Cited by 436Ferroptosis and cancer prognosisIron Metabolism and DisordersNeurological diseases and metabolism

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The Application of Ferroptosis in Diseases

Qiu, Yangmin, Cao, Yue, Cao, Wangjia, Jia, Yifei, Lu, Na·2020·Pharmacological Research

DOI 10.1016/j.phrs.2020.104919

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Abstract

Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron metabolism, lipid metabolism, oxidative stress and biosynthesis of nicotinamide adenine dinucleotide phosphate (NADPH), glutathione (GSH) and coenzyme Q10 (CoQ10). A growing body of evidence suggests that ferroptosis is associated with cancer and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and Huntington's disease). This finding has helped develop a novel cytoprotective strategy to protect cells in neurodegenerative, blood and heart diseases by inhibiting ferroptosis. Meanwhile, the selective induction of ferroptosis has been adopted as a potential treatment strategy in some kinds of cancer. This review aims to summarize the mechanism of ferroptosis regulation and relevance to pathological physiology.

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RETRACTED: Ferroptosis is governed by differential regulation of transcription in liver cancer
Zhang, X., Du, L., Qiao, Y., Zhang, X., Zheng, W., Wu, Q., Chen, Y., Zhu, G., Liu, Y., Bian, Z., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101211 · Cited by 188
Retracted
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695
Parkinson's disease
Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,184
Hepatocellular carcinoma
Forner, A., Reig, M., & Bruix, J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30010-2 · Cited by 5,774
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
Glutathione Metabolism and Its Implications for Health
Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842

Show all 211 references

Research works printed but not linked: 4

Yang, 2008, Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, Chemistry & biology., 15, 234, 10.1016/j.chembiol.2008.02.010 · DOI · Paper page
Lu, 2020, Regulation of glutathione synthesis, Molecular aspects of medicine, 30, 42, 10.1016/j.mam.2008.05.005 · DOI
Brigelius-Flohe, 2013, Glutathione peroxidases, Biochim Biophys Acta., 1830, 3289, 10.1016/j.bbagen.2012.11.020 · DOI · Paper page
Viktorinova, 2018, Iron-mediated oxidative cell death is a potential contributor to neuronal dysfunction induced by neonatal hemolytic hyperbilirubinemia, Arch Biochem Biophys., 654, 185, 10.1016/j.abb.2018.07.022 · DOI

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Gu, X., Huang, Z., Ying, X., Liu, X., Ruan, K., Hua, S., Zhang, X., Jin, H., Liu, Q., & Yang, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02007-1 · Cited by 43
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Zhou, Q., Yang, L., Li, T., Wang, K., Huang, X., Shi, J., & Wang, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1019447 · Cited by 44
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Wu, J., Cai, H., Lei, Z., Li, C., Hu, Y., Zhang, T., Zhu, H., Lu, Y., Cao, J., & Hu, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.993592 · Cited by 41
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Huang, X., Song, Y., Wei, L., Guo, J., Xu, W., & Li, M. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109812 · Cited by 42
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Yue, F., Shi, Y., Wu, S., Lin, X., He, D., Lin, W., Qiu, A., Russell, R., & Zhang, D. (2023) · iScience · doi:10.1016/j.isci.2023.108560 · Cited by 43
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Yang, J., Sun, X., Huang, N., Li, P., He, J., Jiang, L., Zhang, X., Han, S., & Xin, H. (2022) · The FASEB Journal · doi:10.1096/fj.202200241rr · Cited by 40
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Liu, Y., Li, L., Yang, Z., Wen, D., & Hu, Z. (2022) · Journal of Oncology · doi:10.1155/2022/5228874 · Cited by 41
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Li, B., Wang, C., Lü, P., Ji, Y., Wang, X., Liu, C., Lu, X., Xu, X., & Wang, X. (2022) · Biology · doi:10.3390/biology11101392 · Cited by 40
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Guo, L. Y., Bai, S., Ding, S., Zhao, L., Xu, S., & Wang, X. (2022) · Disease Markers · doi:10.1155/2022/7098463 · Cited by 40
Retracted
Identification of key ferroptosis genes in diabetic retinopathy based on bioinformatics analysis
Huang, Y., Peng, J., & Liang, Q.-H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0280548 · Cited by 40

Authors: Qiu, Y., Cao, Y., Cao, W., Jia, Y., & Lu, N.
Affiliations: China Pharmaceutical University (CN)
University of Macau (MO)
Corresponding author: Lu, Na
ORCID: Qiu, Yangmin
Cao, Yue
Cao, Wangjia
Lu, Na
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2020-09
Volume: 159
Pages: 104919
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2020.104919
OpenAlex: W3032712286
Cited by: 415
References: 211
Citations by year: 2026: 18 · 2025: 65 · 2024: 90 · 2023: 113 · 2022: 87 · 2021: 34 · 2020: 8
FWCI: 8.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81872899,81903626)
Jiangsu Science and Technology Department (BE2018711)
Ministry of Science and Technology of the People's Republic of China (2017ZX09101003-005-023, 2017ZX09301014, 2018ZX09711001-003-007)
China Pharmaceutical University (CPU2018GY17)
Natural Science Foundation of Jiangsu Province (BK20180576)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: ferroptosis, regulated cell death, iron-dependent lipid peroxidation, iron metabolism, lipid metabolism, oxidative stress, NADPH, glutathione, coenzyme Q10, cancer, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, ferroptosis inhibitors, cytoprotection
MeSH terms: Ferroptosis, Animals, Antineoplastic Agents, Humans, Iron, Neoplasms, Lipid Peroxidation, Reactive Oxygen Species, Neuroprotective Agents, Neurodegenerative Diseases

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The Application of Ferroptosis in Diseases

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