Cited by 433Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesRegulation of Appetite and Obesity

Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: implications for studies of natural motivation, psychiatry, and drug abuse

Salamone, J.D., Correa, M., Mingote, S., Weber, S.M.·2003·The Journal of Pharmacology and Experimental Therapeutics

Abstract

For several decades, it has been suggested that dopamine (DA), especially in nucleus accumbens, mediates the primary reinforcing characteristics of natural stimuli such as food, as well as drugs of abuse. Yet, several fundamental aspects of primary food reinforcement, motivation, and appetite are left intact after interference with accumbens DA transmission. Recent studies have shown that accumbens DA is involved in responsiveness to conditioned stimuli and activational aspects of motivation. In concurrent choice tasks, accumbens DA depletions cause animals to reallocate their choice behavior in the direction of instrumental behaviors that involve less effort. Also, an emerging body of evidence has demonstrated that the effects of accumbens DA depletions on instrumental food-seeking behavior can vary greatly depending upon the task. For example, some schedules of reinforcement are insensitive to the effects of DA depletions, whereas others are highly sensitive (e.g., large fixed ratios). Accumbens DA depletions slow the rate of operant responding, blunt the rate-facilitating effects of moderate-sized ratios, and enhance the rate-suppressing effects of very large ratios (i.e., produce ratio strain). Accumbens DA may be important for enabling rats to overcome behavioral constraints, such as work-related response costs, and may be critical for the behavioral organization and conditioning processes that enable animals to engage in vigorous responses, such as barrier climbing, or to emit large numbers of responses in ratio schedules in the absence of primary reinforcement. The involvement of accumbens DA in activational aspects of motivation has implications for energy-related disorders in psychiatry, as well as aspects of drug-seeking behavior.

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Crossref · 10.1124/jpet.102.035063

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Authors
Salamone, J. D., Correa, M., Mingote, S., & Weber, S. M.
Affiliations
  • University of Connecticut (US)
  • Universitat Jaume I (ES)
Venue
The Journal of Pharmacology and Experimental Therapeutics
Publisher
Elsevier BV
Published
2003-04
Volume
305
Issue
1
Pages
1-8
ISSN
0022-3565 (ISSN-L)
OpenAlex
W2055018246
Cited by
433
References
69
Citations by year
2026: 7 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 16 · 2021: 17 · 2020: 16 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 23 · 2015: 23 · 2014: 13 · 2013: 19 · 2012: 17
FWCI
10.27
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
nucleus accumbens, dopamine, food-seeking behavior, effort, motivation, natural reinforcement, food reinforcement, drug abuse, operant responding, appetite
MeSH terms
Animals, Dopamine, Humans, Motivation, Nucleus Accumbens, Psychiatry, Reward, Substance-Related Disorders

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