Obesity: Overview of an Epidemic
Open accessAbstract
The obesity epidemic in the United States has proven difficult to reverse. We have not been successful in helping people sustain the eating and physical activity patterns that are needed to maintain a healthy body weight. There is growing recognition that we will not be able to sustain healthy lifestyles until we are able to address the environment and culture that currently support unhealthy lifestyles. Addressing obesity requires an understanding of energy balance. From an energy balance approach it should be easier to prevent obesity than to reverse it. Further, from an energy balance point of view, it may not be possible to solve the problem by focusing on food alone. Currently, energy requirements of much of the population may be below the level of energy intake than can reasonably be maintained over time. Many initiatives are underway to revise how we build our communities, the ways we produce and market our foods, and the ways we inadvertently promote sedentary behavior. Efforts are underway to prevent obesity in schools, worksites, and communities. It is probably too early to evaluate these efforts, but there have been no large-scale successes in preventing obesity to date. There is reason to be optimistic about dealing with obesity. We have successfully addressed many previous threats to public health. It was probably inconceivable in the 1950s to think that major public health initiatives could have such a dramatic effect on reducing the prevalence of smoking in the United States. Yet, this serious problem was addressed via a combination of strategies involving public health, economics, political advocacy, behavioral change, and environmental change. Similarly, Americans have been persuaded to use seat belts and recycle, addressing two other challenges to public health. But, there is also reason to be pessimistic. Certainly, we can learn from our previous efforts for social change, but we must realize that our challenge with obesity may be greater. In the other examples cited, we had clear goals in mind. Our goals were to stop smoking, increase the use of seatbelts, and increase recycling. The difficulty of achieving these goals should not be minimized, but they were clear and simple goals. In the case of obesity, there is no clear agreement about goals. Moreover, experts do not agree on which strategies should be implemented on a widespread basis to achieve the behavioral changes in the population needed to reverse the high prevalence rates of obesity. We need a successful model that will help us understand what to do to address obesity. A good example is the recent HEALTHY study. This comprehensive intervention was implemented in several schools and aimed to reduce obesity by concentrating on behavior and environment. This intervention delivered most of the strategies we believe to be effective in schools. Although the program produced a reduction in obesity, this reduction was not greater than the reduction seen in the control schools that did not receive the intervention. This does not mean we should not be intervening in schools, but rather that it may require concerted efforts across behavioral settings to reduce obesity. Although we need successful models, there is a great deal of urgency in responding to the obesity epidemic. An excellent example is the effort to get menu labeling in restaurants, which is moving rapidly toward being national policy. The evaluation of this strategy is still ongoing, and it is not clear what impact it will have on obesity rates. We should be encouraging efforts like this, but we must evaluate them rigorously. Once we become serious about addressing obesity, it will likely take decades to reverse obesity rates to levels seen 30 years ago. Meanwhile, the prevalence of overweight and obesity remains high and quite likely will continue to increase.
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Roenneberg, T., Allebrandt, K. V., Merrow, M., & Vetter, C. (2012) · Current Biology · doi:10.1016/j.cub.2012.03.038 · Cited by 1,407 · see citing works
Overweight and obesity: prevalence, consequences, and causes of a growing public health problem
Williams, E. P., Mesidor, M., Winters, K., Dubbert, P. M., & Wyatt, S. B. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0169-4 · Cited by 922 · see citing works
Social jetlag, obesity and metabolic disorder: investigation in a cohort study
Parsons, M. J., Moffitt, T. E., Gregory, A. M., Goldman-Mellor, S., Nolan, P. M., Poulton, R., & Caspi, A. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.201 · Cited by 426 · see citing works
Wright, N., Wilson, L., Smith, M., Duncan, B., & McHugh, P. (2017) · Nutrition & Diabetes · doi:10.1038/nutd.2017.3 · Cited by 340 · see citing works
Sleep and Circadian Rhythm Disruption in Social Jetlag and Mental Illness
Foster, R. G., Peirson, S. N., Wulff, K., Winnebeck, E., Vetter, C., & Roenneberg, T. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00011-7 · Cited by 224 · see citing works
Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
Brown, L. M., Clegg, D. J., Benoit, S. C., & Woods, S. C. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.08.008 · Cited by 139 · see citing works
Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention
Iaccarino, G., Franco, D., Sorriento, D., Strisciuglio, T., Barbato, E., & Morisco, C. (2021) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-020-10057-w · Cited by 106 · see citing works
Leptin regulates olfactory-mediated behavior in ob/ob mice
Getchell, T. V., Kwong, K., Saunders, C. P., Stromberg, A. J., & Getchell, M. L. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.11.016 · Cited by 96 · see citing works
Obesity Affects Brain Structure and Function- Rescue by Bariatric Surgery
Nota, M. H. C., Vreeken, D., Wiesmann, M., Aarts, E. O., Hazebroek, E. J., & Kiliaan, A. J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.11.025 · Cited by 86 · see citing works
Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation
Belfort-DeAguiar, R., & Seo, D. (2018) · Current Obesity Reports · doi:10.1007/s13679-018-0303-1 · Cited by 84 · see citing works
Rojas, K. E., Matthews, N., Raker, C., Clark, M. A., Onstad, M., Stuckey, A., & Gass, J. (2018) · Journal of Cancer Survivorship · doi:10.1007/s11764-017-0651-y · Cited by 36 · see citing works
Reduced hippocampal N-acetyl-aspartate (NAA) as a biomarker for overweight
Coplan, J. D., Fathy, H. M., Abdallah, C. G., Ragab, S. A., Kral, J. G., Mao, X., Shungu, D. C., & Mathew, S. J. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2013.12.014 · Cited by 28 · see citing works
Obesity in women who have experienced intimate partner violence
Alhalal, E. (2018) · Journal of Advanced Nursing · doi:10.1111/jan.13797 · Cited by 24 · see citing works
Marshall, L. Z., Gleason, P. P., Friedlander, N., Farley, J., & Urick, B. Y. (2026) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2026.32.3.281 · Cited by 6 · see citing works
- Authors
- Mitchell, N. S., Catenacci, V. A., Wyatt, H. R., & Hill, J. O.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Mitchell, Nia S.
- Venue
- Psychiatric Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 34
- Issue
- 4
- Pages
- 717-732
- ISSN
- 0193-953X (ISSN-L)
- PMC
- PMC3228640
- OpenAlex
- W1996489989
- Cited by
- 526
- References
- 96
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 39 · 2023: 35 · 2022: 29 · 2021: 58 · 2020: 58 · 2019: 45 · 2018: 45 · 2017: 45 · 2016: 24 · 2015: 31 · 2014: 35 · 2013: 20 · 2012: 15
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatric Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK48520, R01DK042549, DK 02703, K23DK078913, DK-42549, R01DK071692, R37DK042549, K23DK002703, P30DK048520)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Health Professions › Pharmacy › Obesity and Health Practices
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- obesity epidemic, energy balance, obesity prevention, physical activity, sedentary behavior, environmental change, social change, school-based intervention, food marketing, community design, public health policy, behavior change, energy requirements, weight maintenance, social determinants of health, food environment, built environment
- MeSH terms
- Energy Metabolism, Ethnicity, Feeding Behavior, Female, Humans, Life Style, Male, Motor Activity, Obesity, Public Health, Social Environment, Socioeconomic Factors, United States, Weight Gain, Prevalence, Epidemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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