The DOI matches its Crossref record; 67 of the 70 references it cites were found in a registry or an index.
Consumption of a healthy dietary pattern results in significant reductions in C-reactive protein levels in adults: a meta-analysis
Abstract
Consumption of healthy dietary patterns has been associated with reduced risk of cardiovascular disease and metabolic syndrome. Dietary intervention targets disease prevention, so studies increasingly use biomarkers of underlying inflammation and metabolic syndrome progression to examine the diet-health relationship. The extent to which these biomarkers contribute to the body of evidence on healthy dietary patterns is unknown. The aim of this meta-analysis was to determine the effect of healthy dietary patterns on biomarkers associated with adiposity, insulin resistance, and inflammation in adults. A systematic search of Scopus, PubMed, Web of Science, and Cochrane Central Register of Controlled Trials (all years to April 2015) was conducted. Inclusion criteria were randomized controlled trials; effects of dietary patterns assessed on C-reactive protein (CRP), total adiponectin, high-molecular-weight adiponectin, tumor necrosis factor-α, adiponectin:leptin, resistin, or retinol binding protein 4. Random effects meta-analyses were conducted to assess the weighted mean differences in change or final mean values for each outcome. Seventeen studies were included in the review. These reflected research on dietary patterns associated with the Mediterranean diet, Nordic diet, Tibetan diet, and the Dietary Approaches to Stop Hypertension diet. Consumption of a healthy dietary pattern was associated with significant reductions in CRP (weighted mean difference, -0.75 [-1.16, -0.35]; P = .0003). Non-significant changes were found for all other biomarkers. This analysis found evidence for favorable effects of healthy dietary patterns on CRP, with limited evidence for other biomarkers. Future research should include additional randomized controlled trials incorporating a greater range of dietary patterns and biomarkers.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Alternatively, the absolute change in levels of CRP or IL-6 with a healthy diet intervention (Neale et al, 2016), or aerobic exercise (Hayashino et al, 2014), is comparable to the absolute difference found in association with sleep disturbance.”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Neale et al, 2016
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
Dietary pattern analysis: a new direction in nutritional epidemiology
Hu, F. B. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00002 · Cited by 4,029
Ridker, P. M., Buring, J. E., Cook, N. R., & Rifai, N. (2003) · Circulation · doi:10.1161/01.cir.0000055014.62083.05 · Cited by 2,292
Research works printed but not linked: 1
- Higgins, 2011, Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 [updated March 2011], Cochrane Collaboration
Cited by
Sorted by citations
Sleep and inflammation: partners in sickness and in health
Irwin, M. R. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0190-z · Cited by 1,138
Sleep health: Reciprocal regulation of sleep and innate immunity
Irwin, M. R., & Opp, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.148 · Cited by 624
“…are similar to those reported by Friedman et al (2005) Alternatively, the absolute change in levels of CRP or IL-6 with a healthy diet intervention (Neale et al, 2016), or aerobic exercise (Hayashino et al, 2014), is comparable to the absolute difference found in association with sleep disturbance.”
ResultImplications of sleep disturbance and inflammation for Alzheimer's disease dementia
Irwin, M. R., & Vitiello, M. V. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30450-2 · Cited by 611
Hariharan, R., Odjidja, E. N., Scott, D. S., Shivappa, N., Hébert, J. R., Hodge, A. M., & de Courten, B. V. (2021) · Obesity Reviews · doi:10.1111/obr.13349 · Cited by 387
“Diet can effectively influence inflammation, independent of weight change.(13,14) For example, the typical”
Nutrition and Cardiovascular Health
Casas, R. M., Castro‐Barquero, S., Estruch, R., & Sacanella, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123988 · Cited by 370
“[100] about 17 RCTs observed that following a healthy diet (MeDiet, Nordic diet, Tibetan diet, and DASH diet) was associated with a significant reduction of CRP levels (−0.”
Background
Metadata
- Authors
- Neale, E. P., Batterham, M. J., & Tapsell, L. C.
- Affiliations
- University of Wollongong (AU)
- Corresponding author
- Neale, E.P.
- Venue
- Nutrition Research
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 36
- Issue
- 5
- Pages
- 391-401
- ISSN
- 0271-5317 (ISSN-L)
- OpenAlex
- W2287836917
- Cited by
- 220
- References
- 70
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 31 · 2023: 17 · 2022: 16 · 2021: 22 · 2020: 24 · 2019: 30 · 2018: 25 · 2017: 22 · 2016: 4
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Research (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- healthy eating patterns, C-reactive protein, inflammation, Mediterranean diet, Nordic diet, Dietary Approaches to Stop Hypertension diet, adiponectin, TNF-α, resistin, retinol-binding protein 4, adiposity, insulin resistance, metabolic syndrome, cardiovascular disease prevention
- MeSH terms
- Red Meat, Diet, Healthy, Adult, C-Reactive Protein, Cardiovascular Diseases, Edible Grain, Diet, Fruit, Humans, Inflammation, Obesity, Vegetables, Biomarkers, Metabolic Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
