Cited by 456Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionEicosanoids and Hypertension Pharmacology

The DOI matches its Crossref record; 201 of the 201 references it cites were found in a registry or an index.

Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?

Open access

Rochette, Luc, Lorin, Julie, Zeller, Marianne, Guilland, Jean-Claude, Lorgis, Luc, Cottin, Yves, Vergely, Catherine·2013·Pharmacology & Therapeutics

DOI 10.1016/j.pharmthera.2013.07.004

Open this paper in CoChat — free account

Abstract

Nitric oxide (NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO synthase isoforms, iNOS, eNOS and nNOS. The synthesis of NO is selectively inhibited by guanidino-substituted analogs of l-Arg or methylarginines such as asymmetric dimethylarginine (ADMA), which results from protein degradation in cells. Many disease states, including cardiovascular diseases and diabetes, are associated with increased plasma levels of ADMA. The N-terminal catalytic domain of these NOS isoforms binds the heme prosthetic group as well as the redox cofactor, tetrahydrobiopterin (BH(4)) associated with a regulatory protein, calmodulin (CaM). The enzymatic activity of NOS depends on substrate and cofactor availability. The importance of BH(4) as a critical regulator of eNOS function suggests that BH(4) may be a rational therapeutic target in vascular disease states. BH(4) oxidation appears to be a major contributor to vascular dysfunction associated with hypertension, ischemia/reperfusion injury, diabetes and other cardiovascular diseases as it leads to the increased formation of oxygen-derived radicals due to NOS uncoupling rather than NO. Accordingly, abnormalities in vascular NO production and transport result in endothelial dysfunction leading to various cardiovascular disorders. However, some disorders including a wide range of functions in the neuronal, immune and cardiovascular system were associated with the over-production of NO. Inhibition of the enzyme should be a useful approach to treat these pathologies. Therefore, it appears that both a lack and excess of NO production in diseases can have various important pathological implications. In this context, NOS modulators (exogenous and endogenous) and their therapeutic effects are discussed.

Integrity signals

Registry

Crossref · 10.1016/j.pharmthera.2013.07.004

Cites

201 of 201 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Proteasome-Dependent Degradation of Guanosine 5′-Triphosphate Cyclohydrolase I Causes Tetrahydrobiopterin Deficiency in Diabetes Mellitus
Xu, J., Wu, Y., Song, P., Zhang, M., Wang, S., & Zou, M. (2007) · Circulation · doi:10.1161/circulationaha.106.684795 · Cited by 193
Retracted
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409
Nitric oxide synthases: structure, function and inhibition
ALDERTON, W. K., COOPER, C. E., & KNOWLES, R. G. (2001) · Biochemical Journal · doi:10.1042/bj3570593 · Cited by 4,110
Arginine metabolism: nitric oxide and beyond
WU, G., & MORRIS, S. M. (1998) · Biochemical Journal · doi:10.1042/bj3360001 · Cited by 2,811
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
Leone, A., Moncada, S., Vallance, P., Calver, A., & Collier, J. (1992) · The Lancet · doi:10.1016/0140-6736(92)90865-z · Cited by 2,107
Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
Bray, G. A., Nielsen, S. J., & Popkin, B. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.537 · Cited by 1,990
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
Rees, D. D., Palmer, R. M. J., Schulz, R., Hodson, H. F., & Moncada, S. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14151.x · Cited by 1,856
Protein Arginine Methylation in Mammals: Who, What, and Why
Bedford, M. T., & Clarke, S. G. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.013 · Cited by 1,810
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa060900 · Cited by 1,729 · cited 1×
“Combined daily administration of folic acid, vitamin B6, and vitamin B12 for five years had no beneficial effects on major vascular events in a high-risk population with vascular disease (Lonn et al., 2006).”
Background
Redefining Oxidative Stress
Jones, D. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1865 · Cited by 1,726
AN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
Kannel, W. B., Feinleib, M., McNAMARA, P. M., Garrison, R. J., & Castelli, W. P. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112813 · Cited by 1,639
Copper, oxidative stress, and human health
Uriu‐Adams, J. Y., & Keen, C. L. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.07.015 · Cited by 995
The chemical biology of nitric oxide: Implications in cellular signaling
Thomas, D. D., Ridnour, L. A., Isenberg, J. S., Flores-Santana, W., Switzer, C. H., Donzelli, S., Hussain, P., Vecoli, C., Paolocci, N., Ambs, S., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.020 · Cited by 975
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock*
López, A., Lorente, J. A., Steingrub, J. S., Bakker, J., McLuckie, A., Willatts, S. M., Brockway, M., Anzueto, A., Holzapfel, L., Breen, D. P., et al. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000105581.01815.c6 · Cited by 917
p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells
Ushio‐Fukai, M., Zafari, A. M., Fukui, T., Ishizaka, N., & Griendling, K. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23317 · Cited by 766
Endogenous Nitric Oxide Synthase Inhibitor
Miyazaki, H., Matsuoka, H., Cooke, J. P., Usui, M., Ueda, S., Okuda, S., & Imaizumi, T. (1999) · Circulation · doi:10.1161/01.cir.99.9.1141 · Cited by 756
Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols
Kuzkaya, N., Weissmann, N., Harrison, D. G., & Dikalov, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302227200 · Cited by 692
Homocysteine Impairs the Nitric Oxide Synthase Pathway
Stuehlinger, M., Tsao, P. S., Her, J. H., Kimoto, M., Balint, R. F., & Cooke, J. P. (2001) · Circulation · doi:10.1161/hc4601.098514 · Cited by 662
Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus
Lin, K. Y., Ito, A., Asagami, T., Tsao, P. S., Adimoolam, S., Kimoto, M., Tsuji, H., Reaven, G. M., & Cooke, J. P. (2002) · Circulation · doi:10.1161/01.cir.0000027109.14149.67 · Cited by 651
Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
Valkonen, V.-P., Päivä, H., Salonen, J. T., Lakka, T. A., Lehtimäki, T., Laakso, J., & Laaksonen, R. (2001) · The Lancet · doi:10.1016/s0140-6736(01)07184-7 · Cited by 562
The role of nitric oxide in cardiovascular diseases
NASEEM, K. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.09.003 · Cited by 557
Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway
Vallance, P., & Leiper, J. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000128897.54893.26 · Cited by 553
The definition and measurement of antioxidants in biological systems
Halliwell, B. B., & Gutteridge, J. M. C. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)91457-3 · Cited by 539
Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease
Alp, N. J., & Channon, K. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000110785.96039.f6 · Cited by 536
A Common Variant of the Endothelial Nitric Oxide Synthase (Glu298→Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK
Hingorani, A. D., Liang, C. F., Fatibene, J., Lyon, A., Monteith, S., Parsons, A., Haydock, S. F., Hopper, R., Stephens, N. G., O’Shaughnessy, K. M., et al. (1999) · Circulation · doi:10.1161/01.cir.100.14.1515 · Cited by 522
Oxidative stress and human health
Rahman, T., Hosen, M. I., Islam, M. M., & Shekhar, H. U. (2012) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2012.327123 · Cited by 514
Tetrahydrobiopterin: biochemistry and pathophysiology
Werner, E. R., Blau, N., & Thöny, B. (2011) · Biochemical Journal · doi:10.1042/bj20110293 · Cited by 493
Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
Schulz, E., Jansen, T., Wenzel, P., Daiber, A., & Münzel, T. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1989 · Cited by 430
Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
Heitzer, T., Krohn, K., Albers, S., & Meinertz, T. (2000) · Diabetologia · doi:10.1007/s001250051551 · Cited by 427
Determination of Arginine, Asymmetric Dimethylarginine, and Symmetric Dimethylarginine in Human Plasma and Other Biological Samples by High-Performance Liquid Chromatography
Teerlink, T., Nijveldt, R. J., de Jong, S., & van Leeuwen, P. A. M. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5575 · Cited by 417
Endothelial Nitric Oxide Synthase Uncoupling Impairs Endothelial Progenitor Cell Mobilization and Function in Diabetes
Thum, T., Fraccarollo, D., Schultheiß, M., Froese, S., Galuppo, P., Widder, J. D., Tsikas, D., Ertl, G., & Bauersachs, J. K. (2007) · Diabetes · doi:10.2337/db06-0699 · Cited by 416
Spironolactone Improves Angiotensin-Induced Vascular Changes and Oxidative Stress
Virdis, A., Neves, M. F., Amiri, F., Viel, É. C., Touyz, R. M., & Schiffrin, E. L. (2002) · Hypertension · doi:10.1161/01.hyp.0000034738.79310.06 · Cited by 397
Asymmetric Dimethylarginine and the Risk of Cardiovascular Events and Death in Patients With Coronary Artery Disease
Schnabel, R. B., Blankenberg, S., Lubos, E., Lackner, K. J., Rupprecht, H. J., Espinola–Klein, C., Jachmann, N., Post, F., Peetz, D., Bickel, C., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000181286.44222.61 · Cited by 377
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease
Altenhöfer, S., Kleikers, P. W. M., Radermacher, K. A., Scheurer, P., Rob Hermans, J. J., Schiffers, P., Ho, H., Wingler, K., & Schmidt, H. H. H. W. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1010-9 · Cited by 371
5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide Production in Human Vessels: Effects on Vascular Tetrahydrobiopterin Availability and Endothelial Nitric Oxide Synthase Coupling
Antoniades, C., Shirodaria, C., Warrick, N., Cai, S., de Bono, J., Lee, J., Leeson, P., Neubauer, S., Ratnatunga, C., Pillai, R., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.612325 · Cited by 365
Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus
Abbasi, F., Asagmi, T., Cooke, J. P., Lamendola, C. A., McLaughlin, T., Reaven, G. M., Stuehlinger, M., & Tsao, P. S. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02063-x · Cited by 357
L-Arginine Therapy in Acute Myocardial Infarction: The Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) Randomized Clinical Trial
Schulman, S. P., Becker, L. C., Kass, D. A., Champion, H. C., Terrin, M. L., Forman, S., Ernst, K. V., Kelemen, M. D., Townsend, S. N., Capriotti, A., et al. (2006) · JAMA · doi:10.1001/jama.295.1.58 · Cited by 357
NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy
Satoh, M., Fujimoto, S., Haruna, Y., Arakawa, S., Horike, H., Komai, N., Sasaki, T., Tsujioka, K., Makino, H., & Kashihara, N. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00221.2004 · Cited by 355
Cellular ADMA: Regulation and action
Teerlink, T., Luo, Z., Palm, F., & Wilcox, C. S. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.08.002 · Cited by 351
Plasma Asymmetric Dimethylarginine and Incidence of Cardiovascular Disease and Death in the Community
Böger, R. H., Sullivan, L. M., Schwedhelm, E., Wang, T. J., Maas, R., Benjamin, E. J., Schulze, F., Xanthakis, V., Benndorf, R. A., & Vasan, R. S. (2009) · Circulation · doi:10.1161/circulationaha.108.838268 · Cited by 351
Iron, oxidative stress and human health
Puntarulo, S. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.07.001 · Cited by 348
Small Molecule Regulators of Protein Arginine Methyltransferases
Cheng, D., Yadav, N., King, R. W., Swanson, M. S., Weinstein, E. J., & Bedford, M. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401853200 · Cited by 344
Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems
Palm, F., Onozato, M. L., Luo, Z., & Wilcox, C. S. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00998.2007 · Cited by 339
Reactive Oxygen Species and Endothelial Function – Role of Nitric Oxide Synthase Uncoupling and Nox Family Nicotinamide Adenine Dinucleotide Phosphate Oxidases
Montezano, A. C. I., & Touyz, R. M. (2011) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2011.00785.x · Cited by 320
Role of inflammation and oxidative stress in atrial fibrillation
Li, J., Solus, J. F., Chen, Q., Rho, Y. H., Milne, G. L., Stein, C. M., & Darbar, D. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.12.009 · Cited by 318
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers
Yoshimatsu, M., Toyokawa, G., Hayami, S., Unoki, M., Tsunoda, T., Field, H. I., Kelly, J. D., Neal, D. E., Maehara, Y., Ponder, B. A. J., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25366 · Cited by 316
Cellular signaling and NO production
Michel, T. M., & Vanhoutte, P. M. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0765-9 · Cited by 296
Low levels of miR‐92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma
Pal, S., Baiocchi, R. A., Byrd, J. C., Grever, M. R., Jacob, S. T., & Sif, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601794 · Cited by 291
Insulin Resistance/Compensatory Hyperinsulinemia, Essential Hypertension, and Cardiovascular Disease
Reaven, G. M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030087 · Cited by 284
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase
Garcin, E. D., Arvai, A. S., Rosenfeld, R. J., Kroeger, M. D., Crane, B. R., Andersson, G., Andrews, G., Hamley, P., Mallinder, P. R., Nicholls, D., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.115 · Cited by 283
Protein arginine methyltransferases: Evolution and assessment of their pharmacological and therapeutic potential
Krause, C. D., Yang, Z.-H., Kim, Y., Lee, J., Cook, J. R., & Pestka, S. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.06.007 · Cited by 278
JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation
Liu, F., Zhao, X., Perna, F., Wang, L., Koppikar, P., Abdel-Wahab, O. I., Harr, M. W., Levine, R. L., Xu, H., Tefferi, A., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.020 · Cited by 273
Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension
Carlström, M., Persson, A. E. G., Larsson, E., Hezel, M., Scheffer, P. G., Teerlink, T., Weitzberg, E., & Lundberg, J. O. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq366 · Cited by 261 · cited 1×
“Increasing bioactive NO by oral administration of nitrate prevented ROS and restored normal levels of ADMA in a rat model of salt-sensitive hypertension (Carlstrom et al., 2011); dietary nitrate attenuated the level of OS.”
Background
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis
Antoniades, C. A., Shirodaria, C. C., Leeson, P., Antonopoulos, A. S., Warrick, N., Van-Assche, T., Cunnington, C., Tousoulis, D., Pillai, R. G., Ratnatunga, C., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp061 · Cited by 258
Redox compartmentalization and cellular stress
Jones, D. P., & Go, Y.-M. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01266.x · Cited by 253
NO synthase: Structures and mechanisms
Daff, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.03.001 · Cited by 251
Evidence for the Pathophysiological Role of Endogenous Methylarginines in Regulation of Endothelial NO Production and Vascular Function
Cardounel, A. J., Cui, H., Samouilov, A., Johnson, W., Kearns, P. N., Tsai, A.-L., Berka, V., & Zweier, J. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603606200 · Cited by 249
NADPH oxidases in the vasculature: Molecular features, roles in disease and pharmacological inhibition
Selemidis, S., Sobey, C. G., Wingler, K., Schmidt, H. H. H. W., & Drummond, G. R. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.08.005 · Cited by 249
Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets
Jaquet, V., Scapozza, L., Clark, R. A., Krause, K. H., & Lambeth, J. D. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2585 · Cited by 245
Vascular NADPH oxidases as drug targets for novel antioxidant strategies
Guzik, T. J., & Harrison, D. G. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.04.003 · Cited by 238
Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin
Moens, A. L., Takimoto, E., Tocchetti, C. G., Chakir, K., Bedja, D., Cormaci, G., Ketner, E., Majmudar, M. D., Gabrielson, K., Halushka, M. K., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.737031 · Cited by 237
Targeting NADPH oxidases in vascular pharmacology
Schramm‐Luc, A., Matusik, P. T., Osmenda, G., & Guzik, T. J. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.02.012 · Cited by 233
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
Crabtree, M. J., & Channon, K. M. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.04.004 · Cited by 230
The molecular mechanisms of the thrombotic complications of atherosclerosis
Libby, P. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01965.x · Cited by 226
Rapid, Direct Effects of Statin Treatment on Arterial Redox State and Nitric Oxide Bioavailability in Human Atherosclerosis via Tetrahydrobiopterin-Mediated Endothelial Nitric Oxide Synthase Coupling
Antoniades, C., Bakogiannis, C., Leeson, P., Guzik, T. J., Zhang, M.-H., Tousoulis, D., Antonopoulos, A. S., Demosthenous, M., Marinou, K., Hale, A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.985150 · Cited by 219
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS
Crabtree, M. J., Smith, C. L., Lam, G., Goligorsky, M. S., & Gross, S. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00823.2007 · Cited by 213
Asymmetric Dimethylarginine, Blood Pressure, and Renal Perfusion in Elderly Subjects
Kielstein, J. T., Bode‐Böger, S. M., Frölich, J. C., Ritz, E., Haller, H. G., & Fliser, D. (2003) · Circulation · doi:10.1161/01.cir.0000060496.23144.a7 · Cited by 210
Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality—An update on patient populations with a wide range of cardiovascular risk
Böger, R. H., Maas, R., Schulze, F., & Schwedhelm, E. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.07.001 · Cited by 205
Arginine-Based Inhibitors of Nitric Oxide Synthase: Therapeutic Potential and Challenges
Víteček, J., Lojek, A., Valacchi, G., & Kubala, L. (2012) · Mediators of Inflammation · doi:10.1155/2012/318087 · Cited by 200
Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice
Xia, N., Daiber, A., Habermeier, A., Closs, E. I., Thum, T., Spanier, G., Lü, Q., Oelze, M. W., Torzewski, M., Lackner, K. J., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.168724 · Cited by 186
The renin–angiotensin–aldosterone system and glucose homeostasis
Luther, J. M., & Brown, N. J. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.07.006 · Cited by 185
ADMA metabolism and clearance
Teerlink, T. (2005) · Vascular Medicine · doi:10.1191/1358863x05vm597oa · Cited by 185
The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis
LEIPER, J. M., & Nandi, M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3358 · Cited by 181
Regression or Progression
Candipan, R. C., Wang, B., Buitrago, R., Tsao, P. S., & Cooke, J. P. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.1.44 · Cited by 180
Diabetes Impairs Stem Cell and Proangiogenic Cell Mobilization in Humans
Fadini, G. P., Albiero, M., de Kreutzenberg, S. V., Boscaro, E., Cappellari, R., Marescotti, M. C., Poncina, N., Agostini, C., & Avogaro, A. (2012) · Diabetes Care · doi:10.2337/dc12-1084 · Cited by 176
The mitochondrial free radical theory of ageing - Where do we stand?
Gruber, J. (2008) · Frontiers in bioscience · doi:10.2741/3174 · Cited by 171
Anti-inflammatory Effects of Resveratrol and Its Potential Use in Therapy of Immune-mediated Diseases
Švajger, U., & Jeras, M. (2012) · International Reviews of Immunology · doi:10.3109/08830185.2012.665108 · Cited by 170
Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells
Lee, W., Ou, H., Hsu, W.-C., Chou, M., Tseng, J., Hsu, S., Tsai, K., & Sheu, W. H. (2010) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2010.04.085 · Cited by 166
Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes
Asagami, T., Abbasi, F., Stuelinger, M., Lamendola, C. A., McLaughlin, T., Cooke, J. P., Reaven, G. M., & Tsao, P. S. (2002) · Metabolism · doi:10.1053/meta.2002.33349 · Cited by 164
Nitric oxide synthase uncoupling: A therapeutic target in cardiovascular diseases
Roe, N. D., & Ren, J. T. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.02.004 · Cited by 161
Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders
Gielis, J. F., Lin, J. Y., Wingler, K., Schil, P. E. V., Schmidt, H. H. H. W., & Moens, A. L. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.018 · Cited by 158
Molecular mechanisms of oxidative stress‐induced carcinogenesis: From epidemiology to oxygenomics
Toyokuni, S. (2008) · IUBMB Life · doi:10.1002/iub.61 · Cited by 152
Nitric oxide synthase inhibitors and hypertension in children and adolescents
Goonasekera, C. D. A., Rees, D. D., Woolard, P., Frend, A. J., Shah, V., & Dillon, M. J. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715080-00015 · Cited by 151
Carbon monoxide: Mechanisms of action and potential clinical implications
Rochette, L., Cottin, Y., Zeller, M., & Vergely, C. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.007 · Cited by 149
Self-citation
Association of Asymmetric Dimethylarginine and Endothelial Dysfunction
Böger, R. H. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.225 · Cited by 147
Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease
Duell, P. B., & MALINOW, M. R. (1997) · Current Opinion in Lipidology · doi:10.1097/00041433-199702000-00007 · Cited by 147
Regulation of Cytokine-Induced Nitric Oxide Synthesis by Asymmetric Dimethylarginine
Ueda, S., Kato, S., Matsuoka, H., Kimoto, M., Okuda, S., Morimatsu, M., & Imaizumi, T. (2003) · Circulation Research · doi:10.1161/01.res.0000052990.68216.ef · Cited by 146
Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects
Katušić, Z. S., d’Uscio, L. V., & Nath, K. A. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.10.003 · Cited by 144
Renin Inhibitor Aliskiren Improves Impaired Nitric Oxide Bioavailability and Protects Against Atherosclerotic Changes
Imanishi, T., Tsujioka, H., Ikejima, H., Kuroi, A., Takarada, S., Kitabata, H., Tanimoto, T., Muragaki, Y., Mochizuki, S., Goto, M., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.111120 · Cited by 144
Role of the PRMT–DDAH–ADMA axis in the regulation of endothelial nitric oxide production
Pope, A. J., Karuppiah, K. M., & Cardounel, A. J. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.07.016 · Cited by 141
Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical NG, NG-dimethylarginine in human essential hypertension1
Delles, C., Schneider, M. P., John, S., Gekle, M., & Schmieder, R. E. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)02278-1 · Cited by 141
Improvement in Left Ventricular Remodeling by the Endothelial Nitric Oxide Synthase Enhancer AVE9488 After Experimental Myocardial Infarction
Fraccarollo, D., Widder, J. D., Galuppo, P., Thum, T., Tsikas, D., Hoffmann, M., Ruetten, H., Ertl, G., & Bauersachs, J. K. (2008) · Circulation · doi:10.1161/circulationaha.107.717702 · Cited by 120
Estrogen Stimulates Dimethylarginine Dimethylaminohydrolase Activity and the Metabolism of Asymmetric Dimethylarginine
Holden, D. P., Cartwright, J. E., Nussey, S., & Whitley, G. S. J. (2003) · Circulation · doi:10.1161/01.cir.0000091083.61609.df · Cited by 117
Effects of resveratrol on membrane biophysical properties: relevance for its pharmacological effects
Brittes, J., Lúcio, M., Nunes, C., Lima, J. L. F. C., & Reis, S. (2010) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2010.07.004 · Cited by 117
The Clinical Significance of Asymmetric Dimethylarginine
Siroen, M. P. C., Teerlink, T., Nijveldt, R. J., Prins, H. A., Richir, M. C., & van Leeuwen, P. A. M. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111320 · Cited by 116
Nitric oxide: a key factor behind the dysfunctionality of endothelial progenitor cells in diabetes mellitus type-2
Hamed, S., Brenner, B., & Roguin, A. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq412 · Cited by 113
A nitric oxide‐mediated mechanism regulates lipolysis in human adipose tissue in vivo
Andersson, K., Gaudiot, N., Ribière, C., Elizalde, M., Giudicelli, Y., & Arner, P. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702430 · Cited by 111
Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophagesThis article is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.
Sarna, L. K., Wu, N., Hwang, S., Siow, Y. L., & Karmin, O. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-136 · Cited by 108
Asymmetric dimethylarginine, oxidative stress, and vascular nitric oxide synthase in essential hypertension
Wang, D., Strandgaard, S., Iversen, J., & Wilcox, C. S. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90506.2008 · Cited by 108
Metabolic Syndrome: Comparison of the Two Commonly Used Animal Models
Oron‐Herman, M., Kamari, Y., Grossman, E., Yeger, G., Peleg, E., Shabtay, Z., Shamiss, A., & Sharabi, Y. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.218 · Cited by 108
Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy
Satoh, M., Fujimoto, S., Arakawa, S., Yada, T., Namikoshi, T., Haruna, Y., Horike, H., Sasaki, T., & Kashihara, N. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn357 · Cited by 106
NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging
Oudot, A., Martin, C., Busseuil, D., Vergely, C., Demaison, L., & Rochette, L. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.02.020 · Cited by 103
Self-citation
Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan‐induced hyperglycaemia
Masuda, H., Goto, M., Tamaoki, S., & Azuma, H. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702298 · Cited by 99
Expression of NG,NG-Dimethylarginine Dimethylaminohydrolase and Protein Arginine N-Methyltransferase Isoforms in Diabetic Rat Kidney
Onozato, M. L., Tojo, A., LEIPER, J. M., Fujita, T., Palm, F., & Wilcox, C. S. (2007) · Diabetes · doi:10.2337/db06-1772 · Cited by 98
Endogenous Methylarginines Modulate Superoxide as Well as Nitric Oxide Generation from Neuronal Nitric-oxide Synthase
Cardounel, A. J., Xia, Y., & Zweier, J. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410241200 · Cited by 97
Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia
Fukuda, Y. (2002) · Heart · doi:10.1136/heart.87.3.264 · Cited by 93
Electron Transfer by Neuronal Nitric-oxide Synthase Is Regulated by Concerted Interaction of Calmodulin and Two Intrinsic Regulatory Elements
Roman, L. J., & Masters, B. S. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603671200 · Cited by 92
Antiatherosclerotic Effects of Small-Molecular-Weight Compounds Enhancing Endothelial Nitric-Oxide Synthase (eNOS) Expression and Preventing eNOS Uncoupling
Wohlfart, P., Xu, H., Endlich, A., Habermeier, A., Closs, E. I., Hübschle, T., Mang, C. F., Strobel, H., Suzuki, T. C., Kleinert, H., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.128009 · Cited by 91
Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk
Zhang, L., Rao, F., Zhang, K., Khandrika, S., Das, M., Vaingankar, S. M., Bao, X., Rana, B. K., Smith, D. W., Wessel, J., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31093 · Cited by 90
Virtual Screening and Biological Characterization of Novel Histone Arginine Methyltransferase PRMT1 Inhibitors
Heinke, R., Spannhoff, A., Meier, R., Trojer, P., Bauer, I., Jung, M., & Sippl, W. (2008) · ChemMedChem · doi:10.1002/cmdc.200800301 · Cited by 89
3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibition Prevents Endothelial NO Synthase Downregulation by Atherogenic Levels of Native LDLs
Martínez‐González, J., Raposo, B., Rodrı́guez, C., & Badimón, L. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.5.804 · Cited by 88
Mineralocorticoid Receptor Blockade Improves Vasomotor Dysfunction and Vascular Oxidative Stress Early After Myocardial Infarction
Sartório, C. L., Fraccarollo, D., Galuppo, P., Leutke, M., Ertl, G., Stefanon, I., & Bauersachs, J. K. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.093450 · Cited by 88
Asymmetric Dimethylarginine and Reactive Oxygen Species
Wilcox, C. S. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.187310 · Cited by 85
Nebivolol Treatment Reduces Serum Levels of Asymmetric Dimethylarginine and Improves Endothelial Dysfunction in Essential Hypertensive Patients
Pasini, A. F., Garbin, U., Stranieri, C., Boccioletti, V., Mozzini, C., Manfro, S., Pasini, A. M. F., Cominacini, M., & Cominacini, L. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.260 · Cited by 84
Plasma concentrations of asymmetric-dimethyl-arginine in type 2 diabetes associate with glycemic control and glomerular filtration rate but not with risk factors of vasculopathy
Päivä, H., Lehtimäki, T. J., Laakso, J. T., Ruokonen, I., Rantalaiho, V. M., Wirta, O., Pasternack, A. I., & Laaksonen, R. (2003) · Metabolism · doi:10.1053/meta.2003.50048 · Cited by 83
Angiotensin II and NADPH Oxidase Increase ADMA in Vascular Smooth Muscle Cells
Luo, Z., Teerlink, T., Griendling, K. K., Aslam, S., Welch, W. J., & Wilcox, C. S. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.152959 · Cited by 83
Impact of Asymmetric Dimethylarginine on Mortality After Acute Myocardial Infarction
Zeller, M., Korandji, C., Guilland, J.-C., Sicard, P., Vergely, C., Lorgis, L., Beer, J., Duvillard, L., Lagrost, A.-C., Moreau, D., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.162768 · Cited by 81
Self-citation
Resveratrol and diabetic cardiac function: focus on recent in vitro and in vivo studies
Turan, B., Tuncay, E., & Vassort, G. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9429-0 · Cited by 79
Sub-cellular targeting of constitutive NOS in health and disease
Zhang, Y. H., & Casadei, B. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.09.006 · Cited by 79
Antioxidative and Prooxidative Action of Stilbene Derivatives
Miura, T., Muraoka, S., Ikeda, N., Watanabe, M., & Fujimoto, Y. (2000) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2000.d01-36.x · Cited by 77
The impact of rapid atrial pacing on ADMA and endothelial NOS
Goette, A., Hammwöhner, M., Bukowska, A., Scalera, F., Martens‐Lobenhoffer, J., Dobrev, D., Ravens, U., Weinert, S., Medunjanin, S., Lendeckel, U., et al. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.09.004 · Cited by 77
Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)
Sun, Q.-A., Hess, D. T., Wang, B., Miyagi, M., & Stamler, J. S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.046 · Cited by 76
Pharmacophore-Based Virtual Screening and Biological Evaluation of Small Molecule Inhibitors for Protein Arginine Methylation
Wang, J., Chen, L., Sinha, S. H., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300521m · Cited by 74
Nω-Nitroarginine-Containing Dipeptide Amides. Potent and Highly Selective Inhibitors of Neuronal Nitric Oxide Synthase
Huang, H., Pavel Martasek, E., Roman, L. J., Masters, B. S. S., & Silverman, R. B. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm990111c · Cited by 72
Intra-coronary administration of ?-arginine aggravates myocardial stunning through production of peroxynitrite in dogs
Mori, E. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00146-1 · Cited by 71
Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice
Cheang, W. S., Wong, W. T., Tian, X. Y., Yang, Q., Lee, H. K., He, G., Yao, X., & Huang, Y. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr233 · Cited by 70
Discovery and Mechanistic Study of a Class of Protein Arginine Methylation Inhibitors
Feng, Y., Li, M., Wang, B., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100416n · Cited by 70
NADPH oxidase inhibitors: a patent review
Kim, J., Neupane, G. P., Lee, E. S., Jeong, B., Park, B. C., & Thapa, P. (2011) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2011.584870 · Cited by 70
Sequence Variation in DDAH1 and DDAH2 Genes Is Strongly and Additively Associated with Serum ADMA Concentrations in Individuals with Type 2 Diabetes
Abhary, S., Burdon, K. P., Kuot, A., Javadiyan, S., Whiting, M. J., Kasmeridis, N., Petrovsky, N., & Craig, J. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009462 · Cited by 70
l-Arginine transporters in cardiovascular disease: A novel therapeutic target
Chin-Dusting, J. P. F., Willems, L., & Kaye, D. M. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.08.001 · Cited by 69
Insulin, nitric oxide and the sympathetic nervous system
Sartori, C. S., & Scherrer, U. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917110-00003 · Cited by 67
Identification and quantification of free radicals during myocardial ischemia and reperfusion using electron paramagnetic resonance spectroscopy
Vergely, C., Maupoil, V., Clermont, G., Bril, A., & Rochette, L. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.07.007 · Cited by 66
Self-citation
Influence of the Severity of Myocardial Ischemia on the Intensity of Ascorbyl Free Radical Release and on Postischemic Recovery during Reperfusion
Vergely, C., Maupoil, V., Benderitter, M., et al. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00282-7 · Cited by 66
Self-citation
Emodin and rhein inhibit LIGHT-induced monocytes migration by blocking of ROS production
Heo, S., Yun, H., Noh, E., et al. (2010) · Vascular Pharmacology · doi:10.1016/j.vph.2010.03.002 · Cited by 66
Decreased production of neuronal NOS‐derived hydrogen peroxide contributes to endothelial dysfunction in atherosclerosis
Capettini, L. D. S. A., Côrtes, S. F., da Silva, J. F., Alvarez-Leite, J. I., & Lemos, V. S. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01500.x · Cited by 65
Association of Elevated Homocysteine Levels With a Higher Risk of Recurrent Coronary Events and Mortality in Patients With Acute Myocardial Infarction
Matetzky, S., Freimark, D., Ben-Ami, S., et al. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.16.1933 · Cited by 64
Elevated concentration of asymmetric dimethylarginine (ADMA) in individuals with metabolic syndrome
Palomo, I. F., Contreras, A., Alarcón, M. A., Elba Leiva, M., Guzmán, L., Mujica, V., Icaza, G., Díaz, N. S., González, D. R., & Moore‐Carrasco, R. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.03.002 · Cited by 63
The Role of the Methoxyphenol Apocynin, a Vascular NADPH Oxidase Inhibitor, as a Chemopreventative Agent in the Potential Treatment of Cardiovascular Diseases
Yu, J., Weïwer, M., Linhardt, R. J., & Dordick, J. S. (2008) · Current Vascular Pharmacology · doi:10.2174/157016108784911984 · Cited by 62
Targets in Epigenetics: Inhibiting the Methyl Writers of the Histone Code
Yost, J. M., Korboukh, I., Liu, F., Gao, C., & Jin, J. J. (2011) · Current Chemical Genomics · doi:10.2174/1875397301005010072 · Cited by 61
Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease
Wadham, C., & Mangoni, A. A. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250902785172 · Cited by 61
Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets
Sato, Y., Ito, T., Udaka, N., Kanisawa, M., Noguchi, Y., Cushman, S. W., & Satoh, S. (1996) · Tissue and Cell · doi:10.1016/s0040-8166(96)80067-x · Cited by 59
Circulating leukocyte telomere length and oxidative stress: A new target for statin therapy
Saliques, S., Teyssier, J., Vergely, C., Lorgis, L., Lorin, J., Farnier, M., Donzel, A., Sicard, P., Berchoud, J., Lagrost, A.-C., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.09.011 · Cited by 57
Self-citation
The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium
Wunderlich, C., Schober, K., Schmeißer, A., Heerwagen, C., Tausche, A., Steinbronn, N., Brandt, A., Kasper, M. E., Schwencke, C., Braun-Dullaeus, R. C., et al. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.02.275 · Cited by 57
Glycemic Control Modulates Arginine and Asymmetrical-Dimethylarginine Levels during Critical Illness by Preserving Dimethylarginine-Dimethylaminohydrolase Activity
Ellger, B., Richir, M. C., van Leeuwen, P. A. M., Debaveye, Y. A., Langouche, L., Vanhorebeek, I., Teerlink, T., & den Berghe, G. V. (2008) · Endocrinology · doi:10.1210/en.2007-1558 · Cited by 56
Selective Substrate-Based Inhibitors of Mammalian Dimethylarginine Dimethylaminohydrolase
Rossiter, S., Smith, C. L., Malaki, M., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050187a · Cited by 56
Protein arginine methyltransferases (PRMTs) as therapeutic targets
Cha, B., & Jho, E. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.688030 · Cited by 56
Plasma asymmetric dimethylarginine and mortality in patients with acute decompensation of chronic heart failure
Zairis, M. N., Patsourakos, N. G., Tsiaousis, G. Z., Georgilas, A. T., Melidonis, A. I., Makrygiannis, S. S., Velissaris, D., Batika, P. C., Argyrakis, K. S., Tzerefos, S., et al. (2012) · Heart · doi:10.1136/heartjnl-2011-301372 · Cited by 54
Role of the human erythrocyte in generation and storage of asymmetric dimethylarginine
Davids, M., van Hell, A. J., Visser, M., Nijveldt, R. J., van Leeuwen, P. A. M., & Teerlink, T. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01205.2011 · Cited by 53
AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats
Yang, Q., Xue, H., Wong, W. T., Tian, X., Huang, Y., Tsui, S. K., Ng, P. K., Wohlfart, P., Li, H., Xia, N., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01308.x · Cited by 50
The free oxygen radicals test (FORT) to assess circulating oxidative stress in patients with acute myocardial infarction
Lorgis, L., Zeller, M., Dentan, G., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.09.018 · Cited by 50
Self-citation
Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice
Jacobi, J., Maas, R., Cordasic, N., Koch, K., Schmieder, R. E., Böger, R. H., & Hilgers, K. F. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01103.2007 · Cited by 50
Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius
Martin, C., Dubouchaud, H., Mosoni, L., Chardigny, J., Oudot, A., Fontaine, E. M., Vergely, C., Kériel, C., Rochette, L., Leverve, X. M., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00271.x · Cited by 49
Self-citation
Anti-hypertensive effects of Rosuvastatin are associated with decreased inflammation and oxidative stress markers in hypertensive rats
Sicard, P., Delemasure, S., Korandji, C., Grand, A. S.-L., Lauzier, B., Guilland, J.-C., Duvillard, L., Zeller, M., Cottin, Y., Vergely, C., et al. (2008) · Free Radical Research · doi:10.1080/10715760701885380 · Cited by 45
Self-citation
The peroxisome proliferator-activated receptor-α (PPAR-α) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats
Linz, W., Wohlfart, P., Baader, M., Breitschopf, K., Falk, E., Schäfer, H., Gerl, M., Kramer, W., & Rütten, H. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.58 · Cited by 44
Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure
Moens, A. L., Ketner, E., Takimoto, E., Schmidt, T. S., O’neill, C. A., Wolin, M. S., Alp, N. J., Channon, K. M., & Kass, D. A. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.05.017 · Cited by 44
A direct comparison of endothelial progenitor cell dysfunction in rat metabolic syndrome and diabetes
Kuliszewski, M. A., Ward, M. R., Kowalewski, J. W., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.09.029 · Cited by 42
The eNOS enhancer AVE 9488: a novel cardioprotectant against ischemia reperfusion injury
Frantz, S., Adamek, A., Fraccarollo, D., Tillmanns, J., Widder, J. D., Dienesch, C., Schäfer, A., Podolskaya, A. A., Held, M. C., Ruetten, H., et al. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0041-3 · Cited by 41
Modulating the NO generating system from a medicinal chemistry perspective: Current trends and therapeutic options in cardiovascular disease
Schade, D., Kotthaus, J., & Clement, B. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.02.005 · Cited by 40
Protein arginine methylation: a new handle on T lymphocytes?
Parry, R. V., & Ward, S. G. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.006 · Cited by 40
Tissue-specific and age-dependent expression of protein arginine methyltransferases (PRMTs) in male rat tissues
Hong, E., Lim, Y., Lee, E., et al. (2012) · Biogerontology · doi:10.1007/s10522-012-9379-2 · Cited by 39
Maintenance of cellular tetrahydrobiopterin homeostasis
Kim, H.-L., & Park, Y. S. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.9.584 · Cited by 39
?-Arginine administration prevents reperfusion-induced cardiomyocyte hypercontracture and reduces infarct size in the pig
Padilla, F. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00048-1 · Cited by 39
Symmetric Double-Headed Aminopyridines, a Novel Strategy for Potent and Membrane-Permeable Inhibitors of Neuronal Nitric Oxide Synthase
Xue, F., Fang, J., Delker, S. L., Li, H., Pavel Martasek, E., Roman, L. J., Poulos, T. L., & Silverman, R. B. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101071n · Cited by 37
Arterial endothelial cells: still the craftsmen of regenerated endothelium
Hagensen, M. K., Vanhoutte, P. M., & Bentzon, J. F. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs182 · Cited by 36
Protective effects of apocynin, an inhibitor of NADPH oxidase activity, in splanchnic artery occlusion and reperfusion
Paterniti, I., Galuppo, M., Mazzon, E., Impellizzeri, D., Esposito, E., Bramanti, P., & Cuzzocrea, S. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0610322 · Cited by 36
Asymmetric dimethylarginine (ADMA) and hyperhomocysteinemia in patients with acute myocardial infarction
Korandji, C., Zeller, M., Guilland, J.-C., Vergely, C., Sicard, P., Duvillard, L., Gambert, P., Moreau, D., Cottin, Y., & Rochette, L. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.08.004 · Cited by 34
Self-citation
Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells
Aoki, C., Nakano, A., Tanaka, S., Yanagi, K., Ohta, S., Jojima, T., Kasai, K., Takekawa, H., Hirata, K., & Hattori, Y. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.10.029 · Cited by 34
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells
Shimizu, S., Hiroi, T., Ishii, M., Hagiwara, T., Wajima, T., Miyazaki, A., & Kiuchi, Y. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.10.011 · Cited by 34
Effects of Angiotensin-1 Converting Enzyme Inhibition on Oxidative Stress and Bradykinin Receptor Expression During Doxorubicin-induced Cardiomyopathy in Rats
Richard, C., Lauzier, B., Delemasure, S., et al. (2008) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181865f28 · Cited by 33
Plasma lipid peroxidation in critically ill patients: Importance of mechanical ventilation
Benbaouali, A., Aube, H., Maupoil, V., Blettery, B., & Rochette, L. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90147-3 · Cited by 33
Self-citation
Forgotten Radicals in Biology
Laboratoire De Physiopathologie Et Pharmacologie Cardiovasculaires Experimentales, F. D. M. E. P., Vergely, C., & Luc, R. (2008) · International Journal of Biomedical Science · doi:10.59566/ijbs.2008.4255 · Cited by 33
Self-citation
Effect of acute variations of insulin and glucose on plasma concentrations of asymmetric dimethylarginine in young people with Type 1 diabetes
Marcovecchio, M. L., Widmer, B., Dunger, D. B., & Dalton, R. N. (2008) · Clinical Science · doi:10.1042/cs20080079 · Cited by 31
The Nitric Oxide Pathway and Oxidative Stress in Heart Failure
Searles, C. D. (2002) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2002.00715.x · Cited by 31
Time course of asymmetric dimethylarginine (ADMA) and oxidative stress in fructose-hypertensive rats: A model related to metabolic syndrome
Korandji, C., Zeller, M., Guilland, J.-C., Collin, B., Lauzier, B., Sicard, P., Duvillard, L., Goirand, F., Moreau, D., Cottin, Y., et al. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.11.014 · Cited by 30
Self-citation
Effect of angiotensin-converting enzyme inhibitor on serum asymmetric dimethylarginine and coronary circulation in patients with type 2 diabetes mellitus
Kawata, T., Daimon, M., Hasegawa, R., et al. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.08.066 · Cited by 30
Effect of endogenous estrogen on endothelial function in women with coronary heart disease and its mechanism
Li, X.-P., Zhou, Y., Zhao, S., et al. (2003) · Clinica Chimica Acta · doi:10.1016/j.cccn.2003.10.006 · Cited by 29
Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase Kinetic Analysis in Mesenteric Arteries of Patients With Type 2 Diabetes
Nunes, S. F. L. D. C., Figueiredo, I. V., Pereira, J. S., et al. (2011) · Physiological Research · doi:10.33549/physiolres.931982 · Cited by 29
Structure-Guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase
Huang, H., Li, H., Pavel Martasek, E., Roman, L. J., Poulos, T. L., & Silverman, R. B. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4000984 · Cited by 28
Structural Basis for Pterin Antagonism in Nitric-oxide Synthase
Kotsonis, P., Fröhlich, L. G., Raman, C. S., Li, H., Berg, M., Gerwig, R., Groehn, V., Kang, Y., Al-Masoudi, N. A., Taghavi‐Moghadam, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011469200 · Cited by 28
Forgotten radicals in biology.
Rochette, L., & Vergely, C. (2008) · Europe PMC (PubMed Central) · Cited by 27
Self-citation
Variance of DDAH/PRMT/ADMA pathway in atrial fibrillation dogs
Liu, H., Qu, X., Liang, Z., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.080 · Cited by 26
Isolated perfused rat hearts release secondary free radicals during ischemia reperfusion injury: Cardiovascular effects of the spin trap α-phenylN-tert-butylnitrone
Vergely, C., Tabard, A., Maupoil, V., et al. (2001) · Free Radical Research · doi:10.1080/10715760100301491 · Cited by 24
Self-citation
Electron Spin Resonance Detection of Nitric Oxide Generation in Major Organs from LPS-Treated Rats
Lecour, S., Maupoil, V., Siri, O., Tabard, A., & Rochette, L. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199901000-00012 · Cited by 24
Self-citation
ESR techniques for the detection of nitric oxide in vivo as an index of endothelial function.
Fink, B., Dikalov, S., & Fink, N. (2006) · PubMed · Cited by 21
Atrial and Vascular Oxidative Stress in Patients with Heart Failure
Rochette, L., Tatou, E., Maupoil, V., Zeller, M., Cottin, Y., Jazayeri, S., Brenot, R., Girard, C., David, M., & Vergely, C. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000329951 · Cited by 20
Self-citation
Tetrahydrobiopterin Protects Soluble Guanylate Cyclase against Oxidative Inactivation
Schmidt, K., Neubauer, A., Kolesnik, B., Stasch, J., Werner, E. R., Gorren, A. C. F., & Mayer, B. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.079855 · Cited by 20
Tetrahydrobiopterin, L-Arginine and Vitamin C Act Synergistically to Decrease Oxidative Stress, Increase Nitric Oxide and Improve Blood Flow after Induction of Hindlimb Ischemia in the Rat
Yan, J., Tie, G., & Messina, L. M. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00103 · Cited by 19
Heme-Coordinating Inhibitors of Neuronal Nitric Oxide Synthase. Iron−Thioether Coordination Is Stabilized by Hydrophobic Contacts without Increased Inhibitor Potency
Martell, J. D., Li, H., Doukov, T. I., Pavel Martasek, E., Roman, L. J., Soltis, S. M., Poulos, T. L., & Silverman, R. B. (2009) · Journal of the American Chemical Society · doi:10.1021/ja908544f · Cited by 19
Biology and chemistry of the inhibition of nitric oxide synthases by pteridine‐derivatives as therapeutic agents
Matter, H., & Kotsonis, P. (2004) · Medicinal Research Reviews · doi:10.1002/med.20005 · Cited by 19
Postischemic Recovery and Oxidative Stress Are Independent of Nitric-Oxide Synthases Modulation in Isolated Rat Heart
Vergely, C., Perrin‐Sarrado, C., Clermont, G., & Rochette, L. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.036871 · Cited by 18
Self-citation
A Functional Variant of the Dimethylarginine Dimethylaminohydrolase-2 Gene Is Associated with Insulin Sensitivity
Andreozzi, F., Presta, I., Mannino, G. C., Scarpelli, D., Silvestre, S. D., Pietro, N. D., Succurro, E., Sciacqua, A., Pandolfi, A., Consoli, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036224 · Cited by 17
Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase
Li, H., Xue, F., Kraus, J. M., Ji, H., Labby, K. J., Mataka, J., Delker, S. L., Pavel Martasek, E., Roman, L. J., Poulos, T. L., et al. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.12.019 · Cited by 13
Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): A focus on selectivity over arginase
Kotthaus, J., Schade, D., Kotthaus, J., & Clement, B. (2011) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2011.573480 · Cited by 12
Redox Equivalents and Mitochondrial Bioenergetics
Roede, J. R., Go, Y., & Jones, D. P. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-382-0_17 · Cited by 12
Nitric oxide fails to confer endogenous antiarrhythmic cardioprotection in the primate heart in vitro
Pabla, R., & Curtis, M. J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707143 · Cited by 11
Nitric Oxide Manipulation: A Therapeutic Target for Peripheral Arterial Disease?
Williams, G. H., Shiwen, X., Abraham, D., Selvakumar, S., Baker, D., & Tsui, J. C. S. (2012) · Cardiology Research and Practice · doi:10.1155/2012/656247 · Cited by 11
Plasma iron status and lipid peroxidation following thrombolytic therapy for acute myocardial infarction
Cottin, Y., Doise, J.-M., Maupoil, V., Zeller, M., Dalloz, F., Maynadié, M., Walker, M., Louis, P., Carli, P., Wolf, J., et al. (1998) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1998.tb00947.x · Cited by 11
Self-citation
Direct demonstration of nitric oxide formation in organs of rabbits treated by transdermal glyceryl trinitrate using an in vivo spin trapping technique
Clermont, G., Lecour, S., Vergely, C., Zeller, M., Perrin‐Sarrado, C., Maupoil, V., Bouchot, O., & Rochette, L. (2003) · Fundamental and Clinical Pharmacology · doi:10.1046/j.1472-8206.2003.00199.x · Cited by 10
Self-citation
Homocysteine increase after acute myocardial infarction--can it explain the differences between case-control and cohort studies?
Gomes, E., Duarte, R., Reis, R. P., et al. (2002) · PubMed · Cited by 8
Twin Layers of Lightning
Pi, X., & Patterson, C. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.156786 · Cited by 5

Sorted by citations

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Endothelial dysfunction and coronary artery disease: assessment, prognosis, and treatment
Matsuzawa, Y., & Lerman, A. (2014) · Coronary Artery Disease · doi:10.1097/mca.0000000000000178 · Cited by 249
Emerging comorbidities in adult asthma: risks, clinical associations, and mechanisms
Kankaanranta, H., Kauppi, P., Tuomisto, L. E., & Ilmarinen, P. (2016) · Mediators of Inflammation · doi:10.1155/2016/3690628 · Cited by 122
Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1–Dependent Uncoupling of Endothelial Nitric Oxide Synthase
Villalba, N., Sackheim, A. M., Nunez, I. A., Hill-Eubanks, D. C., Nelson, M. T., Wellman, G. C., & Freeman, K. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2015.4340 · Cited by 99
The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches
Zhu, H.-Y., Hong, F.-F., & Yang, S.-L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094540 · Cited by 84

See all 456

Authors: Rochette, L., Lorin, J., Zeller, M., Guilland, J.-C., Lorgis, L., Cottin, Y., & Vergely, C.
Affiliations: Université de Bourgogne (FR)
Inserm (FR)
Corresponding author: Rochette, Luc
ORCID: Rochette, Luc
Zeller, Marianne
Lorgis, Luc
Cottin, Yves
Vergely, Catherine
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2013-12
Volume: 140
Issue: 3
Pages: 239-257
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/j.pharmthera.2013.07.004
OpenAlex: W2035714184
Cited by: 456
References: 201
Citations by year: 2026: 17 · 2025: 36 · 2024: 29 · 2023: 50 · 2022: 42 · 2021: 40 · 2020: 31 · 2019: 39 · 2018: 36 · 2017: 40 · 2016: 29 · 2015: 37 · 2014: 23 · 2013: 5
FWCI: 3.45
Type: journal article
Language: en
Open access: green
ube.hal.science
Licence: other-oa
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: nitric oxide synthase inhibition, nitric oxide, oxidative stress, cardiovascular disease, asymmetric dimethylarginine, tetrahydrobiopterin, endothelial dysfunction, endothelial nitric oxide synthase, NOS isoforms, calmodulin, hypertension, ischemia-reperfusion injury, diabetes mellitus, vascular dysfunction, therapeutic target
MeSH terms: Animals, Cardiovascular Diseases, Enzyme Inhibitors, Humans, Nitric Oxide, Oxidative Stress, Nitric Oxide Synthase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks