Oxytocin plasma concentrations after single intranasal oxytocin administration–a study in healthy men
Abstract
The neuropeptide oxytocin has become a subject of great interest in studies investigating human social cognition. Single intranasal administration of the hormone has been reported to have positive behavioral effects, such as increasing trust or facilitating social approach, 45-80 min after administration. However, little is still known about the long-term pharmacokinetics of oxytocin nasal spray application in humans. This study addressed the question how long oxytocin plasma levels remain elevated following nasal spray administration. Another goal was to examine the influence of oxytocin administration on endogenous steroid hormones since such alterations might modulate social behavior via an indirect way. Eight healthy Caucasian men were challenged with a single intranasal application of 26 international units of oxytocin. Changes in oxytocin blood plasma levels, as well as steroid hormone levels of progesterone, testosterone and estradiol were assessed at 5 consecutive time points over a period of 3.5 h (-5, +30, +90, +150, +210 min relative to oxytocin administration). Results gave evidence for a substantial rise of oxytocin plasma levels 30 min after intranasal administration, observed in 7 of 8 participants. Group mean oxytocin plasma level was found to have returned to baseline already 90 min post administration, though in some individuals the plasma levels was still elevated relative to sampling at post 150 min. Steroid hormone analyses yielded a slight augmentation of endogenous testosterone levels 210 min after oxytocin administration. Our data confirms previous findings that oxytocin administered as a nasal spray enters the blood circulation, elevating oxytocin plasma levels for a limited time. Our findings suggest that this time window differs between individuals, but that, for the used dose, it does not extend beyond 150 min post administration. The data further provides preliminary evidence that intranasal oxytocin has an enhancing effect on testosterone in healthy men.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Intranasal oxytocin raises the concentration of endogenous oxytocin in blood plasma and saliva.
“Although there is good evidence that intranasal OXT increases the concentration of endogenous OXT found in blood plasma and saliva (Daughters et al., 2015;Gossen et al., 2012;Weisman et al., 2012)”
From Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear (2017) · cites this paper as Gossen et al., 2012
Salivary oxytocin concentrations peaked at 30 minutes after intranasal oxytocin administration.
“This significant difference lasted until the end of testing, approximately 108 minutes after administration, and peaked at 30 minutes.”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [18]
The impact of intranasal oxytocin lasts for at least 90 minutes in both plasma and saliva.
“except to corroborate other evidence that the impact of IN-OT lasts for at least 90 minutes in both plasma and saliva [18].”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [18]
Cites
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · see citing works
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · see citing works
Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans
Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., Dziobek, I., Gallinat, J., Wagner, M., Maier, W., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5538-09.2010 · Cited by 771 · see citing works
Ordered Hypotheses for Multiple Treatments: A Significance Test for Linear Ranks
Page, E. B. (1963) · Journal of the American Statistical Association · doi:10.1080/01621459.1963.10500843 · Cited by 688 · see citing works
Light, K. C., Grewen, K. M., & Amico, J. A. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2004.11.002 · Cited by 470 · see citing works
Brambilla, D. J., Matsumoto, A. M., Araujo, A. B., & McKinlay, J. B. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1902 · Cited by 448 · see citing works
Mens, W. B. J., Witter, A., & Van Wimersma Greidanus, T. B. (1983) · Brain Research · doi:10.1016/0006-8993(83)90478-x · Cited by 360 · see citing works
van Anders, S. M., Goldey, K. L., & Kuo, P. X. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.001 · Cited by 321 · see citing works
Graham, J. M., & Desjardins, C. (1980) · Science · doi:10.1126/science.7434016 · Cited by 268 · see citing works
Tribollet, E., Audigier, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90232-z · Cited by 203 · see citing works
The acute effects of intranasal oxytocin administration on endocrine and sexual function in males
Burri, A., Heinrichs, M., Schedlowski, M., & Kruger, T. H. C. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.01.014 · Cited by 168 · see citing works
Winslow, J., & Insel, T. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-07-02032.1991 · Cited by 145 · see citing works
Associations between testosterone secretion and sexual activity in women
van Anders, S. M., Hamilton, L. D., Schmidt, N., & Watson, N. V. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.01.003 · Cited by 101 · see citing works
The presence of a woman increases testosterone in aggressive dominant men
van der Meij, L., Buunk, A. P., Vandesande, J., & Salvador, A. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.07.001 · Cited by 87 · see citing works
Pharmacokinetics of oxytocin in the human subject.
Leake, R. D., Weitzman, R. E., & Fisher, D. A. (1980) · PubMed · Cited by 80 · see citing works
Frayne, J., & Nicholson, H. D. (1995) · Biology of Reproduction · doi:10.1095/biolreprod52.6.1268 · Cited by 69 · see citing works
Testosterone and Cortisol Release among Spanish Soccer Fans Watching the 2010 World Cup Final
van der Meij, L., Almela, M., Hidalgo, V., Villada, C., IJzerman, H., Lange, P. A. M. V., & Salvador, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034814 · Cited by 57 · see citing works
Plasma Oxytocin Concentrations in Man after Different Routes of Administration of Synthetic Oxytocin
Landgraf, R. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1210444 · Cited by 51 · see citing works
Uvnäs-Moberg, K., Eklund, M., Hillegaart, V., & Ahlénius, S. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(99)00112-3 · Cited by 26 · see citing works
[Effect of oxytocin on regional 3H-orotic acid uptake in rat brain].
Landgraf, R., Hess, J., & Hartmann, E. (1977) · PubMed · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“Indeed, intranasal OT administration also leads to increases in OT in plasma and saliva in humans (Gossen et al., 2012; van Ijzendoorn et al., 2012) and rhesus macaques (Modi et al., 2014).”
BackgroundIncreased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511 · see citing works
Striepens, N., Kendrick, K. M., Hanking, V., Landgraf, R., Wüllner, U., Maier, W., & Hurlemann, R. (2013) · Scientific Reports · doi:10.1038/srep03440 · Cited by 452 · see citing works
Baribeau, D. A., & Anagnostou, E. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00335 · Cited by 229 · see citing works
Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218 · see citing works
Self-citationYamasue, H., Okada, T., Munesue, T., Kuroda, M., Fujioka, T., Uno, Y., Matsumoto, K., Kuwabara, H., Mori, D., Okamoto, Y., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0097-2 · Cited by 185 · see citing works
MacDonald, K., & Feifel, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00035 · Cited by 181 · see citing works
CSF and blood oxytocin concentration changes following intranasal delivery in macaque
Dal Monte, O., Noble, P. L., Turchi, J., Cummins, A., & Averbeck, B. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103677 · Cited by 177 · see citing works
Intranasal administration of oxytocin: behavioral and clinical effects, a review
Veening, J. G., & Olivier, B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.012 · Cited by 169 · see citing works
Oxytocin administration, salivary testosterone, and father–infant social behavior
Weisman, O., Zagoory‐Sharon, O., & Feldman, R. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.11.006 · Cited by 160 · see citing works
Frye, R. E. (2018) · CNS Drugs · doi:10.1007/s40263-018-0556-y · Cited by 157 · see citing works
Fan, Y., Herrera-Meléndez, A. L., Pestke, K., Feeser, M., Aust, S., Otte, C., Pruessner, J. C., Böker, H., Bajbouj, M., & Grimm, S. (2014) · Human Brain Mapping · doi:10.1002/hbm.22553 · Cited by 134 · see citing works
Blevins, J. E., & Baskin, D. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.023 · Cited by 132 · see citing works
Oxytocin blunts social vigilance in the rhesus macaque
Ebitz, R. B., Watson, K. K., & Platt, M. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305230110 · Cited by 132 · see citing works
Ebert, A., Kolb, M., Heller, J., Edel, M.-A., Roser, P., & Brüne, M. (2013) · Social Neuroscience · doi:10.1080/17470919.2013.807301 · Cited by 129 · see citing works
Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques
Freeman, S. M., Samineni, S., Allen, P. C., Stockinger, D., Bales, K. L., Hwa, G. G. C., & Roberts, J. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.014 · Cited by 128 · see citing works
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.018 · Cited by 123 · see citing works
Role of oxytocin signaling in the regulation of body weight
Blevins, J. E., & Ho, J. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9260-x · Cited by 108 · see citing works
Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans
Kirkpatrick, M. G., Francis, S. M., Lee, R., de Wit, H., & Jacob, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.006 · Cited by 106 · see citing works
Oxytocin for the treatment of drug and alcohol use disorders
Lee, M. R., & Weerts, E. M. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000258 · Cited by 105 · see citing works
Quintana, D. S., Westlye, L. T., Rustan, Ø. G., Tesli, N., Poppy, C. L., Smevik, H., Tesli, M., Røine, M., Mahmoud, R. A., Smerud, K. T., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.93 · Cited by 103 · see citing works
Intranasal oxytocin effects on social cognition: A critique
Evans, S. L., Dal Monte, O., Noble, P., & Averbeck, B. B. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.008 · Cited by 97 · see citing works
Evidence for Intranasal Oxytocin Delivery to the brain: Recent Advances and Future Perspectives
Quintana, D. S., Smerud, K. T., Andreassen, O. A., & Djupesland, P. G. (2018) · Therapeutic Delivery · doi:10.4155/tde-2018-0002 · Cited by 94 · see citing works
Aoki, Y., Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Takao, H., Kawakubo, Y., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.74 · Cited by 95 · see citing works
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Kerem, L., & Lawson, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147737 · Cited by 94 · see citing works
Daughters, K., Manstead, A. S. R., Hubble, K., Rees, A., Thapar, A., & van Goozen, S. H. M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0145104 · Cited by 92 · see citing works
“Several studies have now shown that OT concentrations in both plasma [18, 26] and saliva [13] peak at 30 minutes, if not earlier.”
BackgroundResultCalcagnoli, F., Kreutzmann, J. C., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.019 · Cited by 92 · see citing works
Martins, D., Gabay, A. S., Mehta, M. A., & Paloyelis, Y. (2020) · eLife · doi:10.7554/elife.62456 · Cited by 91 · see citing works
Kuypers, K. P. C., de la Torre, R., Farre, M., Yubero-Lahoz, S., Dziobek, I., Van den Bos, W., & Ramaekers, J. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100719 · Cited by 88 · see citing works
Munesue, T., Nakamura, H., Kikuchi, M., Miura, Y., Takeuchi, N., Anme, T., Nanba, E., Adachi, K., Tsubouchi, K., Sai, Y., et al. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00002 · Cited by 84 · see citing works
Improving social perception in schizophrenia: The role of oxytocin
Fischer-Shofty, M., Brüne, M., Ebert, A., Shefet, D., Levkovitz, Y., & Shamay‐Tsoory, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.006 · Cited by 83 · see citing works
Intrapartum Synthetic Oxytocin and Its Effects on Maternal Well‐Being at 2 Months Postpartum
Gu, V., Feeley, N., Gold, I., Hayton, B. C., Robins, S., MacKinnon, A., Samuel, S., Carter, C. S., & Zelkowitz, P. (2015) · Birth · doi:10.1111/birt.12198 · Cited by 81 · see citing works
Husarova, V. M., Lakatošová, S., Pivovarciova, A., Babinská, K., Bakoš, J., Durdiaková, J., Kubranská, A., Ondrejka, I., & Ostatníková, D. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.2.174 · Cited by 78 · see citing works
Li, Q., Becker, B., Wernicke, J., Chen, Y., Zhang, Y., Li, R., Le, J., Kou, J., Zhao, W., & Kendrick, K. M. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.11.016 · Cited by 85 · see citing works
Gong, L., Gao, F., Li, J., Li, J., Yu, X., Ma, X., Zheng, W., Cui, S., Liu, K., Zhang, M., et al. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.058 · Cited by 74 · see citing works
Peled‐Avron, L., Abu-Akel, A. M., & Shamay‐Tsoory, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.023 · Cited by 73 · see citing works
Buemann, B., & Uvnäs-Moberg, K. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109597 · Cited by 66 · see citing works
Targeting the Oxytocin System: New Pharmacotherapeutic Approaches
Gulliver, D. W., Werry, E. L., Reekie, T. A., Katte, T. A., Jorgensen, W. T., & Kassiou, M. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.11.001 · Cited by 63 · see citing works
Preclinical Toxicity Screening of Intrathecal Oxytocin in Rats and Dogs
Yaksh, T. L., Hobo, S., Peters, C. M., Osborn, K. G., Richter, P. J., Rossi, S. S., Grafe, M. R., & Eisenach, J. C. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000148 · Cited by 63 · see citing works
Weisman, O., Pelphrey, K. A., Leckman, J. F., Feldman, R., Lu, Y., Chong, A., Chen, Y., Monakhov, M. V., Chew, S. H., & Ebstein, R. P. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.04.007 · Cited by 60 · see citing works
Ferris, C. F., Yee, J. R., Kenkel, W. M., Dumais, K. M., Moore, K., Veenema, A. H., Kulkarni, P. P., Perkybile, A. M., & Carter, C. S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00245 · Cited by 60 · see citing works
The role of oxytocin and vasopressin in emotional and social behaviors
Bachner‐Melman, R., & Ebstein, R. P. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00004-6 · Cited by 62 · see citing works
Ebert, A., & Brüne, M. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_21 · Cited by 62 · see citing works
Oxytocin and cardioprotection in diabetes and obesity
Jankowski, M., Broderick, T. L., & Gutkowska, J. (2016) · BMC Endocrine Disorders · doi:10.1186/s12902-016-0110-1 · Cited by 59 · see citing works
Current findings on the role of oxytocin in the regulation of food intake
Spetter, M. S., & Hallschmid, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.007 · Cited by 58 · see citing works
Frantz, M., Pellissier, L. P., Pflimlin, E., Loison, S., Gandía, J., MARSOL, C., Durroux, T., Mouillac, B., Becker, J. A. J., Merrer, J. L., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00697 · Cited by 57 · see citing works
Oxytocin and Eating Disorders: A Narrative Review on Emerging Findings and Perspectives
Giel, K. E., Zipfel, S., & Hallschmid, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171128143158 · Cited by 53 · see citing works
Fragkaki, I., Cima, M., & Granic, I. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.11.005 · Cited by 52 · see citing works
Muin, D. A., Wolzt, M., Marculescu, R., Sheikh Rezaei, S., Salama, M., Fuchs, C., Luger, A., Bragagna, E., Litschauer, B., & Bayerle-Eder, M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.06.010 · Cited by 48 · see citing works
Urinary and plasma oxytocin changes in response to MDMA or intranasal oxytocin administration
Francis, S. M., Kirkpatrick, M. G., de Wit, H., & Jacob, S. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.011 · Cited by 46 · see citing works
Hubble, K., Daughters, K., Manstead, A. S. R., Rees, A., Thapar, A., & van Goozen, S. H. M. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.10.019 · Cited by 41 · see citing works
Vasopressin and oxytocin in CSF and plasma of patients with aneurysmal subarachnoid haemorrhage
Martin, J., Kagerbauer, S. M., Schuster, T., Blobner, M., Kochs, E. F., & Landgraf, R. (2014) · Neuropeptides · doi:10.1016/j.npep.2013.12.004 · Cited by 40 · see citing works
Theodoridou, A., Rowe, A. C., & Mohr, C. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00197 · Cited by 40 · see citing works
“This time window is likely sensitive to OT effects; Gossen et al. (2012) showed that OT reaches its peak plasma level at approximately 30 min after a dose of 26 IU intranasal OT.”
BackgroundThe Role of Intranasal Oxytocin in the Treatment of Patients with Schizophrenia: A Systematic Review
Berardis, D. D., Marini, S., Iasevoli, F., Tomasetti, C., de Bartolomeis, A., Mazza, M., Valchera, A., Fornaro, M., Cavuto, M., Srinivasan, V., et al. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312020012 · Cited by 38 · see citing works
Oxytocin and potential benefits for obesity treatment
Olszewski, P. K., Klockars, A., & Levine, A. S. (2017) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000351 · Cited by 37 · see citing works
Daughters, K., Manstead, A. S. R., Velden, F. S. T., & Dreu, C. K. W. D. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.039 · Cited by 35 · see citing works
Muscle weakness during aging: a deficiency state involving declining angiogenesis
Ambrose, C. T. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.03.005 · Cited by 36 · see citing works
Rapid-onset anorectic effects of intranasal oxytocin in young men
Burmester, V., Higgs, S., & Terry, P. (2018) · Appetite · doi:10.1016/j.appet.2018.08.003 · Cited by 34 · see citing works
Abu-Akel, A. M., Fischer-Shofty, M., Levkovitz, Y., Jean Decety, A., & Shamay‐Tsoory, S. (2014) · Psychological Medicine · doi:10.1017/s003329171400097x · Cited by 33 · see citing works
Donadon, M. F., Martín‐Santos, R., & Osório, F. D. L. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110098 · Cited by 32 · see citing works
Ågmo, A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.10.003 · Cited by 33 · see citing works
The Neuropeptide Hormone Oxytocin in Eating Disorders
Plessow, F., Eddy, K. T., & Lawson, E. A. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0957-0 · Cited by 32 · see citing works
Oxytocin Expression and Function in the Posterior Retina: A Novel Signaling Pathway
Halbach, P., Pillers, D.-A. M., York, N., Asuma, M. P., Chiu, M. A., Luo, W., Tokarz, S. A., Bird, I. M., & Pattnaik, B. R. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15646 · Cited by 31 · see citing works
Maternal Oxytocin Is Linked to Close Mother-Infant Proximity in Grey Seals (Halichoerus grypus)
Robinson, K. J., Twiss, S. D., Hazon, N., & Pomeroy, P. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144577 · Cited by 30 · see citing works
Bridging the gap between rodents and humans: The role of non‐human primates in oxytocin research
Putnam, P. T., Young, L. J., & Gothard, K. M. (2018) · American Journal of Primatology · doi:10.1002/ajp.22756 · Cited by 28 · see citing works
“Taken together with similar results from studies performed in humans (Gossen et al., 2012; Striepens et al., 2013), these results clearly suggest that OT enters the CSF of primates and elevates OT levels in the brain when peripherally administered at appropriate doses.”
ResultOxytocin as an Anti-obesity Treatment
Niu, J., Tong, J., & Blevins, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.743546 · Cited by 30 · see citing works
Salivary vasopressin increases following intranasal oxytocin administration
Weisman, O., Schneiderman, I., Zagoory‐Sharon, O., & Feldman, R. (2012) · Peptides · doi:10.1016/j.peptides.2012.12.004 · Cited by 29 · see citing works
Intranasal oxytocin does not reduce age-related difficulties in social cognition
Grainger, S. A., Henry, J. D., Steinvik, H. R., Vanman, E. J., Rendell, P. G., & Labuschagne, I. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.01.009 · Cited by 27 · see citing works
Wiśniewski, K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9504-2_11 · Cited by 28 · see citing works
Razo, R. A., Berger, T., Conley, A. J., Freeman, S. M., Goetze, L. R., Jacob, S., Lawrence, R. H., Mendoza, S. P., Rothwell, E. S., Savidge, L. E., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104494 · Cited by 28 · see citing works
Oxytocin increases bias, but not accuracy, in face recognition line-ups
Bate, S., Bennetts, R. J., Parris, B. A., Bindemann, M., Udale, R. C., & Bussunt, A. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu150 · Cited by 28 · see citing works
Berends, Y. R., Tulen, J. H. M., Wierdsma, A. I., PELT, J. V., Feldman, R., Zagoory‐Sharon, O., de Rijke, Y. B., Kushner, S. A., & Marle, H. J. C. V. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.027 · Cited by 27 · see citing works
Breastfeeding dynamically changes endogenous oxytocin levels and emotion recognition in mothers
Matsunaga, M., Kikusui, T., Mogi, K., Nagasawa, M., Ooyama, R., & Myowa, M. (2020) · Biology Letters · doi:10.1098/rsbl.2020.0139 · Cited by 26 · see citing works
Guoynes, C. D., & Marler, C. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244033 · Cited by 28 · see citing works
Nielsen, E. I., Al-Saqi, S. H., Jonasson, A. F., & Uvnäs‐Moberg, K. (2017) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.961 · Cited by 26 · see citing works
Gong, L., Li, J., Tang, Y., Han, T., Wei, C., Yu, X., Li, J., Wang, R., Ma, X., Liu, K., et al. (2016) · Scientific Reports · doi:10.1038/srep31452 · Cited by 24 · see citing works
Effects of Intranasal Oxytocin on Stress-Induced Cigarette Craving in Daily Smokers
Hedger, K. V., Bershad, A. K., Lee, R., & de Wit, H. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty159 · Cited by 24 · see citing works
Liu, C., Lan, C., Li, K., Zhou, F., Yao, S., Xu, L., Yang, N., Zhou, X., Yang, J., Yong, X., et al. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.04.009 · Cited by 23 · see citing works
The Role of Endogenous Oxytocin in Anxiolysis: Structural and Functional Correlates
Lancaster, K., Goldbeck, L., Pournajafi‐Nazarloo, H., Connelly, J. J., Carter, C. S., & Morris, J. P. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.10.003 · Cited by 23 · see citing works
Leeds, A., Dennis, P. M., Lukas, K. E., Stoinski, T. S., Willis, M. A., & Schook, M. W. (2018) · Primates · doi:10.1007/s10329-018-0678-3 · Cited by 23 · see citing works
Hall, K., Smith, M. F., Russell, J. L., Lambeth, S. P., Schapiro, S. J., & Brosnan, S. F. (2019) · Animal Behavior and Cognition · doi:10.26451/abc.06.01.04.2019 · Cited by 23 · see citing works
L’ocytocine et la dépression du post-partum
Cardaillac, C., Rua, C., Simon, E. G., & El‐Hage, W. (2016) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2016.05.002 · Cited by 22 · see citing works
Tsegay, K. B., Adeyemi, C. M., Gniffke, E. P., Sather, D. N., Walker, J. K., & Smith, S. E. P. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.685308 · Cited by 22 · see citing works
Effects of intranasal oxytocin in food intake and craving: A meta-analysis of clinical trials
Chen, C., Chiang, Y.-C., Kuo, T., Tam, K., & Loh, E. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.08.011 · Cited by 22 · see citing works
Discussions and perspectives regarding oxytocin as a biomarker in human investigations
Mera, J. C. C., Molano, M. A. C., López, C. C. G., Triana, C. A., & Cotrina, J. A. M. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08289 · Cited by 21 · see citing works
Barengolts, E. I. (2016) · Endocrine Practice · doi:10.4158/ep151192.ra · Cited by 21 · see citing works
Effects of Intranasal Oxytocin on Steroid Hormones in Men and Women
Wirth, M. M., Gaffey, A. E., & Martinez, B. S. (2015) · Neuropsychobiology · doi:10.1159/000381023 · Cited by 21 · see citing works
Zierhut, M. M., Bergmann, N., Hahne, I., Wohlthan, J., Kraft, J., Braun, A., Ta, T. M. T., Hellmann‐Regen, J., Ripke, S., Bajbouj, M., et al. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.01.014 · Cited by 21 · see citing works
Sherman, B. J., Baker, N. L., Brady, K. T., Joseph, J. E., Nunn, L. M., & McRae‐Clark, A. L. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05516-w · Cited by 19 · see citing works
Butovskaya, M., Rostovtseva, V., Butovskaya, P., Burkova, V., Dronova, D., Filatova, V., Sukhodolskaya, E., Vasiliev, V., Mesa, T., Rosa, A., et al. (2020) · Journal of Physiological Anthropology · doi:10.1186/s40101-020-00232-y · Cited by 17 · see citing works
Increased Serum and Urinary Oxytocin Concentrations after Nasal Administration in Beagle Dogs
Temesi, A., Thuróczy, J., Balogh, L., & Miklósi, Á. (2017) · Frontiers in Veterinary Science · doi:10.3389/fvets.2017.00147 · Cited by 18 · see citing works
Oxytocin conditions trait-based rule adherence
Gross, J., & Dreu, C. K. W. D. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw138 · Cited by 18 · see citing works
Prinsen, J., Brams, S., & Alaerts, K. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.02.016 · Cited by 19 · see citing works
A phase II randomised controlled trial of intranasal oxytocin in anorexia nervosa
Maguire, S., Kesby, A., Brownlow, R. S., Hunt, G. E., Kim, M., McAulay, C., Grisham, J. R., McGregor, I. S., Suraev, A. S., Kevin, R. C., et al. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107032 · Cited by 17 · see citing works
Sedative Effects of Intranasal Oxytocin in Rabbits and Rhesus Monkeys
HESS, L., Votava, M., Málek, J., Kurzová, A., & Slíva, J. (2016) · Physiological Research · doi:10.33549/physiolres.933513 · Cited by 17 · see citing works
Stauffer, C. S., Meinzer, N. K., Morrison, T., Wen, J., Radanovich, L., Leung, D., Niles, A. N., O’Donovan, A., Batki, S. L., & Woolley, J. D. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14217 · Cited by 17 · see citing works
Oxytocin in neurodevelopmental disorders: Autism spectrum disorder and Prader-Willi syndrome
Josselsohn, A., Zhao, Y., Espinoza, D., & Hollander, E. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108734 · Cited by 16 · see citing works
Lan, C., Liu, C., Li, K., Zhao, Z., Yang, J., Ma, Y., Scheele, D., Yao, S., Kendrick, K. M., & Becker, B. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac037 · Cited by 16 · see citing works
Oliva, J. L., Mengoli, M., Mendonça, T., Cozzi, A., Pageat, P., Chabaud, C., Teruel, E., Lafont‐Lecuelle, C., & Bienboire‐Frosini, C. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02141 · Cited by 15 · see citing works
Effects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women
Procyshyn, T. L., Lombardo, M. V., Lai, M., Bonnie Auyeung, B., Crockford, S. K., Deakin, J., Soubramanian, S., Sule, A., Baron‐Cohen, S., & Bethlehem, R. A. I. (2020) · Molecular Autism · doi:10.1186/s13229-020-00326-5 · Cited by 15 · see citing works
- Authors
- Gossen, A., Hahn, A., Westphal, L., Prinz, S., Schultz, R. T., Gründer, G., & Spreckelmeyer, K. N.
- Affiliations
- Jülich Aachen Research Alliance (DE)
- RWTH Aachen University (DE)
- University of Pennsylvania (US)
- Corresponding author
- Spreckelmeyer, K.N.
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 46
- Issue
- 5
- Pages
- 211-215
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W2136974459
- Cited by
- 189
- References
- 21
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 14 · 2021: 16 · 2020: 18 · 2019: 11 · 2018: 22 · 2017: 13 · 2016: 16 · 2015: 17 · 2014: 12 · 2013: 15 · 2012: 1
- FWCI
- 21.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, intranasal administration, plasma oxytocin, pharmacokinetics, testosterone, steroid hormones, progesterone, estradiol, social behavior, healthy men
- MeSH terms
- Administration, Intranasal, Adult, Estradiol, Humans, Male, Oxytocin, Progesterone, Testosterone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
