The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744

Functional interactions between the gut microbiota and host metabolism

Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387

Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781

The gut microbiota--masters of host development and physiology

Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

Gut flora in health and disease

Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,480

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315

Bacterial Community Variation in Human Body Habitats Across Space and Time

Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231

Normal gut microbiota modulates brain development and behavior

Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Agus, A., Planchais, J., & Sokol, H. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.003 · Cited by 3,180

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

Larsen, N., Vogensen, F. K., van den Berg, F. W. J., Nielsen, D. S., Andreasen, A. S., Pedersen, B. K., Al-Soud, W. A., Sørensen, S. J., Hansen, L. H., & Jakobsen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009085 · Cited by 2,952

Development of the Human Infant Intestinal Microbiota

Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877

Colonic Health: Fermentation and Short Chain Fatty Acids

Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00015 · Cited by 2,739

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677

The gut microbiota influences blood-brain barrier permeability in mice

Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409

Short-chain fatty acids in control of body weight and insulin sensitivity

Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298

Gut microbiome alterations in Alzheimer’s disease

Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137

Blood-brain barrier breakdown in the aging human hippocampus

Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.032 · Cited by 2,102

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

O’Mahony, S. M., Clarke, G., Borre, Y. E., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.027 · Cited by 2,012

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Dominy, S. S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau3333 · Cited by 1,966

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893

Alzheimer's disease

Masters, C. L., Bateman, R., Blennow, K., Rowe, C. C., Sperling, R. A., & Cummings, J. L. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.56 · Cited by 1,853

Dietary fiber and prebiotics and the gastrointestinal microbiota

Holscher, H. D. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1290756 · Cited by 1,808

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

Frost, G., Sleeth, M. L., Sahuri-Arisoylu, M., Lizarbe, B., Cerdan, S., Brody, L., Anastasovska, J., Ghourab, S., Hankir, M., Zhang, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4611 · Cited by 1,771

The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754

Epidemiology of Alzheimer disease

Reitz, C., Brayne, C., & Mayeux, R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.2 · Cited by 1,675

The interplay between the intestinal microbiota and the brain

Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Platten, M., Nollen, E. A. A., Röhrig, U. F., Fallarino, F., & Opitz, C. A. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0016-5 · Cited by 1,586

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Rothhammer, V., Mascanfroni, I. D., Bunse, L., Takenaka, M. C., Kenison, J. E., Mayo, L., Chao, C.-C., Patel, B., Yan, R., Blain, M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4106 · Cited by 1,559

Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

Odamaki, T., Kato, K., Sugahara, H., Hashikura, N., Takahashi, S., Xiao, J.-Z., Abe, F., & Osawa, R. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0708-5 · Cited by 1,521

Gut/brain axis and the microbiota

Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503

Antibiotics, birth mode, and diet shape microbiome maturation during early life

Bokulich, N. A., Chung, J., Battaglia, T., Henderson, N., Jay, M., Li, H., D. Lieber, A., Wu, F., Perez-Perez, G. I., Chen, Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7121 · Cited by 1,469

The pros, cons, and many unknowns of probiotics

Suez, J., Zmora, N., Segal, E., & Elinav, E. (2019) · Nature Medicine · doi:10.1038/s41591-019-0439-x · Cited by 1,398

Reduced anxiety-like behavior and central neurochemical change in germ-free mice: Behavior in germ-free mice

Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Cattaneo, A., Cattane, N., Galluzzi, S., Provasi, S., Lopizzo, N., Festari, C., Ferrari, C., Guerra, U. P., Paghera, B., Muscio, C., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.019 · Cited by 1,382

Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health

Cervenka, I., Agudelo, L. Z., & Ruas, J. L. (2017) · Science · doi:10.1126/science.aaf9794 · Cited by 1,382

The gut microbiome in neurological disorders

Cryan, J. F., O'Riordan, K. J., Sandhu, K., Peterson, V., & Dinan, T. G. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30356-4 · Cited by 1,336

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

Reigstad, C. S., Salmonson, C. E., III, J. F. R., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., & Kashyap, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259598 · Cited by 1,335

Gut microbiota and aging

O’Toole, P. W., & Jeffery, I. B. (2015) · Science · doi:10.1126/science.aac8469 · Cited by 1,202

The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

Rothhammer, V., & Quintana, F. J. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0125-8 · Cited by 1,197

Minireview: Gut microbiota: The neglected endocrine organ

Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192

Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189

Serotonin signalling in the gut: functions, dysfunctions and therapeutic targets

Mawe, G. M., & Hoffman, J. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.105 · Cited by 1,165

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

Unger, M. M., Spiegel, J., Dillmann, K.-U., Grundmann, D., Philippeit, H., Bürmann, J., Faßbender, K., Schwiertz, A., & Schäfer, K.-H. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.08.019 · Cited by 1,159

γ-Aminobutyric acid production by culturable bacteria from the human intestine

Barrett, E., Ross, R. P., O'Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05344.x · Cited by 1,156

Enterotypes in the landscape of gut microbial community composition

Costea, P. I., Hildebrand, F., Arumugam, M., Bäckhed, F., Blaser, M. J., Bushman, F. D., de Vos, W. M., Ehrlich, S. D., Fraser, C. M., Hattori, M., et al. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0072-8 · Cited by 1,138

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4

Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.014 · Cited by 1,066

Indole as an intercellular signal in microbial communities

Lee, J.-H., & Lee, J. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2009.00204.x · Cited by 1,059

Correlation between the human fecal microbiota and depression

Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044

The Intestinal Microbiome in Early Life: Health and Disease

Arrieta, M.-C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., & Finlay, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00427 · Cited by 1,024

Role of Glutamate and NMDA Receptors in Alzheimer’s Disease

Wang, R., & Reddy, P. H. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160763 · Cited by 1,009

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months

Azad, M. B., Konya, T., Maughan, H., Guttman, D. S., Field, C. J., Chari, R. S., Sears, M. R., Becker, A. B., Scott, J. A., & Kozyrskyj, A. L. (2013) · Canadian Medical Association Journal · doi:10.1503/cmaj.121189 · Cited by 989

Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice

Burokas, A., Arboleya, S., Moloney, R. D., Peterson, V. L., Murphy, K., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.031 · Cited by 952

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946

Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600549103 · Cited by 912

Bacterial infection causes stress-induced memory dysfunction in mice

Gareau, M. G., Wine, E., Rodrigues, D. M., Cho, J. H., Whary, M. T., Philpott, D. J., MacQueen, G., & Sherman, P. M. (2011) · Gut · doi:10.1136/gut.2009.202515 · Cited by 909

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

Harach, T., Marungruang, N., Duthilleul, N., Cheatham, V., Mc Coy, K. D., Frisoni, G., Neher, J. J., Fåk, F., Jucker, M., Lasser, T., et al. (2017) · Scientific Reports · doi:10.1038/srep41802 · Cited by 901

Lactobacillus reuteri induces gut intraepithelial CD4 + CD8αα + T cells

Cervantes-Barragan, L., Chai, J. N., Tianero, M. D., Di Luccia, B., Ahern, P. P., Merriman, J., Cortez, V. S., Caparon, M. G., Donia, M. S., Gilfillan, S., et al. (2017) · Science · doi:10.1126/science.aah5825 · Cited by 896

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

Bell, R. D., & Zloković, B. V. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0522-3 · Cited by 883

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

Bansal, T., Alaniz, R. C., Wood, T. K., & Jayaraman, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906112107 · Cited by 868

Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804

GPR109A Is a G-protein–Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4466 · Cited by 789

Dynamics and stabilization of the human gut microbiome during the first year of life

Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.05.012 · Cited by 738

Intestinal microbiota in human health and disease: the impact of probiotics

Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0229-7 · Cited by 724

History and progress of hypotheses and clinical trials for Alzheimer’s disease

Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723

Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factorα Signaling during Peripheral Organ Inflammation

D'Mello, C., Le, T., & Swain, M. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-08.2009 · Cited by 675

Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract

Monteleone, I., Rizzo, A., Sarra, M., Sica, G., Sileri, P., Biancone, L., MacDonald, T. T., Pallone, F., & Monteleone, G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.007 · Cited by 656

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., et al. (2016) · Scientific Reports · doi:10.1038/srep30028 · Cited by 655

The bowel and beyond: The enteric nervous system in neurological disorders

Rao, M., & Gershon, M. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.107 · Cited by 629

Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats

Crumeyrolle-Arias, M., Jaglin, M., Bruneau, A., Vancassel, S., Cardona, A., Daugé, V., Naudon, L., & Rabot, S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.01.014 · Cited by 581

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

Kimura, A., Naka, T., Nohara, K., Fujii‐Kuriyama, Y., & Kishimoto, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804231105 · Cited by 561

Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells

Chimerel, C., Emery, E., Summers, D. K., Keyser, U., Gribble, F. M., & Reimann, F. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.032 · Cited by 548

Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice

Sun, J., Xu, J., Ling, Y., Wang, F., Gong, T., Yang, C., Ye, S., Ye, K., Wei, D., Song, Z., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0525-3 · Cited by 532

Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions

Zhang, L., & Davies, S. S. (2016) · Genome Medicine · doi:10.1186/s13073-016-0296-x · Cited by 521

Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

Stevens, B. R., Goel, R., Seungbum, K., Richards, E. M., Holbert, R. C., Pepine, C. J., & Raizada, M. K. (2018) · Gut · doi:10.1136/gutjnl-2017-314759 · Cited by 508

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

Ge, H., Li, X., Weiszmann, J., Wang, P., Baribault, H., Chen, J., Tian, H., & Li, Y. (2008) · Endocrinology · doi:10.1210/en.2008-0059 · Cited by 503

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496

Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

Thomas, C. M., Hong, T., van Pijkeren, J. P., Hemarajata, P., Trinh, D. V., Hu, W., Britton, R. A., Kalkum, M., & Versalovic, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031951 · Cited by 491

Short-chain fatty acids manifest stimulative and protective effects on intestinal barrier function through the inhibition of NLRP3 inflammasome and autophagy

Feng, Y., Wang, Y., Wang, P., Huang, Y., & Wang, F. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000492853 · Cited by 471

Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis

Möhle, L., Mattei, D., Heimesaat, M. M., Bereswill, S., Fischer, A., Alutis, M., French, T., Hambardzumyan, D., Matzinger, P., Dunay, I. R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.074 · Cited by 470

Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review

Indiani, C. M. D. S. P., Rizzardi, K. F., Castelo, P. M., Ferraz, L. F. C., Darrieux, M., & Parisotto, T. M. (2018) · Childhood Obesity · doi:10.1089/chi.2018.0040 · Cited by 460

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

Mascanfroni, I. D., Takenaka, M. C., Yeste, A., Patel, B., Wu, Y., Kenison, J. E., Siddiqui, S., Basso, A. S., Otterbein, L. E., Pardoll, D. M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3868 · Cited by 457

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02587-2 · Cited by 453

Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

Zhang, L., Wang, Y., Xiayu, X., Shi, C., Chen, W., Song, N., Fu, X., Zhou, R., Xu, Y.-F., Huang, L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170020 · Cited by 449

Synthesis of γ-Aminobutyric Acid by Lactic Acid Bacteria Isolated from a Variety of Italian Cheeses

Siragusa, S., De Angelis, M., Di Cagno, R., Rizzello, C. G., Coda, R., & Gobbetti, M. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01064-07 · Cited by 438

Pathogens Penetrating the Central Nervous System: Infection Pathways and the Cellular and Molecular Mechanisms of Invasion

Dando, S. J., Mackay-Sim, A., Norton, R., Currie, B. J., St. John, J. A., Ekberg, J. A. K., Batzloff, M., Ulett, G. C., & Beacham, I. R. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00118-13 · Cited by 428

Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer's disease: A randomized, double-blind, controlled trial

Tamtaji, O. R., Heidari‐Soureshjani, R., Mirhosseini, N. Z., Kouchaki, E., Bahmani, F., Aghadavod, E., Ebrahimi, M. T., & Asemi, Z. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.11.034 · Cited by 416

Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder

Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2167-7 · Cited by 412

Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer’s disease

Kobayashi, Y., Sugahara, H., Shimada, K., Mitsuyama, E., Kuhara, T., Yasuoka, A., Kondo, T., Abe, K., & Xiao, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-13368-2 · Cited by 411

Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid

Chyan, Y., Pöeggeler, B., Omar, R., Chain, D. G., Frangione, B., Ghiso, J. A., & Pappolla, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21937 · Cited by 409

Structure and function of the healthy pre-adolescent pediatric gut microbiome

Hollister, E. B., Riehle, K., Luna, R. A., Weidler, E. M., Rubio-Gonzales, M., Mistretta, T.-A., Raza, S., Doddapaneni, H. V., Metcalf, G. A., Muzny, D. M., et al. (2015) · Microbiome · doi:10.1186/s40168-015-0101-x · Cited by 406

Commensal bacteria-dependent indole production enhances epithelial barrier function in the colon

Shimada, Y., Kinoshita, M., Harada, K., Mizutani, M., Masahata, K., Kayama, H., & Takeda, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080604 · Cited by 404

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S. G., Patterson, A. D., & Perdew, G. H. (2015) · Scientific Reports · doi:10.1038/srep12689 · Cited by 377

Incidence of Alzheimer Disease in a Biracial Urban Community: Relation to Apolipoprotein E Allele Status

Evans, D. A., Bennett, D. A., Wilson, R. S., Bienias, J. L., Morris, M. C., Scherr, P. A., Hebert, L. E., Aggarwal, N., Beckett, L. A., Joglekar, R., et al. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.185 · Cited by 370

Bifidobacteria modulate cognitive processes in an anxious mouse strain

Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365

Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort study

Chen, C.-K., Wu, Y.-T., & Chang, Y.-C. (2017) · Alzheimer's Research & Therapy · doi:10.1186/s13195-017-0282-6 · Cited by 359

Distal gut microbiota of adolescent children is different from that of adults: Gut microbiota of adolescents differs from that of adults

Agans, R., Rigsbee, L., Kenche, H., Michail, S., Khamis, H. J., & Paliy, O. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01120.x · Cited by 343

Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration

Friedland, R. P. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142841 · Cited by 338

Can oral bacteria affect the microbiome of the gut?

Olsen, I., & Yamazaki, K. (2019) · Journal of Oral Microbiology · doi:10.1080/20002297.2019.1586422 · Cited by 328

Intestinal microbiota influence the early postnatal development of the enteric nervous system

Collins, J., Borojevic, R., Verdu, E. F., Huizinga, J. D., & Ratcliffe, E. M. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12236 · Cited by 318

Kynurenines in the CNS: from endogenous obscurity to therapeutic importance

Stone, T. W. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00032-0 · Cited by 306

Effect of Clostridium butyricum against Microglia‐Mediated Neuroinflammation in Alzheimer's Disease via Regulating Gut Microbiota and Metabolites Butyrate

Sun, J., Xu, J., Yang, B., Chen, K., Kong, Y., Fang, N., Gong, T., Wang, F., Ling, Z., & Liu, J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900636 · Cited by 302

Bacteroides fragilis Lipopolysaccharide and Inflammatory Signaling in Alzheimer’s Disease

Lukiw, W. J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01544 · Cited by 294

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

Dodiya, H. B., Kuntz, T., Shaik, S. M., Baufeld, C., Leibowitz, J., Zhang, X., Gottel, N., Zhang, X., Butovsky, O., Gilbert, J. A., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182386 · Cited by 288

SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model

Bonfili, L., Cecarini, V., Cuccioloni, M., Angeletti, M., Berardi, S., Scarpona, S., Rossi, G., & Eleuteri, A. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0973-4 · Cited by 282

HDAC inhibitor sodium butyrate-mediated epigenetic regulation enhances neuroprotective function of microglia during ischemic stroke

Patnala, R., Arumugam, T. V., Gupta, N., & Dheen, S. T. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0149-z · Cited by 278

Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats

Chunchai, T., Thunapong, W., Yasom, S., Wanchai, K., Eaimworawuthikul, S., Metzler, G., Lungkaphin, A., Pongchaidecha, A., Sirilun, S., Chaiyasut, C., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1055-2 · Cited by 277

Periodontal disease associates with higher brain amyloid load in normal elderly

Kamer, A. R., Pirraglia, E., Tsui, W., Rusinek, H., Vallabhajosula, S., Mosconi, L., Li, Y., McHugh, P. F., Craig, R. G., Svetcov, S., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.10.038 · Cited by 276

Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice

Kibe, R., Kurihara, S., Sakai, Y., Suzuki, H., Ooga, T., Sawaki, E., Muramatsu, K., Nakamura, A., Yamashita, A., Kitada, Y., et al. (2014) · Scientific Reports · doi:10.1038/srep04548 · Cited by 273

Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study

Leblhuber, F., Steiner, K., Schuetz, B., Fuchs, D., & Gostner, J. M. (2018) · Current Alzheimer Research · doi:10.2174/1389200219666180813144834 · Cited by 269

Efficacy and Safety of Lactobacillus Plantarum C29-Fermented Soybean (DW2009) in Individuals with Mild Cognitive Impairment: A 12-Week, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Hwang, Y., Park, S., Paik, J., Chae, S., Kim, D., Jeong, D., Ha, E., Kim, M., Hong, G., Park, S., et al. (2019) · Nutrients · doi:10.3390/nu11020305 · Cited by 263

Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota

Ni, Y., Yang, X., Zheng, L., Wang, Z., Wu, L., Jiang, J., Yang, T., Ma, L., & Fu, Z. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900603 · Cited by 255

The role of the microbiota-gut-brain axis in neuropsychiatric disorders

Generoso, J. S., Giridharan, V. V., Lee, J., Macêdo, D. S., & Barichello, T. (2020) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-0987 · Cited by 250

Does Severity of Alzheimer's Disease Contribute to Its Responsiveness to Modifying Gut Microbiota? A Double Blind Clinical Trial

Agahi, A., Hamidi, G. A., Kakhaki, R. D., Hamdieh, M., Soheili, M., Alinaghipour, A., Taba, S. M. E., & Salami, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00662 · Cited by 248

Cathepsin B plays a critical role in inducing Alzheimer’s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice

Wu, Z., Ni, J., Liu, Y., Teeling, J. L., Takayama, F., Collcutt, A. W., Ibbett, P., & Nakanishi, H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.002 · Cited by 246

Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects

Al-Lahham, S., Roelofsen, H., Rezaee, F., Weening, D., Hoek, A., Vonk, R. J., & Venema, K. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02590.x · Cited by 241

Anti-Alzheimer Properties of Probiotic, Lactobacillus plantarum MTCC 1325 in Alzheimer’s Disease induced Albino Rats

Nimgampalle, M. (2017) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2017/26106.10428 · Cited by 241

Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory/excitatory genes in the frontal cortex of an autism model

Kratsman, N., Getselter, D., & Elliott, E. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.003 · Cited by 239

A Clinician's Primer on the Role of the Microbiome in Human Health and Disease

Khanna, S., & Tosh, P. K. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.011 · Cited by 237

Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP

Distrutti, E., O’Reilly, J.-A., McDonald, C., Cipriani, S., Renga, B., Lynch, M. A., & Fiorucci, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106503 · Cited by 237

Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats

Wang, T., Hu, X., Liang, S., Li, W., Wu, X., Wang, L., & Jin, F. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0177 · Cited by 233

Tryptophan availability for kynurenine pathway metabolism across the life span: Control mechanisms and focus on aging, exercise, diet and nutritional supplements

Badawy, A. A. ‐. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.015 · Cited by 228

Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis

Chen, D., Yang, X., Yang, J., Lai, G., Yong, T., Tang, X., Shuai, O., Zhou, G., Xie, Y., & Wu, Q. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00403 · Cited by 227

Analysis of the relationship between the gut microbiome and dementia: a cross-sectional study conducted in Japan

Saji, N., Niida, S., Murotani, K., Hisada, T., Tsuduki, T., Sugimoto, T., Kimura, A., Toba, K., & Sakurai, T. (2019) · Scientific Reports · doi:10.1038/s41598-018-38218-7 · Cited by 224

Microbial endocrinology: Host-microbiota neuroendocrine interactions influencing brain and behavior

Lyte, M. (2014) · Gut Microbes · doi:10.4161/gmic.28682 · Cited by 217

Microbe-host interactions: influence of the gut microbiota on the enteric nervous system

Hyland, N. P., & Cryan, J. F. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.06.027 · Cited by 207

Biosynthetic Manipulation of Tryptophan in Bacteria: Pathways and Mechanisms

Alkhalaf, L. M., & Ryan, K. S. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.02.005 · Cited by 206

Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells

Marinelli, L., Martin‐Gallausiaux, C., Bourhis, J., Béguet-Crespel, F., Blottière, H. M., & Lapaque, N. (2019) · Scientific Reports · doi:10.1038/s41598-018-37019-2 · Cited by 198

Fuel utilization in colonocytes of the rat

Ardawi, M. S., & Newsholme, E. A. (1985) · Biochemical Journal · doi:10.1042/bj2310713 · Cited by 195

GABAergic Function in Alzheimer's Disease: Evidence for Dysfunction and Potential as a Therapeutic Target for the Treatment of Behavioural and Psychological Symptoms of Dementia

Lanctôt, K. L., Herrmann, N., Mazzotta, P., Khan, L. R., & Ingber, N. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900705 · Cited by 191

Periodontitis and Alzheimer’s Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation

Teixeira, F. B., Saito, M. T., MATHEUS, F. C., Prediger, R. D., Yamada, E. S., Maia, C. D. S. F., & Lima, R. R. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00327 · Cited by 189

Probiotics Improve Inflammation-Associated Sickness Behavior by Altering Communication between the Peripheral Immune System and the Brain

D'Mello, C., Ronaghan, N., Zaheer, R., Dicay, M., Le, T., MacNaughton, W. K., Surrette, M. G., & Swain, M. G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0575-15.2015 · Cited by 187

Indole‐3‐propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus

Hwang, I. K., Yoo, K., Li, H., Park, O. K., Lee, C. H., Choi, J. H., Jeong, Y., Lee, Y. L., Kim, Y., Kwon, Y., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22030 · Cited by 186

Acid Resistance in Escherichia coli

Richard, H. T., & Foster, J. W. (2003) · Advances in Applied Microbiology · doi:10.1016/s0065-2164(03)01007-4 · Cited by 178

Prolonged elevation in hippocampal Aβ and cognitive deficits following repeated endotoxin exposure in the mouse

Kahn, M. S., Kranjac, D., Alonzo, C. A., Haase, J. H., Cedillos, R. O., McLinden, K. A., Boehm, G. W., & Chumley, M. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.01.010 · Cited by 177

Abnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice

Zhan, G., Yang, N., Li, S., Huang, N., Fang, X., Zhang, J., Zhu, B., Yang, L., Yang, C., & Luo, A. (2018) · Aging · doi:10.18632/aging.101464 · Cited by 175

Amine neuromediators, their precursors, and oxidation products in the culture of Escherichia coli k-12

Shishov, V. A., Kirovskaya, T. A., Kudrin, V. S., & Oleskin, A. V. (2009) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683809050068 · Cited by 174

Obesity Alters the Microbial Community Profile in Korean Adolescents

Hu, H., Park, S.-G., Jang, H. B., Choi, M.-G., Park, K., Kang, J., Park, S. I., Lee, H.-J., & Cho, S.-H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134333 · Cited by 172

Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community

Lim, E. S., Rodríguez, C., & Holtz, L. R. (2018) · Microbiome · doi:10.1186/s40168-018-0475-7 · Cited by 170

Examining the Role of the Microbiota-Gut-Brain Axis in Stroke

Durgan, D. J., Lee, J., McCullough, L. D., & Bryan, R. M. (2019) · Stroke · doi:10.1161/strokeaha.119.025140 · Cited by 169

Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children

Cheng, J., Ringel‐Kulka, T., Jong, I. H., Ringel, Y., Carroll, I. M., de Vos, W. M., Salojärvi, J., & Satokari, R. M. (2015) · The ISME Journal · doi:10.1038/ismej.2015.177 · Cited by 167

Detection of neurotransmitter amines in microorganisms with the use of high-performance liquid chromatography.

Tsavkelova, E. A., Botvinko, I. V., Кудрин, В. С., & Oleskin, A. V. (2000) · PubMed · Cited by 162

The relationship between the gut microbiome and mild cognitive impairment in patients without dementia: a cross-sectional study conducted in Japan

Saji, N., Murotani, K., Hisada, T., Tsuduki, T., Sugimoto, T., Kimura, A., Niida, S., Toba, K., & Sakurai, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-55851-y · Cited by 161

The enteric nervous system promotes intestinal health by constraining microbiota composition

Rolig, A. S., Mittge, E. K., Ganz, J., Troll, J. V., Melancon, E., Wiles, T. J., Alligood, K., Stephens, W. Z., Eisen, J. S., & Guillemin, K. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2000689 · Cited by 152

The vagus nerve modulates BDNF expression and neurogenesis in the hippocampus

O’Leary, O. F., Ogbonnaya, E. S., Felice, D., Levone, B. R., C. Conroy, L., Fitzgerald, P., Bravo, J. A., Forsythe, P., Bienenstock, J., Dinan, T. G., et al. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.12.004 · Cited by 151

Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD).

Zhao, Y., & Lukiw, W. J. (2015) · PubMed · Cited by 149

Fructooligosaccharides Ameliorating Cognitive Deficits and Neurodegeneration in APP/PS1 Transgenic Mice through Modulating Gut Microbiota

Sun, J., Liu, S., Ling, Z., Wang, F., Ling, Y., Gong, T., Fang, N., Ye, S., Si, J., & Liu, J. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b07313 · Cited by 148

Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

de J.R. De-Paula, V., Forlenza, A. S., & Forlenza, O. V. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.07.007 · Cited by 145

Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice

Smith, C. J., Emge, J. R., Berzins, K., Lung, L., Khamishon, R., Shah, P., Rodrigues, D. M., Sousa, A. J., Reardon, C., Sherman, P. M., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00238.2014 · Cited by 143

Topical butyrate for acute radiation proctitis: randomised, crossover trial

Vernia, P., Fracasso, P., Casale, V., Villotti, G., Marcheggiano, A., Stigliano, V., Pinnarò, P., Bagnardi, V., & Caprilli, R. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02787-2 · Cited by 139

Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells

Jin, U.-H., Cheng, Y., Park, H., Davidson, L. A., Callaway, E. S., Chapkin, R. S., Jayaraman, A., Asante, A., Allred, C. D., Weaver, E. A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10824-x · Cited by 137

Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model

Hoffman, J. D., Yanckello, L. M., Chlipala, G. E., Hammond, T. C., McCulloch, S. D., Parikh, I. J., Sun, S., Morganti, J. M., Green, S. J., & Lin, A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221828 · Cited by 137

Fecal metabolite of a gnotobiotic mouse transplanted with gut microbiota from a patient with Alzheimer’s disease

Fujii, Y., Nguyen, T. T. T., Fujimura, Y., Kameya, N., Nakamura, S., Arakawa, K., & Morita, H. (2019) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2019.1644149 · Cited by 135

Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice

Wang, Q., Shen, Y., Wang, X., Fu, S., Zhang, X., Zhang, Y., & Wang, R. (2020) · Aging · doi:10.18632/aging.102645 · Cited by 135

The Gut-Microglia Connection: Implications for Central Nervous System Diseases

Wang, Y., Wang, Z., Wang, Y., Li, F., Jia, J., Song, X., Qin, S., Wang, R., Jin, F., Kitazato, K., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02325 · Cited by 130

Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity

Spitzer, P., Condic, M., Herrmann, M., Oberstein, T. J., Scharin-Mehlmann, M., Gilbert, D. F., Friedrich, O., Grömer, T., Kornhuber, J., Lang, R., et al. (2016) · Scientific Reports · doi:10.1038/srep32228 · Cited by 128

Bifidobacterium Breve A1 Supplementation Improved Cognitive Decline in Older Adults with Mild Cognitive Impairment: An Open-Label, Single-Arm Study

Kobayashi, Y., Kinoshita, T., Matsumoto, A., Yoshino, K., Saito, I., & Xiao, J. (2019) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2018.32 · Cited by 126

Antibiotic-induced dysbiosis of the microbiota impairs gut neuromuscular function in juvenile mice

Caputi, V., Marsilio, I., Filpa, V., Cerantola, S., Orso, G., Bistoletti, M., Paccagnella, N., De Martin, S., Montopoli, M., Dall'Acqua, S., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13965 · Cited by 124

Stress matters: randomized controlled trial on the effect of probiotics on neurocognition

Papalini, S., Michels, F., Kohn, N., Wegman, J., van Hemert, S., Roelofs, K., Arias-Vasquez, A., & Aarts, E. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.100141 · Cited by 123

Microbiota modulation as preventative and therapeutic approach in Alzheimer’s disease

Bonfili, L., Cecarini, V., Gogoi, O., Gong, C., Cuccioloni, M., Angeletti, M., Rossi, G., & Eleuteri, A. M. (2020) · FEBS Journal · doi:10.1111/febs.15571 · Cited by 123

Gut changes attributed to ageing: effects on intestinal microflora

Hébuterne, X. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200301000-00008 · Cited by 120

A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer’s Disease

Sun, M., Ma, K., Wen, J., Wang, G., Zhang, C., Li, Q., Bao, X., & Wang, H. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190872 · Cited by 113

Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress

Vodička, M., Ergang, P., Hrnčíř, T., Mikulecká, A., Kvapilová, P., Vagnerová, K., Šestáková, B., Fajstová, A., Hermanová, P., Hudcovic, T., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.007 · Cited by 112

Effects of Oligosaccharides From Morinda officinalis on Gut Microbiota and Metabolome of APP/PS1 Transgenic Mice

Yang, X., Diling, C., Yang, J. T., Ting, L., Guoyan, H., Hualun, L., Xiaocui, T., Lai, G., Shuai, O., Chaoqun, Z., et al. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00412 · Cited by 110

Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer’s disease

Cui, B., Su, D., Li, W., She, X., Zhang, M., Wang, R., & Zhai, Q. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1223-4 · Cited by 108

Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice

Arnoldussen, I. A. C., Wiesmann, M., Pelgrim, C. E., Wielemaker, E. M., van Duyvenvoorde, W., Amaral-Santos, P. L., Verschuren, L., Keijser, B. J. F., Heerschap, A., Kleemann, R., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.52 · Cited by 101

Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice

Huang, S., Chen, L., Wang, M.-F., Hsu, C.-C., Chan, C.-H., Li, J.-X., & Huang, H.-Y. (2018) · Nutrients · doi:10.3390/nu10070894 · Cited by 100

A novel synbiotic delays Alzheimer’s disease onset via combinatorial gut-brain-axis signaling in Drosophila melanogaster

Westfall, S., Lomis, N., & Prakash, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214985 · Cited by 100

Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats

O’Hagan, C., Li, J. V., Marchesi, J. R., Plummer, S. F., Garaiová, I., & Good, M. A. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.05.015 · Cited by 98

Kynurenine pathway metabolism and immune activation: Peripheral measurements in psychiatric and co-morbid conditions

Strasser, B., Becker, K., Fuchs, D., & Gostner, J. M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.030 · Cited by 97

Probiotics and Prebiotics as a Therapeutic Strategy to Improve Memory in a Model of Middle-Aged Rats

Romo-Araiza, A., Gutiérrez-Salmeán, G., Galván, E. J., Hernández-Frausto, M., Herrera-López, G., Romo-Parra, H., García-Contreras, V., Fernández-Presas, A. M., Jasso-Chávez, R., Borlongan, C. V., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00416 · Cited by 93

Toll like receptor-2 regulates production of glial-derived neurotrophic factors in murine intestinal smooth muscle cells

Brun, P., Gobbo, S., Caputi, V., Spagnol, L., Schirato, G., Pasqualin, M., Levorato, E., Palù, G., Giron, M. C., & Castagliuolo, I. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.03.018 · Cited by 92

β-Amyloid or its precursor protein is found in epithelial cells of the small intestine and is stimulated by high-fat feeding

Galloway, S., Jian, L., Johnsen, R. D., Chew, S., & Mamo, J. C. L. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.07.003 · Cited by 91

Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia

Lim, J. S., Lim, M. Y., Choi, Y., & Ko, G. (2017) · Molecular Brain · doi:10.1186/s13041-017-0292-0 · Cited by 89

Overexpression of Mutant Amyloid-β Protein Precursor and Presenilin 1 Modulates Enteric Nervous System

Puig, K. L., Lutz, B. M., Urquhart, S. A., Rebel, A. A., Zhou, X., Manocha, G. D., Sens, M. A., Tuteja, A. K., Foster, N. L., & Combs, C. K. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142259 · Cited by 80

Long-Term Diet Supplementation with Lactobacillus paracasei K71 Prevents Age-Related Cognitive Decline in Senescence-Accelerated Mouse Prone 8

Corpuz, H. M., Ichikawa, S., Arimura, M., Mihara, T., Kumagai, T., Mitani, T., Nakamura, S., & Katayama, S. (2018) · Nutrients · doi:10.3390/nu10060762 · Cited by 79

Bacillus Subtilis Delays Neurodegeneration and Behavioral Impairment in the Alzheimer’s Disease Model Caenorhabditis Elegans

Cogliati, S., Clementi, V., Francisco, M., Crespo, C., Argañaraz, F., & Grau, R. R. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190837 · Cited by 79

Lactobacillus probiotics improved the gut microbiota profile of a Drosophila melanogaster Alzheimer’s disease model and alleviated neurodegeneration in the eye

Tan, F. H. P., Liu, G., Lau, S.-Y. A., Jaafar, M. H., Park, Y.-H., Azzam, G., Li, Y., & Liong, M. (2020) · Beneficial Microbes · doi:10.3920/bm2019.0086 · Cited by 79

Fecal zonulin is elevated in Crohn’s disease and in cigarette smokers

Malíčková, K., Francová, I., Lukáš, M., Kolář, M., Králíková, E., Bortlík, M., Ďuricová, D., Štěpánková, L., Zvolská, K., Pánková, A., et al. (2017) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2017.09.001 · Cited by 78

Oral sodium butyrate impacts brain metabolism and hippocampal neurogenesis, with limited effects on gut anatomy and function in pigs

Val‐Laillet, D., Guérin, S., Coquery, N., Nogret, I., Formal, M., Rome, V., Normand, L. L., Meurice, P., Randuineau, G., Guilloteau, P., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700547rr · Cited by 75

Promising effects of neurorestorative diets on motor, cognitive, and gastrointestinal dysfunction after symptom development in a mouse model of Parkinson's disease

Perez-Pardo, P., de Jong, E. M., Broersen, L. M., van Wijk, N., Attali, A., Garssen, J., & Kraneveld, A. D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00057 · Cited by 74

Histamine receptor 2 is a key influence in immune responses to intestinal histamine-secreting microbes

Ferstl, R., Frei, R., Schiavi, E., Konieczna, P., Barcik, W., Ziegler, M., Lauener, R. P., Chassard, C., Lacroix, C., Akdis, C. A., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.04.034 · Cited by 70

Anti-inflammaging effects of Lactobacillus brevis OW38 in aged mice

Jeong, J.-J., Kim, K. A., Hwang, Y., Han, M. J., & Kim, D.-H. (2016) · Beneficial Microbes · doi:10.3920/bm2016.0016 · Cited by 69

Infection-Induced Systemic Inflammation Is a Potential Driver of Alzheimer's Disease Progression

Giridharan, V. V., Masud, F. N., Petronilho, F. C., Dal‐Pizzol, F., & Barichello, T. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00122 · Cited by 68

Bugging inflammation: role of the gut microbiota

Shen, S., & Wong, C. H. Y. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.12 · Cited by 67

Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice

Fan, Y., Han, W., Zhan, G., Li, S., Xiang, S., Zhu, B., Jiang, X., Yang, L., Luo, A., Hua, F., et al. (2019) · Aging · doi:10.18632/aging.101978 · Cited by 66

Improving effect of a probiotic mixture on memory and learning abilities in d-galactose–treated aging mice

Ho, S., Hsieh, Y.-T., Wang, S., & Chen, M. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-15811 · Cited by 64

Dietary polydextrose and galactooligosaccharide increase exploratory behavior, improve recognition memory, and alter neurochemistry in the young pig

Fleming, S. A., Monaikul, S., Patsavas, A. J., Waworuntu, R. V., Berg, B. M., & Dilger, R. N. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1415280 · Cited by 61

Hippocampal activation of 5‐HT1B receptors and BDNF production by vagus nerve stimulation in rats under chronic restraint stress

Shin, H. C., Jo, B. G., Lee, C., Lee, K., & Namgung, U. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14368 · Cited by 56

Gamma-aminobutyric acid acts as a specific virulence regulator in Pseudomonas aeruginosa

Dagorn, A., Hillion, M., Chapalain, A., Lesouhaitier, O., Duclairoir Poc, C., Vieillard, J., Chevalier, S., Taupin, L., Le Derf, F., & Feuilloley, M. G. J. (2013) · Microbiology · doi:10.1099/mic.0.061267-0 · Cited by 51

Chronic Psychosocial Stress and Gut Health in Children: Associations With Calprotectin and Fecal Short-Chain Fatty Acids

Michels, N., Van de Wiele, T., & De Henauw, S. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000413 · Cited by 47

Amyloid-β colocalizes with apolipoprotein B in absorptive cells of the small intestine

Galloway, S., Takechi, R., Pallebage‐Gamarallage, M. M., Dhaliwal, S. S., & Mamo, J. C. L. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-46 · Cited by 45

Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health

Stevens, M. J. (2010) · Cited by 42

Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343

The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment

Varesi, A., Pierella, E., Romeo, M., Piccini, G. B., Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., et al. (2022) · Nutrients · doi:10.3390/nu14030668 · Cited by 225

Understanding the Gut–Brain Axis and Its Therapeutic Implications for Neurodegenerative Disorders

Zheng, Y., Bonfili, L., Wei, T., & Eleuteri, A. M. (2023) · Nutrients · doi:10.3390/nu15214631 · Cited by 175

Gut microbiota-driven neuroinflammation in Alzheimer's disease: from mechanisms to therapeutic opportunities

Lei, W., Cheng, Y., Liu, X., Gao, J., Zhu, Z., Ding, W., Xu, X., Li, Y., Ling, Z., Jiang, R., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1582119 · Cited by 68

Short Chain Fatty Acids Protect the Cognitive Function of Sepsis Associated Encephalopathy Mice via GPR43

Liao, H., Li, H., Bao, H., Jiang, L., Du, J., Guo, Y., & Si, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.909436 · Cited by 55

GAMBARAN KOMPOSISI FILUM FIRMICUTES DAN BACTEROIDETES PADA OBESITAS (STUDI LITERATUR)

Agustina, D., Mutiyani, M., Suparman, S., & Mulyo, G. P. E. (2022) · Jurnal Kesehatan Siliwangi · doi:10.34011/jks.v2i3.889

RATIO OF MAIN PHYLOTYPES OF GUT MICROBIOTA IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE DEPENDING ON THE BODY MASS INDEX

Fadieienko, G. D., Черелюк, Н. І., & Gal'chinskaya, V. Y. (2021) · Wiadomości Lekarskie · doi:10.36740/wlek202103126 · Cited by 4

DIETARY FACTORS AFFECTING FIRMICUTES AND BACTEROIDETES RATIO IN SOLVING OBESITY PROBLEM: A LITERATURE REVIEW

Sutoyo, D. A. R., Atmaka, D. R., & Sidabutar, L. M. G. B. (2020) · Media Gizi Indonesia · doi:10.20473/mgi.v15i2.94-109 · Cited by 27

Development of a real-time PCR method forFirmicutesandBacteroidetesin faeces and its application to quantify intestinal population of obese and lean pigs

Guo, X., Xia, X., Tang, R., Zhou, J., Zhao, H., & Wang, K. (2008) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2008.02408.x · Cited by 513

Bacteroidetes and Firmicutes levels in gut microbiota and effects of hosts TLR2/TLR4 gene expression levels in adult type 1 diabetes patients in Istanbul, Turkey

Demırci, M., Tokman, H. B., Taner, Z., Keskin, F. E., Çağatay, P., Bakar, Y. O., Özyazar, M., Kiraz, N., & Kocazeybek, B. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.107449 · Cited by 75