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Cited by 671Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsPain Management and Treatment

The DOI matches its Crossref record; 188 of the 194 references it cites were found in a registry or an index.

Neurobiology of fibromyalgia and chronic widespread pain

Open access
Sluka, Kathleen A., Clauw, Daniel J.·2016·Neuroscience
DOI 10.1016/j.neuroscience.2016.06.006PMC PMC5083139
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Abstract

Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation. We will explore the data and neurobiology related to the role of the CNS in nociceptive processing, followed by a short review of studies examining potential peripheral nervous system changes and cytokine involvement. We will not only explore the data from human subjects with fibromyalgia but will relate this to findings from animal models of fibromyalgia. We conclude that fibromyalgia and related disorders are heterogenous conditions with a complicated pathobiology with patients falling along a continuum with one end a purely peripherally driven painful condition and the other end of the continuum is when pain is purely centrally driven.

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  1. Dawes JM, Andersson DA, Bennett DLH, Bevan S, McMahon SB (2013) Inflammatory mediators and modulators of pain. In: Melzack and wall’s textbook of pain, vol. 6th ed., (McMahon, SB et al., eds), p 48 Philadelphia: Elsevier
  2. Dina, 2011, Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress, Eur J Pain
  3. Gregory, 2015, ASIC3 is required for development of fatigue-induced hyperalgesia, Mol Neurobiol, 53, 10
  4. Petzke, 1999, What do tender points measure?, Arthritis Rheum, 42, S342
  5. Petzke, 1999, Pain sensitivity in patients with fibromyalgia (FM): expectancy effects on pain measurements, Arthritis Rheum, 42, S342
  6. Russell, 1996, Characteristics of spinal fluid (CSF) substance p (SP) and calcitonin gene related peptide (CGRP) in fibromyalgia syndrome (FMS), Arthritis Rheum, 39, S275

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Metadata

Authors
Sluka, K. A., & Clauw, D. J.
Affiliations
  • University of Iowa (US)
  • University of Michigan (US)
Corresponding author
Sluka, Kathleen A.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2016-12
Volume
338
Pages
114-129
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2016.06.006
PMC
PMC5083139
OpenAlex
W2415752306
Cited by
671
References
194
Citations by year
2026: 49 · 2025: 68 · 2024: 71 · 2023: 70 · 2022: 96 · 2021: 78 · 2020: 89 · 2019: 64 · 2018: 42 · 2017: 39 · 2016: 3
FWCI
7.04
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Drug Abuse (R01DA038261)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (UM1AR063381, R01AR061371)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
fibromyalgia, chronic widespread pain, central sensitization, nociceptive processing, central nervous system, psychological stress, peripheral nervous system, systemic inflammation, cytokines
MeSH terms
Animals, Brain, Fibromyalgia, Humans, Spinal Cord, Chronic Pain

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