The DOI matches its Crossref record; 207 of the 211 references it cites were found in a registry or an index.
The Application of Ferroptosis in Diseases
Abstract
Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron metabolism, lipid metabolism, oxidative stress and biosynthesis of nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH) and coenzyme Q10 (CoQ10). A growing body of evidence suggests that ferroptosis is associated with cancer and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and Huntington's disease). This finding has helped develop a novel cytoprotective strategy to protect cells in neurodegenerative, blood and heart diseases by inhibiting ferroptosis. Meanwhile, the selective induction of ferroptosis has been adopted as a potential treatment strategy in some kinds of cancer. This review aims to summarize the mechanism of ferroptosis regulation and relevance to pathological physiology.
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“Crucially, glutathione plays a pivotal role in governing lipid metabolism by inhibiting impaired fatty acid metabolism, counteracting lipid peroxidation, and reducing lipid storage concomitant with fatty acid metabolism (Miess et al., 2018; Qiu et al., 2020).”
From Lactiplantibacillus plantarum N4 ameliorates lipid metabolism and gut microbiota structure in high fat diet-fed rats (2024) · cites this paper as Qiu et al., 2020
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1 retracted
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Cited by
Sorted by citations
Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases
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Metadata
- Authors
- Qiu, Y., Cao, Y., Cao, W., Jia, Y., & Lu, N.
- Affiliations
- China Pharmaceutical University (CN)
- University of Macau (MO)
- Corresponding author
- Lu, Na
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 159
- Pages
- 104919
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W3032712286
- Cited by
- 415
- References
- 211
- Citations by year
- 2026: 18 · 2025: 65 · 2024: 90 · 2023: 113 · 2022: 87 · 2021: 34 · 2020: 8
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81872899,81903626)
- Jiangsu Science and Technology Department (BE2018711)
- Ministry of Science and Technology of the People's Republic of China (2017ZX09101003-005-023, 2017ZX09301014, 2018ZX09711001-003-007)
- China Pharmaceutical University (CPU2018GY17)
- Natural Science Foundation of Jiangsu Province (BK20180576)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- ferroptosis, regulated cell death, iron-dependent lipid peroxidation, iron metabolism, lipid metabolism, oxidative stress, NADPH, glutathione, coenzyme Q10, cancer, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, ferroptosis inhibitors, cytoprotection
- MeSH terms
- Ferroptosis, Animals, Antineoplastic Agents, Humans, Iron, Neoplasms, Lipid Peroxidation, Reactive Oxygen Species, Neuroprotective Agents, Neurodegenerative Diseases
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