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Cited by 93Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin EffectsSodium Intake and Health

Effects of a nitrate-rich meal on arterial stiffness and blood pressure in healthy volunteers

Liu, Alex H., Bondonno, Catherine P., Croft, Kevin D., Puddey, Ian B., Woodman, Richard J., Rich, Lisa, Ward, Natalie C., Vita, Joseph A. +1 more·2013·Nitric Oxide
DOI 10.1016/j.niox.2013.10.001
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Abstract

An increase in nitrate intake can augment circulating nitrite and nitric oxide. This may lead to lower blood pressure and improved vascular function. Green leafy vegetables, such as spinach, are rich sources of nitrate. We aimed to assess the acute effects of a nitrate-rich meal containing spinach on arterial stiffness and blood pressure in healthy men and women. Twenty-six participants aged 38-69years were recruited to a randomized controlled cross-over trial. The acute effects of two energy-matched (2000kJ) meals, administered in random order, were compared. The meals were either high nitrate (220mg of nitrate derived from spinach [spinach]) or low nitrate [control]. Outcome measurements were performed pre-meal and at specific time points up to 210min post meal. Spinach resulted in an eightfold increase in salivary nitrite and a sevenfold increase in salivary nitrate concentrations from pre-meal (P<0.001) to 120min post meal. Spinach compared with control resulted in higher large artery elasticity index (P<0.001), and lower pulse pressure (P<0.001) and systolic blood pressure (P<0.001). Post meal carotid-femoral pulse wave velocity (P=0.07), augmentation index (P=0.63), small artery elasticity index (P=0.98) and diastolic blood pressure (P=0.13) were not significantly altered by spinach relative to control. Therefore, consumption of a nitrate-rich meal can lower systolic blood pressure and pulse pressure and increase large artery compliance acutely in healthy men and women. If sustained, these effects could contribute to better cardiovascular health.

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Crossref · 10.1016/j.niox.2013.10.001

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  • Oral supplementation with either nitrite or nitrate increases circulating nitrite levels and prevents and reverses endothelial dysfunction in a dose-dependent manner in mice and in healthy, hypertensive, and obese individuals, or in those with hypercholesterolemia and peripheral arterial disease.

    “Oral supplementation with either nitrite or nitrate increases circulating nitrite levels and prevents and reverses endothelial dysfunction in a dose-dependent manner both in mice[68,69] and in healthy[70,71,97,111,112], hypertensive[113], and obese individuals[114], or in those with hypercholesterolemia[115] and peripheral arterial disease[116].”

    From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [111]

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Authors
Liu, A. H., Bondonno, C. P., Croft, K. D., Puddey, I. B., Woodman, R. J., Rich, L., Ward, N. C., Vita, J. A., & Hodgson, J. M.
Affiliations
  • The University of Western Australia (AU)
  • Flinders University (AU)
  • Boston University (US)
Corresponding author
Hodgson, Jonathan M.
ORCID
Venue
Nitric Oxide
Publisher
Elsevier BV
Published
2013-11
Volume
35
Pages
123-130
ISSN
1089-8603 (ISSN-L)
DOI
10.1016/j.niox.2013.10.001
OpenAlex
W2049514222
Semantic Scholar
e334fd301cf271952a054b834f57c133c0bc5c26
Cited by
93
References
32
Citations by year
2026: 6 · 2025: 9 · 2024: 8 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 11 · 2017: 10 · 2016: 9 · 2015: 10 · 2014: 5
FWCI
5.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Nitric Oxide (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • eSpace (Curtin University) (submittedVersion)
Funders
National Health and Medical Research Council of Australia (634387)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
dietary nitrate, spinach, arterial stiffness, blood pressure, pulse pressure, nitrite, large artery compliance, pulse wave velocity, augmentation index, small artery elasticity, healthy adults
MeSH terms
Adult, Aged, Blood Pressure, Diet, Female, Humans, Male, Middle Aged, Nitrates, Nitric Oxide, Nitrites, Saliva, Cross-Over Studies, Spinacia oleracea, Vascular Stiffness

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