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Cited by 158Neuroendocrine regulation and behaviorMaternal and Perinatal Health InterventionsPregnancy-related medical research

Plasma Oxytocin Concentrations in Men, Nonpregnant Women, and Pregnant Women before and during Spontaneous Labor*

LEAKE, ROSEMARY D., WEITZMAN, RICHARD E., GLATZ, THEODORE H., FISHER, DELBERT A.·1981·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-53-4-730
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Abstract

Baseline plasma oxytocin (OT) concentrations were measured in 25 healthy men, 102 nonpregnant women, and 59 pregnant women from 15-42 weeks gestation. In addition, plasma OT levels were measured at the onset, peak, and immediately after a single uterine contraction in 6 women in the latent phase and 14 women in the active phases of labor, as well as in 19 women at initial presentation of the fetal head on the perineum (+3 station) and 11 women at the time of delivery of the head during a normal vaginal delivery. Baseline plasma OT concentrations did not vary significantly among men (1.5 +/- 0.2 microunits/ml), nonpregnant women (1.4 +/- 0.2 microunits/ml), or pregnant women before labor (1.3 +/- 0.1 microunits/ml) and did not differ in an additional subgroup of 20 women receiving oral contraceptive medication (1.8 +/- 0.7 microunits/ml). In studies conducted during labor, plasma OT concentrations did not correlate with uterine pressure measurements and did not increase significantly over baseline pregnancy concentrations during the latent (1.3 +/- 0.2 microunits/ml) or active (1.6 +/- 0.2 microunits/ml) phases of labor. There was a significant increase in plasma OT levels from the time of initial visualization of the fetal head to the time of delivery of the head (1.1 +/- 0.1 to 4.2 +/- 1.1 microunits/ml, respectively; P less than 0.05). These data support the view that maternal plasma OT levels remain low during pregnancy until late in the second stage of labor.

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Crossref · 10.1210/jcem-53-4-730

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  • Enzymatic degradation of oxytocin is a problem only when measuring in plasma from pregnant women, and extraction procedures can remove such enzymes efficiently.

    “Fortunately, enzymatic degradation of oxytocin is a problem only when measuring in plasma from pregnant women 54, and extraction procedures can remove such enzymes efficiently.”

    From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [54]

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Authors
LEAKE, R. D., WEITZMAN, R. E., GLATZ, T. H., & FISHER, D. A.
Affiliations
University of California, Los Angeles (US)
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1981-10
Volume
53
Issue
4
Pages
730-733
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-53-4-730
OpenAlex
W1964255419
Cited by
158
References
22
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 5 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 4 · 2013: 3 · 2012: 1
FWCI
8.77
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
Keywords
plasma oxytocin, labor, pregnancy, uterine contraction, second stage of labor, latent phase of labor, active phase of labor, oral contraceptives, uterine pressure, vaginal delivery, oxytocin secretion
MeSH terms
Female, Humans, Labor, Obstetric, Male, Neurophysins, Oxytocin, Pregnancy, Radioimmunoassay

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