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Cited by 347Gut microbiota and healthAlzheimer's disease research and treatmentsGastrointestinal motility and disorders

The DOI matches its Crossref record; 213 of the 213 references it cites were found in a registry or an index.

The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology

Doifode, Tejaswini, Giridharan, Vijayasree V., Generoso, Jaqueline S., Bhatti, Gursimrat, Collodel, Allan, Schulz, Paul E., Forlenza, Orestes V., Barichello, Tatiana·2021·Pharmacological Research
DOI 10.1016/j.phrs.2020.105314
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Abstract

The gut microbiota is a complex ecosystem that comprises of more than 100 trillion symbiotic microbial cells. The microbiota, the gut, and the brain form an association, 'the microbiota-gut-brain axis,' and synchronize the gut with the central nervous system and modify the behavior and brain immune homeostasis. The bidirectional communication between gut and brain occurs via the immune system, the vagus nerve, the enteric nervous system, and microbial metabolites, including short-chain fatty acids (SCFAs), proteins, and tryptophan metabolites. Recent studies have implicated the gut microbiota in many neurodegenerative diseases, including Alzheimer's disease (AD). In this review, we present an overview of gut microbiota, including Firmicutes, Bacteroidetes, SCFA, tryptophan, bacterial composition, besides age-related changes in gut microbiota composition, the microbiota-gut-brain axis pathways, the role of gut metabolites in amyloid-beta clearance, and gut microbiota modulation from experimental and clinical AD models. Understanding the role of the microbiota may provide new targets for treatment to delay the onset, progression, or reverse AD, and may help in reducing the prevalence of AD.

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Research works printed but not linked: 14

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  2. Bonfili, 2017, Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels, Sci. Rep., 7, 017, 10.1038/s41598-017-02587-2 · DOI · Paper page
  3. Bonfili, 2018, SLAB51 probiotic formulation activates SIRT1 pathway promoting antioxidant and neuroprotective effects in an AD mouse model, Mol. Neurobiol., 55, 7987, 10.1007/s12035-018-0973-4 · DOI
  4. Chen, 2017, Prebiotic effect of fructooligosaccharides from Morinda officinalis on alzheimer’s disease in rodent models by targeting the microbiota-gut-Brain Axis, Front. Aging Neurosci., 9, 10.3389/fnagi.2017.00403 · DOI · Paper page
  5. Chunchai, 2018, Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats, J. Neuroinflammation, 15, 018, 10.1186/s12974-018-1055-2 · DOI
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  7. Corpuz, 2018, Long-term diet supplementation with Lactobacillus paracasei K71 prevents age-related cognitive decline in senescence-accelerated mouse prone 8, Nutrients, 10
  8. Fleming, 2019, Dietary polydextrose and galactooligosaccharide increase exploratory behavior, improve recognition memory, and alter neurochemistry in the young pig, Nutr. Neurosci., 22, 499, 10.1080/1028415X.2017.1415280 · DOI
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  10. Möhle, 2016, Ly6C(hi) monocytes provide a link between antibiotic-induced changes in gut microbiota and adult hippocampal neurogenesis, Cell Rep., 15, 1945, 10.1016/j.celrep.2016.04.074 · DOI · Paper page
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  13. Westfall, 2019, A novel synbiotic delays Alzheimer’s disease onset via combinatorial gut-brain-axis signaling in Drosophila melanogaster, PLoS One, 14
  14. Zhan, 2018, Abnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice, Aging, 10, 1257, 10.18632/aging.101464 · DOI

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Metadata

Authors
Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T.
Affiliations
  • The University of Texas Health Science Center at Houston (US)
  • Universidade do Extremo Sul Catarinense (BR)
  • Universidade de São Paulo (BR)
Corresponding author
Barichello, Tatiana
ORCID
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2021-02
Volume
164
Pages
105314
ISSN
1043-6618 (ISSN-L)
DOI
10.1016/j.phrs.2020.105314
OpenAlex
W3107364628
Cited by
347
References
213
Citations by year
2026: 50 · 2025: 78 · 2024: 78 · 2023: 70 · 2022: 48 · 2021: 23
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Pharmacological Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • the Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), USA
  • Graduate Program in Health Sciences, University of Southern Santa Catarina
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação de Amparo à Pesquisa e Inovação de Santa Catarina
  • Alzheimer’s Association
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
microbiota-gut-brain axis, Alzheimer's disease, gut microbiota, short-chain fatty acids, tryptophan metabolites, amyloid-beta clearance, vagus nerve, enteric nervous system, neuroinflammation, Firmicutes, Bacteroidetes, gut microbiota modulation, neurodegenerative diseases
MeSH terms
Gastrointestinal Microbiome, Alzheimer Disease, Animals, Brain, Humans

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