Computational modeling of transcranial direct current stimulation (tDCS) in obesity: impact of head fat and dose guidelines
Open accessAbstract
Recent studies show that acute neuromodulation of the prefrontal cortex with transcranial direct current stimulation (tDCS) can decrease food craving, attentional bias to food, and actual food intake. These data suggest potential clinical applications for tDCS in the field of obesity. However, optimal stimulation parameters in obese individuals are uncertain. One fundamental concern is whether a thick, low-conductivity layer of subcutaneous fat around the head can affect current density distribution and require dose adjustments during tDCS administration. The aim of this study was to investigate the role of head fat on the distribution of current during tDCS and evaluate whether dosing standards for tDCS developed for adult individuals in general are adequate for the obese population. We used MRI-derived high-resolution computational models that delineated fat layers in five human heads from subjects with body mass index (BMI) ranging from "normal-lean" to "super-obese" (20.9 to 53.5 kg/m(2)). Data derived from these simulations suggest that head fat influences tDCS current density across the brain, but its relative contribution is small when other components of head anatomy are added. Current density variability between subjects does not appear to have a direct and/or simple link to BMI. These results indicate that guidelines for the use of tDCS can be extrapolated to obese subjects without sacrificing efficacy and/or treatment safety; the recommended standard parameters can lead to the delivery of adequate current flow to induce neuromodulation of brain activity in the obese population.
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Inter-individual anatomical differences can affect response to tDCS due to differing amounts of current reaching cortical tissue.
“Furthermore, increasing evidence to suggests that inter-individual anatomical differences can affect response to tDCS due to differing amounts of current reaching cortical tissue.”
From Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial (2023) · cites this paper as [62]
Variations in skull thickness, white matter hyperintensities, and adipose tissue can also affect current density.
“In addition, variations in skull thickness, white matter hyperintensities, and adipose tissue can also affect current density [60–62].”
From Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial (2023) · cites this paper as [62]
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- Authors
- Truong, D. Q., Magerowski, G., Blackburn, G. L., Bikson, M., & Alonso-Alonso, M.
- Affiliations
- City College of New York (US)
- Beth Israel Deaconess Medical Center (US)
- Venue
- NeuroImage: Clinical
- Publisher
- Elsevier BV
- Published
- 2013
- Volume
- 2
- Pages
- 759-766
- ISSN
- 2213-1582 (ISSN-L)
- PMC
- PMC3778260
- OpenAlex
- W2159567046
- Cited by
- 183
- References
- 40
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 12 · 2023: 15 · 2022: 10 · 2021: 18 · 2020: 20 · 2019: 15 · 2018: 11 · 2017: 14 · 2016: 25 · 2015: 20 · 2014: 11 · 2013: 2 · 2012: 1
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- NeuroImage Clinical (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- CUNY Academic Works (City University of New York) (submittedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- Boston Nutrition and Obesity Research Center (5 P30 DK046200)
- Nutrition Obesity Research Center at Harvard (P30 DK040561)
- Wallace H Coulter Foundation Translational Career Award
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- transcranial direct current stimulation, obesity, current density distribution, prefrontal cortex, neuromodulation, food cravings, body mass index, super obesity
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