Etiology and Treatment of Pain and Psychosocial Issues in Patients With Inflammatory Bowel Diseases
Abstract
There is increasing evidence that brain-gut interactions are altered during development of inflammatory bowel diseases (IBDs). Understanding the relationship between the neurobiology, psychological symptoms, and social ramifications of IBD can guide comprehensive care for the whole patient. The most common psychological conditions in patients with IBD are chronic abdominal pain, anxiety, and depression. We review the evidence-based data and rates of these conditions and their respective relationship to IBD and the diagnostic approaches to identify patients with these conditions. Different treatment options for pain and psychosocial conditions are discussed, and new models of team-based IBD care are introduced. Providing the health care provider with tools to diagnose and manage psychological conditions in patients with Crohn's disease or ulcerative colitis is necessary for their total care and should be part of quality-improvement initiatives.
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Comorbid psychological difficulties in IBD are associated with disease activity, flares, treatment response, and the necessity of surgical intervention.
“Indeed, comorbid psychological difficulties are associated with disease activity, flares, treatment response, and the necessity of surgical intervention [2,6,8,9,10,11,12,13,14,15].”
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- Authors
- Regueiro, M., Greer, J. B., & Szigethy, E.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Szigethy, Eva
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 152
- Issue
- 2
- Pages
- 430-439.e4
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2547348541
- Semantic Scholar
- 1a08355df42fa5ac26ff74601c03df38638c19d3
- Cited by
- 142
- References
- 168
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 11 · 2023: 20 · 2022: 18 · 2021: 19 · 2020: 17 · 2019: 13 · 2018: 15 · 2017: 10 · 2016: 2
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, chronic abdominal pain, anxiety, depression, psychosocial problems, gut-brain axis, pain etiology, pain management, team-based care, quality improvement
- MeSH terms
- Anxiety, Behavior Therapy, Depression, Humans, Sleep Initiation and Maintenance Disorders, Inflammatory Bowel Diseases, Abdominal Pain, Cognitive Behavioral Therapy, Chronic Pain
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