Evidence accumulation during a sensorimotor decision task revealed by whole-brain imaging
Abstract
Although animals can accumulate sensory evidence over considerable time scales to appropriately select behavior, little is known about how the vertebrate brain as a whole accomplishes this. In this study, we developed a new sensorimotor decision-making assay in larval zebrafish based on whole-field visual motion. Fish responded by swimming in the direction of perceived motion, such that the latency to initiate swimming and the fraction of correct turns were modulated by motion strength. Using whole-brain functional imaging, we identified neural activity relevant to different stages of the decision-making process, including the momentary evaluation and accumulation of sensory evidence. This activity is distributed in functional clusters across different brain regions and is characterized by a wide range of time constants. In addition, we found that the caudal interpeduncular nucleus (IPN), a circular structure located ventrally on the midline of the brain, reliably encodes the left and right turning rates.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Output neurons in the intermediate and deep layers of the teleost optic tectum are able to initiate orientation or avoidance responses through their projections to the reticular formation and other pre-motor cell groups in the brainstem, which activate motoneurons in oculomotor nuclei and spinal cord that control orienting eye and body movements.
“the output neurons in the intermediate and deep layers of the teleost optic tectum are able to initiate orientation or avoidance responses through their projections to the reticular formation and other pre-motor cell groups in the brainstem, which in turn activate the motoneurons in the oculomotor nuclei and spinal cord that control orienting eye and body movements”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [141]
Cites
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474 · see citing works
Ratcliff, R. (1978) · Psychological Review · doi:10.1037/0033-295x.85.2.59 · Cited by 4,513 · see citing works
The Neural Basis of Decision Making
Gold, J. I., & Shadlen, M. N. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113038 · Cited by 3,764 · see citing works
The time course of perceptual choice: The leaky, competing accumulator model.
Usher, M., & McClelland, J. L. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.550 · Cited by 2,152 · see citing works
Neural Basis of a Perceptual Decision in the Parietal Cortex (Area LIP) of the Rhesus Monkey
Shadlen, M. N., & Newsome, W. T. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.4.1916 · Cited by 1,755 · see citing works
Newsome, W., & Pare, E. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-06-02201.1988 · Cited by 1,615 · see citing works
Roitman, J. D., & Shadlen, M. N. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09475.2002 · Cited by 1,589 · see citing works
Neuronal correlates of a perceptual decision
Newsome, W. T., Britten, K. H., & Movshon, J. A. (1989) · Nature · doi:10.1038/341052a0 · Cited by 1,177 · see citing works
Neural Control of Voluntary Movement Initiation
Hanes, D. P., & Schall, J. D. (1996) · Science · doi:10.1126/science.274.5286.427 · Cited by 1,145 · see citing works
Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque
Kim, J.-N., & Shadlen, M. N. (1999) · Nature Neuroscience · doi:10.1038/5739 · Cited by 950 · see citing works
A supramodal accumulation-to-bound signal that determines perceptual decisions in humans
O'Connell, R. G., Dockree, P. M., & Kelly, S. P. (2012) · Nature Neuroscience · doi:10.1038/nn.3248 · Cited by 755 · see citing works
Motion perception: seeing and deciding.
Shadlen, M. N., & Newsome, W. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.628 · Cited by 723 · see citing works
Models for choice-reaction time
Stone, M. (1960) · Psychometrika · doi:10.1007/bf02289729 · Cited by 696 · see citing works
A role for neural integrators in perceptual decision making
Mazurek, M. E., Roitman, J. D., Ditterich, J., & Shadlen, M. N. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg097 · Cited by 620 · see citing works
Rats and Humans Can Optimally Accumulate Evidence for Decision-Making
Brunton, B. W., Botvinick, M., & Brody, C. D. (2013) · Science · doi:10.1126/science.1233912 · Cited by 607 · see citing works
Optim: A mathematical optimization package for Julia
Mogensen, P. K., & Riseth, A. N. (2018) · The Journal of Open Source Software · doi:10.21105/joss.00615 · Cited by 509 · see citing works
Distinct relationships of parietal and prefrontal cortices to evidence accumulation
Hanks, T. D., Kopec, C. D., Brunton, B. W., Duan, C. A., Erlich, J. C., & Brody, C. D. (2015) · Nature · doi:10.1038/nature14066 · Cited by 486 · see citing works
Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish
Neuhauss, S. C. F., Biehlmaier, O., Seeliger, M. W., Das, T., Kohler, K., Harris, W. A., & Baier, H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08603.1999 · Cited by 414 · see citing works
Posterior parietal cortex represents sensory history and mediates its effects on behaviour
Akrami, A., Kopec, C. D., Diamond, M. E., & Brody, C. D. (2018) · Nature · doi:10.1038/nature25510 · Cited by 380 · see citing works
Torsten Rohlfing, B., & Maurer, C. R. (2003) · IEEE Transactions on Information Technology in Biomedicine · doi:10.1109/titb.2003.808506 · Cited by 373 · see citing works
Optimal decision-making theories: linking neurobiology with behaviour
Bogacz, R. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.12.006 · Cited by 367 · see citing works
Microstimulation of macaque area LIP affects decision-making in a motion discrimination task
Hanks, T. D., Ditterich, J., & Shadlen, M. N. (2006) · Nature Neuroscience · doi:10.1038/nn1683 · Cited by 360 · see citing works
Neural circuits underlying visually evoked escapes in larval zebrafish
Dunn, T. W., Gebhardt, C., Naumann, E. A., Riegler, C., Ahrens, M. B., Engert, F., & Del Bene, F. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.021 · Cited by 347 · see citing works
Separate Signals for Target Selection and Movement Specification in the Superior Colliculus
Horwitz, G. D., & Newsome, W. T. (1999) · Science · doi:10.1126/science.284.5417.1158 · Cited by 346 · see citing works
The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain
Bianco, I. H., & Wilson, S. W. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0213 · Cited by 344 · see citing works
Robinson, D. A. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000341 · Cited by 323 · see citing works
From Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response
Naumann, E. A., Fitzgerald, J. E., Dunn, T. W., Rihel, J., Sompolinsky, H., & Engert, F. (2016) · Cell · doi:10.1016/j.cell.2016.10.019 · Cited by 315 · see citing works
Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior
Portugues, R., Feierstein, C. E., Engert, F., & Orger, M. B. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.019 · Cited by 305 · see citing works
Self-citationRhythmic Fluctuations in Evidence Accumulation during Decision Making in the Human Brain
Wyart, V., de Gardelle, V., Scholl, J., & Summerfield, C. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.015 · Cited by 281 · see citing works
Dissociated functional significance of decision-related activity in the primate dorsal stream
Katz, L. N., Yates, J. L., Pillow, J. W., & Huk, A. C. (2016) · Nature · doi:10.1038/nature18617 · Cited by 277 · see citing works
Control of visually guided behavior by distinct populations of spinal projection neurons
Orger, M. B., Kampff, A. R., Severi, K. E., Bollmann, J. H., & Engert, F. (2008) · Nature Neuroscience · doi:10.1038/nn2048 · Cited by 274 · see citing works
Neural control and modulation of swimming speed in the larval zebrafish
Severi, K. E., Portugues, R., Marques, J. C., O’Malley, D. M., Orger, M. B., & Engert, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.032 · Cited by 239 · see citing works
Self-citationPan-neuronal calcium imaging with cellular resolution in freely swimming zebrafish
Kim, D. H., Kim, J., Marques, J. C., Grama, A., Hildebrand, D. G. C., Gu, W., Li, J. M., & Robson, D. N. (2017) · Nature Methods · doi:10.1038/nmeth.4429 · Cited by 228 · see citing works
Perception of Fourier and non-Fourier motion by larval zebrafish
Orger, M. B., Smear, M. C., Anstis, S., & Baier, H. (2000) · Nature Neuroscience · doi:10.1038/80649 · Cited by 211 · see citing works
Neural underpinnings of the evidence accumulator
Brody, C. D., & Hanks, T. D. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.01.003 · Cited by 184 · see citing works
Kubo, F., Hablitzel, B., Dal Maschio, M., Driever, W., Baier, H., & Arrenberg, A. B. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.043 · Cited by 182 · see citing works
Fronto-parietal Cortical Circuits Encode Accumulated Evidence with a Diversity of Timescales
Scott, B. B., Constantinople, C. M., Akrami, A., Hanks, T. D., Brody, C. D., & Tank, D. W. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.013 · Cited by 161 · see citing works
Disentangling decision models: From independence to competition.
Teodorescu, A. R., & Usher, M. (2013) · Psychological Review · doi:10.1037/a0030776 · Cited by 155 · see citing works
History-based action selection bias in posterior parietal cortex
Hwang, E. J., Dahlen, J. E., Mukundan, M., & Komiyama, T. (2017) · Nature Communications · doi:10.1038/s41467-017-01356-z · Cited by 152 · see citing works
Posterior Parietal Cortex Guides Visual Decisions in Rats
Licata, A., Kaufman, M. T., Raposo, D. C., Ryan, M., Sheppard, J. P., & Churchland, A. K. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0105-17.2017 · Cited by 148 · see citing works
Spatial gradients and multidimensional dynamics in a neural integrator circuit
Miri, A., Daie, K., Arrenberg, A. B., Baier, H., Aksay, E., & Tank, D. W. (2011) · Nature Neuroscience · doi:10.1038/nn.2888 · Cited by 138 · see citing works
Sensorimotor computation underlying phototaxis in zebrafish
Wolf, S., Dubreuil, A. M., Bertoni, T., Böhm, U. L., Bormuth, V., Candelier, R., Karpenko, S., Hildebrand, D. G. C., Bianco, I. H., Monasson, R., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00310-3 · Cited by 134 · see citing works
Spinal projection neurons control turning behaviors in zebrafish
Huang, K.-H., Ahrens, M. B., Dunn, T. W., & Engert, F. (2013) · Current Biology · doi:10.1016/j.cub.2013.06.044 · Cited by 133 · see citing works
Separate, Causal Roles of the Caudate in Saccadic Choice and Execution in a Perceptual Decision Task
Ding, L., & Gold, J. I. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.021 · Cited by 125 · see citing works
Gold, J. I., Law, C.-T., Connolly, P. M., & Bennur, S. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90629.2008 · Cited by 123 · see citing works
Aksay, E., Baker, R., Seung, H. S., & Tank, D. W. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.2.1035 · Cited by 119 · see citing works
FoxP influences the speed and accuracy of a perceptual decision in Drosophila
Dasgupta, S., Ferreira, C. H., & Miesenböck, G. (2014) · Science · doi:10.1126/science.1252114 · Cited by 102 · see citing works
Štih, V., Petrucco, L., Kist, A. M., & Portugues, R. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006699 · Cited by 93 · see citing works
Self-citationMorley, B. J. (1986) · International review of neurobiology · doi:10.1016/s0074-7742(08)60108-7 · Cited by 76 · see citing works
Sharp, P. E., Turner-Williams, S., & Tuttle, S. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.07.004 · Cited by 74 · see citing works
A tale of two species: Neural integration in zebrafish and monkeys
Joshua, M., & Lisberger, S. G. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.048 · Cited by 47 · see citing works
Spatial Patterns of Persistent Neural Activity Vary with the Behavioral Context of Short-Term Memory
Daie, K., Goldman, M. S., & Aksay, E. R. F. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.006 · Cited by 42 · see citing works
Deficits in landmark navigation and path integration after lesions of the interpeduncular nucleus.
Clark, B. J., & Taube, J. S. (2009) · Behavioral Neuroscience · doi:10.1037/a0015477 · Cited by 36 · see citing works
Whole-field visual motion drives swimming in larval zebrafish via a stochastic process
Portugues, R., Haesemeyer, M., Blum, M. L., & Engert, F. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.118299 · Cited by 29 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
A Diversity of Intrinsic Timescales Underlie Neural Computations
Cavanagh, S. E., Hunt, L. T., & Kennerley, S. W. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.615626 · Cited by 109 · see citing works
Neural dynamics and architecture of the heading direction circuit in zebrafish
Petrucco, L., Lavian, H., Wu, Y. K., Svara, F., Štih, V., & Portugues, R. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01308-5 · Cited by 110 · see citing works
Self-citationTheory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition
Wang, X.-J. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-035434 · Cited by 83 · see citing works
Imaging whole-brain activity to understand behaviour
Lin, A., Witvliet, D. K., Hernandez-Nunez, L., Linderman, S. W., Samuel, A. D. T., & Venkatachalam, V. (2022) · Nature Reviews Physics · doi:10.1038/s42254-022-00430-w · Cited by 77 · see citing works
A cerebellar internal model calibrates a feedback controller involved in sensorimotor control
Markov, D. A., Petrucco, L., Kist, A. M., & Portugues, R. (2021) · Nature Communications · doi:10.1038/s41467-021-26988-0 · Cited by 68 · see citing works
Self-citationSpatial Cognition in Teleost Fish: Strategies and Mechanisms
Rodríguez, F., Quintero, B., Amores, L., Madrid, D., Salas-Peña, C., & Salas, C. (2021) · Animals · doi:10.3390/ani11082271 · Cited by 59 · see citing works
A brainstem integrator for self-location memory and positional homeostasis in zebrafish
Yang, E., Zwart, M., James, B., Rubinov, M., Wei, Z., Narayan, S., Vladimirov, N., Mensh, B. D., Fitzgerald, J. E., & Ahrens, M. B. (2022) · Cell · doi:10.1016/j.cell.2022.11.022 · Cited by 61 · see citing works
Roesch, E., Greener, J. G., MacLean, A. L., Nassar, H., Rackauckas, C., Holy, T. E., & Stumpf, M. P. H. (2023) · Nature Methods · doi:10.1038/s41592-023-01832-z · Cited by 48 · see citing works
Current Methods to Investigate Nociception and Pain in Zebrafish
Ohnesorge, N., Heinl, C., & Lewejohann, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.632634 · Cited by 48 · see citing works
Response competition between neurons and antineurons in the mushroom body
Vrontou, E., Groschner, L. N., Szydlowski, S. N., Brain, R., Krebbers, A., & Miesenböck, G. (2021) · Current Biology · doi:10.1016/j.cub.2021.09.008 · Cited by 50 · see citing works
Okamoto, H., Cherng, B., Nakajo, H., Chou, M., & Kinoshita, M. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.12.005 · Cited by 47 · see citing works
A rise-to-threshold process for a relative-value decision
Vijayan, V., Wang, F., Wang, K., Chakravorty, A., Adachi, A., Akhlaghpour, H., Dickson, B. J., & Maimon, G. (2023) · Nature · doi:10.1038/s41586-023-06271-6 · Cited by 49 · see citing works
The Visual Systems of Zebrafish
Baier, H., & Scott, E. K. (2024) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-111020-104854 · Cited by 49 · see citing works
Collective behavior emerges from genetically controlled simple behavioral motifs in zebrafish
Harpaz, R., Aspiras, A., Chambule, S., Tseng, S., Bind, M.-A. C., Engert, F., Fishman, M., & Bahl, A. (2021) · bioRxiv · doi:10.1126/sciadv.abi7460 · Cited by 48 · see citing works
Whole-brain interactions underlying zebrafish behavior
Loring, M. D., Thomson, E. E., & Naumann, E. A. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.09.011 · Cited by 43 · see citing works
Cherng, B., Islam, T., Torigoe, M., Tsuboi, T., & Okamoto, H. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108143 · Cited by 39 · see citing works
Neural substrates involved in the cognitive information processing in teleost fish
Calvo, R. A., & Schluessel, V. (2021) · Animal Cognition · doi:10.1007/s10071-021-01514-3 · Cited by 39 · see citing works
Dense Circuit Reconstruction to Understand Neuronal Computation: Focus on Zebrafish
Friedrich, R. W., & Wanner, A. A. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110220-013050 · Cited by 33 · see citing works
A Neural Representation of Naturalistic Motion-Guided Behavior in the Zebrafish Brain
Yildizoglu, T., Riegler, C., Fitzgerald, J. E., & Portugues, R. (2020) · Current Biology · doi:10.1016/j.cub.2020.04.043 · Cited by 34 · see citing works
Self-citationFunctional neuronal circuits emerge in the absence of developmental activity
Barabási, D. L., Schuhknecht, G. F. P., & Engert, F. (2024) · Nature Communications · doi:10.1038/s41467-023-44681-2 · Cited by 31 · see citing works
The preoptic area and dorsal habenula jointly support homeostatic navigation in larval zebrafish
Palieri, V., Paoli, E., Wu, Y. K., Haesemeyer, M., Kadow, I. C. G., & Portugues, R. (2024) · Current Biology · doi:10.1016/j.cub.2023.12.030 · Cited by 26 · see citing works
Self-citationFrom perception to behavior: The neural circuits underlying prey hunting in larval zebrafish
Zhu, S., & Goodhill, G. J. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1087993 · Cited by 31 · see citing works
Circuit Organization Underlying Optic Flow Processing in Zebrafish
Matsuda, K., & Kubo, F. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.709048 · Cited by 30 · see citing works
Naturalistic neuroscience and virtual reality
Thurley, K. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.896251 · Cited by 28 · see citing works
Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
Ramirez, A. D., & Aksay, E. R. F. (2021) · Nature Communications · doi:10.1038/s41467-021-24336-w · Cited by 24 · see citing works
Goodwin, R. A., Lai, Y. G., Taflin, D. E., Smith, D. L., McQuirk, J., Trang, R., & Reeves, R. L. (2023) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2023.703946 · Cited by 24 · see citing works
Brain-wide, scale-wide physiology underlying behavioral flexibility in zebrafish
Mu, Y., Narayan, S., Mensh, B. D., & Ahrens, M. B. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.08.013 · Cited by 17 · see citing works
Structural and functional organization of visual responses in the inferior olive of larval zebrafish
Félix, R., Markov, D. A., Renninger, S. L., Tomás, A. R., Laborde, A., Carey, M. R., Orger, M. B., & Portugues, R. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.2352-21.2023 · Cited by 15 · see citing works
Self-citationA connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brainPreprint
Petkova, M. D., Januszewski, M., Blakely, T. M., Herrera, K. J., Schuhknecht, G. F. P., Tiller, R., Choi, J., Schalek, R. L., Boulanger-Weill, J., Peleg, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.10.658982 · Cited by 14 · see citing works
Neural dynamics and architecture of the heading direction circuit in a vertebrate brainPreprint
Petrucco, L., Lavian, H., Wu, Y. K., Svara, F., Štih, V., & Portugues, R. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.27.489672 · Cited by 13 · see citing works
Self-citationWagle, M. D., Zarei, M., Lovett-Barron, M., Poston, K. T., Xu, J., Ramey, V., Pollard, K. S., Prober, D. A., Schulkin, J. A., Deisseroth, K. A., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01567-x · Cited by 13 · see citing works
Zaupa, M., Nagaraj, N., Sylenko, A., Baier, H., Sawamiphak, S., & Filosa, A. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.001 · Cited by 11 · see citing works
Attentional switching in larval zebrafish
Krishnan, K., Muthukumar, A. V., Sterrett, S. C., Pflitsch, P., Fairhall, A. L., Fishman, M. C., Bahl, A., Zwaka, H., & Engert, F. (2025) · Science Advances · doi:10.1126/sciadv.ads4994 · Cited by 14 · see citing works
Feierstein, C. E., de Goeij, M. H. M., Ostrovsky, A. D., Laborde, A., Portugues, R., Orger, M. B., & Machens, C. K. (2023) · Current Biology · doi:10.1016/j.cub.2023.08.037 · Cited by 10 · see citing works
Self-citationBoulanger-Weill, J., Kämpf, F., Schuhknecht, G. F. P., Schalek, R. L., Garza, R., Petkova, M. D., Vohra, S. K., Wu, Y., Savaliya, J. H., Tiller, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.14.643363 · Cited by 8 · see citing works
Visuomotor decision-making through multifeature convergence in the larval zebrafish hindbrain
Slangewal, K., Aimon, S., Capelle, M. Q., Kämpf, F., Naumann, H., Slanchev, K., Baier, H., & Bahl, A. (2026) · Nature Communications · doi:10.1038/s41467-026-69633-4 · Cited by 12 · see citing works
Artificial embodied circuits uncover neural architectures of vertebrate visuomotor behaviors
Liu, X., Loring, M. D., Zunino, L., Fouke, K. E., Longchamp, F. A., Bernardino, A., Ijspeert, A. J., & Naumann, E. A. (2025) · Science Robotics · doi:10.1126/scirobotics.adv4408 · Cited by 8 · see citing works
Lavian, H., Prat, O., Petrucco, L., Štih, V., & Portugues, R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.25.614953 · Cited by 8 · see citing works
Self-citationSpatiotemporal visual statistics of aquatic environments in the natural habitats of zebrafish
Cai, L. T., Krishna, V. S., Hladnik, T. C., Guilbeault, N. C., Vijayakumar, C., Arunachalam, M., Juntti, S. A., Arrenberg, A. B., Thiele, T. R., & Cooper, E. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-36099-z · Cited by 8 · see citing works
Anatomical and functional organization of the interpeduncular nucleus in larval zebrafishPreprint
Wu, Y. K., Petrucco, L., & Portugues, R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.09.617353 · Cited by 7 · see citing works
Self-citationLavian, H., Prat, O., Petrucco, L., Štih, V., & Portugues, R. (2025) · Nature Communications · doi:10.1038/s41467-025-66084-1 · Cited by 6 · see citing works
Self-citationA cerebellar internal model calibrates a feedback controller involved in sensorimotor controlPreprint
Markov, D. A., Petrucco, L., Kist, A. M., & Portugues, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.12.945956 · Cited by 6 · see citing works
Self-citationNature over Nurture: Functional neuronal circuits emerge in the absence of developmental activityPreprint
Barabási, D. L., Schuhknecht, G. F. P., & Engert, F. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.24.513526 · Cited by 6 · see citing works
On analogies in vertebrate and insect visual systems
Tanaka, R., & Portugues, R. (2025) · Nature Reviews Neuroscience · doi:10.1038/s41583-025-00932-3 · Cited by 5 · see citing works
Self-citationA brainstem integrator for self-localization and positional homeostasisPreprint
Yang, E., Zwart, M., Rubinov, M., James, B., Wei, Z., Narayan, S., Vladimirov, N., Mensh, B. D., Fitzgerald, J. E., & Ahrens, M. B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.26.468907 · Cited by 5 · see citing works
Algorithmic dissection of optic flow memory in larval zebrafish
Tanaka, R., & Portugues, R. (2025) · Current Biology · doi:10.1016/j.cub.2025.08.047 · Cited by 5 · see citing works
Self-citationMigault, G., Beiza-Canelo, N., Chatterjee, S., Debrégeas, G., & Bormuth, V. (2026) · Communications Biology · doi:10.1038/s42003-026-10141-y · Cited by 4 · see citing works
Theoretical principles for illuminating sensorimotor processing with brain-wide neuronal recordings
Tirthabir Biswas, A., Bishop, W. E., & Fitzgerald, J. E. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.10.021 · Cited by 4 · see citing works
Stevens, R. H., & Galloway, T. L. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2021.606823 · Cited by 4 · see citing works
Attentional Switching in Larval Zebrafish: The Attentive Leaky IntegratorPreprint
Krishnan, K., Muthukumar, A. V., Sterrett, S. C., Pflitsch, P., Fairhall, A. L., Fishman, M. C., Bahl, A., Zwaka, H., & Engert, F. (2023) · Research Square · doi:10.21203/rs.3.rs-3486824/v1 · Cited by 4 · see citing works
Linking brain and behavior states in Zebrafish Larvae locomotion using hidden Markov models
Dommanget-Kott, M., Fernández-de-Cossio-Díaz, J., Coraggioso, M., Bormuth, V., Monasson, R., Debrégeas, G., & Cocco, S. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013762 · Cited by 4 · see citing works
Synchronization of behavioral and cardiac dynamics in larval zebrafish
Herrera, K. J., Zarghani-Shiraz, A., Ahrens, M. B., Engert, F., & Fishman, M. C. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.116947 · Cited by 3 · see citing works
Distinct distributed neural dynamics predict pallium-dependent social approach
Lifshitz, I., Prag, A., Livneh, N., Moshkovitz, M., Karmi, A., & Avitan, L. (2026) · Nature Communications · doi:10.1038/s41467-026-71666-8 · Cited by 3 · see citing works
A thalamus–brainstem attractor network drives history-biased decisions
Zhao, S., Shan, H., Liu, X., Qian, Y., Huang, J., Liu, Y., Jiao, Z., Ye, L., Cong, L., Wang, X., et al. (2026) · Nature · doi:10.1038/s41586-026-10623-3 · Cited by 3 · see citing works
Brain-Wide Impacts of Sedation on Spontaneous Activity and Auditory Processing in Larval Zebrafish
Favre‐Bulle, I. A., Müller, E. J., Lee, C. C. Y., Scholz, L. A., Arnold, J., Munn, B., Wainstein, G., Shine, J. M., & Scott, E. K. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0204-24.2025 · Cited by 4 · see citing works
Modulation of habenula axon terminals supports action-outcome associations in larval zebrafishPreprint
Paoli, E., Palieri, V., Shenoy, A., & Portugues, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.13.638047 · Cited by 3 · see citing works
Self-citationResearch status and trends of models integrating fish behavior and eco-hydraulic dynamics
Minne, L., Wang, Y., Xinyuan, W., Xiaobing, L., Lin, C., Xiaolong, C., Chen, Q., & Shi, X. (2024) · Journal of Lake Sciences · doi:10.18307/2024.0502 · Cited by 2 · see citing works
Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades
Ramirez, A. D., & Aksay, E. R. F. (2021) · RePEc: Research Papers in Economics · Cited by 2 · see citing works
Collective behavior emerges from genetically controlled simple behavioral motifs in zebrafishPreprint
Aspiras, A. C., Harpaz, R., Chambule, S., Tseng, S.-M., Engert, F., Fishman, M. C., & Bahl, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.03.433803 · Cited by 2 · see citing works
Behavioral adaptation to changing energy constraints via altered frequency of movement selectionPreprint
Darveniza, T., Zhu, S., Pujic, Z., Sun, B., Levendosky, M., Wong, R., Agarwal, R., McCullough, M., & Goodhill, G. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.08.566262 · Cited by 2 · see citing works
Algorithmic dissection of optic flow memory in larval zebrafishPreprint
Tanaka, R., & Portugues, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.15.648832 · Cited by 2 · see citing works
Self-citationCardiac interoception impacts behavior and brain-wide neuronal dynamicsPreprint
Herrera, K. J., Zarghani-Shiraz, A., Ahrens, M. B., Engert, F., & Fishman, M. C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.25.650721 · Cited by 2 · see citing works
Behavioral alignment as an organizing principle in sensory codingPreprint
Huang, S., Portugues, R., & Fitzgerald, J. E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.04.703828 · Cited by 2 · see citing works
Self-citationMatsuda, K., Wang, C., Kakinuma, H., Toyoda, A., Shiraki, T., Kawakami, K., & Kubo, F. (2026) · Nature Communications · doi:10.1038/s41467-026-71371-6 · Cited by 1 · see citing works
Neural temporal scaling accounts for robust hunting behavior across temperatures
Tamari, S. T., Rubinstein, Y., Livneh, N., Moshkovitz, M., Karmi, A., & Avitan, L. (2026) · Nature Communications · doi:10.1038/s41467-026-71640-4 · Cited by 1 · see citing works
Modulation of habenula axon terminals supports action-outcome associations in larval zebrafish
Paoli, E., Palieri, V., Shenoy, A., & Portugues, R. (2026) · Nature Communications · doi:10.1038/s41467-026-76267-z · Cited by 4 · see citing works
Self-citationWen, C., & Kimura, K. D. (2020) · Japanese Journal of Applied Physics · doi:10.35848/1347-4065/ab77f3 · Cited by 1 · see citing works
Ramp-to-Threshold Dynamics in a Hindbrain Population Controls the Timing of Spontaneous SaccadesPreprint
Ramirez, A. D., & Aksay, E. R. F. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/430645 · Cited by 1 · see citing works
Petrucco, L. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16613 · Cited by 1 · see citing works
Distinct brain-wide neural dynamics predict social approach behaviorPreprint
Lifshitz, I., Livneh, N., Moshkovitz, M., Karmi, A., & Avitan, L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.09.663340 · Cited by 1 · see citing works
Slangewal, K., Aimon, S., Capelle, M. Q., Kämpf, F., Naumann, H., Baier, H., Slanchev, K., & Bahl, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.12.669772 · Cited by 1 · see citing works
Lim, J.-X., Wei, Z., Narayan, S., Zhang, Y., Hasseman, J. P., Kolb, I., Zheng, J., Sheikhattar, A., Mi, X., Zheng, W. H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.05.704034 · Cited by 1 · see citing works
Garza, R., Hady, A. E., & Bahl, A. (2026) · Communications Biology · doi:10.64898/2026.03.01.708829 · Cited by 1 · see citing works
Distributed representations of chemosensory valence in a naïve vertebrate brainPreprint
Jenkins, B., & Frank, T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.17.732810 · Cited by 2 · see citing works
Opposing influences of sensory and response history in larval zebrafishPreprint
Mangalwedhekar, A., Hunt, S. A., Hachen, I., & Bahl, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.30.741669 · Cited by 1 · see citing works
A neural circuit basis for binasal input-enhanced chemosensory avoidancePreprint
Sy, S. K. H., Chan, D. C. W., Chan, R. C. H., Lyu, J., Li, Z., Wong, K. K. Y., Choi, C. H. J., Mok, V., Lai, H. M., Hu, Y., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.20.431946
Mirror-assisted light-sheet microscopy: a simple upgrade to enable bi-directional sample excitation
Zylbertal, A., & Bianco, I. H. (2024) · Neurophotonics · doi:10.1117/1.nph.11.3.035006
It’s about time: neural temporal scaling accounts for robust hunting behavior across temperaturesPreprint
Tamari, S. T., Rubinstein, Y., Livneh, N., Moshkovitz, M., Karmi, A., & Avitan, L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.20.665717
Motor history influences behavioral strategy more than response outcome in Drosophila melanogasterPreprint
Bruzzone, M., Menti, G. M., Maschio, M. D., & Megighian, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.11.664321
Wong, A. K., Cherng, B., Kakinuma, H., Wyart, C., & Okamoto, H. (2025) · The Journal of Comparative Neurology · doi:10.1002/cne.70105
Klusmann, F. S., Kögler, A. C., Slangewal, K., Önder, O., Naumann, H., Marx, A., Bahl, A., & Müller, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.01.691575
Lee, S. H., Nemenman, I. M., & Levchenko, A. (2026) · Cell Systems · doi:10.1016/j.cels.2025.101507
Control of wildtype zebrafish optomotor response with a photoswitchable drugPreprint
Camerin, L., Martínez‐Tambella, J., Schuhknecht, G. F. P., Wang, V. M., Krishnan, K., Pflitsch, P., Engert, F., & Gorostiza, P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.05.709743
Light-seeking navigation in zebrafish larva : from behavior to neural circuits
Karpenko, S. (2020) · theses.fr (ABES) · doi:10.70675/0f60462czd06dz458ez91bcz84d501e2f9a9
The neuronal basis of auditory-induced and spontaneous behavior in the zebrafish larva
Privat, M. (2021) · theses.fr (ABES) · doi:10.70675/c7cf74ebze0c8z47f3zb7daz88662078804c
Latent factors capturing evolution of behavior in larval zebrafish
Han, C., Gong, Y., Sun, L., Du, J., & Ji, P. (2026) · Chaos An Interdisciplinary Journal of Nonlinear Science · doi:10.1063/5.0354035
Remote control of wildtype zebrafish optomotor response with a photoswitchable drug
Camerin, L., Martínez‐Tambella, J., Schuhknecht, G. F. P., Wang, V. M., Krishnan, K., Pflitsch, P., Engert, F., & Gorostiza, P. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1916443
Innate sensorimotor policies constrain cerebellar adaptive correctionPreprint
Shenoy, A. K., & Portugues, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.01.754451
Self-citationAimon, S., Naumann, H., & Bahl, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.30.752102
- Authors
- Dragomir, E. I., Štih, V., & Portugues, R.
- Affiliations
- Max Planck Institute of Neurobiology (DE)
- Venue
- Nature Neuroscience
- Published
- 2019-12-02
- Volume
- 23
- Issue
- 1
- Pages
- 85-93
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2991078956
- Cited by
- 89
- References
- 54
- Citations by year
- 2026: 20 · 2025: 17 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 16 · 2020: 9 · 2018: 1
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Max-Planck-Gesellschaft
- Graduate School of Systemic Neurosciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- evidence accumulation, sensorimotor decision making, zebrafish larvae, turning behavior, stimulus strength
- MeSH terms
- Animals, Brain, Decision Making, Zebrafish
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review