Dopamine Receptor D2 Gene Polymorphisms Are Associated in Taiwanese Children With Tourette Syndrome
Abstract
The pathophysiology of Tourette syndrome may involve the dopamine system. Dysfunction of the dopamine receptor D2 gene leads to many neuropsychiatric disorders. The objective of this study is to test the hypothesis that the dopamine receptor D2 gene may play a role in Tourette syndrome. A total of 151 children with Tourette syndrome and 183 normal control subjects were included in the study. Polymerase chain reaction was used to identify the Taq I DRD2 and DRD2 (H313H) polymorphisms of the dopamine receptor D2 gene. The genotype proportions of Taq I DRD2 and DRD2 (H313H) polymorphisms in the two groups were significantly different (P < 0.01 for both). The odds ratio for developing Tourette syndrome in individuals with the Taq I DRD2 A1 homozygote was 2.253 (95% confidence interval, 1.124-4.517) compared with individuals with the Taq I DRD2 A2 homozygote. The odds ratio for developing Tourette syndrome in individuals with the DRD2 (H313H) C homozygote was 2.96 (95% confidence interval, 1.398-6.269) compared with individuals with DRD2 (H313H) T homozygote. This study has demonstrated an association between the dopamine receptor D2 gene and Tourette syndrome. These data suggest that the dopamine receptor D2 gene or a closely linked gene might be one of the susceptibility factors for Tourette syndrome.
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Variants in the DA receptor gene DRD2 have been associated with genetic risk for TS, but this finding is not consistent.
“Variants in the DA receptor gene DRD2 have also been associated with genetic risk for TS [626-628], but this finding is not consistent [629-633].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [628]
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- Authors
- Lee, C.-C., Chou, I.-C., Tsai, C.-H., Wang, T.-R., Li, T.-C., & Tsai, F.-J.
- Affiliations
- China Medical University Hospital (TW)
- National Taiwan University (TW)
- China Medical University (TW)
- Corresponding author
- Tsai, Chang-Hai
- Venue
- Pediatric Neurology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 33
- Issue
- 4
- Pages
- 272-276
- ISSN
- 0887-8994 (ISSN-L)
- OpenAlex
- W2055799496
- Cited by
- 63
- References
- 41
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 7 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- Tourette syndrome, dopamine D2 receptor, DRD2 gene polymorphism, TaqI polymorphism, genetic susceptibility, children, dopaminergic system, Taiwanese children
- MeSH terms
- Child, Child, Preschool, Female, Gene Frequency, Genotype, Tourette Syndrome, Humans, Male, Polymorphism, Genetic, Taiwan, Receptors, Dopamine D2, Genetic Predisposition to Disease, Asian People
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