Cited by 211Neuropeptides and Animal PhysiologyNeuroendocrine regulation and behaviorStress Responses and Cortisol

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Behavioral effects of neuropeptides in rodent models of depression and anxiety

Rotzinger, Susan, Lovejoy, David A., Tan, Laura A.·2010·Peptides

DOI 10.1016/j.peptides.2009.12.015

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Abstract

In recent years, studies have advocated neuropeptide systems as modulators for the behavioral states found in mood disorders such as depression and anxiety disorders. Neuropeptides have been tested in traditional animal models and screening procedures that have been validated by known antidepressants and anxiolytics. However, it has become clear that although these tests are very useful, neuropeptides have distinct behavioral effects and dose-dependent characteristics, and therefore, use of these tests with neuropeptides must be done with an understanding of their unique characteristics. This review will focus on the behavioral actions of neuropeptides and their synthetic analogs, particularly in studies utilizing various preclinical tests of depression and anxiety. Specifically, the following neuropeptide systems will be reviewed: corticotropin-releasing factor (CRF), urocortin (Ucn), teneurin C-terminal associated peptide (TCAP), neuropeptide Y (NPY), arginine vasopressin (AVP), oxytocin, the Tyr-MIF-1 family, cholecystokinin (CCK), galanin, and substance P. These neuropeptide systems each have a unique role in the regulation of stress-like behavior, and therefore provide intriguing therapeutic targets for mood disorder treatment.

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Authors: Rotzinger, S., Lovejoy, D. A., & Tan, L. A.
Affiliations: University of Toronto (CA)
Corresponding author: Tan, Laura A.
ORCID: Rotzinger, Susan
Lovejoy, David A.
Venue: Peptides
Publisher: Elsevier BV
Published: 2010-04
Volume: 31
Issue: 4
Pages: 736-756
ISSN: 0196-9781 (ISSN-L)
DOI: 10.1016/j.peptides.2009.12.015
OpenAlex: W2087834131
Cited by: 211
References: 245
Citations by year: 2026: 3 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 12 · 2014: 21 · 2013: 24 · 2012: 27
FWCI: 1.97
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Peptides (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (FRN 72027622)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: neuropeptides, depression, anxiety, mood disorders, corticotropin-releasing factor, urocortin, neuropeptide Y, vasopressin, oxytocin, cholecystokinin, galanin, substance P, antidepressant screening, rodent models, therapeutic target
MeSH terms: Animals, Anxiety, Arginine Vasopressin, Behavior, Animal, Cholecystokinin, Corticotropin-Releasing Hormone, Depression, Disease Models, Animal, Humans, MSH Release-Inhibiting Hormone, Neuropeptide Y, Neuropeptides, Neuropsychological Tests, Oxytocin, Social Behavior, Galanin, Urocortins

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Behavioral effects of neuropeptides in rodent models of depression and anxiety

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