Cited by 671Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsPain Management and Treatment

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Neurobiology of fibromyalgia and chronic widespread pain

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Sluka, Kathleen A., Clauw, Daniel J.·2016·Neuroscience

DOI 10.1016/j.neuroscience.2016.06.006PMC PMC5083139

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Abstract

Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation. We will explore the data and neurobiology related to the role of the CNS in nociceptive processing, followed by a short review of studies examining potential peripheral nervous system changes and cytokine involvement. We will not only explore the data from human subjects with fibromyalgia but will relate this to findings from animal models of fibromyalgia. We conclude that fibromyalgia and related disorders are heterogenous conditions with a complicated pathobiology with patients falling along a continuum with one end a purely peripherally driven painful condition and the other end of the continuum is when pain is purely centrally driven.

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Authors: Sluka, K. A., & Clauw, D. J.
Affiliations: University of Iowa (US)
University of Michigan (US)
Corresponding author: Sluka, Kathleen A.
ORCID: Sluka, Kathleen A.
Clauw, Daniel J.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2016-12
Volume: 338
Pages: 114-129
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2016.06.006
PMC: PMC5083139
OpenAlex: W2415752306
Cited by: 671
References: 194
Citations by year: 2026: 49 · 2025: 68 · 2024: 71 · 2023: 70 · 2022: 96 · 2021: 78 · 2020: 89 · 2019: 64 · 2018: 42 · 2017: 39 · 2016: 3
FWCI: 7.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA038261)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (UM1AR063381, R01AR061371)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: fibromyalgia, chronic widespread pain, central sensitization, nociceptive processing, central nervous system, psychological stress, peripheral nervous system, systemic inflammation, cytokines
MeSH terms: Animals, Brain, Fibromyalgia, Humans, Spinal Cord, Chronic Pain

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Neurobiology of fibromyalgia and chronic widespread pain

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