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Cited by 186Curcumin's Biomedical ApplicationsParaoxonase enzyme and polymorphismsNatural Products and Biological Research

The DOI matches its Crossref record; 126 of the 133 references it cites were found in a registry or an index.

Effects of curcumin on HDL functionality

Open access
Ganjali, Shiva, Blesso, Christopher N., Banach, Maciej, Pirro, Matteo, Majeed, Muhammed, Sahebkar, Amirhossein·2017·Pharmacological Research
DOI 10.1016/j.phrs.2017.02.008
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Abstract

Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subsequently, may alleviate hyperlipidemia and atherosclerosis. Plasma HDL cholesterol (HDL-C) is an independent negative risk predictor of cardiovascular disease (CVD). However, numerous clinical and genetic studies have yielded disappointing results about the therapeutic benefit of raising plasma HDL-C levels. Therefore, research efforts are now focused on improving HDL functionality, independent of HDL-C levels. The quality of HDL particles can vary considerably due to heterogeneity in composition. Consistent with its complexity in composition and metabolism, a wide range of biological activities is reported for HDL, including antioxidant, anti-glycation, anti-inflammatory, anti-thrombotic, anti-apoptotic and immune modulatory activities. Protective properties of curcumin may influence HDL functionality; therefore, we reviewed the literature to determine whether curcumin can augment HDL function. In this review, we concluded that curcumin may modulate markers of HDL function, such as apo-AI, CETP, LCAT, PON1, MPO activities and levels. Curcumin may subsequently improve conditions in which HDL is dysfunctional and may have potential as a therapeutic drug in future. Further clinical trials with bioavailability-improved formulations of curcumin are warranted to examine its effects on lipid metabolism and HDL function.

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Citations

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Research works printed but not linked: 8

  1. Voight, 2012, Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study, Lancet (London England), 380, 572, 10.1016/S0140-6736(12)60312-2 · DOI · Paper page
  2. Momtazi, 2016, Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases, Mol. Diagn. Ther., 20, 335, 10.1007/s40291-016-0202-7 · DOI
  3. Ganjali, 2014, Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial, Sci. World J., 2014, 898361, 10.1155/2014/898361 · DOI
  4. Sahebkar, 2014, Curcuminoids for the management of hypertriglyceridaemia, Nat. Rev. Cardiol., 11, 123, 10.1038/nrcardio.2013.140-c1 · DOI · Paper page
  5. Sahebkar, 2014, Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis, Phytother. Res., 28, 633, 10.1002/ptr.5045 · DOI
  6. Sahebkar, 2016, Curcumin downregulates human tumor necrosis factor-α levels: a systematic review and meta-analysis ofrandomized controlled trials, Pharmacol. Res., 107, 234, 10.1016/j.phrs.2016.03.026 · DOI
  7. Zhao, 2011, Curcumin reduces inflammatory reactions following transient cerebral ischemia/reperfusion injury, Neural Regener. Res., 6, 219
  8. Kontush, 2006, Antiatherogenic small, dense HDL-guardian angel of the arterial wall? Nature clinical practice, Cardiovasc. Med., 3, 144

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Related

Metadata

Authors
Ganjali, S., Blesso, C. N., Banach, M., Pirro, M., Majeed, M., & Sahebkar, A.
Affiliations
  • Mashhad University of Medical Sciences (IR)
  • University of Connecticut (US)
  • Medical University of Lodz (PL)
  • University of Perugia (IT)
Corresponding author
Sahebkar, Amirhossein
ORCID
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2017-05
Volume
119
Pages
208-218
ISSN
1043-6618 (ISSN-L)
DOI
10.1016/j.phrs.2017.02.008
OpenAlex
W2586622953
Cited by
186
References
133
Citations by year
2026: 6 · 2025: 19 · 2024: 8 · 2023: 24 · 2022: 20 · 2021: 16 · 2020: 11 · 2019: 27 · 2018: 35 · 2017: 20
FWCI
1.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmacological Research (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
Keywords
curcumin, HDL function, HDL cholesterol, HDL dysfunction, apolipoprotein A-I, cholesteryl ester transfer protein, lecithin:cholesterol acyltransferase, paraoxonase 1, myeloperoxidase, lipid metabolism, hyperlipidemia, atherosclerosis, cardiovascular disease, polyphenols, bioavailability
MeSH terms
Animals, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Curcumin, Humans, Lipoproteins, HDL, Curcuma, Dyslipidemias, Atherosclerosis

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