Antioxidant Activity and Hepatoprotective Effects of Whey Protein and Spirulina in Rats

Gad, Ahmed S.; Khadrawy, Yasser A.; El-Nekeety, Aziza A.; Mohamed, Sherif R.; Hassan, Nabila S.; Abdel-Wahhab, Mosaad A.

doi:10.1016/j.nut.2010.04.002

Cited by 218Drug-Induced Hepatotoxicity and ProtectionAntioxidant Activity and Oxidative StressSeaweed-derived Bioactive Compounds

Antioxidant Activity and Hepatoprotective Effects of Whey Protein and Spirulina in Rats

Gad, Ahmed S., Khadrawy, Yasser A., El-Nekeety, Aziza A., Mohamed, Sherif R., Hassan, Nabila S., Abdel-Wahhab, Mosaad A.·2011·Nutrition

DOI 10.1016/j.nut.2010.04.002

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Abstract

Objectives The aims of the present study were to evaluate the antioxidant, radical scavenging, and metal-chelating activity of whey protein concentrate (WPC) and Spirulina alone or in combination in vitro and to evaluate their hepatoprotective effects against CCl(4) in vivo.Methods Five concentrations (20, 40, 60, 80, and 100 mg/100 mL) of WPC, Spirulina, and their combination were tested in vitro. In the in vivo study, eight groups of male rats comprised the control group and the groups treated with WPC, Spirulina alone, or in combination with or without CCl(4) were used.Results The in vitro study showed that WPC and Spirulina showed antioxidant, radical scavenging, and metal-chelating activities in dose-dependent manner. The in vivo study showed that both agents succeeded in preventing liver damage induced by CCl(4). This prevention was more pronounced in rats receiving the combination of WPC and Spirulina.Conclusion Whey protein concentrate and Spirulina have free radical scavenging properties and antioxidant activity.

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Novel visible-light-sensitized Chl-Mg/P25 catalysts for photocatalytic degradation of rhodamine B
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Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion
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SPIRULINA: A SPOTLIGHT ON ITS NUTRACEUTICAL PROPERTIES AND FOOD PROCESSING APPLICATIONS
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Dietary silicon-enriched spirulina improves early atherosclerosis markers in hamsters on a high-fat diet
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Protein Nutritional Support: The Classical and Potential New Mechanisms in the Prevention and Therapy of Sarcopenia
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Green Extraction Process of Food Grade C-phycocyanin: Biological Effects and Metabolic Study in Mice
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Nanoencapsulation of thyme essential oil: a new avenue to enhance its protective role against oxidative stress and cytotoxicity of zinc oxide nanoparticles in rats
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Nanoencapsulation of basil essential oil alleviates the oxidative stress, genotoxicity and DNA damage in rats exposed to biosynthesized iron nanoparticles
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Biopeptides with antioxidant activity extracted from the biomass of Spirulina sp. LEB 18
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Systematical characterization of functional and antioxidative properties of heat-induced polymerized whey proteins
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Effect of Dietary Blue-Green Microalgae Inclusion as a Replacement to Soybean Meal on Laying Hens’ Performance, Egg Quality, Plasma Metabolites, and Hematology
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Whey protein isolate protects against cyclophosphamide-induced acute liver and kidney damage in rats
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Antioxidant, anti-cancer and ameliorative activities of Spirulina platensis and pomegranate juice against hepatic damage induced by CCl4
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Effect of Spirulina and Vitamin E on Reproduction and in vitro Embryo Production in Heat-stressed Rabbits
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Assessment of the Oxidative Damage and Genotoxicity of Titanium Dioxide Nanoparticles and Exploring the Protective Role of Holy Basil Oil Nanoemulsions in Rats
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Efficacy of Organo-Modified Nano Montmorillonite to Protect against the Cumulative Health Risk of Aflatoxin B1 and Ochratoxin A in Rats
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Current and Prospective Insights on Food and Pharmaceutical Applications of Spirulina
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Protective activity of kudzu (Pueraria thunbergiana) vine on chemically-induced hepatotoxicity: in vitro and in vivo studies
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Whey Protein Hydrolysate Enhances HSP90 but Does Not Alter HSP60 and HSP25 in Skeletal Muscle of Rats
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Trends in the Uses of Spirulina Microalga: A mini-review
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Spirulina
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Authors: Gad, A. S., Khadrawy, Y. A., El-Nekeety, A. A., Mohamed, S. R., Hassan, N. S., & Abdel-Wahhab, M. A.
Affiliations: National Research Centre (EG)
Corresponding author: Abdel-Wahhab, Mosaad A.
ORCID: Gad, Ahmed S.
Khadrawy, Yasser A.
Hassan, Nabila S.
Abdel-Wahhab, Mosaad A.
Venue: Nutrition
Publisher: Elsevier BV
Published: 2011-05
Volume: 27
Issue: 5
Pages: 582-589
ISSN: 0899-9007 (ISSN-L)
DOI: 10.1016/j.nut.2010.04.002
OpenAlex: W2053062973
Cited by: 218
References: 83
Citations by year: 2026: 6 · 2025: 7 · 2024: 6 · 2023: 23 · 2022: 19 · 2021: 25 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 12 · 2016: 18 · 2015: 18 · 2014: 6 · 2013: 10 · 2012: 11
FWCI: 8.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords: whey protein concentrate, Spirulina, antioxidant activity, hepatoprotection, free radical scavenging, metal chelating activity, carbon tetrachloride-induced liver injury, combination supplementation, liver injury prevention
MeSH terms: Whey Proteins, Administration, Oral, Animals, Antioxidants, Carbon Tetrachloride, Chelating Agents, Dose-Response Relationship, Drug, Iron, Liver Diseases, Male, Milk Proteins, Lipid Peroxidation, Free Radical Scavengers, Rats, Sprague-Dawley, Oxidative Stress, Rats, Spirulina

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Antioxidant Activity and Hepatoprotective Effects of Whey Protein and Spirulina in Rats

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