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Cited by 80Neurotransmitter Receptor Influence on BehaviorBiochemical Analysis and Sensing TechniquesOlfactory and Sensory Function Studies

Taste pathways that mediate accumbens dopamine release by sapid sucrose

Hajnal, Andras, Norgren, Ralph·2005·Physiology & Behavior
DOI 10.1016/j.physbeh.2004.12.014
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Abstract

Although it has been associated with the release of dopamine in the forebrain, reward remains a conundrum in neuroscience. Sucrose is inherently rewarding and its sensory message reaches the brain via the gustatory system. In rodents, the central gustatory system bifurcates in the pontine parabrachial nuclei, one arm forming a standard thalamocortical axis, the other distributing widely in the limbic forebrain. We report here that lesions of the gustatory thalamus fail to affect dopamine overflow during sucrose licking (149+/-5% vs. 149+/-4% for controls). Similar damage to the parabrachial nuclei, which severs the limbic taste projection, substantially reduces dopamine release from the nucleus accumbens (121+/-4% vs. 168+/-9% for sham operated controls; p<0.02). This represents the first demonstration that the affective character of a sensory stimulus might separate from the thalamocortical system as early as the second central synapse.

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Crossref · 10.1016/j.physbeh.2004.12.014

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51 of 51 references verified0 citation errors · 0 not checkable

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  • Dopamine is involved in responses to tasting palatable foods that are mediated through the insula.

    “Even though the modulation of insular activity by DA has been poorly investigated, it is recognized that DA is involved in the responses to tasting of palatable foods that are mediated through the insula (142).”

    From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [142]

  • DA is involved in responses to tasting palatable foods mediated through the insula.

    “Even though the modulation of insular activity by DA has been poorly investigated, it is recognized that DA is involved in responses to the tasting of palatable foods that are mediated through the insula (101).”

    From The Addictive Dimensionality of Obesity (2013) · cites this paper as [101]

  • DA is involved in the responses to tasting of palatable foods that are mediated through the insula.

    “Though the modulation of insular activity by DA has been poorly investigated it is recognized that DA is involved in the responses to tasting of palatable foods that are mediated through the insula (Hajnal and Norgren 2005).”

    From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Hajnal and Norgren 2005

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Authors
Hajnal, A., & Norgren, R.
Affiliations
Pennsylvania State University (US)
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2005-03
Volume
84
Issue
3
Pages
363-369
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2004.12.014
OpenAlex
W2019211448
Cited by
80
References
51
Citations by year
2024: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 2
FWCI
2.41
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Deafness and Other Communication Disorders (DC 00240, R01DC000240)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK065709, R01DK065709)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
sucrose, dopamine release, nucleus accumbens, parabrachial nucleus, taste pathway, reward, limbic forebrain, thalamocortical system
MeSH terms
Animals, Brain Mapping, Cerebral Cortex, Dopamine, Limbic System, Male, Motivation, Neural Pathways, Synaptic Transmission, Nucleus Accumbens, Pons, Taste, Thalamic Nuclei, Rats, Sprague-Dawley, Rats

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