicting modular functions and neural coding of behavior from a synaptic wiring diagram (2024) · cites this paper as [54]
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“Our work similarly informs line attractor network models, for which the VPNI has served as a model system 53,54 .”
- Authors
- Joshua, M., & Lisberger, S. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Joshua, M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 296
- Pages
- 80-91
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC4216779
- OpenAlex
- W2071040101
- Cited by
- 47
- References
- 14
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 3
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute (EY017210)
- Human Frontiers Science Program
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- neural integration, neural integrator, eye movements, zebrafish, non-human primates, brainstem circuits, cross-species generalization, zebrafish larvae, computational modeling of neural circuits, model organism selection
- MeSH terms
- Animals, Haplorhini, Brain, Brain Stem, Eye Movements, Nerve Net, Neurons, Saccades, Species Specificity, Zebrafish, Models, Animal
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