Cited by 671Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsPain Management and Treatment

The DOI matches its Crossref record; 188 of the 194 references it cites were found in a registry or an index.

Neurobiology of fibromyalgia and chronic widespread pain

Open access

Sluka, Kathleen A., Clauw, Daniel J.·2016·Neuroscience

DOI 10.1016/j.neuroscience.2016.06.006PMC PMC5083139

Open this paper in CoChat — free account

Abstract

Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation. We will explore the data and neurobiology related to the role of the CNS in nociceptive processing, followed by a short review of studies examining potential peripheral nervous system changes and cytokine involvement. We will not only explore the data from human subjects with fibromyalgia but will relate this to findings from animal models of fibromyalgia. We conclude that fibromyalgia and related disorders are heterogenous conditions with a complicated pathobiology with patients falling along a continuum with one end a purely peripherally driven painful condition and the other end of the continuum is when pain is purely centrally driven.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuroscience.2016.06.006

Cites

188 of 188 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563
Fibromyalgia: A Clinical Review
Clauw, D. J. (2014) · JAMA · doi:10.1001/jama.2014.3266 · Cited by 1,674
Self-citation
An fMRI-Based Neurologic Signature of Physical Pain
Wager, T. D., Atlas, L. Y., Lindquist, M. A., Roy, M., Woo, C.-W., & Kross, E. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1204471 · Cited by 1,597
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
Gracely, R. H., Petzke, F., Wolf, J. M., & Clauw, D. J. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10225 · Cited by 1,263
Self-citation
Common symptoms in ambulatory care: incidence, evaluation, therapy, and outcome
Kroenke, K., & Mangelsdorff, A. D. (1989) · The American Journal of Medicine · doi:10.1016/0002-9343(89)90293-3 · Cited by 947
Basic and clinical aspects of visceral hyperalgesia
Mayer, E. A., & Gebhart, G. F. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90086-8 · Cited by 920
Primary fibromyalgia (fibrositis): Clinical study of 50 patients with matched normal controls
Yunus, M., Masi, A. T., Calabro, J. J., Miller, K. A., & Feigenbaum, S. L. (1981) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(81)90096-2 · Cited by 910
Pain catastrophizing and neural responses to pain among persons with fibromyalgia
Gracely, R. H. (2004) · Brain · doi:10.1093/brain/awh098 · Cited by 892
Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.
Dickenson, A. H., & Sullivan, A. F. (1987) · Neuropharmacology · doi:10.1016/0028-3908(87)90275-9 · Cited by 843
Evidence of augmented central pain processing in idiopathic chronic low back pain
Giesecke, T., Gracely, R. H., Grant, M. A. B., NACHEMSON, A. L., Petzke, F. W., Williams, D. A., & Clauw, D. J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20063 · Cited by 818
Self-citation

Flagged first, then by citations

Show all 194 references

6 of the 194 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

Dawes JM, Andersson DA, Bennett DLH, Bevan S, McMahon SB (2013) Inflammatory mediators and modulators of pain. In: Melzack and wall’s textbook of pain, vol. 6th ed., (McMahon, SB et al., eds), p 48 Philadelphia: Elsevier
Dina, 2011, Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress, Eur J Pain
Gregory, 2015, ASIC3 is required for development of fatigue-induced hyperalgesia, Mol Neurobiol, 53, 10
Petzke, 1999, What do tender points measure?, Arthritis Rheum, 42, S342
Petzke, 1999, Pain sensitivity in patients with fibromyalgia (FM): expectancy effects on pain measurements, Arthritis Rheum, 42, S342
Russell, 1996, Characteristics of spinal fluid (CSF) substance p (SP) and calcitonin gene related peptide (CGRP) in fibromyalgia syndrome (FMS), Arthritis Rheum, 39, S275

Sorted by citations

Items 201–300 of 669

Cellular mechanisms underlying central sensitization in a mouse model of chronic muscle pain
Lin, Y., Yang, Z.-S., Wong, W.-Y., Lin, S.-C., Wang, S., Chen, S., Cheng, J., Lü, H., & Lien, C. (2022) · eLife · doi:10.7554/elife.78610 · Cited by 24
Mechanisms hypothesized for pain-relieving effects of exercise in fibromyalgia: a scoping review
Neelapala, Y. V. R., Mercuri, D., Macedo, L. G., Hanna, S., Kobsar, D., & Carlesso, L. C. (2023) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x231182894 · Cited by 20
The crosstalk of the pathophysiologic models in fibromyalgia
Ghavidel‐Parsa, B., & Bidari, A. (2023) · Clinical Rheumatology · doi:10.1007/s10067-023-06778-3 · Cited by 21
Excitatory and inhibitory responses in the brain to experimental pain: A systematic review of MR spectroscopy studies
Archibald, J., MacMillan, E. L., Enzler, A., Jutzeler, C. R., Schweinhardt, P., & Kramer, J. L. K. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116794 · Cited by 20
Recent Advancements in Animal Models of Fibromyalgia
Nagakura, Y. (2015) · MYOPAIN · doi:10.1080/24708593.2016.1273986 · Cited by 21
Implication of the Nociplastic Features for Clinical Diagnosis of Fibromyalgia: Development of the Preliminary Nociplastic‐Based Fibromyalgia Features ( NFF ) Tool
Ghavidel‐Parsa, B., Bidari, A., Atrkarroushan, Z., & Khosousi, M. (2021) · ACR Open Rheumatology · doi:10.1002/acr2.11390 · Cited by 19
The OPRM1 gene and interactions with the 5-HT1a gene regulate conditioned pain modulation in fibromyalgia patients and healthy controls
Tour, J., Sandström, A., Kadetoff, D., Schalling, M., & Kosek, E. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277427 · Cited by 18
Management perspectives from patients with fibromyalgia experiences with the healthcare pathway: a qualitative study
Kachaner, A., Harim, M., Combier, A., Trouvin, A., Avouac, J., Ranque, B., & Piot, M. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1231951 · Cited by 19
Opioid Use in Fibromyalgia Continues Despite Guidelines That Do Not Support Its Efficacy or Risk
Bruce, B. K., Allman, M. E., Rivera, F. A., Abril, A., Gehin, J. M., Oliphant, L. M., Nordan, L. M., White, L. J., Martinez, D., & Niazi, S. K. (2020) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000001273 · Cited by 20
Sleep Dysfunction in Fibromyalgia and Therapeutic Approach Options
Lawson, K. (2020) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2001049 · Cited by 19
Assessing our approach to diagnosing Fibromyalgia
Hackshaw, K. V. (2020) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2020.1858054 · Cited by 19
Functional Disruptions of the Brain in Low Back Pain: A Potential Imaging Biomarker of Functional Disability
Lamichhane, B., Jayasekera, D., Jakes, R. S., Ray, W. Z., Leuthardt, E. C., & Hawasli, A. H. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.669076 · Cited by 20
Association between multisite musculoskeletal pain and disability trajectories among community-dwelling older adults
Liu, P., Chen, H., Tong, B., Zhu, D., Cong, X. S., & Shang, S. (2024) · Aging Clinical and Experimental Research · doi:10.1007/s40520-024-02764-0 · Cited by 21
Peripheral nociceptive mechanisms in an experimental rat model of fibromyalgia induced by repeated cold stress
Wakatsuki, K., Takeda‐Uchimura, Y., Matsubara, T., Nasu, T., Mizumura, K., & Taguchi, T. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.12.015 · Cited by 18
Impact of isometric and concentric resistance exercise on pain and fatigue in fibromyalgia
Berardi, G., Senefeld, J. W., Hunter, S. K., & Bement, M. H. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04600-z · Cited by 20
Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model
Nagakura, Y. (2022) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.121.001051 · Cited by 21
Subtypes of complex regional pain syndrome—a systematic review of the literature
Knudsen, L., Santoro, L., Bruehl, S. P., Harden, N. R., & Brunner, F. (2023) · PAIN Reports · doi:10.1097/pr9.0000000000001111 · Cited by 18
Hospitalization in fibromyalgia: a cohort-level observational study of in-patient procedures, costs and geographical variation in England
Soni, A., Santos-Paulo, S., Segerdahl, A. R., Javaid, M. K., Pinedo‐Villanueva, R., & Tracey, I. (2019) · Rheumatology · doi:10.1093/rheumatology/kez499 · Cited by 17
How Pain Shapes Depression and Anxiety: A Hybrid Self-regulatory/Predictive Mind Perspective
Karoly, P. (2020) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-019-09693-5 · Cited by 18
Hyper-connectivity between the left motor cortex and prefrontal cortex is associated with the severity of dysfunction of the descending pain modulatory system in fibromyalgia
Franco, Á. D. O., Alves, C. F. D. S., Serrano, P. V., Bandeira, J. S., Aratanha, M. A., Torres, I. L. D. S., Fregni, F., & Caumo, W. (2022) · PLoS ONE · doi:10.1371/journal.pone.0247629 · Cited by 18
Central Sensitization and Nociplastic Pain: Shared Mechanisms in Fibromyalgia, Osteoarthritis, and Inflammatory Arthritis
Hladkykh, F. V., Liadova, T., Matvieienko, M. S., Komorovsky, R., Smiyan, S., & Student, V. (2026) · Journal of Pain Research · doi:10.2147/jpr.s571311 · Cited by 22
Fibromyalgia: Centralized Pain Processing and Neuroimaging
Richard, J. Y., Hurley, R. A., & Taber, K. H. (2019) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.19050107 · Cited by 17
Chronic generalized pain disrupts whole brain functional connectivity in mice
Nasseef, M. T., Ma, W., Singh, J. P., Dozono, N., Lançon, K., Séguéla, P., Darcq, E., Ueda, H., & Kieffer, B. L. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00438-9 · Cited by 17
Comparison of the serum brain-derived neurotrophic factor (BDNF) between fibromyalgia and nociceptive pain groups; and effect of duloxetine on the BDNF level
Bidari, A., Ghavidel‐Parsa, B., & Gharibpoor, F. (2022) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-022-05369-8 · Cited by 17
Pain neuroscience education improves quality of life when added to aquatic exercise therapy for women with fibromyalgia: randomized controlled clinical trial
de Sousa, A. P., Almeida, L. A., Lourenço, B. P., Alvares, L. D., & Ávila, M. A. (2023) · Disability and Rehabilitation · doi:10.1080/09638288.2023.2201510 · Cited by 20
Associations Between Brain-Gut Axis and Psychological Distress in Fibromyalgia: A Microbiota and Magnetic Resonance Imaging Study
Nhu, N. T., Chen, D. Y. T., Yang, Y. S. H., Lo, Y., & Kang, J. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.10.015 · Cited by 18
Functional MRI of the Reserpine-Induced Putative Rat Model of Fibromyalgia Reveals Discriminatory Patterns of Functional Augmentation to Acute Nociceptive Stimuli
Wells, J. A., Shibata, S., Fujikawa, A., Takahashi, M., Saga, T., & Aoki, I. (2017) · Scientific Reports · doi:10.1038/srep38325 · Cited by 17
Vagus Nerve Stimulation
Vonck, K. E. J., & Larsen, L. E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805353-9.00018-8 · Cited by 18
Implication of invalidation concept in fibromyalgia diagnosis
Ghavidel‐Parsa, B., Bidari, A., Tohidi, S., Masooleh, I. S., Leili, E. K., Hosseini, K., & Khosousi, M. (2021) · Clinical Rheumatology · doi:10.1007/s10067-020-05515-4 · Cited by 20
Changes in Brain GABA and Glutamate and Improvements in Physical Functioning Following Intensive Pain Rehabilitation in Youth With Chronic Pain
Pigott, T., McPeak, A., de Chastelain, A., DeMayo, M. M., Rasic, N. F., Rayner, L., Noel, M. E., Miller, J. V., & Harris, A. D. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.02.027 · Cited by 17
Dissociative features of fibromyalgia syndrome
Berkol, T. D., Balcıoğlu, Y. H., Kırlıoglu, S. S., Erensoy, H., & Vural, M. (2017) · Neurosciences · doi:10.17712/nsj.2017.3.20160538 · Cited by 17
Efficacy of a Multicomponent Intervention for Fibromyalgia Based on Pain Neuroscience Education, Exercise Therapy, Psychological Support, and Nature Exposure (NAT-FM): Study Protocol of a Randomized Controlled Trial
Serrat, M., Sanabria‐Mazo, J. P., García-Troiteiro, E., Fontcuberta, A., Canedo, C. M., Almirall, M., Feliu‐Soler, A., Méndez-Ulrich, J. L., Sanz, A., & Luciano, J. V. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17020634 · Cited by 18
A practical guide to recognize, assess, treat and evaluate (RATE) primary care patients with chronic pain
Gebke, K. B., McCarberg, B. H., Shaw, E., Turk, D. C., Wright, W. L., & Semel, D. (2022) · Postgraduate Medicine · doi:10.1080/00325481.2021.2017201 · Cited by 20
Palmitoylethanolamide and acetyl-L-carnitine act synergistically with duloxetine and pregabalin in fibromyalgia: results of a randomised controlled study
Salaffi, F., Farah, S., Sarzi‐Puttini, P., & Carlo, M. D. (2023) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/pmdzcq · Cited by 17
Precision, integrative medicine for pain management in sickle cell disease
Smith, W. R., Valrie, C. R., Jaja, C., & Kenney, M. O. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1279361 · Cited by 18
Machine learning identifies fatigue as a key symptom of fibromyalgia reflected in tyrosine, purine, pyrimidine, and glutaminergic metabolism
Zetterman, T., Nieminen, A. I., Markkula, R., Kalso, E. A., & Lötsch, J. (2024) · Clinical and Translational Science · doi:10.1111/cts.13740 · Cited by 17
Polygenic risk scores indicates genetic overlap between peripheral pain syndromes and chronic postsurgical pain
van Reij, R. R. I., Voncken, J. W., Joosten, E. A. J., & van den Hoogen, N. J. (2020) · Neurogenetics · doi:10.1007/s10048-020-00614-5 · Cited by 16
Exploring Associations Between Metabolites and Symptoms of Fatigue, Depression and Pain in Women With Fibromyalgia
Menzies, V. S., Starkweather, A. R., Yao, Y., Kelly, D. L., Garrett, T. J., Yang, G., Booker, S. Q., Swift‐Scanlan, T., Mahmud, I., & Lyon, D. (2020) · Biological Research For Nursing · doi:10.1177/1099800420941109 · Cited by 16
Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice
Meloto, C. B., Ingelmo, P. M., Perez, E. V., Pitt, R., Cárdenas, V. H. G., Mohamed, N., Sotocinal, S. G., Bourassa, V., Lima, L. V., Ribeiro‐da‐Silva, A., et al. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000902 · Cited by 16
The impact of COVID-19 stress on pain and fatigue in people with and without a central sensitivity syndrome
Koppert, T. Y., Jacobs, J. W. G., Lumley, M. A., & Geenen, R. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110655 · Cited by 18
Fibromyalgia in women: association of inflammatory plasma proteins, muscle blood flow, and metabolism with body mass index and pain characteristics
Ghafouri, B., Edman, E., Löf, M., Lund, E., Leinhard, O. D., Lundberg, P., Forsgren, M. F., Gerdle, B. U. C., & Dong, H. (2022) · PAIN Reports · doi:10.1097/pr9.0000000000001042 · Cited by 15
Acupotomy for Musculoskeletal Pain: Exploring Therapeutic Potential and Future Directions
Hu, J., Tong, H., Zhang, J., & Jiang, L.-J. (2025) · Journal of Pain Research · doi:10.2147/jpr.s518705 · Cited by 12
What do people search online concerning the “elusive” fibromyalgia? Insights from a qualitative and quantitative analysis of Google Trends
Bragazzi, N. L., Amital, H., Adawi, M., Brigo, F., Watad, S., Aljadeff, G., Amital, D., & Watad, ‬. (2017) · Clinical Rheumatology · doi:10.1007/s10067-017-3665-y · Cited by 15
Maternal and neonatal outcomes among pregnant women with fibromyalgia: a population-based study of 12 million births
Magtanong, G. G., Spence, A. R., Czuzoj‐Shulman, N., & Abenhaim, H. A. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1381684 · Cited by 15
Effectiveness of a multicomponent treatment versus conventional treatment in patients with fibromyalgia
Araya‐Quintanilla, F., Gutiérrez‐Espinoza, H., Muñoz-Yánez, M. J., Cavero‐Redondo, I., Álvarez‐Bueno, C., & Martínez‐Vizcaíno, V. (2020) · Medicine · doi:10.1097/md.0000000000018833 · Cited by 15
Phoneutria nigriventer Tx3-3 peptide toxin reduces fibromyalgia symptoms in mice
Pedron, C., Antunes, F. T. T., Rebelo, I. N., Campos, M. M., Corrêa, Á. P., Klein, C. P., de Oliveira, I. B., Cordeiro, M. N., Gomez, M. V., & de Souza, A. H. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102094 · Cited by 15
Impact of Fibromyalgia in the Hippocampal Subfields Volumes of Women—An MRI Study
Llamas, J. L. L., Villafaina, S., Murillo-García, Á., & Gusi, N. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041549 · Cited by 16
Difficult-to-treat rheumatoid arthritis. What is it?
Gordeev, A. V., Olyunin, Y. A., Galushko, E. A., Zotkin, E. G., & Lila, A. M. (2021) · Modern Rheumatology Journal · doi:10.14412/1996-7012-2021-5-7-11 · Cited by 15
Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables
Gerdle, B. U. C., Leinhard, O. D., Lund, E., Bengtsson, A., Lundberg, P., Ghafouri, B., & Forsgren, M. F. (2022) · Journal of Pain Research · doi:10.2147/jpr.s376590 · Cited by 14
Acupuncture decreased the risk of coronary heart disease in patients with fibromyalgia in Taiwan: a nationwide matched cohort study
Wu, M., Huang, M., Chiang, J., Sun, M.-F., Lee, Y., & Yen, H. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1239-7 · Cited by 15
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats
Siemian, J. N., Li, S., Seaman, R. W., Zhu, Q., Zhang, Y., & Li, J. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000454 · Cited by 16
A single administration of Neurotropin reduced the elongated immobility time in the forced swimming test of rats exposed to repeated cold stress
Nasu, T., Kubo, A., Queme, L. F., & Mizumura, K. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000488 · Cited by 15
Attitudes Towards and Management of Opioid-induced Hyperalgesia
Kum, E., Buckley, N., de León-Casasola, O. A., Lema, M. J., & Busse, J. W. (2020) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000814 · Cited by 15
Editorial: Differences in Pain Biology, Perception, and Coping Strategies: Towards Sex and Gender Specific Treatments
Gazerani, P., Aloisi, A. M., & Ueda, H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.697285 · Cited by 18
Thalamocortical bistable switch as a theoretical model of fibromyalgia pathogenesis inferred from a literature survey
Demori, I., Giordano, G., Mucci, V., Losacco, S., Marinelli, L., Massobrio, P., Blanchini, F., & Burlando, B. (2022) · Journal of Computational Neuroscience · doi:10.1007/s10827-022-00826-8 · Cited by 14
Juvenile Fibromyalgia
Weiss, J. E., & Kashikar‐Zuck, S. (2021) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2021.07.002 · Cited by 17
Effectiveness, cost-utility and physiological underpinnings of the FIBROWALK multicomponent therapy in online and outdoor format in individuals with fibromyalgia: Study protocol of a randomized, controlled trial (On&Out study)
Serrat, M., Ferrés, S., Auer, W., Almirall, M., Lluch, E., D’Amico, F., Maes, M. H. J., Lorente, S., Navarrete, J., Montero‐Marín, J., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1046613 · Cited by 15
Identification of Resting-State Network Functional Connectivity and Brain Structural Signatures in Fibromyalgia Using a Machine Learning Approach
Nhu, N. T., Chen, D. Y. T., & Kang, J. (2022) · Biomedicines · doi:10.3390/biomedicines10123002 · Cited by 15
The association between adverse childhood experiences, self-silencing behaviours and symptoms in women with fibromyalgia
Bacon, A. M., & White, L. (2022) · Psychology Health & Medicine · doi:10.1080/13548506.2022.2159459 · Cited by 15
Assessing Ethnic Minority Representation in Fibromyalgia Clinical Trials: A Systematic Review of Recruitment Demographics
Henley, P. P., Martins, T., & Zamani, R. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20247185 · Cited by 14
Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies
Gkouvi, A., Tsiogkas, S. G., Bogdanos, D. P., Gika, H., Goulis, D. G., & Grammatikopoulou, M. G. (2024) · Current Pain and Headache Reports · doi:10.1007/s11916-024-01244-4 · Cited by 16
Mirtazapine, an α2 Antagonist-Type Antidepressant, Reverses Pain and Lack of Morphine Analgesia in Fibromyalgia-Like Mouse Models
Neyama, H., Dozono, N., Uchida, H., & Ueda, H. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.265942 · Cited by 14
Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model
Hassan, F. E., Sakr, H. I., Mohie, P. M., Suliman, H. S., Mohamed, A. S., Attia, M. H., & Eid, D. (2021) · Annals of Medicine · doi:10.1080/07853890.2021.1916069 · Cited by 15
Suggesting a mechanism for acupuncture as a global percutaneous needle fasciotomy that respects tensegrity principles for treating fibromyalgia
Plaut, S. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.952159 · Cited by 13
Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia
Hung, C., Tsai, M., Wang, P.-S., Liang, F., Hsu, C., Lee, K., Fong, Y.-O., Han, D., Lee, C., Lai, C., et al. (2023) · RMD Open · doi:10.1136/rmdopen-2022-002741 · Cited by 13
Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content
Gerdle, B. U. C., Leinhard, O. D., Lund, E., Lundberg, P., Forsgren, M. F., & Ghafouri, B. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1288024 · Cited by 17
Unveiling the link: exploring muscle oxygen saturation in fibromyalgia and its implications for symptomatology and therapeutic strategies
Rubio-Zarapuz, A., Parraça, J. A., Tornero-Aguilera, J. F., & Clemente‐Suárez, V. J. (2024) · Medical Gas Research · doi:10.4103/mgr.medgasres-d-24-00013 · Cited by 13
The psychological and physiological effects of a virtual reality-based treatment program in female patients with fibromyalgia syndrome: A randomized controlled trial
Sarı, F., Aran, A. S., & Alp, G. (2025) · Assistive Technology · doi:10.1080/10400435.2025.2458260 · Cited by 13
Altered Serum Oxytocinase and Enkephalin-Degrading Aminopeptidase Activities in Patients With Fibromyalgia
Martı́nez-Martos, J. M., Correa‐Rodríguez, M., Rus, A., Molina, F., Ramı́rez-Expósito, M. J., & Aguilar‐Ferrándiz, M. E. (2019) · Biological Research For Nursing · doi:10.1177/1099800419854207 · Cited by 13
Dietary Intake Is Unlikely to Explain Symptom Severity and Syndrome-Specific Microbiome Alterations in a Cohort of Women with Fibromyalgia
Minerbi, A., Brereton, N. J. B., Anjarkouchian, A., Moyen, A., González, E., Fitzcharles, M., Shir, Y., & Chevalier, S. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063254 · Cited by 13
A two‐component model of hair cortisol concentration in fibromyalgia: Independent effects of pain chronicity and severity
del Paso, G. A. R., Garcia‐Hernandez, A., Contreras‐Merino, A. M., Galvez-Sánchez, C. M., de la Coba, P., Montoro, C. I., & Davydov, D. M. (2023) · European Journal of Pain · doi:10.1002/ejp.2223 · Cited by 16
Chronic non-inflammatory muscle pain: central and peripheral mediators
Lesnak, J. B., & Sluka, K. A. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.06.006 · Cited by 14
Self-citation
Strength Assessment Under Dual Task Conditions in Women with Fibromyalgia: A Test–Retest Reliability Study
Llamas, J. L. L., Villafaina, S., Murillo-García, Á., Collado‐Mateo, D., Domínguez‐Muñoz, F. J., Sánchez-Gómez, J. M., & Gusi, N. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16244971 · Cited by 15
Application of Salivary Biomarkers in the Diagnosis of Fibromyalgia
Montes, R. I., Costela-Ruiz, V. J., Melguizo‐Rodríguez, L., Luna‐Bertos, E. D., Ruíz, C., & Ramos‐Torrecillas, J. (2021) · Diagnostics · doi:10.3390/diagnostics11010063 · Cited by 19
Altered cerebral blood flow velocity features in fibromyalgia patients in resting-state conditions
Rodríguez, A., Tembl, J. I., Mesa‐Gresa, P., Muñoz, M. Á., Montoya, P., & Solaz, B. R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180253 · Cited by 12
Increased nociceptive behaviors and spinal c-Fos expression in the formalin test in a rat repeated cold stress model
Nasu, T., Kainuma, R., Ota, H., Mizumura, K., & Taguchi, T. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.06.010 · Cited by 12
Nociplastic pain mechanisms and toll-like receptors as promising targets for its management
Rodríguez-Palma, E. J., de la Cruz, S. H., Islas-Espinoza, A. M., Castañeda‐Corral, G., Granados‐Soto, V., & Khanna, R. (2024) · Pain · doi:10.1097/j.pain.0000000000003238 · Cited by 14
The role of the gut microbiome in neuroinflammation and chemotherapy-induced peripheral neuropathy
Shatunova, S., Aktar, R., Peiris, M., Lee, J. Y. P., Vetter, I., & Starobova, H. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176818 · Cited by 15
Postacute COVID-19 syndrome and fibromyalgia syndrome are associated with anti-satellite glial cell IgG serum autoantibodies but only fibromyalgia syndrome serum-IgG is pronociceptive
Berwick, R., Sahbaie, P., Kenny, G., Guo, T., Neiland, H., Andersson, D. A., Clark, J. D., Mallon, P. W. G., & Göebel, A. (2025) · Pain · doi:10.1097/j.pain.0000000000003629 · Cited by 14
LOWER EXTREMITY AEROBIC EXERCISE AS A TREATMENT FOR SHOULDER PAIN
Wassinger, C. A., Lumpkins, L., & Sole, G. (2020) · International Journal of Sports Physical Therapy · doi:10.26603/ijspt20200074 · Cited by 12
Recommendations by the Spanish Society of Rheumatology on Fibromyalgia. Part 1: Diagnosis and treatment
Redondo, J. R., Fontecha, P. D. D. C., de Miquel, C. A., Almirall, M., Fernández, B. C., Ojeda, C. C., Cruz, A. C., Montesó‐Curto, P., Palao, Á., Calvo, E. T., et al. (2021) · Reumatología Clínica (English Edition) · doi:10.1016/j.reumae.2021.02.002 · Cited by 12
Higher Pain Sensitivity Predicts Efficacy of a Wearable Transcutaneous Electrical Nerve Stimulation Device for Persons With Fibromyalgia: A Randomized Double-Blind Sham-Controlled Trial
Jamison, R. N., Curran, S., Wan, L., Ross, E. L., Gilligan, C. J., & Edwards, R. R. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13463 · Cited by 13
Replication of neural responses to monetary incentives and exploration of reward-influenced network connectivity in fibromyalgia
Park, S. H., Deng, E. Z., Baker, A. K., MacNiven, K. H., Knutson, B. D., & Martucci, K. T. (2022) · Neuroimage Reports · doi:10.1016/j.ynirp.2022.100147 · Cited by 13
The Effect of Virtual Reality on Cold Pain Sensitivity in Patients with Fibromyalgia and Pain-Free Individuals: A Randomized Crossover Study
Christensen, S. W., Almsborg, H., Vain, T. S., & Vægter, H. B. (2022) · Games for Health Journal · doi:10.1089/g4h.2022.0138 · Cited by 12
Characterization of Fragile X Mental Retardation Protein expression in human nociceptors and their axonal projections to the spinal dorsal horn
Mitchell, M. E., Cook, L. C., Shiers, S. I., Tavares‐Ferreira, D., Akopian, A. N., Dussor, G. O., & Price, T. J. (2023) · The Journal of Comparative Neurology · doi:10.1002/cne.25463 · Cited by 12
Where has the ‘bio’ in bio-psycho-social gone?
Schweinhardt, P. (2019) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000420 · Cited by 12
Acupuncture decreased the risk of stroke among patients with fibromyalgia in Taiwan: A nationwide matched cohort study
Huang, M., Yen, H., Lin, C., Lee, Y., Sun, M.-F., & Wu, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239703 · Cited by 13
Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model
Ejiri, Y., Uta, D., Ota, H., Mizumura, K., & Taguchi, T. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.03.005 · Cited by 12
Assessing the balance between excitation and inhibition in chronic pain through the aperiodic component of EEGPreprint
Ávila, C. G., May, E. S., Bott, F. S., Tiemann, L., Hohn, V. D., Heitmann, H., Zebhauser, P. T., Groß, J., & Ploner, M. (2024) · eLife · doi:10.7554/elife.101727 · Cited by 17
“INTEGRO INTEGRated Psychotherapeutic InterventiOn” on the Management of Chronic Pain in Patients with Fibromyalgia: The Role of the Therapeutic Relationship
Pasini, I., Perlini, C., Donisi, V., Mason, A., Schweiger, V., Secchettin, E., Lugoboni, F., Valenza, G., & Piccolo, L. D. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20053973 · Cited by 13
Perceived and endocrine acute and chronic stress indicators in fibromyalgia syndrome
Beiner, E., Hermes, M., Reichert, J., Kleinke, K., Vock, S., Löffler, A., Ader, L., Sirazitdinov, A., Keil, S., Schmidt, T., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-76635-z · Cited by 11
Dose–response association between multi-site musculoskeletal pain and work ability in physical therapists: a cross-sectional study
Ezzatvar, Y., Calatayud, J., Andersen, L. L., Vinstrup, J., Alarcón-Jiménez, J., & Casaña, J. (2020) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-020-01533-6 · Cited by 13
Time to Stop the Fibromyalgia Criteria Wars and Refocus on Identifying and Treating Individuals With This Type of Pain Earlier in Their Illness
Clauw, D. J. (2020) · Arthritis Care & Research · doi:10.1002/acr.24198 · Cited by 11
Self-citation
Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain
Lenert, M. E., Szabo-Pardi, T. A., & Burton, M. D. (2022) · Molecular Pain · doi:10.1177/17448069221110691 · Cited by 12
A sensitive and selective ELISA methodology quantifies a demyelination marker in experimental and clinical samples
Remacle, A. G., Dolkas, J., Angert, M., Hullugundi, S. K., Chernov, A. V., Jones, R. C. W., Shubayev, V. I., & Strongin, A. Y. (2018) · Journal of Immunological Methods · doi:10.1016/j.jim.2018.02.002 · Cited by 11
Association between daily level of objective physical activity and C-Reactive protein in a representative national sample of adults with self-reported diagnosed arthritis or fibromyalgia
Kingsbury, C., Karelis, A. D., Hains-Monfette, G., & Bernard, P. (2020) · Rheumatology International · doi:10.1007/s00296-020-04571-y · Cited by 11
Plasma protein patterns are strongly correlated with pressure pain thresholds in women with chronic widespread pain and in healthy controls—an exploratory case-control study
Gerdle, B. U. C., Wåhlén, K., & Ghafouri, B. (2020) · Medicine · doi:10.1097/md.0000000000020497 · Cited by 11
Assessing the Impact of IL-6 and Serotonin on Pain and Symptomatology in Fibromyalgia: An Exploratory Clinical Study
Loçasso, F., Filho, H., Alvarenga, R., Schimidt, S., Fiorelli, F., Ramos, P., Leidersnaider, S., Blum, K., Lewandrowski, K.-U., Cunha-Junior, E., et al. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14080886 · Cited by 10
Emotional arousal and valence in patients with fibromyalgia: a pilot study
Ciuffini, R., Cofini, V., Muselli, M., Necozione, S., Piroli, A., & Marrelli, A. (2023) · Frontiers in Pain Research · doi:10.3389/fpain.2023.1075722 · Cited by 8
How does chronic psychosocial distress induce pain? Focus on neuroinflammation and neuroplasticity changes
Fülöp, B., Borbély, É., & Helyes, Z. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.100964 · Cited by 13

Authors: Sluka, K. A., & Clauw, D. J.
Affiliations: University of Iowa (US)
University of Michigan (US)
Corresponding author: Sluka, Kathleen A.
ORCID: Sluka, Kathleen A.
Clauw, Daniel J.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2016-12
Volume: 338
Pages: 114-129
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2016.06.006
PMC: PMC5083139
OpenAlex: W2415752306
Cited by: 671
References: 194
Citations by year: 2026: 49 · 2025: 68 · 2024: 71 · 2023: 70 · 2022: 96 · 2021: 78 · 2020: 89 · 2019: 64 · 2018: 42 · 2017: 39 · 2016: 3
FWCI: 7.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA038261)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (UM1AR063381, R01AR061371)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: fibromyalgia, chronic widespread pain, central sensitization, nociceptive processing, central nervous system, psychological stress, peripheral nervous system, systemic inflammation, cytokines
MeSH terms: Animals, Brain, Fibromyalgia, Humans, Spinal Cord, Chronic Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurobiology of fibromyalgia and chronic widespread pain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks