A novel model of chronic sleep restriction reveals an increase in the perceived incentive reward value of cocaine in high drug-taking rats
Open accessAbstract
Substance abuse and sleep deprivation are major problems in our society. Clinical studies suggest that measures of poor sleep quality effectively predict relapse to substance abuse. Previously, our laboratory has shown that acute sleep deprivation increases the rate and efficiency (i.e., the goal-directed nature of responding) of cocaine self-administration using a progressive ratio (PR) schedule of reinforcement. However, the problem of sleep deprivation in our nation is largely one of chronicity. Therefore, the current study used a rodent model of chronic sleep restriction more akin to that experienced by humans (approximately 25% reduction in baseline sleep over the course of 8 days) to assess the impact of chronic sleep deprivation on cocaine-seeking and cocaine-taking behaviors in rats early during acquisition of self-administration. While low drug-taking rats were unaffected by chronic sleep restriction, high drug-takers in the chronic sleep restriction (CSR) group exhibited enhanced fixed ratio (FR) responding by the fourth day of FR training and significantly higher PR breakpoints than their non-sleep restriction (NSR) counterparts. This study is the first to directly assess the impact of chronic sleep deprivation on drug self-administration. These results show that chronic sleep deprivation early during acquisition of self-administration has a significant effect on the perceived incentive reward value of cocaine in high drug-takers, as indicated by both increased FR responding and an increased willingness to work for drug. Thus, it is important to be mindful of such factors in clinical settings designed for treatment of addiction and relapse prevention.
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Animal studies have recapitulated the phenomenon of sleep loss-enhanced reward seeking observed in humans.
“animal studies have recapitulated the phenomenon of sleep loss-enhanced reward seeking observed in humans.”
From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [102]
Acute sleep deprivation or chronic partial sleep restriction in animals often leads to enhanced risk taking and reward seeking, including cocaine and alcohol intake, sucrose self-administration, and intracranial self-stimulation.
“Acute sleep deprivation or chronic partial sleep restrictions in animals often leads to enhanced risk taking and reward seeking, including cocaine and alcohol intake, sucrose self-administration, as well as intra-cranial self-stimulations (99–103).”
From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [102]
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Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents
Logan, R. W., Hasler, B. P., Forbes, E. E., Franzen, P. L., Torregrossa, M. M., Huang, Y. H., Buysse, D. J., Clark, D. B., & McClung, C. A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.035 · Cited by 194 · see citing works
Prefrontal cortex to accumbens projections in sleep regulation of reward
Liu, Z., Wang, Y., Cai, L., Li, Y., Chen, B., Dong, Y., & Huang, Y. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0347-16.2016 · Cited by 66 · see citing works
- Authors
- Puhl, M. D., Boisvert, M., Guan, Z., Fang, J., & Grigson, P. S.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Grigson, Patricia S.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 109
- Pages
- 8-15
- ISSN
- 0091-3057 (ISSN-L)
- PMC
- PMC3740787
- OpenAlex
- W1966151645
- Cited by
- 51
- References
- 53
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 11 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R37DA009815, F31DA023315, DA023315, DA009815, R01DA009815)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- chronic sleep restriction, sleep deprivation, cocaine self-administration, incentive rewards, incentive salience, cocaine seeking, fixed-ratio responding, addiction relapse, addiction treatment
- MeSH terms
- Animals, Chronic Disease, Cocaine, Disease Models, Animal, Electroencephalography, Electromyography, Male, Motivation, Self Administration, Sleep Deprivation, Rats, Sprague-Dawley, Rats
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