Cited by 63Obsessive-Compulsive Spectrum DisordersNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Dopamine Receptor D2 Gene Polymorphisms Are Associated in Taiwanese Children With Tourette Syndrome

Lee, Cheng-Chun, Chou, I.-Ching, Tsai, Chang-Hai, Wang, Tso-Ren, Li, Tsai-Chung, Tsai, Fuu-Jen·2005·Pediatric Neurology

Abstract

The pathophysiology of Tourette syndrome may involve the dopamine system. Dysfunction of the dopamine receptor D2 gene leads to many neuropsychiatric disorders. The objective of this study is to test the hypothesis that the dopamine receptor D2 gene may play a role in Tourette syndrome. A total of 151 children with Tourette syndrome and 183 normal control subjects were included in the study. Polymerase chain reaction was used to identify the Taq I DRD2 and DRD2 (H313H) polymorphisms of the dopamine receptor D2 gene. The genotype proportions of Taq I DRD2 and DRD2 (H313H) polymorphisms in the two groups were significantly different (P < 0.01 for both). The odds ratio for developing Tourette syndrome in individuals with the Taq I DRD2 A1 homozygote was 2.253 (95% confidence interval, 1.124-4.517) compared with individuals with the Taq I DRD2 A2 homozygote. The odds ratio for developing Tourette syndrome in individuals with the DRD2 (H313H) C homozygote was 2.96 (95% confidence interval, 1.398-6.269) compared with individuals with DRD2 (H313H) T homozygote. This study has demonstrated an association between the dopamine receptor D2 gene and Tourette syndrome. These data suggest that the dopamine receptor D2 gene or a closely linked gene might be one of the susceptibility factors for Tourette syndrome.

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Crossref · 10.1016/j.pediatrneurol.2005.05.005

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Authors
Lee, C.-C., Chou, I.-C., Tsai, C.-H., Wang, T.-R., Li, T.-C., & Tsai, F.-J.
Affiliations
  • China Medical University Hospital (TW)
  • National Taiwan University (TW)
  • China Medical University (TW)
Corresponding author
Tsai, Chang-Hai
Venue
Pediatric Neurology
Publisher
Elsevier BV
Published
2005-10
Volume
33
Issue
4
Pages
272-276
ISSN
0887-8994 (ISSN-L)
OpenAlex
W2055799496
Cited by
63
References
41
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 7 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 5
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Locations
  • Pediatric Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
Tourette syndrome, dopamine D2 receptor, DRD2 gene polymorphism, TaqI polymorphism, genetic susceptibility, children, dopaminergic system, Taiwanese children
MeSH terms
Child, Child, Preschool, Female, Gene Frequency, Genotype, Tourette Syndrome, Humans, Male, Polymorphism, Genetic, Taiwan, Receptors, Dopamine D2, Genetic Predisposition to Disease, Asian People

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