Anxiogenic effects of a Lactobacillus, inulin and the synbiotic on healthy juvenile rats
Open accessAbstract
Gut microbiota interventions, including probiotic and prebiotic use can alter behavior in adult animals and healthy volunteers. However, little is known about their effects in younger individuals. To investigate this, male Sprague-Dawley rats (post-natal day 21, PND21) received Lactobacillus casei 54-2-33 (10 4 cfu/ml), inulin as prebiotic (16mg/ml), or both together (synbiotic) via drinking water for 14days. Control rats received water alone. Open field (OF) and elevated plus maze (EPM) behaviors were evaluated at PND34 and 35, respectively. 30min after EPM, brains and trunk blood were collected to evaluate hippocampal 5-HT 1A (mRNA and protein) and plasma corticosterone (CORT). Lactobacillus, inulin and synbiotic-treated rats had fewer entries to the OF's center and spent more time in its periphery than controls. Synbiotic-fed rats explored the EPM's open arms longer than probiotic and inulin-fed rats. Synbiotic, but not Lactobacillus nor inulin-fed rats had lower levels of EPM-evoked CORT than controls. Basal CORT levels, evaluated in a naïve cohort, were higher in Lactobacillus- and inulin-fed rats than controls. In naïve synbiotic-fed rats, 5-HT 1A mRNA levels were higher in dentate gyrus and cornus ammonis 1 layer (CA1), than in all other naïve groups, while hippocampal 5-HT 1A protein levels were lower in bacteria-fed rats than controls. 5-HT 1A mRNA changes suggest complex effects of gut microbes on hippocampal gene expression machinery, probably involving endogenous/…
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In a combined pre/pro-biotic study, L. casei and inulin fed rats enhanced 5-HT 1A mRNA levels in the DG and CA1 areas of the hippocampus in healthy juvenile rats.
“In a combined pre/pro-biotic study, L. casei and inulin fed rats enhanced 5-HT 1A mRNA levels in the DG and CA1 areas of the hippocampus in healthy juvenile rats, indicating an early behavioral change as a direct result of synbiotic administration (Barrera-Bugueno et al., 2017).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Barrera-Bugueno et al., 2017
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- Authors
- Barrera-Bugueño, C., Realini, O., Escobar-Luna, J., Sotomayor-Zárate, R., Gotteland, M., Julio-Pieper, M., & Bravo, J. A.
- Affiliations
- Pontificia Universidad Católica de Valparaíso (CL)
- Corresponding author
- Bravo, Javier A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 359
- Pages
- 18-29
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2726455676
- Cited by
- 38
- References
- 60
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 2
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Funders
- FONDECYT
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus casei, inulin, synbiotics, probiotics, prebiotics, gut microbiota, anxiety-like behavior, young rats, corticosterone, hypothalamic-pituitary-adrenal axis, stress response, dentate gyrus, CA1, open field behavior, elevated plus maze
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Corticosterone, Hippocampus, Inulin, Lacticaseibacillus casei, Male, RNA, Messenger, Rats, Sprague-Dawley, Receptor, Serotonin, 5-HT1A, Synbiotics
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