Cited by 89Neural dynamics and brain functionZebrafish Biomedical Research ApplicationsVisual perception and processing mechanisms

Evidence accumulation during a sensorimotor decision task revealed by whole-brain imaging

Dragomir, Elena I., Štih, Vilim, Portugues, Ruben·2020·Nature Neuroscience

Abstract

Although animals can accumulate sensory evidence over considerable time scales to appropriately select behavior, little is known about how the vertebrate brain as a whole accomplishes this. In this study, we developed a new sensorimotor decision-making assay in larval zebrafish based on whole-field visual motion. Fish responded by swimming in the direction of perceived motion, such that the latency to initiate swimming and the fraction of correct turns were modulated by motion strength. Using whole-brain functional imaging, we identified neural activity relevant to different stages of the decision-making process, including the momentary evaluation and accumulation of sensory evidence. This activity is distributed in functional clusters across different brain regions and is characterized by a wide range of time constants. In addition, we found that the caudal interpeduncular nucleus (IPN), a circular structure located ventrally on the midline of the brain, reliably encodes the left and right turning rates.

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Crossref · 10.1038/s41593-019-0535-8

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  • Output neurons in the intermediate and deep layers of the teleost optic tectum are able to initiate orientation or avoidance responses through their projections to the reticular formation and other pre-motor cell groups in the brainstem, which activate motoneurons in oculomotor nuclei and spinal cord that control orienting eye and body movements.

    “the output neurons in the intermediate and deep layers of the teleost optic tectum are able to initiate orientation or avoidance responses through their projections to the reticular formation and other pre-motor cell groups in the brainstem, which in turn activate the motoneurons in the oculomotor nuclei and spinal cord that control orienting eye and body movements”

    From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [141]

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Authors
Dragomir, E. I., Štih, V., & Portugues, R.
Affiliations
Max Planck Institute of Neurobiology (DE)
Venue
Nature Neuroscience
Published
2019-12-02
Volume
23
Issue
1
Pages
85-93
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2991078956
Cited by
89
References
54
Citations by year
2026: 20 · 2025: 17 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 16 · 2020: 9 · 2018: 1
FWCI
4.65
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • Max-Planck-Gesellschaft
  • Graduate School of Systemic Neurosciences
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
evidence accumulation, sensorimotor decision making, zebrafish larvae, turning behavior, stimulus strength
MeSH terms
Animals, Brain, Decision Making, Zebrafish

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