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Cited by 55Diabetes Management and ResearchRegulation of Appetite and ObesityEating Disorders and Behaviors

Food cravings during acute hypoglycaemia in adults with type 1 diabetes

Strachan, Mark W.J, Ewing, Fiona M.E, Frier, Brian M, Harper, Alison, Deary, Ian J·2004·Physiology & Behavior
DOI 10.1016/j.physbeh.2003.12.003
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Abstract

Background Food craving is defined as an intense desire to eat a specific foodstuff. It may be distinguished from the sensation of hunger, which is relieved by nonspecific foodstuffs. No controlled studies have examined the effects of hypoglycaemia on food cravings. Thus, the aim of this study was to examine change in cravings for eight specified food types during euglycaemia and insulin-induced hypoglycaemia.Methods Thirteen adults with Type 1 diabetes attended two experimental sessions where acute hypoglycaemia was induced with either insulin aspart or human soluble insulin. Food cravings were assessed, using a questionnaire, at baseline and at the onset of the autonomic reaction to hypoglycaemia ("R").Results The mean arterialised blood glucose concentration at baseline was 6.0+/-0.3 mmol l(-1) and at R was 1.9+/-0.4 mmol l(-1) (P<.01). Fifteen percent of subjects reported having a craving for food during euglycaemia. The prevalence increased to 65% during hypoglycaemia (P<.01). Cravings for seven of the eight food types increased during hypoglycaemia, but the greatest effect sizes (>1.0 standard deviations) were observed for three food types that had a high carbohydrate content.Conclusions In people with Type 1 diabetes, acute hypoglycaemia produces a highly reliable generalised increase in cravings for food, particularly foodstuffs with a high content of carbohydrate. The mechanisms behind this response remain to be elicited.

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  • Simultaneously, hunger and cravings for high-GL foods increase, setting the stage for a vicious cycle.

    “Simultaneously, hunger and cravings for high-GL foods (i.e., those that rapidly raise blood glucose) increase, setting the stage for a vicious cycle.”

    From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [23]

  • The combination of these physiologic events may foster food cravings with a special preference for high-GI carbohydrates, thereby propagating cycles of overeating.

    “This combination of physiologic events may foster food cravings with a special preference for high-GI carbohydrates (16, 17), thereby propagating cycles of overeating.”

    From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [17]

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Authors
Strachan, M. W. J., Ewing, F. M. E., Frier, B. M., Harper, A., & Deary, I. J.
Affiliations
  • Edinburgh Royal Infirmary (GB)
  • University of Edinburgh (GB)
Corresponding author
Deary, Ian J
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2004-02
Volume
80
Issue
5
Pages
675-682
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2003.12.003
OpenAlex
W2045039072
Cited by
55
References
37
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 1
FWCI
1.86
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
Novo Nordisk
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
food cravings, type 1 diabetes, insulin-induced hypoglycemia, insulin aspart, carbohydrate craving, normoglycemia, hunger
MeSH terms
Adult, Appetite, Blood Glucose, Diabetes Mellitus, Type 1, Dietary Carbohydrates, Female, Food Preferences, Humans, Hypoglycemia, Male

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