Racial and ethnic disparities in birth outcomes: a life-course perspective
Abstract
Background In the United States, Black infants have significantly worse birth outcomes than do White infants. The cause of these persisting racial disparities remains unexplained. Most extant studies focus on differential exposures to protective and risk factors during pregnancy, such as current socioeconomic status, maternal risky behaviors, prenatal care, psychosocial stress, or perinatal infections. These risk factors during pregnancy, however, do not adequately account for the disparities.Methods We conducted a literature review for longitudinal models of health disparities, and presented a synthesis of two leading models, using a life-course perspective. Traditional risk factors during pregnancy are then reexamined within their life-course context. We conclude with a discussion of the limitations and implications of the life-course perspective for future research, practice, and policy development.Results Two leading longitudinal models of health disparities were identified and discussed. The early programming model posits that exposures in early life could influence future reproductive potential. The cumulative pathways model conceptualizes decline in reproductive health resulting from cumulative wear and tear to the body's allostatic systems. We propose a synthesis of these two models, using the life-course perspective. Disparities in birth outcomes are the consequences of differential developmental trajectories set forth by early life experiences and cumulative allostatic load over the life course.Conclusions Future research on racial disparities in birth outcomes needs to examine differential exposures to risk and protective factors not only during pregnancy, but over the life course of women. Eliminating disparities requires interventions and policy development that are more longitudinally and contextually integrated than currently prevail.
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The Life Course Perspective is not new to public health.
“The Life Course Perspective (LCP) is not new to public health (213).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [213]
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The social determinants of health: It’s time to consider the causes of the causes
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Health Disparities Beginning in Childhood: A Life-Course Perspective
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Lifecourse Health Development: Past, Present and Future
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Self-citationA Life Course Perspective on How Racism May Be Related to Health Inequities
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The Contribution of Maternal Stress to Preterm Birth: Issues and Considerations
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Self-citationRacial discrimination and adverse birth outcomes: an integrative review
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Racial differences in birth outcomes: the role of general, pregnancy, and racism stress
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What Causes Racial Disparities in Very Preterm Birth? A Biosocial Perspective
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Social epidemiology: social determinants of health in the United States: are we losing ground?
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Global report on preterm birth and stillbirth (6 of 7): ethical considerations
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A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health
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A New Performance Measurement System for Maternal and Child Health in the United States
Kogan, M. D., Dykton, C., Hirai, A. H., Strickland, B. B., Bethell, C. D., Naqvi, I., Cano, C. E., Downing-Futrell, S. L., & Lu, M. C. (2015) · Maternal and Child Health Journal · doi:10.1007/s10995-015-1739-5 · Cited by 39 · see citing works
Self-citationBringing the MCH Life Course Perspective to Life
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“Nonetheless, as Lu and Halfon (2003) explained, the considerable evidence that social support improves health makes the construct central to models of how life course factors affect health.”
BackgroundMethodInfluentialRebouças, P., Paixão, E. S., Ramos, D., Pescarini, J., Pinto-Junior, E. P., Falcão, I. R., Ichihara, M. Y., Sena, S., Veiga, R., Ribeiro, R., et al. (2024) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2024.100833 · Cited by 14 · see citing works
Warren, M. D., & Kavanagh, L. D. (2025) · Maternal and Child Health Journal · doi:10.1007/s10995-023-03629-0 · Cited by 9 · see citing works
“The life course theory recognizes the vital role of social, economic, and environmental factors in influencing health outcomes, including health inequities (Lu & Halfon, 2003).”
- Authors
- Lu, M. C., & Halfon, N.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Lu, Michael C.
- Venue
- Maternal and Child Health Journal
- Published
- 2003-03
- Volume
- 7
- Issue
- 1
- Pages
- 13-30
- ISSN
- 1092-7875 (ISSN-L)
- 1573-6628
- OpenAlex
- W1577991876
- Cited by
- 979
- References
- 132
- Citations by year
- 2026: 17 · 2025: 49 · 2024: 40 · 2023: 39 · 2022: 49 · 2021: 51 · 2020: 58 · 2019: 44 · 2018: 44 · 2017: 61 · 2016: 59 · 2015: 57 · 2014: 56 · 2013: 58 · 2012: 43
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Maternal and Child Health Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (5U93MC00099)
- National Institute on Minority Health and Health Disparities
- Maternal and Child Health Bureau
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD001281, HD01281-03)
- Topics
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Social Sciences › Sociology and Political Science › Racial and Ethnic Identity Research
- Keywords
- racial disparities, ethnic disparities, birth outcomes, life course perspective, allostatic load, early life exposure, reproductive health, Black infants, health disparities, developmental trajectories
- MeSH terms
- Black or African American, Female, Health Services Accessibility, Humans, Infant Mortality, Infant, Newborn, Longitudinal Studies, Maternal Welfare, Models, Theoretical, Pregnancy, Pregnancy Outcome, Quality of Health Care, Risk Factors, Risk-Taking, Socioeconomic Factors, United States, Health Behavior, Life Tables, Women's Health, White People, Racial Groups
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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