CoChat
Sign Up
Cited by 186Curcumin's Biomedical ApplicationsParaoxonase enzyme and polymorphismsNatural Products and Biological Research

The DOI matches its Crossref record; 126 of the 133 references it cites were found in a registry or an index.

Effects of curcumin on HDL functionality

Open access
Ganjali, Shiva, Blesso, Christopher N., Banach, Maciej, Pirro, Matteo, Majeed, Muhammed, Sahebkar, Amirhossein·2017·Pharmacological Research
DOI 10.1016/j.phrs.2017.02.008
Open this paper in CoChat — free account

Abstract

Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subsequently, may alleviate hyperlipidemia and atherosclerosis. Plasma HDL cholesterol (HDL-C) is an independent negative risk predictor of cardiovascular disease (CVD). However, numerous clinical and genetic studies have yielded disappointing results about the therapeutic benefit of raising plasma HDL-C levels. Therefore, research efforts are now focused on improving HDL functionality, independent of HDL-C levels. The quality of HDL particles can vary considerably due to heterogeneity in composition. Consistent with its complexity in composition and metabolism, a wide range of biological activities is reported for HDL, including antioxidant, anti-glycation, anti-inflammatory, anti-thrombotic, anti-apoptotic and immune modulatory activities. Protective properties of curcumin may influence HDL functionality; therefore, we reviewed the literature to determine whether curcumin can augment HDL function. In this review, we concluded that curcumin may modulate markers of HDL function, such as apo-AI, CETP, LCAT, PON1, MPO activities and levels. Curcumin may subsequently improve conditions in which HDL is dysfunctional and may have potential as a therapeutic drug in future. Further clinical trials with bioavailability-improved formulations of curcumin are warranted to examine its effects on lipid metabolism and HDL function.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.phrs.2017.02.008

Cites

126 of 126 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 133 references

Research works printed but not linked: 8

  1. Voight, 2012, Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study, Lancet (London England), 380, 572, 10.1016/S0140-6736(12)60312-2 · DOI · Paper page
  2. Momtazi, 2016, Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases, Mol. Diagn. Ther., 20, 335, 10.1007/s40291-016-0202-7 · DOI
  3. Ganjali, 2014, Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial, Sci. World J., 2014, 898361, 10.1155/2014/898361 · DOI
  4. Sahebkar, 2014, Curcuminoids for the management of hypertriglyceridaemia, Nat. Rev. Cardiol., 11, 123, 10.1038/nrcardio.2013.140-c1 · DOI · Paper page
  5. Sahebkar, 2014, Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis, Phytother. Res., 28, 633, 10.1002/ptr.5045 · DOI
  6. Sahebkar, 2016, Curcumin downregulates human tumor necrosis factor-α levels: a systematic review and meta-analysis ofrandomized controlled trials, Pharmacol. Res., 107, 234, 10.1016/j.phrs.2016.03.026 · DOI
  7. Zhao, 2011, Curcumin reduces inflammatory reactions following transient cerebral ischemia/reperfusion injury, Neural Regener. Res., 6, 219
  8. Kontush, 2006, Antiatherogenic small, dense HDL-guardian angel of the arterial wall? Nature clinical practice, Cardiovasc. Med., 3, 144

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Ganjali, S., Blesso, C. N., Banach, M., Pirro, M., Majeed, M., & Sahebkar, A.
Affiliations
  • Mashhad University of Medical Sciences (IR)
  • University of Connecticut (US)
  • Medical University of Lodz (PL)
  • University of Perugia (IT)
Corresponding author
Sahebkar, Amirhossein
ORCID
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2017-05
Volume
119
Pages
208-218
ISSN
1043-6618 (ISSN-L)
DOI
10.1016/j.phrs.2017.02.008
OpenAlex
W2586622953
Cited by
186
References
133
Citations by year
2026: 6 · 2025: 19 · 2024: 8 · 2023: 24 · 2022: 20 · 2021: 16 · 2020: 11 · 2019: 27 · 2018: 35 · 2017: 20
FWCI
1.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmacological Research (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
Keywords
curcumin, HDL function, HDL cholesterol, HDL dysfunction, apolipoprotein A-I, cholesteryl ester transfer protein, lecithin:cholesterol acyltransferase, paraoxonase 1, myeloperoxidase, lipid metabolism, hyperlipidemia, atherosclerosis, cardiovascular disease, polyphenols, bioavailability
MeSH terms
Animals, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Curcumin, Humans, Lipoproteins, HDL, Curcuma, Dyslipidemias, Atherosclerosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review