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Ultra-processed diet, systemic oxidative stress, and breach of immunologic tolerance

Martínez Leo, Edwin E., Peñafiel, Abigail Meza, Hernández Escalante, Víctor M., Cabrera Araujo, Zulema M.·2021·Nutrition
DOI 10.1016/j.nut.2021.111419
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Abstract

In recent years, consumption of ultra-processed food around the world has been increasing. The nutritional profile of an ultra-processed diet is associated with the development of cellular alterations that lead to oxidative stress. The chronic prooxidative state leads to an environment that influences the proliferation, apoptosis, and signaling pathways of immune cells. Likewise, the decrease in the transcription factor NRF2, owing to exacerbated production of reactive oxygen species, leads to changes in immune function and response to infections. This review aims to analyze the connection between an ultra-processed diet, systemic oxidative stress, and immune tolerance, as a contribution to the scientific evidence on the impact of oxidative stress on health and the possible risk of infections-an important consideration in the association of eating pattern and the immune response.

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Metadata

Authors
Martínez Leo, E. E., Peñafiel, A. M., Hernández Escalante, V. M., & Cabrera Araujo, Z. M.
ORCID
Venue
Nutrition
Publisher
Elsevier BV
Published
2021-11
Volume
91-92
Pages
111419
ISSN
0899-9007
DOI
10.1016/j.nut.2021.111419
Cited by
49
References
16
Language
en
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