Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243 · see citing works

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works

Progress in Psychobiology and Physiological Psychology

Fluharty, S. J., & Grill, H. J. (2003) · Progress in psychobiology and physiological psychology · doi:10.1108/s0363-0951200318 · Cited by 1,701 · see citing works

Identification of targets of leptin action in rat hypothalamus.

Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,475 · see citing works

Signals That Regulate Food Intake and Energy Homeostasis

Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,169 · see citing works

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114 · see citing works

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in <i>ob/ob</i> Mice

Schwartz, M. W., Baskin, D. G., Bukowski, T. R., Kuijper, J. L., Foster, D., Lasser, G., Prunkard, D. E., Porte, D., Woods, S. C., Seeley, R. J., et al. (1996) · Diabetes · doi:10.2337/diab.45.4.531 · Cited by 904 · see citing works

Diabetes, Obesity, and the Brain

Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841 · see citing works

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., & Rossetti, L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-861 · Cited by 719 · see citing works

Obesity: Overview of an Epidemic

Mitchell, N. S., Catenacci, V. A., Wyatt, H. R., & Hill, J. O. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.08.005 · Cited by 526 · see citing works

The OB Protein (Leptin) Pathway - A Link Between Adipose Tissue Mass and Central Neural Networks

Campfield, L. A., Smith, F., & Burn, P. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979867 · Cited by 505 · see citing works

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

Baura, G. D., Foster, D. M., Porte, D., Kahn, S. E., Bergman, R. N., Cobelli, C., & Schwartz, M. W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116773 · Cited by 489 · see citing works

Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus

Niswender, K. D., Morrison, C. D., Clegg, D. J., Olson, R., Baskin, D. G., Myers, M. G., Seeley, R. J., & Schwartz, M. W. (2003) · Diabetes · doi:10.2337/diabetes.52.2.227 · Cited by 476 · see citing works

PI3K integrates the action of insulin and leptin on hypothalamic neurons

Xu, A. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524301 · Cited by 420 · see citing works

The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

Benoit, S. C., Air, E. L., Coolen, L. M., Strauss, R., Jackman, A., Clegg, D. J., Seeley, R. J., & Woods, S. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09048.2002 · Cited by 417 · see citing works

Insulin Signaling in the Central Nervous System

Porte, D., Baskin, D. G., & Schwartz, M. W. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1264 · Cited by 336 · see citing works

Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

Clegg, D. J., Riedy, C. A., Smith, K. A. B., Benoit, S. C., & Woods, S. C. (2003) · Diabetes · doi:10.2337/diabetes.52.3.682 · Cited by 332 · see citing works

Insulin and the Blood-Brain Barrier

Woods, S. C., Seeley, R. J., Baskin, D. G., & Schwartz, M. W. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033455323 · Cited by 321 · see citing works

Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats

Seeley, R. J., van Dijk, G., Campfield, L. A., Smith, F., Burn, P., Nelligan, J., Bell, S. M., Baskin, D. S., Woods, S. C., & Schwartz, M. W. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979874 · Cited by 253 · see citing works

Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

Schwartz, M. W., Baskin, D. G., Bukowski, T. R., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.4.531 · Cited by 247 · see citing works

Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs. Quantitative aspects and implications for transport.

Schwartz, M. W., Bergman, R. N., Kahn, S. E., Taborsky, G. J., Fisher, L. D., Sipols, A. J., Woods, S. C., Steil, G. M., & Porte, D. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115431 · Cited by 183 · see citing works

Central insulin enhances sensitivity to cholecystokinin

RIEDY, C., Chavez, M., Figlewicz, D. P., & WOODS, S. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00108-u · Cited by 172 · see citing works

Increased feeding in response to bilateral injection of insulin antibodies in the VMH

STRUBBE, J. H., & Mein, C. G. (1977) · Physiology & Behavior · doi:10.1016/0031-9384(77)90343-2 · Cited by 161 · see citing works

Acute third ventricular administration of insulin decreases food intake in two paradigms

Air, E. L., Benoit, S. C., Smith, K. A. B., Clegg, D. J., & Woods, S. C. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00780-8 · Cited by 153 · see citing works

Regional study of cerebral ventricle sensitive sites to angiotensin II

Hoffman, W. E., & Phillips, M. I. (1976) · Brain Research · doi:10.1016/0006-8993(76)90405-4 · Cited by 134 · see citing works

Chronic intrahypothalamic infusions of insulin or insulin antibodies alter body weight and food intake in the rat

McGowan, M. K., Andrews, K. M., & Grossman, S. P. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90112-f · Cited by 133 · see citing works

Health and wealth

Zagorsky, J. L. (2005) · Economics & Human Biology · doi:10.1016/j.ehb.2005.05.003 · Cited by 129 · see citing works

Intraventricular insulin and the level of maintained body weight in rats.

Chavez, M., Kaiyala, K. J., Madden, L. J., Schwartz, M. W., & Woods, S. C. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.3.528 · Cited by 111 · see citing works

Intraventricular insulin and the level of maintained body weight in rats.

Chavez, M., Kaiyala, K. J., Madden, L. J., et al. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.3.528 · Cited by 96 · see citing works

NPY increases food intake in white-crowned sparrows: effect in short and long photoperiods

Richardson, R. D., Boswell, T. C., Raffety, B. D., Seeley, R. J., Wingfield, J. C., & Woods, S. C. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.268.6.r1418 · Cited by 94 · see citing works

Central insulin and macronutrient intake in the rat

Chavez, M., Riedy, C. A., van Dijk, G., & Woods, S. C. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.3.r727 · Cited by 68 · see citing works

Intraventricular insulin reduces food intake and body weight of marmots during the summer feeding period

Florant, G. L., Singer, L. K., Scheurink, A. J. W., Park, C. R., Richardson, R. D., & Woods, S. C. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90053-q · Cited by 54 · see citing works

Obesity: Overview of an Epidemic

Hill, J. O., Catenacci, V. A., & Wyatt, H. R. (2005) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.09.010 · Cited by 51 · see citing works

Method of leptin dosing, strain, and group housing influence leptin sensitivity in high-fat-fed weanling mice

Bowen, H. M., Mitchell, T. D., & Harris, R. B. S. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00431.2002 · Cited by 39 · see citing works

Distribution of intraventricularly administered antiamyloid‐beta peptide (Aβ) antibody in the mouse brain

Chauhan, N. B., Siegel, G. J., & Lichtor, T. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1215 · Cited by 34 · see citing works

Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis

Cepoi, D., Phillips, T., Cismowski, M., Goodfellow, V. S., Ling, N., Cone, R. D., & Fan, W. (2004) · Brain Research · doi:10.1016/j.brainres.2003.10.041 · Cited by 31 · see citing works

Intracerebroventricular corticotropin-releasing factor decreases food intake in white-crowned sparrows

Richardson, R. D., Boswell, T., Woods, S. C., & Wingfield, J. C. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00326-7 · Cited by 27 · see citing works

Effect of Somatostatin-28 on Dynamics of Insulin Secretion in Perfused Rat Pancreas

Ensinck, J. W., Laschansky, E. C., Vogel, R. E., & D’Alessio, D. A. (1991) · Diabetes · doi:10.2337/diab.40.9.1163 · Cited by 25 · see citing works

Intraventricular Angiotensin Elicits Drinking in the Baboon

Lotter, E. C., McKay, L. D., Mangiapane, M. L., Simpson, J. B., Vogel, K. W., Porte, D., & Woods, S. C. (1980) · Experimental Biology and Medicine · doi:10.3181/00379727-163-40720 · Cited by 22 · see citing works

Cholecystokinin octapeptide decreases food intake in white-crowned sparrows

Richardson, R. D., Boswell, T. C., Weatherford, S. C., Wingfield, J. C., & Woods, S. C. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.5.r852 · Cited by 16 · see citing works

Effect of somatostatin-28 on dynamics of insulin secretion in perfused rat pancreas

Ensinck, J. W., Laschansky, E. C., Vogel, R. E., et al. (1991) · Diabetes · doi:10.2337/diabetes.40.9.1163 · Cited by 10 · see citing works

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

Kullmann, S., Heni, M., Hallschmid, M., Fritsche, A., Preissl, H. T., & Häring, H. (2016) · Physiological Reviews · doi:10.1152/physrev.00032.2015 · Cited by 632 · see citing works

Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome

Plagemann, A., Harder, T., Brunn, M., Harder, A., Roepke, K., Wittrock‐Staar, M., Ziska, T., Schellong, K., Rodekamp, E., Melchior, K., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.176156 · Cited by 439 · see citing works

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis.

Varela, L., & Horvath, T. L. (2012) · The EMBO Reports · doi:10.1038/embor.2012.174 · Cited by 426 · see citing works

Insulin in the Brain: Sources, Localization and Functions

Ghasemi, R., Haeri, A., Dargahi, L., Mohamed, Z., & Ahmadiani, A. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8339-9 · Cited by 291 · see citing works

CNS leptin and insulin action in the control of energy homeostasis

Belgardt, B., & Brüning, J. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05799.x · Cited by 275 · see citing works

The Role of the Autonomic Nervous System in the Pathophysiology of Obesity

Guarino, D., Nannipieri, M., Iervasi, G., Taddei, S., & Bruno, R. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00665 · Cited by 244 · see citing works

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons

Klöckener, T., Heß, S., Belgardt, B., Paeger, L., Verhagen, L. A. W., Husch, A., Sohn, J., Hampel, B., Dhillon, H., Zigman, J. M., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2847 · Cited by 239 · see citing works

Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels

Qiu, J., Zhang, C., Borgquist, A., Nestor, C. C., Smith, A. W., Bosch, M. A., Ku, S., Wagner, E. J., Rønnekleiv, O. K., & Kelly, M. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.004 · Cited by 233 · see citing works

Tau deletion promotes brain insulin resistance

Marciniak, E., Leboucher, A., Caron, E., Ahmed, T., Tailleux, A., Dumont, J., Issad, T., Gerhardt, E., Pagesy, P., Vileno, M., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20161731 · Cited by 205 · see citing works

Brain insulin signalling in metabolic homeostasis and disease

Scherer, T., Sakamoto, K., & Buettner, C. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00498-x · Cited by 205 · see citing works

Consumption of a high-fat diet induces central insulin resistance independent of adiposity

Clegg, D. J., Gotoh, K., Kemp, C., Wortman, M. D., Benoit, S. C., Brown, L. M., D’Alessio, D. A., Tso, P., Seeley, R. J., & Woods, S. C. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.01.010 · Cited by 187 · see citing works

AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity

Vohra, M. S., Benchoula, K., Serpell, C. J., & Wong, E. H. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174611 · Cited by 181 · see citing works

Intranasal Insulin for Alzheimer’s Disease

Hallschmid, M. (2021) · CNS Drugs · doi:10.1007/s40263-020-00781-x · Cited by 182 · see citing works

The Leptin Receptor Complex: Heavier Than Expected?

Wauman, J., Zabeau, L., & Tavernier, J. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00030 · Cited by 178 · see citing works

Insulin controls food intake and energy balance via NPY neurons

Loh, K., Zhang, L., Brandon, A. E., Wang, Q., Begg, D. P., Qi, Y., Fu, M., Kulkarni, R. N., Teo, J. D., Baldock, P. A. J., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.03.013 · Cited by 173 · see citing works

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

Belgardt, B., Mauer, J., Wunderlich, F. T., Ernst, M. B., Pál, M., Spohn, G., Brönneke, H. S., Brodesser, S., Hampel, B., Schauss, A. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001796107 · Cited by 168 · see citing works

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

Jauch‐Chara, K., Friedrich, A., Rezmer, M., Melchert, U. H., Scholand-Engler, H. G., Hallschmid, M., & Oltmanns, K. M. (2012) · Diabetes · doi:10.2337/db12-0025 · Cited by 164 · see citing works

Estrogen as a key regulator of energy homeostasis and metabolic health

Mahboobifard, F., Pourgholami, M. H., Jorjani, M., Dargahi, L., Amiri, M., Sadeghi, S., & Tehrani, F. R. (2022) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2022.113808 · Cited by 154 · see citing works

Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

Ott, V., Benedict, C., Schultes, B., Born, J., & Hallschmid, M. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01490.x · Cited by 139 · see citing works

Obesity – A neuropsychological disease? Systematic review and neuropsychological model

Jauch‐Chara, K., & Oltmanns, K. M. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.001 · Cited by 121 · see citing works

Intranasal insulin

Hallschmid, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12934 · Cited by 113 · see citing works

Protein Quality and the Protein to Carbohydrate Ratio within a High Fat Diet Influences Energy Balance and the Gut Microbiota In C57BL/6J Mice

McAllan, L., Skuse, P., Cotter, P. D., Connor, P. O., Cryan, J. F., Ross, R. P., Fitzgerald, G., Roche, H. M., & Nilaweera, K. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088904 · Cited by 106 · see citing works

Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis

Davis, K. E., Carstens, E. J., Irani, B. G., Gent, L. M., Hahner, L., & Clegg, D. J. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.02.004 · Cited by 103 · see citing works

Regulation of the mesolimbic dopamine circuit by feeding peptides

Liu, S., & Borgland, S. L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.046 · Cited by 100 · see citing works

Balancing ovulation and anovulation: integration of the reproductive and energy balance axes by neuropeptides

Evans, J. J., & Anderson, G. M. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms004 · Cited by 101 · see citing works

Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

Kullmann, S., Heni, M., Veit, R., Scheffler, K., Machann, J., Häring, H., Fritsche, A., & Preissl, H. T. (2017) · Scientific Reports · doi:10.1038/s41598-017-01907-w · Cited by 92 · see citing works

Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation

Belfort-DeAguiar, R., & Seo, D. (2018) · Current Obesity Reports · doi:10.1007/s13679-018-0303-1 · Cited by 84 · see citing works

Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing

Moss, C., Dhillo, W. S., Frost, G. S., & Hickson, M. (2011) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2011.01211.x · Cited by 83 · see citing works

Deregulation of brain insulin signaling in Alzheimer’s disease

Chen, Y., Deng, Y., Zhang, B., & Gong, C. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1408-x · Cited by 83 · see citing works

Neuroanatomical Framework of the Metabolic Control of Reproduction

Hill, J. W., & Elias, C. F. (2018) · Physiological Reviews · doi:10.1152/physrev.00033.2017 · Cited by 79 · see citing works

Insulin action in the brain: Roles in energy and glucose homeostasis

Dodd, G. T., & Tiganis, T. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12513 · Cited by 75 · see citing works

Insulin signalling elicits hunger-induced feeding in Drosophila

Sudhakar, S. R., Pathak, H., Rehman, N., Fernandes, J., Vishnu, S., & Varghese, J. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.11.013 · Cited by 75 · see citing works

Targeting Intermediary Metabolism in the Hypothalamus as a Mechanism to Regulate Appetite

Lopaschuk, G. D., Ussher, J. R., & Jaswal, J. S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002428 · Cited by 68 · see citing works

Central insulin suppresses feeding behavior via melanocortins in chicks

Shiraishi, J., Yanagita, K., Fujita, M., & Bungo, T. (2007) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2007.05.002 · Cited by 66 · see citing works

Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice

Berends, L. M., Dearden, L., Tung, Y. L., Voshol, P. J., Fernandez‐Twinn, D. S., & Ozanne, S. E. (2018) · Diabetologia · doi:10.1007/s00125-018-4694-z · Cited by 65 · see citing works

Development of an Assay for High-Throughput Energy Expenditure Monitoring in the Zebrafish

Renquist, B. J., Zhang, C., Williams, S. Y., & Cone, R. D. (2013) · Zebrafish · doi:10.1089/zeb.2012.0841 · Cited by 64 · see citing works

Topiramate Treatment Improves Hypothalamic Insulin and Leptin Signaling and Action and Reduces Obesity in Mice

Caricilli, A. M., Penteado, É., de Abreu, L. L., Quaresma, P. G. F., Santos, A. C., Guadagnini, D., Razolli, D. S., Mittestainer, F. C., Carvalheira, J. B. C., Velloso, L. A., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1272 · Cited by 63 · see citing works

Differences in the Central Anorectic Effects of Glucagon-Like Peptide-1 and Exendin-4 in Rats

Barrera, J. G., D’Alessio, D. A., Drucker, D. J., Woods, S. C., & Seeley, R. J. (2009) · Diabetes · doi:10.2337/db09-0281 · Cited by 63 · see citing works

Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance

Qiu, J., Bosch, M. A., Meza, C., Navarro, U.-V., Nestor, C. C., Wagner, E. J., Rønnekleiv, O. K., & Kelly, M. J. (2017) · Endocrinology · doi:10.1210/en.2017-00793 · Cited by 62 · see citing works

Interactions between the central nervous system and pancreatic islet secretions: a historical perspective

Begg, D. P., & Woods, S. C. (2013) · AJP Advances in Physiology Education · doi:10.1152/advan.00167.2012 · Cited by 61 · see citing works

Hypothalamic Reactive Oxygen Species Are Required for Insulin-Induced Food Intake Inhibition

Jaillard, T., Roger, M., Galinier, A., Guillou, P., Bénani, A., Leloup, C., Casteilla, L., Pénicaud, L., & Lorsignol, A. (2009) · Diabetes · doi:10.2337/db08-1039 · Cited by 64 · see citing works

MANF regulates hypothalamic control of food intake and body weight

Yang, S., Yang, H., Chang, R., Yin, P., Yang, Y., Yang, W., Huang, S., Gaertig, M. A., Li, S., & Li, X. (2017) · Nature Communications · doi:10.1038/s41467-017-00750-x · Cited by 61 · see citing works

Functional heterogeneity of POMC neurons relies on mTORC1 signaling

Saucisse, N., Mazier, W., Simon, V., Binder, E., Catania, C., Bellocchio, L., Romanov, R. A., Leon, S., Matias, I., Zizzari, P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109800 · Cited by 60 · see citing works

The effect of yellow pea protein and fibre on short-term food intake, subjective appetite and glycaemic response in healthy young men

Smith, C. E., Mollard, R. C., Luhovyy, B. L., & Anderson, G. H. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000700 · Cited by 60 · see citing works

Brain to bone: What is the contribution of the brain to skeletal homeostasis?

Idelevich, A., & Baron, R. (2018) · Bone · doi:10.1016/j.bone.2018.05.018 · Cited by 60 · see citing works

Neurophysiological and cognitive changes in pregnancy

Grattan, D. R., & Ladyman, S. R. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64239-4.00002-3 · Cited by 63 · see citing works

The regulation of food intake by insulin in the central nervous system

Mitchell, C. S., & Begg, D. P. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12952 · Cited by 60 · see citing works

Insulin and leptin excite anorexigenic pro‐opiomelanocortin neurones via activation of TRPC 5 channels

Qiu, J., Wagner, E. J., Rønnekleiv, O. K., & Kelly, M. J. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12501 · Cited by 59 · see citing works

Evidence for Central Regulation of Glucose Metabolism

Carey, M., Kehlenbrink, S., & Hawkins, M. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.506782 · Cited by 57 · see citing works

Central actions of insulin during pregnancy and lactation

Ladyman, S. R., & Brooks, V. L. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12946 · Cited by 56 · see citing works

Reversal of Diet-Induced Obesity Increases Insulin Transport into Cerebrospinal Fluid and Restores Sensitivity to the Anorexic Action of Central Insulin in Male Rats

Begg, D. P., Mul, J. D., Liu, M., Reedy, B. M., D’Alessio, D. A., Seeley, R. J., & Woods, S. C. (2013) · Endocrinology · doi:10.1210/en.2012-1929 · Cited by 49 · see citing works

Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons

Stincic, T. L., Rønnekleiv, O. K., & Kelly, M. J. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.04.001 · Cited by 47 · see citing works

Insulin Signals Through the Dorsal Vagal Complex to Regulate Energy Balance

Filippi, B., Bassiri, A., Abraham, M. A., Duca, F. A., Yue, J. T. Y., & Lam, T. K. T. (2013) · Diabetes · doi:10.2337/db13-1044 · Cited by 46 · see citing works

Cellular insulin resistance disrupts hypothalamic mHypoA-POMC/GFP neuronal signaling pathways

Nazarians-Armavil, A., Chalmers, J. A., Lee, C. B., Ye, W., & Belsham, D. D. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0334 · Cited by 45 · see citing works

Insulin reduces excitation in gastric-related neurons of the dorsal motor nucleus of the vagus

Blake, C. B., & Smith, B. N. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00276.2012 · Cited by 41 · see citing works

Insulin and glucagon signaling in the central nervous system

Filippi, B., Abraham, M. A., Yue, J. T. Y., & Lam, T. K. T. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9258-4 · Cited by 42 · see citing works

Insulin action in the hypothalamus and dorsal vagal complex

Abraham, M. A., Filippi, B., Kang, G. M., Kim, M., & Lam, T. K. T. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.079962 · Cited by 41 · see citing works

Ventromedial hypothalamus–specific Ptpn1 deletion exacerbates diet-induced obesity in female mice

Chiappini, F., Catalano, K. J., Lee, J., Peroni, O. D., Lynch, J. E., Dhaneshwar, A. S., Wellenstein, K., Sontheimer-Phelps, A., Neel, B. G., & Kahn, B. B. (2014) · Journal of Clinical Investigation · doi:10.1172/jci68585 · Cited by 40 · see citing works

Melanocortin neurons: Multiple routes to regulation of metabolism

Shen, W.-J., Yao, T. S., Kong, X., Williams, K. W., & Liu, T. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.05.007 · Cited by 41 · see citing works

Polymorphisms of the LEP , LEPR and HTR2C Gene: Obesity and BMI Change in Patients Using Antipsychotic Medication in a Naturalistic Setting

Gregoor, J. G., van der Weide, J., Loovers, H. M., van Megen, H. J. G. M., Egberts, T. C. G., & Heerdink, E. R. (2011) · Pharmacogenomics · doi:10.2217/pgs.11.40 · Cited by 40 · see citing works

Inconsistencies in the assessment of food intake

Woods, S. C., & Langhans, W. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00415.2012 · Cited by 38 · see citing works

Insulin Activates Vagal Afferent Neurons Including those Innervating Pancreas via Insulin Cascade and Ca2+ Influx: Its Dysfunction in IRS2-KO Mice with Hyperphagic Obesity

Iwasaki, Y., Shimomura, K., Kohno, D., Dezaki, K., Ayush, E., Nakabayashi, H., Kubota, N., Kadowaki, T., Kakei, M., Nakata, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067198 · Cited by 38 · see citing works

Effect of Insulin‐Induced Hypoglycaemia on the Central Nervous System : Evidence from Experimental Studies

Jensen, V. F. H., Bøgh, I. B., & Lykkesfeldt, J. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12133 · Cited by 37 · see citing works

Outcomes and clinical implications of intranasal insulin administration to the central nervous system

Santiago, J. C. P., & Hallschmid, M. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.03.007 · Cited by 36 · see citing works

Peroxiredoxin 6 Is a Key Antioxidant Enzyme in Modulating the Link between Glycemic and Lipogenic Metabolism

Arriga, R., Pacifici, F., Capuani, B., Coppola, A., Orlandi, A., Scioli, M. G., Pastore, D., Andreadi, A., Sbraccia, P., Tesauro, M., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9685607 · Cited by 36 · see citing works

Pregnancy-induced adaptation of central sensitivity to leptin and insulin

Aung, Z. K., Grattan, D. R., & Ladyman, S. R. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110933 · Cited by 36 · see citing works

The Central Insulin System and Energy Balance

Begg, D. P., & Woods, S. C. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-24716-3_5 · Cited by 35 · see citing works

Characterization of the central neural projections to brown, white, and beige adipose tissue

Wiedmann, N. M., Stefanidis, A., & Oldfield, B. J. (2017) · The FASEB Journal · doi:10.1096/fj.201700433r · Cited by 33 · see citing works

Appetite regulation by plant-derived bioactive peptides for promoting health

Kaneko, K. (2021) · Peptides · doi:10.1016/j.peptides.2021.170608 · Cited by 31 · see citing works

Insulin Transport into the Brain and Cerebrospinal Fluid

Begg, D. P. (2015) · Vitamins and hormones · doi:10.1016/bs.vh.2014.12.007 · Cited by 31 · see citing works

Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism

Haigh, J., New, L. E., & Filippi, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.580879 · Cited by 29 · see citing works

Sleep deprivation alters energy homeostasis through non-compensatory alterations in hypothalamic insulin receptors in Wistar rats

de Moraes, D. A., Venâncio, D. P., & Suchecki, D. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.08.015 · Cited by 29 · see citing works

Increased Airway Reactivity and Hyperinsulinemia in Obese Mice Are Linked by ERK Signaling in Brain Stem Cholinergic Neurons

Leiria, L. O., Arantes-Costa, F. M., Calixto, M. C., Alexandre, E. C., de Moura, R. F., Folli, F. B., Prado, C. M., Prado, M. A. M., Prado, V. F., Velloso, L. A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.012 · Cited by 28 · see citing works

TRPCing around the hypothalamus

Kelly, M. J., Qiu, J., & Rønnekleiv, O. K. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.05.004 · Cited by 30 · see citing works

Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model

Leboucher, A., Ahmed, T., Caron, É., Tailleux, A., Raison, S., Joly‐Amado, A., Marciniak, E., Carvalho, K., Hamdane, M., Bantubungi, K., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.008 · Cited by 25 · see citing works

cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice

Blake, C. B., & Smith, B. N. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00138.2014 · Cited by 26 · see citing works

mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin

Haissaguerre, M., Ferrière, A., Simon, V., Saucisse, N., Dupuy, N., André, C., Clark, S., Guzmán‐Quevedo, O., Tabarin, A., & Cota, D. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.04.002 · Cited by 25 · see citing works

Molecules affecting hypothalamic control of core body temperature in response to calorie intake

Bartfai, T., & Conti, B. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00184 · Cited by 25 · see citing works

Impact of Hunger, Satiety, and Oral Glucose on the Association Between Insulin and Resting-State Human Brain Activity

Al-Zubaidi, A., Heldmann, M., Mertins, A., Brabant, G. E., Nolde, J. M., Jauch‐Chara, K., & Münte, T. F. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00162 · Cited by 25 · see citing works

Estradiol Protects Neuropeptide Y/Agouti-Related Peptide Neurons against Insulin Resistance in Females

Qiu, J., Bosch, M. A., Zhang, C., Rønnekleiv, O. K., & Kelly, M. J. (2019) · Neuroendocrinology · doi:10.1159/000501560 · Cited by 24 · see citing works

Heparin Increases Food Intake through AgRP Neurons

Zhu, C., Xu, P., He, Y., Yuan, Y., Wang, T., Cai, X., Yu, L., Yang, L., Wu, J., Wang, L., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.049 · Cited by 22 · see citing works

The central melanocortin system as a treatment target for obesity and diabetes: A brief overview

Goit, R. K., Taylor, A. W., & Lo, A. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174956 · Cited by 22 · see citing works

Central administration of metformin into the third ventricle of C57BL/6 mice decreases meal size and number and activates hypothalamic S6 kinase

Kim, H. J., Park, E.-Y., Oh, M.-J., Park, S. S., Shin, K.-H., Choi, S.-H., Chun, B., & Kim, D. H. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00099.2013 · Cited by 22 · see citing works

Region-Specific Suppression of Hypothalamic Responses to Insulin To Adapt to Elevated Maternal Insulin Secretion During Pregnancy

Ladyman, S. R., & Grattan, D. R. (2017) · Endocrinology · doi:10.1210/en.2017-00600 · Cited by 20 · see citing works

Alcohol Drinking in MCH Receptor‐1‐Deficient Mice

Duncan, E. A., Sorrell, J. E., Adamantidis, A., Rider, T., Jandacek, R. J., Seeley, R. J., Lakaye, B., & Woods, S. C. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00427.x · Cited by 20 · see citing works

In Vivo Changes in Central and Peripheral Insulin Sensitivity in a Large Animal Model of Obesity

Adam, C. L., Findlay, P. A., Aitken, R. P., Milne, J. S., & Wallace, J. M. (2012) · Endocrinology · doi:10.1210/en.2012-1134 · Cited by 17 · see citing works

Insulin and Estrogen Independently and Differentially Reduce Macronutrient Intake in Healthy Men

Krug, R., Mohwinkel, L., Drotleff, B., Born, J., & Hallschmid, M. (2018) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2017-01835 · Cited by 16 · see citing works

Subfornical organ insulin receptors tonically modulate cardiovascular and metabolic function

Jeong, J. K., Horwath, J. A., Simonyan, H., Blackmore, K. A., Butler, S. D., & Young, C. N. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00021.2019 · Cited by 16 · see citing works

Surfactant Protein D Deficiency in Mice Is Associated with Hyperphagia, Altered Fat Deposition, Insulin Resistance, and Increased Basal Endotoxemia

Stidsen, J. V., Khorooshi, R., Rahbek, M. T., Kirketerp-Møller, K. L., Hansen, P., Bie, P., Kejling, K., Mandrup, S., Hawgood, S. B., Nielsen, O., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035066 · Cited by 15 · see citing works

No effect of adjunctive, repeated dose intranasal insulin treatment on body metabolism in patients with schizophrenia

Li, J., Li, X., Liu, E., Copeland, P. M., Freudenreich, O., GOFF, D. C., Henderson, D. C., Song, X., & Fan, X. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.034 · Cited by 15 · see citing works

A look on food intake and satiety: from humans to rodent models

Costa, D. G., Almeida, C., Cavadas, C., & Carmo‐Silva, S. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac010 · Cited by 14 · see citing works

Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice

Sahu, M., Anamthathmakula, P., & Sahu, A. (2016) · Neuroendocrinology · doi:10.1159/000445523 · Cited by 14 · see citing works

An orally active plant Rubisco-derived peptide increases neuronal leptin responsiveness

Kaneko, K., Takekuma, Y., Goto, T., & Ohinata, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-12595-6 · Cited by 13 · see citing works

Regulation of Energy and Glucose Homeostasis by the Nucleus of the Solitary Tract and the Area Postrema

Bruce, K., Garrido, A. N., Zhang, S., & Lam, T. K. T. (2024) · Endocrinology and Metabolism · doi:10.3803/enm.2024.2025 · Cited by 13 · see citing works

Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus

Onoue, T., Goto, M., Tominaga, T., Sugiyama, M., Tsunekawa, T., Hagiwara, D., Banno, R., Suga, H., Sugimura, Y., & Arima, H. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.03.011 · Cited by 13 · see citing works

Hypoglycaemic activity of Bauhinia holophylla through GSK3-β inhibition and glycogenesis activation

Camaforte, N. A. D. P., Saldanha, L. L., Vareda, P. M. P., Rezende-Neto, J. M., Senger, M. R., Delgado, A. Q., Morgan, H. J. N., Violato, N. M., Pieroni, L. G., Dokkedal, A. L., et al. (2019) · Pharmaceutical Biology · doi:10.1080/13880209.2019.1599962 · Cited by 13 · see citing works

Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice

Wang, Z., Khor, S., & Cai, D. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005429 · Cited by 13 · see citing works

ICV vs. VMH injection of leptin: Comparative effects on hypothalamic gene expression

Ambati, S., Duan, J., Choi, Y., Hartzell, D. L., Della‐Fera, M. A., & Baile, C. A. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.014 · Cited by 13 · see citing works

Leptin’s Immune Action: A Review Beyond Satiety

Bardagi, A. A., Paschoal, C. D. S., Favero, G. G., Riccetto, L., Dias, M. L. A., Guerra, G., & Degasperi, G. (2022) · Immunological Investigations · doi:10.1080/08820139.2022.2129381 · Cited by 11 · see citing works

Circulating insulin and leptin in women with and without premenstrual disphoric disorder in the menstrual cycle

Aktürk, M., Törüner, F. B., Aslan, S., Altınova, A. E., Çakır, N., Elbeğ, Ş., & Arslan, M. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2013.769512 · Cited by 12 · see citing works

Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats

Seeley, R. J., van Dijk, G., Campfield, L. A., Smith, F., Burn, P., Nelligan, J., Bell, S. M., Baskin, D. S., Woods, S. C., & Schwartz, M. W. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979874 · Cited by 253 · see citing works

Insulin and Leptin Combine Additively to Reduce Food Intake and Body Weight in Rats

Air, E. L., Benoit, S. C., Clegg, D. J., Seeley, R. J., & Woods, S. C. (2002) · Endocrinology · doi:10.1210/endo.143.6.8948 · Cited by 131 · see citing works

Intraventricular insulin reduces food intake and body weight of lean but not obese zucker rats

Ikeda, H., West, D. B., Pustek, J. J., Figlewicz, D. P., Greenwood, M. R. C., Porte, D., & Woods, S. C. (1986) · Appetite · doi:10.1016/s0195-6663(86)80006-x · Cited by 230 · see citing works

Intracerebroventricular Administration of Insulin and Glucose Inhibits the Anorectic Action of Leptin in Rats

Fujita, N., Sakamaki, H., Uotani, S., Takahashi, R., Kuwahara, H., Kita, A., Oshima, K., Yamasaki, H., Yamaguchi, Y., & Eguchi, K. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322801009 · Cited by 19 · see citing works

The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Diabetes 45: 1446–1450

Cusin, I., Rohner-jeanrenaud, F., Stricker‐Krongrad, A., & Jeanrenaud, B. (1996)