Repeated sucrose access influences dopamine D2 receptor density in the striatum
Open accessAbstract
A decrease in D2 dopamine receptor subtype (D2R) binding in the striatum has been reported in obese individuals and drug addicts. We examined D2R density in the striatum of food-restricted rats that had contingent access to food with different incentive values. Results showed that animals receiving limited access to 0.3 M sucrose paired 2 h with a chow meal for 7 days had a significantly lower D2R binding in nucleus accumbens shell and dorsolateral striatum compared with animals that had limited access to chow. There was no differential binding, however, in the accumbens core in any of the groups. These findings indicate that feeding conditions and sucrose intake influence D2R density specifically in subregions of the striatum.
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In rodents, regular intake of high-fat and high-sugar foods leads to downregulation of postsynaptic D2 receptors.
“In rodents, regular intake of high-fat and high-sugar foods leads to downregulation of postsynaptic D2 receptors.177–179”
From Early life adversity and health-risk behaviors: Proposed psychological and neural mechanisms (2018) · cites this paper as [178]
Repeated sucrose access can upregulate dopamine release and dopamine transporter, and change dopamine D1 and D2 receptor availability in the nucleus accumbens.
“The limited information available suggests that repeated sucrose access can upregulate dopamine release ([5](#B5)) and dopamine transporter ([9](#B9)), and change dopamine D1 and D2 receptor availability ([5](#B5), [8](#B8)) in the nucleus accumbens.”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [8]
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- Authors
- Bello, N. T., Lucas, L. R., & Hajnal, A.
- Affiliations
- Pennsylvania State University (US)
- ORCID
- Bello, Nicholas T.
- Venue
- Neuroreport
- Published
- 2002-08
- Volume
- 13
- Issue
- 12
- Pages
- 1575-1578
- ISSN
- 0959-4965 (ISSN-L)
- PMC
- PMC1945096
- OpenAlex
- W2132751606
- Cited by
- 144
- References
- 23
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 12 · 2017: 7 · 2016: 13 · 2015: 14 · 2014: 8 · 2013: 7 · 2012: 7
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institutes of Health (5p01mh043787-10)
- National Institute of Mental Health (MH-43787)
- National Institute on Deafness and Other Communication Disorders (R03DC004751, DC 04751, DC 00240, R01DC000240)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D2 receptor, striatum, nucleus accumbens shell, dorsolateral striatum, nucleus accumbens core, sucrose, food reward, incentive value, dietary restriction, receptor binding, obesity, drug addiction
- MeSH terms
- Animals, Autoradiography, Corpus Striatum, Dopamine, Feeding Behavior, Homeostasis, Male, Nucleus Accumbens, Sucrose, Rats, Sprague-Dawley, Receptors, Dopamine D2, Rats
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