Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
Open accessAbstract
Gut microbiota has a proven role in regulating multiple neuro-chemical pathways through the highly interconnected gut-brain axis. Oral bacteriotherapy thus has potential in the treatment of central nervous system-related pathologies, such as Alzheimer’s disease (AD). Current AD treatments aim to prevent onset, delay progression and ameliorate symptoms. In this work, 3xTg-AD mice in the early stage of AD were treated with SLAB51 probiotic formulation, thereby affecting the composition of gut microbiota and its metabolites. This influenced plasma concentration of inflammatory cytokines and key metabolic hormones considered therapeutic targets in neurodegeneration. Treated mice showed partial restoration of two impaired neuronal proteolytic pathways (the ubiquitin proteasome system and autophagy). Their cognitive decline was decreased compared with controls, due to a reduction in brain damage and reduced accumulation of amyloid beta aggregates. Collectively, our results clearly prove that modulation of the microbiota induces positive effects on neuronal pathways that are able to slow down the progression of Alzheimer’s disease.
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The 3xTg mouse model of AD treated with probiotics in the early stage showed a promising reduction of inflammatory cytokines and decreased cognitive decline associated with reduced brain damage and Aβ aggregate accumulation.
“Accordingly, the 3xTg mouse model of AD treated with probiotics in the early stage showed a promising reduction of inflammatory cytokines and decreased cognitive decline associated with reduced brain damage and Aβ aggregate accumulation (166).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [166]
Plasma ghrelin levels reduce gradually in 3xTg-AD mice with aging, which is reversed by the multi-strain probiotics formulation SLAB51, leading to attenuation of cognitive impairment.
“plasma ghrelin levels reduce gradually in 3xTg-AD mice with aging, which is reversed by the administration of multi-strain probiotics formulation (SLAB51), leading to the attenuation of cognitive impairment.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [555]
Elevation of plasma leptin levels via chronic administration of multi-strain probiotics ameliorates Aβ pathology in 3xTg-AD mice.
“the elevation of plasma leptin levels via chronic administration of multi-strain probiotics has been shown to ameliorate Aβ pathology in 3xTg-AD mice.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [555]
The probiotic SLAB51 improves cognition and reduces amyloid plaques, brain injury, and inflammatory cytokine plasma levels in AD mice.
“further, the probiotic SLAB51, a formulation of nine live bacterial strains (Streptococcus thermophilus, B. longum, B. breve, B. infantis, L. acidophilus, L. plantarum, L. paracasei, L. delbrueckii subsp. bulgaricus, and L. brevis) improves cognition and reduces the accumulation of amyloid plaques, brain injury, and inflammatory cytokines plasma levels in AD mice [322],”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [322]
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- Authors
- Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M.
- Affiliations
- Università di Camerino (IT)
- Texas A&M University (US)
- Corresponding author
- Bonfili, Laura
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-05-25
- Volume
- 7
- Issue
- 1
- Pages
- 2426-2426
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5445077
- OpenAlex
- W2615406383
- Cited by
- 453
- References
- 98
- Citations by year
- 2026: 28 · 2025: 47 · 2024: 60 · 2023: 54 · 2022: 74 · 2021: 73 · 2020: 46 · 2019: 40 · 2018: 26 · 2017: 5
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Unicam Scientific Publications (University of Camerino) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- OakTrust (Texas A&M University Libraries) (submittedVersion)
- Funders
- Università degli Studi di Camerino
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- Alzheimer's disease, gut microbiota, probiotics, gut-brain axis, 3xTg-AD mice, ubiquitin-proteasome system, autophagy, amyloid-beta, cognitive decline, inflammatory cytokines, gastrointestinal hormones, neurodegeneration
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Autophagy, Cerebral Cortex, Cognition, Disease Models, Animal, Gastrointestinal Hormones, Male, Mice, Transgenic, Neurons, Biomarkers, Cytokines, Disease Progression, Inflammation Mediators, Proteasome Endopeptidase Complex, Mice, Proteolysis, Microbiota
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