The contribution of interindividual factors to variability of response in transcranial direct current stimulation studies
Open accessAbstract
There has been an explosion of research using transcranial direct current stimulation (tDCS) for investigating and modulating human cognitive and motor function in healthy populations. It has also been used in many studies seeking to improve deficits in disease populations. With the slew of studies reporting "promising results" for everything from motor recovery after stroke to boosting memory function, one could be easily seduced by the idea of tDCS being the next panacea for all neurological ills. However, huge variability exists in the reported effects of tDCS, with great variability in the effect sizes and even contradictory results reported. In this review, we consider the interindividual factors that may contribute to this variability. In particular, we discuss the importance of baseline neuronal state and features, anatomy, age and the inherent variability in the injured brain. We additionally consider how interindividual variability affects the results of motor-evoked potential (MEP) testing with transcranial magnetic stimulation (TMS), which, in turn, can lead to apparent variability in response to tDCS in motor studies.
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Self-citationTESTS FOR INTER-SUBJECT AND TOTAL VARIABILITIES UNDER CROSSOVER DESIGNS
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Flagged first, then by citations
Research works printed but not linked: 1
- Ono M. Kubik S. Abernathy C. D. (1990). Atlas of the Cerebral Sulci, 1st Edn. Stuttgart; New York, NY: George Thieme Verlag.
Cited by
Sorted by citations
Mahoney, J. J., Hanlon, C. A., Marshalek, P. J., Rezai, A. R., & Krinke, L. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.117149 · Cited by 121 · see citing works
Improving interference control in ADHD patients with transcranial direct current stimulation (tDCS)
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Genetic Modulation of Transcranial Direct Current Stimulation Effects on Cognition
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Combining top-down and bottom-up interventions targeting the vagus nerve to increase resilience
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Retracted
- Authors
- Li, L. M., Uehara, K., & Hanakawa, T.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- Japan Society for the Promotion of Science (JP)
- Corresponding author
- Hanakawa, Takashi
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-05-12
- Volume
- 9
- Pages
- 181-181
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4428123
- OpenAlex
- W1544668095
- Cited by
- 477
- References
- 150
- Citations by year
- 2026: 38 · 2025: 38 · 2024: 38 · 2023: 47 · 2022: 39 · 2021: 54 · 2020: 53 · 2019: 48 · 2018: 41 · 2017: 39 · 2016: 31 · 2015: 10 · 2012: 1
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Funders
- Wellcome Trust
- Ministry of Education, Culture, Sports, Science and Technology (26120008, 13021041)
- National Center of Neurology and Psychiatry
- Japan Society for the Promotion of Science (26120008)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- transcranial direct current stimulation, interindividual variability, neuroanatomy, age effects, stroke recovery, memory enhancement, motor evoked potentials, transcranial magnetic stimulation, effect size heterogeneity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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